Student theses
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Synthesis and Biological Characterisation of Potential Inhibitors of Microbial β-Lactamases
Author: Iyoha, A. I., Feb 2023Supervisor: Rathbone, D. (Supervisor) & Worthington, T. (Supervisor)
Student thesis: Doctoral Thesis › Doctor of Philosophy
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Predictors of Cognitive Recovery in Paediatric Autoimmune Encephalitis
Author: Billaud, C., Mar 2023Supervisor: Wright, S. (Supervisor), Woodhall, G. L. (Supervisor), Foley, E. (Supervisor), Wassmer, E. (Supervisor), Wood, A. (Supervisor) & Kessler, K. (Supervisor)
Student thesis: Doctoral Thesis › Doctor of Philosophy
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Long-term impacts of preeclampsia on the cardiovascular system using murine models
Author: Correia, Y., Jun 2023Supervisor: Wang, K. (Supervisor) & Ahmad, S. (Supervisor)
Student thesis: Doctoral Thesis › Doctor of Philosophy
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Antimicrobial Efficacy of XF-73 and Photo-Activated XF-73 Against Clinically Relevant Microorganisms in Planktonic and Biofilm Mode of Growth
Author: Romeo-Melody, I. L., Sept 2022Supervisor: Worthington, T. (Supervisor) & Cox, J. A. G. (Supervisor)
Student thesis: Doctoral Thesis › Doctor of Philosophy
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Expression, Solubilisation and Purification of MRP4
Author: Vaitsopoulou, A., Sept 2022Supervisor: Rothnie, A. (Supervisor) & Bill, R. (Supervisor)
Student thesis: Doctoral Thesis › Doctor of Philosophy
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Use of Membrane Proteins as Antifungal Drug Targets
Author: Lodé, A., Sept 2022Supervisor: Rothnie, A. (Supervisor)
Student thesis: Doctoral Thesis › Doctor of Philosophy
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Lipid Nanoparticles for Membrane Protein Target Drug Discovery
Author: Akram, A., Sept 2022Supervisor: Rothnie, A. (Supervisor) & Goddard, A. (Supervisor)
Student thesis: Doctoral Thesis › Doctor of Philosophy
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The Study of Clostridioides difficile Spore Germination for the Development of a Pro-Germination Sporicidal Strategy for the Elimination of C. difficile Spores
Author: Lawler, A. J., Jun 2022Supervisor: Worthington, A. (Supervisor) & Hilton, A. C. (Supervisor)
Student thesis: Doctoral Thesis › Doctor of Philosophy
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The Effect of Hydrogen Sulphide on TNF-α-induced Endothelial Dysfunction
Author: Diaz Sanchez, L., Sept 2022Supervisor: Dias, I. (Supervisor)
Student thesis: Doctoral Thesis › Doctor of Philosophy
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Vectorcardiographic evaluation of electrical dyssynchrony and its role in predicting response to cardiac resynchronization therapy
Author: Okafor, O. N., Aug 2022Supervisor: Leyva, F. (Supervisor) & Wang, K. (Supervisor)
Student thesis: Doctoral Thesis › Doctor of Medicine
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Characterising the structure-function relationships of apoptotic cell-derived extracellular vesicles in modulation of inflammation
Author: Grant, L. R., Mar 2022Supervisor: Devitt, A. (Supervisor), Milic, I. (Supervisor) & Ross, E. (Supervisor)
Student thesis: Doctoral Thesis › Doctor of Philosophy
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Mimicking the Properties of Scar Tissue in Spinal Cord Injuries
Author: Jenkins, D. R., Sept 2022Supervisor: Bill, R. (Supervisor), Perez Esteban, P. (Supervisor) & Hill, E. (Supervisor)
Student thesis: Doctoral Thesis › Doctor of Philosophy
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Structural and Functional Characterisation of Apoptotic Cell-Derived Extracellular Vesicles
Author: Rozo, A., Sept 2022Supervisor: Goddard, A. (Supervisor) & Devitt, A. (Supervisor)
Student thesis: Doctoral Thesis › Doctor of Philosophy
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Deciphering The Role Of Gtpases And The Cytoskeleton In Aquaporin-4 Vesicular Trafficking
Author: Markou, A., Sept 2022Supervisor: Balklava, Z. (Supervisor) & Bill, R. (Supervisor)
Student thesis: Doctoral Thesis › Doctor of Philosophy
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Targeting Inflammatory Mediator Signalling in Pericytes to Resolve Tissue Fibrosis
Author: Bignold, R. E., Jun 2022Supervisor: Johnson, J. (Supervisor) & Gross, S. (Supervisor)
Student thesis: Doctoral Thesis › Doctor of Philosophy
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The Biological Role of Redox Signalling by the Tumour Suppressor PTEN
Author: Smith, S. L., Sept 2022Supervisor: Spickett, C. (Supervisor), Cheong, A. (Supervisor) & Pitt, A. (Supervisor)
Student thesis: Doctoral Thesis › Doctor of Philosophy
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Investigating the effects of FoxO transcriptional activity on metabolic homeostasis
Author: McDonagh, L. R., Feb 2022Supervisor: Slack, C. (Supervisor) & Brown, J. (Supervisor)
Student thesis: Doctoral Thesis › Doctor of Philosophy
