Cell & Tissue Biomedical Research

Research Output

2015

Changes in HbA1c and weight in type 2 diabetes patients initiating dapagliflozin treatment in routine UK primary care

Wilding, J. P. H., Bailey, C. J., Rigney, U., Blak, B., Beekman, W. & Emmas, C. E., Sep 2015, In : Diabetologia. 58, Suppl.1, p. S352-S356 2 p., 737.

Research output: Contribution to journalConference abstract

Description and preliminary results from a structured specialist behavioural weight management group intervention: Specialist Lifestyle Management (SLiM) programme

Brown, A., Gouldstone, A., Fox, E., Field, A., Todd, W., Shakher, J., Bellary, S., Teh, M. M., Azam, M., John, R., Jagielski, A., Arora, T., Thomas, G. N. & Taheri, S., 8 Apr 2015, In : BMJ Open. 5, 4, 10 p., e007217.

Research output: Contribution to journalArticle

Open Access
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Developing accurate models of the human airways

Marshall, L. J., Oguejiofor, W., Willetts, R. S., Griffiths, H. R. & Devitt, A., 2015, In : Journal of Pharmacy and Pharmacology. 67, 3, p. 464-472 9 p.

Research output: Contribution to journalArticle

Open Access
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Development of potent and selective tissue transglutaminase inhibitors: their effect on TG2 function and application in pathological conditions

Badarau, E., Wang, Z., Rathbone, D. L., Costanzi, A., Thibault, T., Murdoch, C. E., El Alaoui, S., Bartkeviciute, M. & Griffin, M., 22 Oct 2015, In : Chemistry and Biology. 22, 10, p. 1347-1361 15 p.

Research output: Contribution to journalArticle

Open Access
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Do little embryos make big decisions? How maternal dietary protein restriction can permanently change an embryo's potential, affecting adult health

Fleming, T. P., Watkins, A. J., Sun, C., Velazquez, M. A., Smyth, N. R. & Eckert, J. J., 3 Mar 2015, In : Reproduction, fertility and development. 27, 4, p. 684-692 9 p.

Research output: Contribution to journalArticle

Open Access
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Early transplantation of mesenchymal stem cells after spinal cord injury relieves pain hypersensitivity through suppression of pain-related signaling cascades and reduced inflammatory cell recruitment

Watanabe, S., Uchida, K., Nakajima, H., Matsuo, H., Sugita, D., Yoshida, A., Honjoh, K., Johnson, W. E. B. & Baba, H., 30 Jun 2015, In : Stem cells. 33, 6, p. 1902-1914 13 p.

Research output: Contribution to journalArticle

Open Access
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Efficacy and safety of dapagliflozin monotherapy in people with Type 2 diabetes: a randomized double-blind placebo-controlled 102-week trial

Bailey, C. J., Morales Villegas, E. C., Woo, V., Tang, W., Ptaszynska, A. & List, J. F., 30 Apr 2015, In : Diabetic Medicine. 32, 4, p. 531-541 11 p.

Research output: Contribution to journalArticle

Enhancing vaccine design strategies: applications for protein science, proteomics and adjuvants

Perrie, Y., Griffiths, H. R. & Jones, D., Mar 2015, In : Journal of Pharmacy and Pharmacology. 67, 3, p. 287-289 3 p.

Research output: Contribution to journalEditorial

Evaluating E-cigarette cytotoxicity in-vitro

Vasanthi Bathri Narayanan, P., Leslie, L. J. & Marshall, L. J., 2015.

Research output: Contribution to conferencePoster

Evaluating the evidence for targeting FOXO3a in breast cancer: a systematic review

Taylor, S., Lam, M., Pararasa, C., Brown, J. E. P., Carmichael, A. R. & Griffiths, H. R., 2015, In : Cancer Cell International. 15, 1, 9 p.

Research output: Contribution to journalArticle

Open Access
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Follicular helper T cell signature in type 1 diabetes

Kenefeck, R., Wang, C. J., Kapadi, T., Wardzinski, L., Attridge, K., Clough, L. E., Heuts, F., Kogimtzis, A., Patel, S., Rosenthal, M., Ono, M., Sansom, D. M., Narendran, P. & Walker, L. S. K., 2 Jan 2015, In : Journal of Clinical Investigation. 125, 1, p. 292-303 12 p.

