Personal profile
Research Interests
Dr Kardeby is a cell signalling scientist with years of experience in drug target identification. Her research is in the field of Thrombosis in Inflammation with a focus on the effect of platelet and endothelial cell activation on vascular remodelling and neurodegeneration. In her work she uses novel pharmacological tools for understanding signalling mechanisms of cardiovascular disease.
My research group currently consists of Dr Marcela Usmari Moraes, Ms Nusratul Firdaus, and Miss Cerys Charles.
Scholarship and Fellowship
Dr Kardeby is a Marie Curie Alumni, she held a Marie Skłodowska-Curie Actions Individual Fellowship funded by Horizon 2020 between 2020 and 2022 (#893262).
In March 2025, Dr Kardeby became a Fellow with Advance HE.
Clinical Experience
Dr Kardeby is a registered clinical Biomedical Scientist with the Swedish National Board of Health and Welfare. She has experience from working in clinical chemistry, histolgy and pathology, fertility laboratory, and a general practician surgery.
Research Projects/Collaborations
The Connection Between Increased Thrombotic Risk and Parkinson’s – Currently recruiting
The full title of this project is Investigating a novel mechanism underlying increased risk of vascular events in Parkinson’s disease:
Dissecting pathological synergy between protein aggregates and glycosaminoglycans. It is funded by the British Heart Foundation and in collaboration with the University Hospitals Birmingham NHS Foundation Trust, this study aims to investigate whether individuals living with Parkinson’s have more easily activated platelets in their blood and to understand how alpha-synuclein and inflammation contributes to thrombosis.
PhD Project – Peripheral blood markers in South Asians with and without established coronary artery disease - Starting soon
This project is a joint collaboration between the Sandwell and West Birmingham Hospitals NHS Trust and Aston University, funded 50-50 by the Listers Group and Aston University. In this project we aim to understand why individuals with South Asian ancestry are at increased risk of cardiovascular disease.
PhD Project – Haemostatic dysregulation as a marker of blood brain barrier malfunction – Starting soon
This project is funded by the Dunhill Medical Trust, it is a part of the Aston Brain Health Cohort Study (ABaHCoS) that sits at the heart of the Aston Research Centre for Health in Ageing. This study will contribute towards finding new tools to identify individuals at risk of dementia earlier. The study is anticipated to start in October 2024 – more information coming soon.
Education/Academic qualification
PG Cert, Learning & Teaching in Higher Education, Aston University
2024 → 2025
Award Date: 3 Mar 2025
PhD, Medical Science, specialisation Biomedicine
18 Nov 2014 → 29 May 2019
Award Date: 2 Jul 2019
MSc, Medical Science, Örebro University
2011 → 2013
BSc, Biomedical laboratory science, Uppsala University
2008 → 2011
BSc, Medical Science, Uppsala University
2008 → 2011
Keywords
- QP Physiology
- Thrombosis
- Platelets
- Endothelial cells
- Haemostasis
- Inflammation
- Glycosaminoglycans
- Neurodegeneration
- R Medicine (General)
- Parkinson's disease
- Aortic Aneurysms
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Collaborations and top research areas from the last five years
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Heparin and heparin proteoglycan-mimetics activate platelets via PEAR1 and PI3Kβ
Kardeby, C., Evans, A., Campos, J., Al-Wahaibi, A. M., Smith, C. W., Slater, A., Martin, E. M., Severin, S., Brill, A., Pejler, G., Sun, Y. & Watson, S. P., 1 Jan 2023, In: Journal of Thrombosis and Haemostasis. 21, 1, p. 101-116 16 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile10 Link opens in a new tab Citations (SciVal)20 Downloads (Pure) -
Is the endogenous ligand for PEAR1 a proteoglycan: clues from the sea
Kardeby, C., Damaskinaki, F.-N., Sun, Y. & Watson, S. P., 18 Aug 2021, In: Platelets. 32, 6, p. 779-785 7 p.Research output: Contribution to journal › Letter, comment/opinion or interview › peer-review
8 Link opens in a new tab Citations (SciVal) -
Synthetic glycopolymers and natural fucoidans cause human platelet aggregation via PEAR1 and GPIbα
Kardeby, C., Fälker, K., Haining, E. J., Criel, M., Lindkvist, M., Barroso, R., Påhlsson, P., Ljungberg, L. U., Tengdelius, M., Rainger, G. E., Watson, S., Eble, J. A., Hoylaerts, M. F., Emsley, J., Konradsson, P., Watson, S. P., Sun, Y. & Grenegård, M., 12 Feb 2019, (E-pub ahead of print) In: Blood advances. 3, 3, p. 275-287 12 p.Research output: Contribution to journal › Article › peer-review
26 Link opens in a new tab Citations (SciVal) -
Trivalent nanobody-based ligands mediate powerful activation of GPVI, CLEC-2 and PEAR1 in human platelets whereas FcγRIIA requires a tetravalent ligand
Martin, E. M., Clark, J. C., Montague, S. J., Moran, L. A., Di, Y., Bull, L. J., Whittle, L., Raka, F., Buka, R. J., Zafar, I., Kardeby, C., Slater, A. & Watson, S. P., Jan 2024, In: Journal of Thrombosis and Haemostasis. 22, 1, p. 271-285 15 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile9 Link opens in a new tab Citations (SciVal)44 Downloads (Pure) -
Novel purine analogues regulate IL-1β release via inhibition of JAK activity in human aortic smooth muscle cells
Paramel, G. V., Lindkvist, M., Idosa, B. A., Sebina, L. S., Kardeby, C., Fotopoulou, T., Pournara, D., Kritsi, E., Ifanti, E., Zervou, M., Koufaki, M., Grenegård, M. & Fransén, K., 15 Aug 2022, In: European Journal of Pharmacology. 929, 10 p., 175128.Research output: Contribution to journal › Article › peer-review
Open AccessFile5 Link opens in a new tab Citations (SciVal)404 Downloads (Pure)
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International Journal of Molecular Sciences (Journal)
Kardeby, C. (Peer reviewer)
2024Activity: Peer-review and editorial work types › Publication peer-review
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European Platelet Network Meeting
Kardeby, C. (Chair)
4 Sept 2023 → 6 Sept 2023Activity: Participating in or organising an event types › Participation in conference
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Cells (Journal)
Kardeby, C. (Peer reviewer)
2023 → …Activity: Peer-review and editorial work types › Publication peer-review
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International Society on Thrombosis And Haemostasis Congress
Kardeby, C. (Participant)
9 Jul 2022 → 13 Jul 2022Activity: Participating in or organising an event types › Participation in conference
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Frontiers in Cardiovascular Medicine (Journal)
Kardeby, C. (Peer reviewer)
2022 → …Activity: Peer-review and editorial work types › Publication peer-review