Cell & Tissue Biomedical Research

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2016

Canine mesenchymal stem cells are neurotrophic and angiogenic: an in vitro assessment of their paracrine activity

Al Delfi, I. R., Sheard, J. J., Wood, C. R., Vernallis, A., Innes, J. F., Myint, P. & Johnson, W. E. B., Nov 2016, In : Veterinary Journal. 217, p. 10-17 8 p.

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Characterization of microvesicles released from human red blood cells

Nguyen, D. B., Thuy Ly, T. B., Wesseling, M. C., Hittinger, M., Torge, A., Devitt, A., Perrie, Y. & Bernhardt, I., 3 Apr 2016, In : Cellular Physiology and Biochemistry. 38, 3, p. 1085-1099 15 p.

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Characterization of neutrophil function in Papillon-Lefèvre syndrome

Roberts, H., White, P., Dias, I., McKaig, S., Veeramachaneni, R., Thakker, N., Grant, M. & Chapple, I., Aug 2016, In : Journal of Leukocyte Biology. 100, 2, p. 433-444 12 p.

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Cholecystokinin-1 receptor antagonists: 5-hydroxy-5-aryl-pyrrol-2-ones as anticancer agents

Lattmann, E., Russell, S. T., Schwalbe, C. H., Shortt, A., Balaram, P. N., Theochari, E., Alharbi, M., Narayanan, R. & Lattmann, P., 1 Jun 2016, In : MedChemComm. 7, 6, p. 1138-1145 8 p.

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Designing liposomal adjuvants for the next generation of vaccines

Perrie, Y., Crofts, F., Devitt, A., Griffiths, H. R., Kastner, E. & Nadella, V., 1 Apr 2016, In : Advanced Drug Delivery Reviews. 99, Part A, p. 85-96 12 p.

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Glycated hemoglobin, body weight and blood pressure in type 2 diabetes patients initiating dapagliflozin treatment in primary care: a retrospective study

Wilding, J., Bailey, C., Rigney, U., Blak, B., Beekman, W. & Emmas, C., 1 Sep 2016, In : Diabetes Therapy. 7, 4, p. 695-711 17 p.

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Health and population effects of rare gene knockouts in adult humans with related parents

Narasimhan, V. M., Hunt, K. A., Mason, D., Baker, C. L., Karczewski, K. J., Barnes, M. R., Barnett, A. H., Bates, C., Bellary, S., Bockett, N. A., Giorda, K., Griffiths, C. J., Hemingway, H., Jia, Z., Kelly, M. A., Khawaja, H. A., Lek, M., McCarthy, S., McEachan, R., O’Donnell-Luria, A. & 16 others, Paigen, K., Parisinos, C. A., Sheridan, E., Southgate, L., Tee, L., Thomas, M., Xue, Y., Schnall-Levin, M., Petkov, P. M., Tyler-Smith, C., Maher, E. R., Trembath, R. C., MacArthur, D. G., Wright, J., Durbin, R. & van Heel, D. A., 1 Apr 2016, In : Science. 352, 6284, p. 474-477 8 p.

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Identification of KasA as the cellular target of an anti-tubercular scaffold

Abrahams, K. A., Chung, C-W., Ghidelli-Disse, S., Rullas, J., Rebollo-López, M. J., Gurcha, S. S., Cox, J. A. G., Mendoza, A., Jiménez-Navarro, E., Martínez-Martínez, M. S., Neu, M., Shillings, A., Homes, P., Argyrou, A., Casanueva, R., Loman, N. J., Moynihan, P. J., Lelièvre, J., Selenski, C., Axtman, M. & 10 others, Kremer, L., Bantscheff, M., Angulo-Barturen, I., Izquierdo, M. C., Cammack, N. C., Drewes, G., Ballell, L., Barros, D., Besra, G. S. & Bates, R. H., 1 Sep 2016, In : Nature Communications. 7, 13 p., 12581.

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Innovative biomarkers for predicting type 2 diabetes mellitus: relevance to dietary management of frailty in older adults

Ikwuobe, J., Bellary, S. & Griffiths, H. R., 1 Jun 2016, In : Biogerontology. 17, 3, p. 511–527 17 p.

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Investigation of the enhanced antimicrobial activity of combination dry powder inhaler formulations of lactoferrin

Marshall, L. J., Oguejiofor, W., Price, R. & Shur, J., 5 Dec 2016, In : International Journal of Pharmaceutics. 514, 2, p. 399-406 8 p.

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Isopeptidase activity of human transglutaminase 2: disconnection from transamidation and characterization by kinetic parameters

Kiraly, R., Thangaraju, K., Nagy, Z., Collighan, R., Nemes, Z., Griffin, M. & Fésüs, L., Jan 2016, In : Amino Acids. 48, 1, p. 31-40 10 p.

