Cell & Tissue Biomedical Research

Research Output

2016

Could cancer drugs provide ammunition against aging?

Slack, C., Alic, N. & Partridge, L., 17 Jan 2016, In : Cell Cycle. 15, 2, p. 153-155 3 p.

Research output: Contribution to journalEditorial

Designing liposomal adjuvants for the next generation of vaccines

Perrie, Y., Crofts, F., Devitt, A., Griffiths, H. R., Kastner, E. & Nadella, V., 1 Apr 2016, In : Advanced Drug Delivery Reviews. 99, Part A, p. 85-96 12 p.

Research output: Contribution to journalArticle

Open Access
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Drug development: the cell wall as a drug target

Cox, J. A. G., Dec 2016, In : International Journal of Mycobacteriology. 5, Supplement 1, p. S156 1 p.

Research output: Contribution to journalConference abstract

Open Access
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Open Access
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Future glucose-lowering drugs for type 2 diabetes

Bailey, C. J., Tahrani, A. A. & Barnett, A. H., 23 Jan 2016, In : The Lancet Diabetes and Endocrinology. 4, 4, p. 350-359 10 p.

Research output: Contribution to journalReview article

Open Access
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Generation of antibodies with varying sequence specifity for Oxidatively-modified peptides from human fibrinogen

Meredith, S. P., Parekh, G., Schouten, J., Wilkins, J., Griffiths, H. R., Davis, P. & Spickett, C. M., 1 Jul 2016, p. S28.

Research output: Contribution to conferenceAbstract

Glycated hemoglobin, body weight and blood pressure in type 2 diabetes patients initiating dapagliflozin treatment in primary care: a retrospective study

Wilding, J., Bailey, C., Rigney, U., Blak, B., Beekman, W. & Emmas, C., 1 Sep 2016, In : Diabetes Therapy. 7, 4, p. 695-711 17 p.

Research output: Contribution to journalArticle

Open Access
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Health and population effects of rare gene knockouts in adult humans with related parents

Narasimhan, V. M., Hunt, K. A., Mason, D., Baker, C. L., Karczewski, K. J., Barnes, M. R., Barnett, A. H., Bates, C., Bellary, S., Bockett, N. A., Giorda, K., Griffiths, C. J., Hemingway, H., Jia, Z., Kelly, M. A., Khawaja, H. A., Lek, M., McCarthy, S., McEachan, R., O’Donnell-Luria, A. & 16 others, Paigen, K., Parisinos, C. A., Sheridan, E., Southgate, L., Tee, L., Thomas, M., Xue, Y., Schnall-Levin, M., Petkov, P. M., Tyler-Smith, C., Maher, E. R., Trembath, R. C., MacArthur, D. G., Wright, J., Durbin, R. & van Heel, D. A., 1 Apr 2016, In : Science. 352, 6284, p. 474-477 8 p.

Research output: Contribution to journalArticle

Identification of KasA as the cellular target of an anti-tubercular scaffold

Abrahams, K. A., Chung, C-W., Ghidelli-Disse, S., Rullas, J., Rebollo-López, M. J., Gurcha, S. S., Cox, J. A. G., Mendoza, A., Jiménez-Navarro, E., Martínez-Martínez, M. S., Neu, M., Shillings, A., Homes, P., Argyrou, A., Casanueva, R., Loman, N. J., Moynihan, P. J., Lelièvre, J., Selenski, C., Axtman, M. & 10 others, Kremer, L., Bantscheff, M., Angulo-Barturen, I., Izquierdo, M. C., Cammack, N. C., Drewes, G., Ballell, L., Barros, D., Besra, G. S. & Bates, R. H., 1 Sep 2016, In : Nature Communications. 7, 13 p., 12581.

Research output: Contribution to journalArticle

Open Access
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Innovative biomarkers for predicting type 2 diabetes mellitus: relevance to dietary management of frailty in older adults

Ikwuobe, J., Bellary, S. & Griffiths, H. R., 1 Jun 2016, In : Biogerontology. 17, 3, p. 511–527 17 p.

Research output: Contribution to journalArticle

Investigation of the enhanced antimicrobial activity of combination dry powder inhaler formulations of lactoferrin

Marshall, L. J., Oguejiofor, W., Price, R. & Shur, J., 5 Dec 2016, In : International Journal of Pharmaceutics. 514, 2, p. 399-406 8 p.

