Personal profile
Biography
Hine gained her PhD in Molecular Biology from UMIST in 1992 and her postdoctoral training at Harvard Medical School (PI: Prof Charles C. Richardson). She returned to the UK to take up a lectureship in Molecular Biology at Aston University in 1995. In 2003 she commenced her combined career in academia and innovation with a Medici Fellowship (commercialisation and entrepreneurial training), which was later followed by a secondment to the University's Business Partnership Unit as the School of Life and Health Sciences' Innovation Fellow. She was promoted to Senior Lecturer in 2006, Reader in 2013, Associate Dean in 2015 and Chair in 2018. The mother of two children, she has worked part time (0.7/0.8 FTE) since 2003.
Research Interests
- Protein Engineering
- Research at the interface between molecular biology and the physical sciences
- Development of enabling technologies for biomedicines
- Protein-DNA interactions of Cys2His2 zinc fingers
- Protein-DNA interactions of single Cys4 zinc fingers
Hine's research centres on combinatorial, synthetic biology and its application to protein-ligand interactions. She was named the BBSRC Commercial Innovator of the Year 2013; an award made for her successful transfer of her group’s inventions in protein engineering into UK-based Biotech company Isogenica Ltd. ColibraTM is now being exploited by Isogenica in the production of their highly-diverse synthetic antibody libraries.
Resulting from numerous multi-disciplinary collaborations, she also has experience of developing novel screens and in exploiting protein-DNA interactions to achieve advances in biotech process engineering. Her interdisciplinary work has generated several photonic biosensors, a generic technology to deliver and release proteins within mammalian cells and most recently, in an international FET-OPEN project is developing synthetic replacements for monoclonal reagent antibodies.
Research Projects/Collaborations
- Prof. Dr. Andreas Plückthun, University of Zurich, Switzerland
- Prof. Dr. Birte Höcker, University of Bayreuth, Germany
- Prof. Charles C. Richardson, Harvard Medical School, USA
- Prof. David Webb, Aston University, UK
Awards
- 2013 BBSRC Commercial Innovator of the Year
- 2013 Aston Excellence Award for Outstanding Contribution to Innovation and/or Technological Improvement
Membership of Professional Bodies
- Fellow of the Royal Society of Biology
- Member of the Biochemical Society
- Senior Fellow of the Higher Education Academy
Employment
- 2018-date Professor of Protein Engineering, Aston University
- 2015-2022 Associate Dean, Enterprise, Aston University
- 2013-2018 Reader in Molecular Biology, Aston University
- 2009-2012 Course Director, MSc Biotechnology, Aston University
- 2006-2013 Senior Lecturer in Molecular Biology, Aston University
- 2005-2006 LHS Innovation Fellow, Business Partnership Unit (partial secondment), Aston University
- 2004-2005 CEO, ProtaMAX Ltd
- 2003-2004 Medici Fellow (Commercialisation and Entrepreneurial Training)
- 1995-2006 Lecturer in Molecular Biology, Aston University
- 1993-94 Research Fellow, Harvard Medical School (PI: Prof. C.C. Richardson)
Qualifications
- 1989-92 PhD, UMIST (Supervisor: Prof. T.A. Brown)
- 1986-89 BSc Hons Biochemistry and Applied Molecular Biology (Class I) UMIST (now integrated into the University of Manchester)
Contact Details
Email: [email protected]
Telephone: +44 (0) 121 204 3961
External positions
Panel Member, EPSRC Engineering prioritisation panel
2023
Member, Chairing Group, UKRI Technology Missions Fund, Engineering Biology Assessment College
2023 → …
Panel Member, BBSRC ICURe Options Roundabout
2022
Panel Chair, BBSRC Follow-on-fund
2021 → 2023
Panel Member, BBSRC Impact Accelerator Awards
2021
Panel Member, EPSRC International Centre to Centre Programme, UKRI-EPSRC
2019
Panel Member, BBSRC Impact Accelerator Awards, UKRI-BBSRC
2017
Panel Member, BBSRC Follow-on-Fund, UKRI-BBSRC
2016 → 2020
Panel Member, BBSRC Excellence with Impact, UKRI-BBSRC
2016
Consultant, Isogenica Ltd
2011 → 2013
Technical Expert, EU Eurostars programme, European Commission
2009 → …
Member of EPSRC College, UKRI-EPSRC
2006 → …
Fingerprint
- 1 Similar Profiles
Collaborations and top research areas from the last five years
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Engineering Protein–Peptide Interfaces via Combinatorial Mutagenesis and Mass Photometric Screening
Hosseini, B., Ashraf, M., Kitchen, P., Chembath, A., Collighan, R., Spickett, C. M., Regan, L. & Hine, A. V., Aug 2025, In: Biomolecules. 15, 8, 15 p., 1183.Research output: Contribution to journal › Article › peer-review