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Lithium promotes longevity through GSK3/NRF2-dependent hormesis

Castillo-Quan, J. I., Li, L., Kinghorn, K. J., Ivanov, D. K., Tain, L. S., Slack, C., Kerr, F., Nespital, T., Thornton, J., Hardy, J., Bjedov, I. & Partridge, L., 19 Apr 2016, In : Cell Reports. 15, 3, p. 638-650 13 p.

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Metformin and the gastrointestinal tract

McCreight, L. J., Bailey, C. J. & Pearson, E. R., 1 Mar 2016, In : Diabetologia. 59, 3, p. 426-435 10 p.

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Microwave decontamination of eyelid warming devices for the treatment of meibomian gland dysfunction

Bilkhu, P., Wolffsohn, J. S., Hilton, A., Matthews, G., Legood, S. & Riley, L., Aug 2016, In : Contact Lens and Anterior Eye. 39, 4, p. 293–297 5 p.

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NKG2D ligands mediate immunosurveillance of senescent cells

Sagiv, A., Burton, D. G. A., Moshayev, Z., Vadai, E., Wensveen, F., Ben-Dor, S., Golani, O., Polic, B. & Krizhanovsky, V., 13 Feb 2016, In : Aging. 8, 2, p. 328-344 17 p.

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Novel, isoform-selective, cholecystokinin A receptor antagonist inhibits colon and pancreatic cancers in preclinical models through novel mechanism of action

Ponnusamy, S., Lattmann, E., Lattmann, P., Thiyagarajan, T., Padinjarethalakal, B. N. & Narayanan, R., Apr 2016, In : Oncology Reports. 35, 4, p. 2097-2106 10 p.

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Novel inhibitors of Mycobacterium tuberculosis GuaB2 identified by a target based high-throughput phenotypic screen

Cox, J. A. G., Mugumbate, G., Vela-Glez del Peral, L., Jankute, M., Abrahams, K. A., Jervis, P., Jackenkroll, S., Perez, A., Alemparte, C., Esquivias, J., Lelièvre, J., Ramon, F., Barros, D., Ballell, L. & Besra, G. S., 16 Dec 2016, In : Scientific Reports. 6, 10 p., 38986.

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Overweight status is associated with extensive signs of microvascular dysfunction and cardiovascular risk

Patel, S. R., Bellary, S., Karimzad, S. & Gherghel, D., 31 Aug 2016, In : Scientific Reports. 6, 8 p., 32282.

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Regulation of ribosomal RNA expression across the lifespan is fine-tuned by maternal diet before implantation

Denisenko, O., Lucas, E. S., Sun, C., Watkins, A. J., Mar, D., Brmsztyk, K. & Fleming, T. P., Jul 2016, In : BBA Gene Regulatory Mechanisms. 1859, 7, p. 906–913 8 p.

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Sensor and software use for the glycaemic management of insulin-treated type 1 and type 2 diabetes patients

Ajjan, R. A., Abougila, K., Bellary, S., Collier, A., Franke, B., Jude, E. B., Rayman, G., Robinson, A. & Singh, B. M., 1 May 2016, In : Diabetes and Vascular Disease Research. 13, 3, p. 211-219 9 p.

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Sporulation of Clostridium difficile in aerobic conditions is significantly protracted when exposed to sodium taurocholate

Worthington, T. & Hilton, A. C., 31 May 2016, In : Journal of Medical Microbiology & Diagnosis. 5, 2, 4 p., 230.

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The housefly Musca domestica as a mechanical vector of Clostridium difficile

Davies, M. P., Anderson, M. & Hilton, A. C., Nov 2016, In : Journal of Hospital Infection. 94, 3, p. 263-267 5 p.

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The impact of bariatric surgery on estimated glomerular filtration rate in patients with type 2 diabetes: a retrospective cohort study

Mirajkar, N., Bellary, S., Ahmed, M., Singhal, R., Daskalakis, M. & Tahrani, A. A., 8 Aug 2016, In : Surgery for Obesity and Related Diseases. In press

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The influence of pH and fluid dynamics on the antibacterial efficacy of 45S5 Bioglass

Begum, S., Johnson, E., Worthington, T. & Martin, R. A., 2 Feb 2016, In : Biomedical Materials. 11, 1, 9 p., 015006.

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THPP target assignment reveals EchA6 as an essential fatty acid shuttle in mycobacteria

Cox, J. A. G., Abrahams, K. A., Alemparte, C., Ghidelli-Disse, S., Rullas, J., Angulo-Barturen, I., Singh, A., Gurcha, S. S., Nataraj, V., Bethell, S., Remuiñán, M. J., Encinas, L., Jervis, P. J., Cammack, N. C., Bhatt, A., Kruse, U., Bantscheff, M., Fütterer, K., Barros, D., Ballell, L. & 2 others, Drewes, G. & Besra, G. S., 18 Jan 2016, In : Nature Microbiology. 1, 15006.