Research output: Contribution to journalArticle

Formulation of Biologically-Inspired Silk-Based Drug Carriers for Pulmonary Delivery Targeted for Lung Cancer

Kim, S. Y., Naskar, D., Kundu, S. C., Bishop, D. P., Doble, P. A., Boddy, A. V., Chan, H-K., Wall, I. B. & Chrzanowski, W., 3 Aug 2015, In : Scientific Reports. 5, 11878.

Research output: Contribution to journalArticle

Open Access
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Human mesenchymal stem cells stimulate EaHy926 endothelial cell migration: combined proteomic and in vitro analysis of the influence of donor-donor variability

Walter, M. N. M., Kohli, N., Khan, N., Major, T., Fuller, H., Wright, K. T., Kuiper, J-H. & Johnson, W. E. B., 30 May 2015, In : Journal of Stem Cells and Regenerative Medicine. 11, 1, p. 18-24 7 p.

Research output: Contribution to journalArticle

Open Access
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Improving T cell-induced response to subunit vaccines: opportunities for a proteomic systems approach

Dunston, C. R., Herbert, R. & Griffiths, H. R., 2015, In : Journal of Pharmacy and Pharmacology. 67, 3, p. 290-299 10 p.

Research output: Contribution to journalArticle

Open Access
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Investigating the ability of antibodies to recognize specific oxidized protein epitopes

Meredith, S., Spickett, C., Parekh, G., Schouten, J., Griffiths, H. & Davis, P., Sep 2015, In : Free Radical Biology and Medicine. 86, Suppl.1, p. S31 1 p., PP36.

Research output: Contribution to journalConference abstract

Investigating the prevalence of Salmonella in dogs within the Midlands region of the United Kingdom

Lowden, P., Wallis, C., Gee, N. & Hilton, A., 17 Sep 2015, In : BMC Veterinary Research. 11, 6 p., 239.

Research output: Contribution to journalArticle

Open Access
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LDL-Lipids from patients with hypercholesterolaemia and Alzheimer's disease are inflammatory to microvascular endothelial cells: mitigation by statin intervention

Dias, I. H. K., Brown, C. L. R., Polidori-Nelles, M. C., Lip, G. Y. H. & Griffiths, H. R., 1 Dec 2015, In : Clinical Science. 129, 12, p. 1195-1206 12 p.

Research output: Contribution to journalArticle

Open Access
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Low gravity rotational culture and the integration of immunomodulatory stem cells reduce human islet allo-reactivity

Qureshi, K. M., Lee, J., Paget, M. B., Bailey, C. J., Curnow, S. J., Murray, H. E. & Downing, R., Jan 2015, In : Clinical Transplantation. 29, 1, p. 90-98 9 p.

Research output: Contribution to journalArticle

MARK-AGE biomarkers of ageing

Bürkle, A., Moreno-Villanueva, M., Bernhard, J., Blasco, M., Zondag, G., Hoeijmakers, J. H. J., Toussaint, O., Grubeck-Loebenstein, B., Mocchegiani, E., Collino, S., Gonos, E. S., Sikora, E., Gradinaru, D., Dollé, M., Salmon, M., Kristensen, P., Griffiths, H. R., Libert, C., Grune, T., Breusing, N. & 10 others, Simm, A., Franceschi, C., Capri, M., Talbot, D., Caiafa, P., Friguet, B., Slagboom, P. E., Hervonen, A., Hurme, M. & Aspinall, R., Nov 2015, In : Mechanisms of Ageing and Development. 151, p. 2-12 11 p.

Research output: Contribution to journalArticle

Open Access
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Maternal nutrition modifies trophoblast giant cell phenotype and fetal growth in mice

Watkins, A. J., Lucas, E. S., Marfy-Smith, S., Bates, N., Kimber, S. J. & Fleming, T. P., 1 Jun 2015, In : Human Reproduction. 149, 6, p. 563-575 13 p.

Research output: Contribution to journalArticle

Open Access
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Microfluidic-controlled manufacture of liposomes for the solubilisation of a poorly water soluble drug

Kastner, E., Verma, V., Lowry, D. & Perrie, Y., 15 May 2015, In : International Journal of Pharmaceutics. 485, 1-2, p. 122-130 9 p.

Research output: Contribution to journalArticle

Open Access
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Novel ageing-biomarker discovery using data-intensive technologies

Griffiths, H. R., Augustyniak, E. M., Bennett, S. J., Debacq-Chainiaux, F., Dunston, C. R., Kristensen, P., Melchjorsen, C. J., Navarrete, S. A., Simm, A. & Toussaint, O., 2015, In : Mechanisms of Ageing and Development. 151, p. 114-121 8 p.