Research output: Contribution to journalArticle

Open Access

Isopeptidase activity of human transglutaminase 2: disconnection from transamidation and characterization by kinetic parameters

Kiraly, R., Thangaraju, K., Nagy, Z., Collighan, R., Nemes, Z., Griffin, M. & Fésüs, L., Jan 2016, In : Amino Acids. 48, 1, p. 31-40 10 p.

Research output: Contribution to journalArticle

Open Access
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Lithium promotes longevity through GSK3/NRF2-dependent hormesis

Castillo-Quan, J. I., Li, L., Kinghorn, K. J., Ivanov, D. K., Tain, L. S., Slack, C., Kerr, F., Nespital, T., Thornton, J., Hardy, J., Bjedov, I. & Partridge, L., 19 Apr 2016, In : Cell Reports. 15, 3, p. 638-650 13 p.

Research output: Contribution to journalArticle

Open Access
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Mass spectrometry based method for measurement of oxysterols

Dias, I. H. K., Milic, I., Devitt, A., Spickett, C. M., Pitt, A. R. & Griffiths, H. R., 1 Jul 2016, p. S27.

Research output: Contribution to conferenceAbstract

Metformin and the gastrointestinal tract

McCreight, L. J., Bailey, C. J. & Pearson, E. R., 1 Mar 2016, In : Diabetologia. 59, 3, p. 426-435 10 p.

Research output: Contribution to journalArticle

Open Access
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Microwave decontamination of eyelid warming devices for the treatment of meibomian gland dysfunction

Bilkhu, P., Wolffsohn, J. S., Hilton, A., Matthews, G., Legood, S. & Riley, L., Aug 2016, In : Contact Lens and Anterior Eye. 39, 4, p. 293–297 5 p.

Research output: Contribution to journalArticle

Open Access
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NKG2D ligands mediate immunosurveillance of senescent cells

Sagiv, A., Burton, D. G. A., Moshayev, Z., Vadai, E., Wensveen, F., Ben-Dor, S., Golani, O., Polic, B. & Krizhanovsky, V., 13 Feb 2016, In : Aging. 8, 2, p. 328-344 17 p.

Research output: Contribution to journalArticle

Open Access
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Novel, isoform-selective, cholecystokinin A receptor antagonist inhibits colon and pancreatic cancers in preclinical models through novel mechanism of action

Ponnusamy, S., Lattmann, E., Lattmann, P., Thiyagarajan, T., Padinjarethalakal, B. N. & Narayanan, R., Apr 2016, In : Oncology Reports. 35, 4, p. 2097-2106 10 p.

Research output: Contribution to journalArticle

Open Access
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Novel inhibitors of Mycobacterium tuberculosis GuaB2 identified by a target based high-throughput phenotypic screen

Cox, J. A. G., Mugumbate, G., Vela-Glez del Peral, L., Jankute, M., Abrahams, K. A., Jervis, P., Jackenkroll, S., Perez, A., Alemparte, C., Esquivias, J., Lelièvre, J., Ramon, F., Barros, D., Ballell, L. & Besra, G. S., 16 Dec 2016, In : Scientific Reports. 6, 10 p., 38986.

Research output: Contribution to journalArticle

Open Access
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Overweight status is associated with extensive signs of microvascular dysfunction and cardiovascular risk

Patel, S. R., Bellary, S., Karimzad, S. & Gherghel, D., 31 Aug 2016, In : Scientific Reports. 6, 8 p., 32282.

Research output: Contribution to journalArticle

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Perfluorocarbons: potential for successful expansion of bone marrow-derived human mesenchymal stem cells in a liquid/liquid two phase system

Hanga, M. P., Coopman, K., Nienow, A. W. & Hewitt, C., 6 Jul 2016, In : European Cells and Materials. 32, Suppl.4, p. 30 1 p.

Research output: Contribution to journalConference abstract

Open Access
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Pharmacology and therapeutic implications of current drugs for type 2 diabetes mellitus

Tahrani, A. A., Barnett, A. H. & Bailey, C. J., Oct 2016, In : Nature Reviews Endocrinology. 12, 10, p. 566–592 27 p.

Research output: Contribution to journalReview article

Open Access
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Preventing hypoglycaemia: an elusive quest

Sinclair, A. J. & Bellary, S., Aug 2016, In : The Lancet Diabetes and Endocrinology. 4, 8, p. 635-636 2 p.