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2015

Ageing, adipose tissue, fatty acids and inflammation

Pararasa, C., Bailey, C. J. & Griffiths, H. R., Jan 2015, In : Biogerontology. 16, 2, p. 235-248 14 p.

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Amyloid β 1-42 induces hypometabolism in human stem cell-derived neuron and astrocyte networks

Tarczyluk, M. A., Nagel, D. A., Parri, H. R., Tse, E. H. Y., Brown, J. E., Coleman, M. D. & Hill, E. J., 1 Aug 2015, In : Journal of Cerebral Bood Fow and Metabolism. 35, 8, p. 1348-1357 10 p.

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An in vitro comparison of the incorporation, growth, and chondrogenic potential of human bone marrow versus adipose tissue mesenchymal stem cells in clinically relevant cell scaffolds used for cartilage repair

Kohli, N., Wright, K. T., Sammons, R. L., Jeys, L., Snow, M. & Johnson, W. E. B., 1 Oct 2015, In : Cartilage. 6, 4, p. 252-263 12 p.

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Ankyrin is the major oxidised protein in erythrocyte membranes from end-stage renal disease patients on chronic haemodialysis and oxidation is decreased by dialysis and vitamin C supplementation

Ruskovska, T., Bennett, S. J., Brown, C. R., Dimitrov, S., Kamcev, N. & Griffiths, H. R., 1 Feb 2015, In : Free Radical Research. 49, 2, p. 175-185 11 p.

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Anticancer effects of Curcuma C20-dialdehyde against colon and cervical cancer cell lines

Chaithongyot, S., Asgar, A., Senawong, G., Yowapuy, A., Lattmann, E., Sattayasai, N. & Senawong, T., 6 Oct 2015, In : Asian Pacific Journal of Cancer Prevention. 16, 15, p. 6513-6519 7 p.

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A predictive in vitro model of the impact of drugs with anticholinergic properties on human neuronal and astrocytic systems

Woehrling, E. K., Parri, H. R., Tse, E. H. Y., Hill, E. J., Maidment, I. D., Fox, G. C. & Coleman, M. D., 4 Mar 2015, In : PLoS ONE. 10, 3, 18 p., e0118786.

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CD4+ T cell surface alpha enolase is lower in older adults

Bennett, S. J., Augustyniak, E. M., Dunston, C. R., Brown, R. A., Shantsila, E., Lip, G. Y. H., Torrão, R. D. C., Pararasa, C., Hussein, A. R., Ladouce, R., Friguet, B. & Griffiths, H. R., Dec 2015, In : Mechanisms of Ageing and Development. 152, p. 56–62 7 p.

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Description and preliminary results from a structured specialist behavioural weight management group intervention: Specialist Lifestyle Management (SLiM) programme

Brown, A., Gouldstone, A., Fox, E., Field, A., Todd, W., Shakher, J., Bellary, S., Teh, M. M., Azam, M., John, R., Jagielski, A., Arora, T., Thomas, G. N. & Taheri, S., 8 Apr 2015, In : BMJ Open. 5, 4, 10 p., e007217.

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Developing accurate models of the human airways

Marshall, L. J., Oguejiofor, W., Willetts, R. S., Griffiths, H. R. & Devitt, A., 2015, In : Journal of Pharmacy and Pharmacology. 67, 3, p. 464-472 9 p.

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Development of potent and selective tissue transglutaminase inhibitors: their effect on TG2 function and application in pathological conditions

Badarau, E., Wang, Z., Rathbone, D. L., Costanzi, A., Thibault, T., Murdoch, C. E., El Alaoui, S., Bartkeviciute, M. & Griffin, M., 22 Oct 2015, In : Chemistry and Biology. 22, 10, p. 1347-1361 15 p.

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Do little embryos make big decisions? How maternal dietary protein restriction can permanently change an embryo's potential, affecting adult health

Fleming, T. P., Watkins, A. J., Sun, C., Velazquez, M. A., Smyth, N. R. & Eckert, J. J., 3 Mar 2015, In : Reproduction, fertility and development. 27, 4, p. 684-692 9 p.

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Early transplantation of mesenchymal stem cells after spinal cord injury relieves pain hypersensitivity through suppression of pain-related signaling cascades and reduced inflammatory cell recruitment

Watanabe, S., Uchida, K., Nakajima, H., Matsuo, H., Sugita, D., Yoshida, A., Honjoh, K., Johnson, W. E. B. & Baba, H., 30 Jun 2015, In : Stem cells. 33, 6, p. 1902-1914 13 p.