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Identification of Immunosuppressive Mechanisms in Glioblastoma Mulltiforme Brain Tumours
Author: Gkanatsiou, O., Apr 2022Supervisor: Devitt, A. (Supervisor) & Attridge, K. (Supervisor)
Student thesis: Doctoral Thesis › Doctor of Philosophy
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Structural characterisation of human tetraspanins and their interaction with cholesterol and gangliosides
Author: Broadbent, L. M., May 2022Supervisor: Bill, R. (Supervisor) & Rothnie, A. (Supervisor)
Student thesis: Doctoral Thesis › Doctor of Philosophy
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Improved Clostridia to produce building-block chemicals
Author: Román Lara, M. M., Feb 2022Supervisor: Goddard, A. (Supervisor), Bill, R. (Supervisor) & Chong, K. (Supervisor)
Student thesis: Doctoral Thesis › Doctor of Philosophy
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Investigating Novel Antimicrobial Strategies to Target Mycobacterium abscessus Infections
Author: Nolan, V. C., 2022Supervisor: Cox, J. A. G. (Supervisor) & Hanga, P. (Supervisor)
Student thesis: Doctoral Thesis › Doctor of Philosophy
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Modelling Ageing Skeletal Muscle In Vitro to Determine the Effect of Aged Skeletal Muscle Secretomes on Macrophage Function and Their Role in Sarcopenia Progression
Author: Chauhan, P., Jun 2022Supervisor: Devitt, A. (Supervisor) & Brown, J. (Supervisor)
Student thesis: Doctoral Thesis › Doctor of Philosophy
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Evaluation of the Utilisation of Copper Within a Clinical Environment
Author: Miruszenko, L., Jun 2021Student thesis: Master's Thesis › Master of Philosophy
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Generation of functional iPSC-derived astrocytes to model the neurodevelopmental disorder, Rett Syndrome
Author: King, M., 2021Supervisor: Parri, R. (Supervisor) & Hill, E. J. (Supervisor)
Student thesis: Doctoral Thesis › Doctor of Philosophy
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Development of an in vitro model for NonReplicating Persistent Mycobacterium tuberculosis, and an investigation of the novel phenotype
Author: Gibson, S., 2021Supervisor: Cox, J. A. G. (Supervisor) & Rathbone, D. (Supervisor)
Student thesis: Doctoral Thesis › Doctor of Philosophy
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Determining the cytotoxic properties of a Fagonia indica extract on breast and colon cancer
Author: Lewis, A., Oct 2021Supervisor: Brown, J. (Supervisor) & Rothnie, A. (Supervisor)
Student thesis: Doctoral Thesis › Doctor of Philosophy
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Engineering Bacteria for the Enhanced Production of High-value Chemicals
Author: Linney, J. A., May 2021Supervisor: Goddard, A. (Supervisor) & Spickett, C. (Supervisor)
Student thesis: Doctoral Thesis › Doctor of Philosophy
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Identification of a MicroRNA Therapy Targeting sFlt-1 in Preeclampsia
Author: Grubliauskiene, M., Feb 2021Supervisor: Ahmed, A. S. (Supervisor) & Ahmad, S. (Supervisor)
Student thesis: Doctoral Thesis › Doctor of Philosophy
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Investigating Mycobacterium abscessus to inform treatment and drug discovery
Author: Lopeman, R. C., Feb 2021Supervisor: Cox, J. A. G. (Supervisor), Desai, M. (External person) (Supervisor) & Lambert, P. (Supervisor)
Student thesis: Doctoral Thesis › Doctor of Philosophy
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PRe-ART (Predictive Reagent-Antibody Replacement Technology): Engineering and analysis of randomised DNA libraries encoding designed armadillo repeat proteins
Author: Wagstaffe, B. P. G., Sept 2021Supervisor: Hine, A. V. (Supervisor) & Sutherland, A. (Supervisor)
Student thesis: Doctoral Thesis › Doctor of Philosophy
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A Role for Metabotropic Glutamate Receptors in Healthy Ageing
Author: Otchere, A., 2021Supervisor: Slack, C. (Supervisor) & Poyner, D. (Supervisor)
Student thesis: Doctoral Thesis › Doctor of Philosophy
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Investigation of a Selective Transglutaminase 2 Antagonist as a Novel Therapeutic Agent for Cystic Fibrosis
Author: Gavin, J., 2021Supervisor: Devitt, A. (Supervisor), Collighan, R. (Supervisor) & Johnson, J. (Supervisor)
Student thesis: Doctoral Thesis › Doctor of Philosophy
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Identification of novel transglutaminase-like proteins associated with sporulation in Clostridioides difficile
Author: Joumsi Tagne, T., Sept 2021Supervisor: Collighan, R. (Supervisor), Hilton, A. (Supervisor) & Worthington, T. (Supervisor)
Student thesis: Doctoral Thesis › Doctor of Philosophy
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Development of human induced pluripotent stem cell-derived neural cultures for seizure-liability testing
Author: Grainger, A., 2020Supervisor: Coleman, M. (Supervisor) & Hill, E. J. (Supervisor)