Research output: Contribution to journalComment/debate

Open Access
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Regulation of ribosomal RNA expression across the lifespan is fine-tuned by maternal diet before implantation

Denisenko, O., Lucas, E. S., Sun, C., Watkins, A. J., Mar, D., Brmsztyk, K. & Fleming, T. P., Jul 2016, In : BBA Gene Regulatory Mechanisms. 1859, 7, p. 906–913 8 p.

Research output: Contribution to journalArticle

Open Access
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Sensor and software use for the glycaemic management of insulin-treated type 1 and type 2 diabetes patients

Ajjan, R. A., Abougila, K., Bellary, S., Collier, A., Franke, B., Jude, E. B., Rayman, G., Robinson, A. & Singh, B. M., 1 May 2016, In : Diabetes and Vascular Disease Research. 13, 3, p. 211-219 9 p.

Research output: Contribution to journalArticle

Sporulation of Clostridium difficile in aerobic conditions is significantly protracted when exposed to sodium taurocholate

Worthington, T. & Hilton, A. C., 31 May 2016, In : Journal of Medical Microbiology & Diagnosis. 5, 2, 4 p., 230.

Research output: Contribution to journalArticle

Open Access
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Stem cell-derived astrocytes: are they physiologically credible?

Hill, E., Nagel, D., Parri, R. & Coleman, M., 15 Nov 2016, In : Journal of Physiology. 594, 22, p. 6595-6606 12 p.

Research output: Contribution to journalBook/Film/Article review

Open Access
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The antimicrobial activity of human adipose tissue derived MSCs

Wood, C. R., Al Dhahri, D., Al-Delfi, I., Sammons, R. L., Worthington, A., Haddow, D. B. & Johnson, W. E. B., 1 Dec 2016, In : International Journal of Experimental Pathology. 97, 6, p. A22

Research output: Contribution to journalConference abstract

The development of a dynamically perfused system for models of the human airways, with automated feeding and sampling capability

Leslie, L. J., Lloyd, H. & Marshall, L. J., 2016, p. P11.

Research output: Contribution to conferencePoster

The effect of oxidative stress on thioredoxin1 distribution and associated binding partners in T cells

Remtulla, A., Torrao, R., Wilmot, C. & Griffiths, H., 1 Jul 2016, p. S40-S41.

Research output: Contribution to conferenceAbstract

The emergence of frailty and sarcopaenia in diabetes mellitus: Description of inter-relationships and clinical importance

Sinclair, A. J., Sinclair, H., Bellary, S. & Rodriguez-Manas, L., 1 Apr 2016, In : Cardiovascular Endocrinology. 5, 2, p. 40-50 11 p.

Research output: Contribution to journalReview article

The harder you run, the longer (and smoother) the road: exercise, muscle and ageing

Close, G. L. & Brown, J. E., 30 Jun 2016, In : Biogerontology. 17, 3, p. 431-433 3 p.

Research output: Contribution to journalEditorial

The housefly Musca domestica as a mechanical vector of Clostridium difficile

Davies, M. P., Anderson, M. & Hilton, A. C., Nov 2016, In : Journal of Hospital Infection. 94, 3, p. 263-267 5 p.

Research output: Contribution to journalArticle

Open Access
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The impact of bariatric surgery on estimated glomerular filtration rate in patients with type 2 diabetes: a retrospective cohort study

Mirajkar, N., Bellary, S., Ahmed, M., Singhal, R., Daskalakis, M. & Tahrani, A. A., 8 Aug 2016, In : Surgery for Obesity and Related Diseases. In press

Research output: Contribution to journalArticle

The influence of pH and fluid dynamics on the antibacterial efficacy of 45S5 Bioglass

Begum, S., Johnson, E., Worthington, T. & Martin, R. A., 2 Feb 2016, In : Biomedical Materials. 11, 1, 9 p., 015006.

Research output: Contribution to journalArticle

Open Access
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The Nrf2 activator methyl bardoxolone exacerbates mitochondrial dysfunction in palmitate-treated breast cancer cells

Refaat, A., Pararasa, C., Brown, J., Ali, A. & Griffiths, H. R., 1 Jul 2016, p. S32-S33.

Research output: Contribution to conferenceAbstract

THPP target assignment reveals EchA6 as an essential fatty acid shuttle in mycobacteria

Cox, J. A. G., Abrahams, K. A., Alemparte, C., Ghidelli-Disse, S., Rullas, J., Angulo-Barturen, I., Singh, A., Gurcha, S. S., Nataraj, V., Bethell, S., Remuiñán, M. J., Encinas, L., Jervis, P. J., Cammack, N. C., Bhatt, A., Kruse, U., Bantscheff, M., Fütterer, K., Barros, D., Ballell, L. & 2 others, Drewes, G. & Besra, G. S., 18 Jan 2016, In : Nature Microbiology. 1, 15006.