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Efficacy and safety of dapagliflozin monotherapy in people with Type 2 diabetes: a randomized double-blind placebo-controlled 102-week trial

Bailey, C. J., Morales Villegas, E. C., Woo, V., Tang, W., Ptaszynska, A. & List, J. F., 30 Apr 2015, In : Diabetic Medicine. 32, 4, p. 531-541 11 p.

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Evaluating the evidence for targeting FOXO3a in breast cancer: a systematic review

Taylor, S., Lam, M., Pararasa, C., Brown, J. E. P., Carmichael, A. R. & Griffiths, H. R., 2015, In : Cancer Cell International. 15, 1, 9 p.

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Follicular helper T cell signature in type 1 diabetes

Kenefeck, R., Wang, C. J., Kapadi, T., Wardzinski, L., Attridge, K., Clough, L. E., Heuts, F., Kogimtzis, A., Patel, S., Rosenthal, M., Ono, M., Sansom, D. M., Narendran, P. & Walker, L. S. K., 2 Jan 2015, In : Journal of Clinical Investigation. 125, 1, p. 292-303 12 p.

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Formulation of Biologically-Inspired Silk-Based Drug Carriers for Pulmonary Delivery Targeted for Lung Cancer

Kim, S. Y., Naskar, D., Kundu, S. C., Bishop, D. P., Doble, P. A., Boddy, A. V., Chan, H-K., Wall, I. B. & Chrzanowski, W., 3 Aug 2015, In : Scientific Reports. 5, 11878.

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Human mesenchymal stem cells stimulate EaHy926 endothelial cell migration: combined proteomic and in vitro analysis of the influence of donor-donor variability

Walter, M. N. M., Kohli, N., Khan, N., Major, T., Fuller, H., Wright, K. T., Kuiper, J-H. & Johnson, W. E. B., 30 May 2015, In : Journal of Stem Cells and Regenerative Medicine. 11, 1, p. 18-24 7 p.

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Improving T cell-induced response to subunit vaccines: opportunities for a proteomic systems approach

Dunston, C. R., Herbert, R. & Griffiths, H. R., 2015, In : Journal of Pharmacy and Pharmacology. 67, 3, p. 290-299 10 p.

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Investigating the prevalence of Salmonella in dogs within the Midlands region of the United Kingdom

Lowden, P., Wallis, C., Gee, N. & Hilton, A., 17 Sep 2015, In : BMC Veterinary Research. 11, 6 p., 239.

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LDL-Lipids from patients with hypercholesterolaemia and Alzheimer's disease are inflammatory to microvascular endothelial cells: mitigation by statin intervention

Dias, I. H. K., Brown, C. L. R., Polidori-Nelles, M. C., Lip, G. Y. H. & Griffiths, H. R., 1 Dec 2015, In : Clinical Science. 129, 12, p. 1195-1206 12 p.

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Low gravity rotational culture and the integration of immunomodulatory stem cells reduce human islet allo-reactivity

Qureshi, K. M., Lee, J., Paget, M. B., Bailey, C. J., Curnow, S. J., Murray, H. E. & Downing, R., Jan 2015, In : Clinical Transplantation. 29, 1, p. 90-98 9 p.

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MARK-AGE biomarkers of ageing

Bürkle, A., Moreno-Villanueva, M., Bernhard, J., Blasco, M., Zondag, G., Hoeijmakers, J. H. J., Toussaint, O., Grubeck-Loebenstein, B., Mocchegiani, E., Collino, S., Gonos, E. S., Sikora, E., Gradinaru, D., Dollé, M., Salmon, M., Kristensen, P., Griffiths, H. R., Libert, C., Grune, T., Breusing, N. & 10 others, Simm, A., Franceschi, C., Capri, M., Talbot, D., Caiafa, P., Friguet, B., Slagboom, P. E., Hervonen, A., Hurme, M. & Aspinall, R., Nov 2015, In : Mechanisms of Ageing and Development. 151, p. 2-12 11 p.

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Maternal nutrition modifies trophoblast giant cell phenotype and fetal growth in mice

Watkins, A. J., Lucas, E. S., Marfy-Smith, S., Bates, N., Kimber, S. J. & Fleming, T. P., 1 Jun 2015, In : Human Reproduction. 149, 6, p. 563-575 13 p.

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Microfluidic-controlled manufacture of liposomes for the solubilisation of a poorly water soluble drug

Kastner, E., Verma, V., Lowry, D. & Perrie, Y., 15 May 2015, In : International Journal of Pharmaceutics. 485, 1-2, p. 122-130 9 p.

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