Research output: Contribution to journalArticle

Open Access
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Pericytes contribute to airway remodeling in a mouse model of chronic allergic asthma

Johnson, J. R., Folestad, E., Rowley, J. E., Noll, E. M., Walker, S. A., Lloyd, C. M., Rankin, S. M., Pietras, K., Eriksson, U. & Fuxe, J., 1 Apr 2015, In : AJP: Lung Cellular and Molecular Physiology. 308, 7, p. L658-L671 14 p.

Research output: Contribution to journalArticle

Open Access
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Pharmacotherapies to manage diabesity: an update

Day, C. & Bailey, C. J., 2015, In : Diabesity in practice. 4, 1, p. 14-23 10 p.

Research output: Contribution to journalArticle

Poly(N-isopropylacrylamide-co-allylamine) (PNIPAM-co-ALA) nanospheres for the thermally triggered release of Bacteriophage K

Hathaway, H., Alves, D. R., Bean, J., Perez Esteban, P., Ouadi, K., Mark Sutton, J. & Jenkins, A. T. A., 1 Oct 2015, In : European Journal of Pharmaceutics and Biopharmaceutics. 96, p. 437-441 5 p.

Research output: Contribution to journalArticle

Redox control of protein degradation

Pajares, M., Jiménez-Moreno, N., Dias, I. H. K., Debelec, B., Vucetic, M., Fladmark, K. E., Basaga, H., Ribaric, S., Milisav, I. & Cuadrado, A., Dec 2015, In : Redox biology. 6, p. 409-420 12 p.

Research output: Contribution to journalArticle

Open Access
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Safety of antidiabetes medications: an update

Bailey, C. J., 31 Aug 2015, In : Clinical pharmacology and therapeutics. 98, 2, p. 185–195 11 p.

Research output: Contribution to journalArticle

Screening for albuminuria in diabetes: the need to do more

Vamvakopoulos, J., John, R., Karri, S. R. & Bellary, S., 11 Mar 2015, In : Diabetic Medicine. 32, Suppl.1, p. 171 1 p., P465.

Research output: Contribution to journalConference abstract

Serum α-tocopherol has a nonlinear inverse association with periodontitis among US adults

Zong, G., Scott, A. E., Griffiths, H. R., Zock, P. L., Dietrich, T. & Newson, R. S., 1 May 2015, In : Journal of Nutrition. 145, 5, p. 893-899 7 p.

Research output: Contribution to journalArticle

Serum α-tocopherol has a nonlinear inverse association with periodontitis among US adults

Zong, G., Scott, A., Griffiths, H., Zock, P., Dietrich, T. & Newson, R., 1 Sep 2015, In : Free Radical Biology and Medicine. 86, Suppl.1, p. S41-S42 2 p., PP67.

Research output: Contribution to journalConference abstract

Statnote 40: Cochran's Q test

Armstrong, R. & Hilton, A., 1 Mar 2015, Microbiologist, 16, 1, p. 31-33 3 p.

Research output: Contribution to specialist publicationArticle

TG2: a credible therapeutic target in fibrotic diseasedue to its multifunctional roles

Griffin, M., Wang, Z., Thibault, T., Murdoch, C. & Rathbone, D., 31 Aug 2015, In : Amino Acids. 47, 8, p. 1629 1 p.

Research output: Contribution to journalConference abstract

The current drug treatment landscape for diabetes and perspectives for the future

Bailey, C. J., 31 Aug 2015, In : Clinical pharmacology and therapeutics. 98, 2, p. 170–184 15 p.

Research output: Contribution to journalArticle

Open Access
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The development of functional astrocyte-neuron networks derived from stem cells

Hill, E. J., 2015.

Research output: Contribution to conferenceAbstract

Open Access

The effect of the senescence-associated secretory phenotype (SASP) on glucose homeostasis in metabolic cells

Rana, K. S., Hill, E. J., Bellary, S. & Brown, J. E., 11 Mar 2015, In : Diabetic Medicine. 32, Suppl.1, p. 93-94 2 p., P208.

Research output: Contribution to journalConference abstract

The interconnectedness of ageing: does the convoy principal apply?

Saffrey, J. & Brown, J. E., Apr 2015, In : Biogerontology. 16, 2, p. 131-132 2 p.