Open AccessFile1 Link opens in a new tab Citation (SciVal)14 Downloads (Pure) -
Modular binder technology by NGS-aided, high-resolution selection in yeast of designed armadillo modules
Stark, Y., Menard, F., Jeliazkov, J., Ernst, P., Chembath, A., Ashraf, M., Hine, A. V. & Plueckthun, A., 2 Jul 2024, In: Proceedings of the National Academy of Sciences of the United States of America. 121, 27, 11 p., e2318198121.Research output: Contribution to journal › Article › peer-review
Open AccessFile3 Link opens in a new tab Citations (Scopus)11 Downloads (Pure) -
Modular peptide binders – development of a predictive technology as alternative for reagent antibodies
Gisdon, F. J., Kynast, J. P., Ayyildiz, M., Hine, A. V., Plückthun, A. & Höcker, B., 1 Apr 2022, In: Biological Chemistry. 403, 5-6, p. 535-543Research output: Contribution to journal › Review article › peer-review
Open AccessFile5 Link opens in a new tab Citations (Scopus)28 Downloads (Pure) -
Nondegenerate Saturation Mutagenesis: Library Construction and Analysis via MAX and ProxiMAX Randomization
Chembath, A., Wagstaffe, B. P. G., Ashraf, M., Amaral, M. M. F., Frigotto, L. & Hine, A. V., 22 Jun 2022, Directed Evolution: Methods in Molecular Biology. Currin, A. & Swainston, N. (eds.). Springer, Vol. 2461. p. 19-41 23 p. (Methods in Molecular Biology; vol. 2461).Research output: Chapter in Book/Published conference output › Chapter (peer-reviewed) › peer-review
4 Link opens in a new tab Citations (Scopus) -
PRe-ART - Creating Synthetic Replacements for Reagent Antibodies
Chembath, A., Ashraf, M., Wagstaffe, B., Stark, Y., Michel, E., Rohrbach, A., Kynast, J., Gisdon, F., Ayyildiz, M., Höcker, B., Plückthun, A. & Hine, A. V., 4 May 2022.Research output: Unpublished contribution to conference › Poster › peer-review
Datasets
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Data underpinning article "A C-terminal cysteine residue is required for peptide-based inhibition of the NGF/TrkA interaction at nM concentrations: implications for peptide-based analgesics."
Poole, A. (Creator), Frigotto, L. (Creator), Baar, M. E. (Creator), Ivanova-Berndt, C. (Creator), Jaulent, A. (Creator), Stace, C. (Creator), Ullman, C. G. (Creator) & Hine, A. V. (Creator), Aston Data Explorer, 5 Sept 2018
DOI: 10.17036/researchdata.aston.ac.uk.00000375
Dataset
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Real-time kinetic binding studies at attomolar concentrations in solution phase using a single-stage opto-biosensing platform based upon infrared surface plasmons
Allsop, T. (Creator), Mou, C. (Contributor), Neal, R. (Contributor), Nagel, D. A. (Contributor), Poole, A. (Contributor), Kalli, K. (Contributor), Hine, A. (Contributor), Webb, D. J. (Contributor), Culverhouse, P. F. (Contributor), Minunni, M. (Contributor), Bennion, I. (Contributor), Tombelli, S. (Contributor) & Mariani, S. (Contributor), Aston Data Explorer, 28 Feb 2017
DOI: 10.17036/researchdata.aston.ac.uk.00000179, https://www.osapublishing.org/oe/abstract.cfm?uri=oe-25-1-39
Dataset
Activities
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BBSRC Follow-on-Fund Committee (External organisation)
Hine, A. V. (Member)
Mar 2016 → Feb 2020Activity: Membership types › Membership of council
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International Advisory Board, Thermo Fisher
Hine, A. V. (Advisor)
May 2010Activity: Consultancy types › Consultancy
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Training placement, funded by the regional council of Languedoc-Roussillon (France).
Hine, A. V. (Host)
Apr 2010 → Jul 2010Activity: Other activity types › Types of External academic engagement - Hosting an academic visitor
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Press/Media
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In a series of three articles, BBSRC Innovator of the Year 2013 winners reveal the secrets behind their innovations.
2/04/13
1 item of Media coverage
Press/Media: Research
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Aston academic wins ‘Commercial Innovator of the Year’ for work with Isogenica
27/03/13
1 item of Media coverage
Press/Media: Research
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Dr Anna Hine wins 'Commercial Innovator of the Year' for work with Isogenica
26/03/13
1 item of Media coverage
Press/Media: Research
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Isogenica Secure Funding from UK’s Technology Strategy Board to Develop Gene Library Synthesis Technology
29/11/12
1 item of Media coverage
Press/Media: Research
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