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Personal profile

Contact Details

email: a.devitt1@aston.ac.uk 
tel:
 +44 (0) 121 204 4165 
fax:
 +44 (0) 121 204 4187
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Research Interests

As an inflammatory cell biologist, my research over 20 years has focused on the innate immune system and its role in protection and tissue repair through the study of phagocyte clearance of dying (apoptotic) cells and microbial challenge. Research within my research group addresses membrane receptors/ligands and cell communication in this phagocytic clearance process.  Current work aims to define the mechanisms by which apoptotic cells communicate via extracellular vesicles (EV).  This BBSRC-funded work is revealing novel EV structure-function relationships that underpin tissue repair and regeneration capacity of EV from both apoptotic and viable cells, including mesenchymal stem cells.  This research has introduced the concept that EV are an active extracellular metabolic compartment capable of modulating inflammation.  The ultimate aim of my group’s research is to modify inflammation for therapeutic gain either through the inhibition of inflammation (e.g. in cardiovascular disease and regenerative medicine applications) or promoting inflammation (e.g. in tumours).

Teaching Activity

Undergraduate:

Year 2 (level 5) Immunology & microbiology

Year F (level 6) Immunology

Postgraduate:

Level 7 Immunology and Cell Biology

Employment

Membership of Professional Bodies

  • Fellow of the Royal Society of Biology
  • Fellow of the Higher Education Academy 
  • Member - UKEV: UK Extracellular Vesicle Society
  • Member - British Society for Immunology
  • Member - International Society for Extracellular Vesicles
  • Member - The Biochemical Society 
  • Member - The Society For Leukocyte Biology 
  • Member - European Cell Death Organization

Education/Academic qualification

PhD

BSc, University of Manchester

External positions

Member -Dunhill Medical Trust Research Grants Committee

Chair BBSRC Committee A

External Examiner, University of Edinburgh

External Examiner, York St John

Keywords

  • QR180 Immunology
  • Intercellular Communication
  • Extracellular Vesicles (EV)

Fingerprint Dive into the research topics where Andrew Devitt is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

  • 3 Similar Profiles
Macrophages Medicine & Life Sciences
Apoptosis Medicine & Life Sciences
Monocytes Medicine & Life Sciences
Phagocytes Medicine & Life Sciences
Cells Chemical Compounds
Liposomes Medicine & Life Sciences
Inflammation Medicine & Life Sciences
Cytophagocytosis Medicine & Life Sciences

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Research Output 1999 2019

Open Access
File
Anaerobiosis
Cystic Fibrosis
Pseudomonas aeruginosa
Virulence
Staphylococcus aureus

Apoptotic cell-derived extracellular vesicles: structure-function relationships.

Grant, L., Milic, I. & Devitt, A., 30 Apr 2019, In : Biochemical Society Transactions. 47, 2, p. 509-516 8 p.

Research output: Contribution to journalReview article

Cells
Physiology
Proteome
Apoptosis
Inflammation

Formulation and manufacturing of lymphatic targeting liposomes using microfluidics

Khadke, S., Roces, C. B., Cameron, A., Devitt, A. & Perrie, Y., 10 Aug 2019, In : Journal of Controlled Release. 307, p. 211-220 10 p.

Research output: Contribution to journalArticle

Microfluidics
Liposomes
Avidin
Biotin
Proteins

Increased production of 27-hydroxycholesterol in human colorectal cancer advanced stage: Possible contribution to cancer cell survival and infiltration

Rossin, D., Dias, I. H. K., Solej, M., Milic, I., Pitt, A. R., Iaia, N., Scoppapietra, L., Devitt, A., Nano, M., Degiuli, M., Volante, M., Caccia, C., Leoni, V., Griffiths, H. R., Spickett, C. M., Poli, G. & Biasi, F., 20 May 2019, In : Free Radical Biology and Medicine. 136, p. 35-44 10 p.

Research output: Contribution to journalArticle

Infiltration
Colorectal Neoplasms
Cell Survival
Cells
Tumors

Communicating with the dead: lipids, lipid mediators and extracellular vesicle

Devitt, A., Griffiths⁎, H. R. & Milic, I., May 2018, In : Biochemical Society Transactions. 46, 3, p. 631-639

Research output: Contribution to journalReview article

Open Access
File
Lipids
Cell death
Inflammation
Cells
Phagocytes

Thesis

Attracted to death: apoptotic cell-derived extracellular vesicles towards a basic characterisation

Author: Cameron, A., 21 Mar 2019

Supervisor: Attridge, K. (Supervisor) & Devitt, A. (Supervisor)

Student thesis: Doctoral ThesisDoctor of Philosophy

File

Characterising the role of ICAM-3 and apoptotic cell-derived extracellular vesicles in the clearance of apoptotic cells

Author: Alghareeb, K., 31 Dec 2017

Supervisor: Devitt, A. (Supervisor) & Griffiths, H. R. (Supervisor)

Student thesis: Doctoral ThesisDoctor of Philosophy

File

Characterization of Transglutaminase 2 in macrophage clearance of apoptotic cells

Author: Nadella, V., 16 Dec 2013

Supervisor: Griffin, M. (Supervisor) & Devitt, A. (Supervisor)

Student thesis: Doctoral ThesisDoctor of Philosophy

File

Formulation and development of cationic liposomes as adjuvants for subunit protein vaccinese

Author: Henriksen, A., 1 Feb 2011

Supervisor: Perrie, Y. (Supervisor) & Devitt, A. (Supervisor)

Student thesis: Doctoral ThesisDoctor of Philosophy

File

Palmitate induces insulin resistance and a pro-atherogenic phenotype in monocytes

Author: Gao, D., 2008

Supervisor: Griffiths, H. R. (Supervisor), Devitt, A. (Supervisor) & Bailey, C. J. (Supervisor)

Student thesis: Doctoral ThesisDoctor of Philosophy

File

Prizes

Fellow of the Institute of Biomedical Science (FIBMS)

Andrew Devitt (Recipient), 2014

Prize: Election to learned society

Fellow of the Royal Society of Biology

Andrew Devitt (Recipient), 2014

Prize: Election to learned society

Fellow of the Higher Education Academy (FHEA)

Andrew Devitt (Recipient), 2008

Prize: Election to learned society

Activities 2008 2017

The Dunhill Medical Trust (External organisation)

Andrew Devitt (Chair)
2017

Activity: Membership typesMembership of committee

Biotechnology and Biological Sciences Research Council (External organisation)

Andrew Devitt (Chair)
May 2015 → …

Activity: Membership typesMembership of council

IZON Science research symposium 2014

Andrew Devitt (Invited speaker)
Sep 2014

Activity: Participating in or organising an event typesParticipation in conference

3rd internation meeting of the International Society for Extracellular Vesicles

Andrew Devitt (Invited speaker)
May 2014

Activity: Participating in or organising an event typesParticipation in conference

Macrophage (Journal)

Andrew Devitt (Editorial board member)
2014 → …

Activity: Publication peer-review and editorial work typesEditorial activity