19992020

Research output per year

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Personal profile

Contact Details

email: a.devitt1@aston.ac.uk 
tel:
 +44 (0) 121 204 4165 
fax:
 +44 (0) 121 204 4187
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Research Interests

As an inflammatory cell biologist, my research over 20 years has focused on the innate immune system and its role in protection and tissue repair through the study of phagocyte clearance of dying (apoptotic) cells and microbial challenge. Research within my research group addresses membrane receptors/ligands and cell communication in this phagocytic clearance process.  Current work aims to define the mechanisms by which apoptotic cells communicate via extracellular vesicles (EV).  This BBSRC-funded work is revealing novel EV structure-function relationships that underpin tissue repair and regeneration capacity of EV from both apoptotic and viable cells, including mesenchymal stem cells.  This research has introduced the concept that EV are an active extracellular metabolic compartment capable of modulating inflammation.  The ultimate aim of my group’s research is to modify inflammation for therapeutic gain either through the inhibition of inflammation (e.g. in cardiovascular disease and regenerative medicine applications) or promoting inflammation (e.g. in tumours).

Teaching Activity

Undergraduate:

Year 2 (level 5) Immunology & microbiology

Year F (level 6) Immunology

Postgraduate:

Level 7 Immunology and Cell Biology

Employment

Membership of Professional Bodies

  • Fellow of the Royal Society of Biology
  • Fellow of the Higher Education Academy 
  • Member - UKEV: UK Extracellular Vesicle Society
  • Member - British Society for Immunology
  • Member - International Society for Extracellular Vesicles
  • Member - The Biochemical Society 
  • Member - The Society For Leukocyte Biology 
  • Member - European Cell Death Organization

Education/Academic qualification

PhD

Award Date: 1 Jun 1995

BSc, University of Manchester

Award Date: 1 Jul 1991

External positions

Member -Dunhill Medical Trust Research Grants Committee

Chair BBSRC Committee A

External Examiner, University of Edinburgh

External Examiner, York St John

Keywords

  • QR180 Immunology
  • Intercellular Communication
  • Extracellular Vesicles (EV)

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Research Output

Biophysical analysis of lipidic nanoparticles

Rozo, A. J., Cox, M. H., Devitt, A., Rothnie, A. J. & Goddard, A. D., 5 May 2020, In : Methods.

Research output: Contribution to journalReview article

  • CD81 extracted in SMALP nanodiscs comprises two distinct protein populations within a lipid environment enriched with negatively charged headgroups

    Ayub, H., Clare, M., Milic, I., Chmel, N. P., Böning, H., Devitt, A., Krey, T., Bill, R. M. & Rothnie, A. J., 28 Jul 2020, In : BBA -Biomembranes. 1862, 11, 183419.

    Research output: Contribution to journalArticle

  • Evidence of sequestration of triclabendazole and associated metabolites by extracellular vesicles of Fasciola hepatica

    Milic, I., Devitt, A., Davis, C. N., Winters, A., Cookson, A., Brophy, P. M. & Morphew, R. M., 10 Aug 2020, In : Scientific Reports. 10, 13445.

    Research output: Contribution to journalArticle

    Open Access
    File
  • Inflammation, lipid (per)oxidation and redox regulation

    Dias, I., Milic, I., Heiss, C., Ademowo, O. S., Polidori, M. C., Devitt, A. & Griffiths, H. R., 20 Jul 2020, In : Antioxidants and Redox Signaling. 33, 3, p. 166-190 25 p.

    Research output: Contribution to journalArticle

  • Anaerobiosis influences virulence properties of Pseudomonas aeruginosa cystic fibrosis isolates and the interaction with Staphylococcus aureus

    Pallett, R., Leslie, L. J., Lambert, P. A., Milic, I., Devitt, A. & Marshall, L. J., 1 May 2019, In : Scientific Reports. 9, 1, 6748.

    Research output: Contribution to journalArticle

    Open Access
    File
  • Datasets

    Phospholipid oxidation and carotenoid supplementation in Alzheimer’s disease patients

    Ademowo, O. S. (Creator), Dias, I. (Creator), Milic, I. (Creator), Devitt, A. (Creator), Moran, R. (Creator), Mulcahy, R. (Creator), Howard, A. (Creator), Nolan, J. (Creator) & Griffiths, H. R. (Creator), Aston Data Explorer, 16 Mar 2017

    Dataset

    CD81 extracted in SMALP nanodiscs comprises two distinct protein populations within a lipid environment enriched with negatively charged headgroups

    Ayub, H. (Creator), Clare, M. (Creator), Milic, I. (Creator), Chmel, N. P. (Creator), Böning, H. (Creator), Devitt, A. (Creator), Krey, T. (Creator), Bill, R. (Creator) & Rothnie, A. (Creator), Aston Data Explorer, 19 Dec 2019

    Dataset

    Phospholipid oxidation and carotenoid supplementation in Alzheimer’s disease patients

    Ademowo, S. (Creator), Dias, I. (Creator), Milic, I. (Creator), Devitt, A. (Creator), Moran, R. (Creator), Mulcahy, R. (Creator), Howard, A. (Creator), Nolan, J. (Creator) & Griffiths, H. (Creator), Aston Data Explorer, 16 Mar 2017

    Dataset

    Porphyromonas gingivalis gingipains cause defective macrophage migration towards apoptotic cells and inhibit phagocytosis of primary apoptotic neutrophils

    Ajay Castro, S. (Creator), Collighan, R. (Creator), Lambert, P. (Creator), Dias, I. (Creator), Chauhan, P. (Creator), Clarke-Bland, C. (Creator), Milic, I. (Creator), Milward, M. (Creator), Cooper, P. R. (Creator) & Devitt, A. (Creator), Aston Data Explorer, 23 Feb 2017

    Dataset

    Prizes

    Fellow of the Institute of Biomedical Science (FIBMS)

    Devitt, Andrew (Recipient), 2014

    Prize: Election to learned society

    Fellow of the Royal Society of Biology

    Devitt, Andrew (Recipient), 2014

    Prize: Election to learned society

    Fellow of the Higher Education Academy (FHEA)

    Devitt, Andrew (Recipient), 2008

    Prize: Election to learned society

    Activities

    The Dunhill Medical Trust (External organisation)

    Andrew Devitt (Chair)

    2017

    Activity: Membership typesMembership of committee

    Biotechnology and Biological Sciences Research Council (External organisation)

    Andrew Devitt (Chair)

    May 2015 → …

    Activity: Membership typesMembership of council

    IZON Science research symposium 2014

    Andrew Devitt (Invited speaker)

    Sep 2014

    Activity: Participating in or organising an event typesParticipation in conference

    3rd internation meeting of the International Society for Extracellular Vesicles

    Andrew Devitt (Invited speaker)

    May 2014

    Activity: Participating in or organising an event typesParticipation in conference

    Scientific Reports (Journal)

    Andrew Devitt (Editorial board member)

    2014 → …

    Activity: Publication peer-review and editorial work typesEditorial activity