Research output: Contribution to journalArticle

Open Access
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The Nrf2-ARE activation protect neurones against oxidative stress

Dias, I. H. K., Ademowo, O. S., Newey, E. & Griffiths, H. R., Sep 2015, In : Free Radical Biology and Medicine. 86, Suppl.1, p. S30-S31 2 p., PP34.

Research output: Contribution to journalConference abstract

The Ras-Erk-ETS-signaling pathway is a drug target for longevity

Slack, C., Alic, N., Foley, A., Cabecinha, M., Hoddinott, M. P. & Partridge, L., 2 Jul 2015, In : Cell. 162, 1, p. 72-83 12 p.

Research output: Contribution to journalArticle

Open Access
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Thiol redox homeostasis in neurodegenerative disease

McBean, G. J., Aslan, M., Griffiths, H. R. & Torrão, R. C., Aug 2015, In : Redox biology. 5, p. 186-194 9 p.

Research output: Contribution to journalArticle

Open Access
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Transglutaminase 2 interacts with syndecan-4 and CD44 at the surface of human macrophages to promote removal of apoptotic cells

Nadella, V., Wang, Z., Johnson, T. S., Griffin, M. & Devitt, A., Jan 2015, In : BBA - Molecular Cell Research. 1853, 1, p. 201-212 12 p.

Research output: Contribution to journalArticle

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Validation of protein carbonyl measurement: a multi-centre study

Augustyniak, E., Adam, A., Wojdyla, K., Rogowska-Wrzesinska, A., Willetts, R., Korkmaz, A., Atalay, M., Weber, D., Grune, T., Borsa, C., Gradinaru, D., Chand Bollineni, R., Fedorova, M. & Griffiths, H., May 2015, In : Redox biology. 4, p. 149–157 9 p.

Research output: Contribution to journalArticle

Open Access
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2014

36 monocyte subpopulations counts and associations with global longitudinal strain in st-elevation myocardial infarction patients with normal ejection fraction

Ghattas, A., Shantsila, E., Griffiths, H. & Lip, G., 30 Jun 2014, In : Heart. 100, Suppl.3, p. A19-A20 2 p.

Research output: Contribution to journalArticle

Altered hMSC functional characteristics in short-term culture and when placed in low oxygen environments: implications for cell retention at physiologic sites

Bain, O., Detela, G., Kim, H-W., Mason, C., Mathur, A. & Wall, I. B., 31 Mar 2014, In : Regenerative medicine. 9, 2, p. 153-165 13 p.

Research output: Contribution to journalArticle

An almond-enriched diet increases plasma α-tocopherol and improves vascular function but does not affect oxidative stress markers or lipid levels

Choudhury, K., Clark, J. & Griffiths, H. R., May 2014, In : Free Radical Research. 48, 5, p. 599-606 8 p.

Research output: Contribution to journalArticle

Open Access
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Analysis of protein carbonylation - pitfalls and promise in commonly used methods

Rogowska-Wrzesinska, A., Wojdyla, K., Nedić, O., Baron, C. P. & Griffiths, H. R., 2014, In : Free Radical Research. 48, 10, p. 1145-1162 18 p.

Research output: Contribution to journalArticle

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A novel role of plasma membrane calcium atpase 4 as a negative-regulator of VEGF-induced angiogenesis

Baggott, R. R., Alfranca, A., López-Maderuelo, M., Mohamed, T. M. A., Escolano, A., Oller, J., Ornés, B. C., Rowther, F., Oceandy, D., Kurusamy, S., Brown, J., Cartwright, E. J., Wang, W., Gómez-del Arco, P., Martínez-Martínez, S., Neyses, L., Redondo, J. M. & Armesilla, A. L., 1 Dec 2014, In : Heart. 100, Suppl.4, p. A17-A17 1 p., 050.

Research output: Contribution to journalConference abstract

A role for epigenetic modulation of the innate immune response during aging

Killick, J. W., Bennett, S. J., Dias, I. H. K., Dunston, C. R. & Griffiths, H. R., 4 Nov 2014, Immunology of aging. Massoud, A. & Rezaei, N. (eds.). Berlin (DE): Springer, p. 37-45 9 p.

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

Aspirin and aspirin analogs on esophageal cancer

Kilari, R. S., Perry, C. J., Devitt, A., Safrany, S. T. & Nicholl, I. D., 1 Oct 2014, In : Cancer Research. 74, 19 Supplement, 1 p., Abstract 2527.

Research output: Contribution to journalConference abstract