19992020

Research output per year

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Personal profile

Contact Details

email: a.devitt1@aston.ac.uk 
tel:
 +44 (0) 121 204 4165 
fax:
 +44 (0) 121 204 4187
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Research Interests

As an inflammatory cell biologist, my research over 20 years has focused on the innate immune system and its role in protection and tissue repair through the study of phagocyte clearance of dying (apoptotic) cells and microbial challenge. Research within my research group addresses membrane receptors/ligands and cell communication in this phagocytic clearance process.  Current work aims to define the mechanisms by which apoptotic cells communicate via extracellular vesicles (EV).  This BBSRC-funded work is revealing novel EV structure-function relationships that underpin tissue repair and regeneration capacity of EV from both apoptotic and viable cells, including mesenchymal stem cells.  This research has introduced the concept that EV are an active extracellular metabolic compartment capable of modulating inflammation.  The ultimate aim of my group’s research is to modify inflammation for therapeutic gain either through the inhibition of inflammation (e.g. in cardiovascular disease and regenerative medicine applications) or promoting inflammation (e.g. in tumours).

Teaching Activity

Undergraduate:

Year 2 (level 5) Immunology & microbiology

Year F (level 6) Immunology

Postgraduate:

Level 7 Immunology and Cell Biology

Employment

Membership of Professional Bodies

  • Fellow of the Royal Society of Biology
  • Fellow of the Higher Education Academy 
  • Member - UKEV: UK Extracellular Vesicle Society
  • Member - British Society for Immunology
  • Member - International Society for Extracellular Vesicles
  • Member - The Biochemical Society 
  • Member - The Society For Leukocyte Biology 
  • Member - European Cell Death Organization

Education/Academic qualification

PhD

Award Date: 1 Jun 1995

BSc, University of Manchester

Award Date: 1 Jul 1991

External positions

Member -Dunhill Medical Trust Research Grants Committee

Chair BBSRC Committee A

External Examiner, University of Edinburgh

External Examiner, York St John

Keywords

  • QR180 Immunology
  • Intercellular Communication
  • Extracellular Vesicles (EV)

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Research Output

Inflammation, lipid (per)oxidation and redox regulation

Dias, I., Milic, I., Heiss, C., Ademowo, O. S., Polidori, M. C., Devitt, A. & Griffiths, H. R., 28 Jan 2020, In : Antioxidants and Redox Signaling.

Research output: Contribution to journalArticle

  • Open Access
    File
  • Apoptotic cell-derived extracellular vesicles: structure-function relationships.

    Grant, L., Milic, I. & Devitt, A., 30 Apr 2019, In : Biochemical Society Transactions. 47, 2, p. 509-516 8 p.

    Research output: Contribution to journalReview article

    Open Access
    File
  • Formulation and manufacturing of lymphatic targeting liposomes using microfluidics

    Khadke, S., Roces, C. B., Cameron, A., Devitt, A. & Perrie, Y., 10 Aug 2019, In : Journal of Controlled Release. 307, p. 211-220 10 p.

    Research output: Contribution to journalArticle

  • Increased production of 27-hydroxycholesterol in human colorectal cancer advanced stage: Possible contribution to cancer cell survival and infiltration

    Rossin, D., Dias, I. H. K., Solej, M., Milic, I., Pitt, A. R., Iaia, N., Scoppapietra, L., Devitt, A., Nano, M., Degiuli, M., Volante, M., Caccia, C., Leoni, V., Griffiths, H. R., Spickett, C. M., Poli, G. & Biasi, F., 20 May 2019, In : Free Radical Biology and Medicine. 136, p. 35-44 10 p.

    Research output: Contribution to journalArticle

    Open Access
    File
  • Thesis

    Attracted to death: apoptotic cell-derived extracellular vesicles towards a basic characterisation

    Author: Cameron, A., 21 Mar 2019

    Supervisor: Attridge, K. (Supervisor) & Devitt, A. (Supervisor)

    Student thesis: Doctoral ThesisDoctor of Philosophy

    File

    Characterising the role of ICAM-3 and apoptotic cell-derived extracellular vesicles in the clearance of apoptotic cells

    Author: Alghareeb, K., 31 Dec 2017

    Supervisor: Devitt, A. (Supervisor) & Griffiths, H. R. (Supervisor)

    Student thesis: Doctoral ThesisDoctor of Philosophy

    File

    Characterization of Transglutaminase 2 in macrophage clearance of apoptotic cells

    Author: Nadella, V., 16 Dec 2013

    Supervisor: Griffin, M. (Supervisor) & Devitt, A. (Supervisor)

    Student thesis: Doctoral ThesisDoctor of Philosophy

    File

    Formulation and development of cationic liposomes as adjuvants for subunit protein vaccinese

    Author: Henriksen, A., 1 Feb 2011

    Supervisor: Perrie, Y. (Supervisor) & Devitt, A. (Supervisor)

    Student thesis: Doctoral ThesisDoctor of Philosophy

    File

    Palmitate induces insulin resistance and a pro-atherogenic phenotype in monocytes

    Author: Gao, D., 2008

    Supervisor: Griffiths, H. R. (Supervisor), Devitt, A. (Supervisor) & Bailey, C. J. (Supervisor)

    Student thesis: Doctoral ThesisDoctor of Philosophy

    File

    Prizes

    Fellow of the Institute of Biomedical Science (FIBMS)

    Andrew Devitt (Recipient), 2014

    Prize: Election to learned society

    Fellow of the Royal Society of Biology

    Andrew Devitt (Recipient), 2014

    Prize: Election to learned society

    Fellow of the Higher Education Academy (FHEA)

    Andrew Devitt (Recipient), 2008

    Prize: Election to learned society

    Activities

    The Dunhill Medical Trust (External organisation)

    Andrew Devitt (Chair)
    2017

    Activity: Membership typesMembership of committee

    Biotechnology and Biological Sciences Research Council (External organisation)

    Andrew Devitt (Chair)
    May 2015 → …

    Activity: Membership typesMembership of council

    IZON Science research symposium 2014

    Andrew Devitt (Invited speaker)
    Sep 2014

    Activity: Participating in or organising an event typesParticipation in conference

    3rd internation meeting of the International Society for Extracellular Vesicles

    Andrew Devitt (Invited speaker)
    May 2014

    Activity: Participating in or organising an event typesParticipation in conference

    British Council (External organisation)

    Andrew Devitt (Member)
    2014 → …

    Activity: Membership typesMembership of council