Student thesis: Doctoral Thesis › Doctor of Philosophy
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Investigation of Metabolic Dysfunction in Alzheimer’s Patient iPSC-derived Neuron and Astrocytic Cells
Author: Alqattan, S., 2020Supervisor: Hill, E. J. (Supervisor) & Brown, J. (Supervisor)
Student thesis: Doctoral Thesis › Doctor of Philosophy
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Aminoacyl-tRNA synthetases: investigations of tRNA specificity for application in ProxiMAX/synthetic biology
Author: Ferreira Amaral, M., 2020Supervisor: Hine, A. V. (Supervisor) & Sutherland, A. (Supervisor)
Student thesis: Doctoral Thesis › Doctor of Philosophy
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The immunochemical characterisation, epitope analysis and diagnostic applications of neo-antigens formed by lipoxidation of human serum albumin
Author: Cardoso Alves De Campos Pinto, I., Jun 2020Supervisor: Spickett, C. M. (Supervisor) & Davis, P. (External person) (Supervisor)
Student thesis: Doctoral Thesis › Doctor of Philosophy
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The Cellular Localisation and Role of S100P in the Motility and Invasion of Trophoblasts
Author: Lancaster, T., 2020Supervisor: Gross, S. R. (Supervisor)
Student thesis: Doctoral Thesis › Doctor of Philosophy
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Cell-free enzymatic biosystem for the conversion of glucose to malate
Author: Mandair, R., 2020Supervisor: Bill, R. (Supervisor) & Karagoz, P. (External person) (Supervisor)
Student thesis: Doctoral Thesis › Doctor of Philosophy
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Analysis of the ERK5 MAPK Signalling Pathway in Endothelial Cells
Author: Alasseri, A., Nov 2020Supervisor: Muller, J. (Supervisor), Ahmed, A. (Supervisor) & Wang, K. (Supervisor)
Student thesis: Doctoral Thesis › Doctor of Philosophy
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Characterisation of Coagulase-negative Staphylococcus Isolates Recovered from Blood Cultures of Patients in a Haematology and Bone Marrow Transplant Unit
Author: Chaudhry, R., 2020Supervisor: Worthington, T. (Supervisor), Hilton, A. (Supervisor) & Das, I. (External person) (Supervisor)
Student thesis: Doctoral Thesis › Doctor of Philosophy
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Characterisation of styrene-maleic acid-solubilised G protein-coupled receptors
Author: Uddin, R., 2020Supervisor: Poyner, D. R. (Supervisor) & Bill, R. (Supervisor)
Student thesis: Doctoral Thesis › Doctor of Philosophy
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The role of metastasis-associated proteins in trophoblast motility and invasion
Author: Ebrahimzadeh Asl Tabrizi, M., Jun 2020Supervisor: Gross, S. R. (Supervisor) & Ahmed, A. S. (Supervisor)
Student thesis: Doctoral Thesis › Doctor of Philosophy
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The effectiveness of exercise in the treatment of polycystic ovary syndrome
Author: Kite, C., Jun 2020Supervisor: Brown, J. (Supervisor), Kyrou, I. (Supervisor) & Lahart, I. M. (External person) (Supervisor)
Student thesis: Doctoral Thesis › Doctor of Philosophy
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Solubilisation and stabilisation of MRP4 using novel detergents for function and structural studies
Author: Hardy, D., 13 Mar 2019Supervisor: Rothnie, A. J. (Supervisor) & Bill, R. M. (Supervisor)
Student thesis: Doctoral Thesis › Doctor of Philosophy
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Novel collagen- based biomaterials for bone regeneration
Author: Choudhery, H., 21 Mar 2019Supervisor: Collighan, R. J. (Supervisor) & Martin, R. A. (Supervisor)
Student thesis: Doctoral Thesis › Doctor of Philosophy
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Using an in vitro model of human cystic fibrosis airways to investigate bacterial strategies which inactivate defence mechanisms and increase infection
Author: Pallett, R., 5 Mar 2019Supervisor: Devitt, A. (Supervisor) & Leslie, L. J. (Supervisor)
Student thesis: Doctoral Thesis › Doctor of Philosophy
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Mathematical modelling of hypoxia and temperature signalling pathways in lifespan
Author: Mulla, S., 28 Jun 2019Supervisor: Cheong, A. (Supervisor) & Stich, M. (Supervisor)
Student thesis: Doctoral Thesis › Doctor of Philosophy
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Attracted to death: apoptotic cell-derived extracellular vesicles towards a basic characterisation
Author: Cameron, A., 21 Mar 2019Supervisor: Attridge, K. (Supervisor) & Devitt, A. (Supervisor)
Student thesis: Doctoral Thesis › Doctor of Philosophy
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Reactive oxygen species in protein sulphenic acid formation during T cell activation; implications for rheumatoid arthritis
Author: Remtulla, A. H., 4 Jun 2019Supervisor: Dias, I. (Supervisor) & Griffiths, H. (Supervisor)
Student thesis: Doctoral Thesis › Doctor of Philosophy
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