Research output: Contribution to journalArticle

Open Access
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Timely intervention in type 2 diabetes: achieving early and sustained glycemic control

Bailey, C. J., 1 Jan 2016, Medicographia, 38, 1, p. 3-8 6 p.

Research output: Contribution to specialist publicationEditorial

Towards an in-vitro multi-cellular human airways model for evaluating the effects of Electronic cigarettes

Vasanthi Bathri Narayanan, P., Leslie, L. J., Brown, J. E. & Marshall, L. J., 2016, p. P20.

Research output: Contribution to conferencePoster

Towards ethical framework for personal care robots: Review and reflection

Mansouri, N. & Goher, K., 19 Sep 2016, In : Asian Social Science. 12, 10, p. 152-162 11 p.

Research output: Contribution to journalReview article

Open Access
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Under-treatment of type 2 diabetes: causes and outcomes of clinical inertia

Bailey, C. J., Dec 2016, In : International Journal of Clinical Practice. 70, 12, p. 988-995 8 p.

Research output: Contribution to journalReview article

2015

Ageing, adipose tissue, fatty acids and inflammation

Pararasa, C., Bailey, C. J. & Griffiths, H. R., Jan 2015, In : Biogerontology. 16, 2, p. 235-248 14 p.

Research output: Contribution to journalArticle

Open Access
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Amyloid β 1-42 induces hypometabolism in human stem cell-derived neuron and astrocyte networks

Tarczyluk, M. A., Nagel, D. A., Parri, H. R., Tse, E. H. Y., Brown, J. E., Coleman, M. D. & Hill, E. J., 1 Aug 2015, In : Journal of Cerebral Bood Fow and Metabolism. 35, 8, p. 1348-1357 10 p.

Research output: Contribution to journalArticle

Open Access
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An in vitro comparison of the incorporation, growth, and chondrogenic potential of human bone marrow versus adipose tissue mesenchymal stem cells in clinically relevant cell scaffolds used for cartilage repair

Kohli, N., Wright, K. T., Sammons, R. L., Jeys, L., Snow, M. & Johnson, W. E. B., 1 Oct 2015, In : Cartilage. 6, 4, p. 252-263 12 p.

Research output: Contribution to journalArticle

Open Access

Ankyrin is the major oxidised protein in erythrocyte membranes from end-stage renal disease patients on chronic haemodialysis and oxidation is decreased by dialysis and vitamin C supplementation

Ruskovska, T., Bennett, S. J., Brown, C. R., Dimitrov, S., Kamcev, N. & Griffiths, H. R., 1 Feb 2015, In : Free Radical Research. 49, 2, p. 175-185 11 p.

Research output: Contribution to journalArticle

Open Access
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Anticancer effects of Curcuma C20-dialdehyde against colon and cervical cancer cell lines

Chaithongyot, S., Asgar, A., Senawong, G., Yowapuy, A., Lattmann, E., Sattayasai, N. & Senawong, T., 6 Oct 2015, In : Asian Pacific Journal of Cancer Prevention. 16, 15, p. 6513-6519 7 p.

Research output: Contribution to journalArticle

Open Access
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A predictive in vitro model of the impact of drugs with anticholinergic properties on human neuronal and astrocytic systems

Woehrling, E. K., Parri, H. R., Tse, E. H. Y., Hill, E. J., Maidment, I. D., Fox, G. C. & Coleman, M. D., 4 Mar 2015, In : PLoS ONE. 10, 3, 18 p., e0118786.

Research output: Contribution to journalArticle

Open Access
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Cardiovascular outcome trials in type 2 diabetes – 2015

Day, C. & Bailey, C. J., 2015, Diabesity in practice, 4, 4, p. 131-133 3 p.

Research output: Contribution to specialist publicationBook/Film/Article review

CD4+ T cell surface alpha enolase is lower in older adults

Bennett, S. J., Augustyniak, E. M., Dunston, C. R., Brown, R. A., Shantsila, E., Lip, G. Y. H., Torrão, R. D. C., Pararasa, C., Hussein, A. R., Ladouce, R., Friguet, B. & Griffiths, H. R., Dec 2015, In : Mechanisms of Ageing and Development. 152, p. 56–62 7 p.

Research output: Contribution to journalArticle

Open Access
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