1994 …2020

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2020

Ligand-induced conformational changes in a SMALP-encapsulated GPCR.

Routledge, S. J., Jamshad, M., Little, H. A., Lin, Y. P., Simms, J., Thakker, A., Spickett, C. M., Bill, R. M., Dafforn, T. R., Poyner, D. R. & Wheatley, M., 1 Jun 2020, In : Biochimica et Biophysica Acta - Biomembranes. 1862, 6, 183235.

Research output: Contribution to journalArticle

Open Access
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2019

Analysis of SMALP co-extracted phospholipids shows distinct membrane environments for three classes of bacterial membrane protein

Teo, A. C. K., Lee, S. C., Pollock, N. L., Stroud, Z., Hall, S., Thakker, A., Pitt, A. R., Dafforn, T. R., Spickett, C. M. & Roper, D. I., 12 Feb 2019, In : Scientific Reports. 9, 1, 1813.

Research output: Contribution to journalArticle

Open Access
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Epitope mapping and characterization of 4-hydroxy-2-nonenal modified-human serum albumin using two different polyclonal antibodies

Campos-pinto, I., Méndez, L., Schouten, J., Wilkins, J., Fedorova, M., Pitt, A., Davis, P. & Spickett, C., 20 Nov 2019, In : Free Radical Biology and Medicine. 144, p. 234-244 11 p.

Research output: Contribution to journalArticle

Open Access
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Evaluation of air oxidized PAPC: A multi laboratory study by LC-MS/MS

Ni, Z., Sousa, B. C., Colombo, S., Afonso, C. B., Melo, T., Pitt, A. R., Spickett, C. M., Domingues, P., Domingues, M. R., Fedorova, M. & Criscuolo, A., 20 Nov 2019, In : Free Radical Biology and Medicine. 144, p. 156-166 11 p.

Research output: Contribution to journalArticle

Open Access
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Increased production of 27-hydroxycholesterol in human colorectal cancer advanced stage: Possible contribution to cancer cell survival and infiltration

Rossin, D., Dias, I. H. K., Solej, M., Milic, I., Pitt, A. R., Iaia, N., Scoppapietra, L., Devitt, A., Nano, M., Degiuli, M., Volante, M., Caccia, C., Leoni, V., Griffiths, H. R., Spickett, C. M., Poli, G. & Biasi, F., 20 May 2019, In : Free Radical Biology and Medicine. 136, p. 35-44 10 p.

Research output: Contribution to journalArticle

Open Access
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Lipoproteins as targets and markers of lipoxidation

Afonso, C. B. & Spickett, C. M., 1 May 2019, In : Redox Biology. 23, 101066.

Research output: Contribution to journalArticle

Open Access
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PARP1 Co-regulates EP300–BRG1-dependent transcription of genes involved in breast cancer cell proliferation and DNA repair

Sobczak, M., Pitt, A. R., Spickett, C. M. & Robaszkiewicz, A., 11 Oct 2019, In : Cancers. 11, 10, 1539.

Research output: Contribution to journalArticle

Open Access
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Short-chain lipid peroxidation products form covalent adducts with pyruvate kinase and inhibit its activity in vitro and in breast cancer cells

Costa Sousa, B., Ahmed, T., Dann, W. L., Ashman, J., Guy, A., Durand, T., Pitt, A. R. & Spickett, C. M., 20 Nov 2019, In : Free Radical Biology and Medicine. 144, p. 223-233 11 p.

Research output: Contribution to journalArticle

Open Access
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SMA-PAGE: A new method to examine complexes of membrane proteins using SMALP nano-encapsulation and native gel electrophoresis

Pollock, N. L., Rai, M., Simon, K. S., Hesketh, S. J., Teo, A. C. K., Parmar, M., Sridhar, P., Collins, R., Lee, S. C., Stroud, Z. N., Bakker, S. E., Muench, S. P., Barton, C. H., Hurlbut, G., Roper, D. I., Smith, C. J. I., Knowles, T. J., Spickett, C. M., East, J. M., Postis, V. & 1 others, Dafforn, T. R., 1 Aug 2019, In : BBA -Biomembranes. 1861, 8, p. 1437-1445 9 p.

Research output: Contribution to journalArticle

Open Access
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The interaction of silver(II) complexes with biological macromolecules and antioxidants

Trotter, K. D., Owojaiye, O., Meredith, S., Keating, P. E., Spicer, M. D., Reglinski, J. & Spickett, C. M., 1 Aug 2019, In : BioMetals. 32, 4, p. 627-640 14 p.

Research output: Contribution to journalArticle

Open Access
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2018

A high-sensitivity electrochemiluminescence-based ELISA for the measurement of the oxidative stress biomarker, 3-nitrotyrosine, in human blood serum and cells

Knight, A. R., Taylor, E., Lukaszewski, R., Tveen Jensen, K., Jones, H. E., Carré, J. E., supov, M. N. I., Littlechild, J. A., Bailey, S. J., Brewer, E., McDonald, T. J., Pitt, A. R., Spickett, C. M. & Winyard, P. G., 20 May 2018, In : Free Radical Biology and Medicine. 120, p. 246-254

Research output: Contribution to journalArticle

Open Access
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A mass spectrometry approach for the identification and localization of small aldehyde modifications of proteins

Afonso, C. B., Sousa, B. C., Pitt, A. R. & Spickett, C. M., 15 May 2018, In : Archives of Biochemistry and Biophysics. 646, p. 38-45

Research output: Contribution to journalArticle

Open Access
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Reprint of: Proteomics in cardiovascular diseases: Unveiling sex and gender differences in the era of precision medicine

Baetta, R., Pontremoli, M., Fernandez, A. M., Spickett, C. M. & Banfi, C., 30 Apr 2018, In : Journal of Proteomics. 178, p. 57-72

Research output: Contribution to journalArticle

Open Access
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The effect of HOCl-induced modifications on phosphatase and tensin homolog (PTEN) structure and function

Verrastro, I., Tveen Jensen, K., Spickett, C. M. & Pitt, A. R., 3 Jan 2018, In : Free Radical Research. p. 1-471

Research output: Contribution to journalArticle

Open Access
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2017

Anti-myeloperoxidase antibodies attenuate the monocyte response to LPS and shape macrophage development

Popat, R. J., Hakki, S., Thakker, A., Coughlan, A. M., Watson, J., Little, M. A., Spickett, C. M., Lavender, P., Afzali, B., Kemper, C. & Robson, M. G., 26 Jan 2017, In : JCI Insight. 2, 2, e87379.

Research output: Contribution to journalArticle

Open Access
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Chemistry and analysis of HNE and other prominent carbonyl-containing lipid oxidation compounds

Sousa, B. C., Pitt, A. R. & Spickett, C. M., 10 Feb 2017, In : Free Radical Biology and Medicine. In press

Research output: Contribution to journalArticle

Open Access
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Corrigendum to "European contribution to the study of ROS: A summary of the findings and prospects for the future from the COST action BM1203 (EU-ROS)" [Redox Biol. 13 (2017) 94-162]

Egea, J., Fabregat, I., Frapart, Y. M., Ghezzi, P., Görlach, A., Kietzmann, T., Kubaichuk, K., Knaus, U. G., Lopez, M. G., Olaso-Gonzalez, G., Petry, A., Schulz, R., Vina, J., Winyard, P., Abbas, K., Ademowo, O. S., Afonso, C. B., Andreadou, I., Antelmann, H., Antunes, F. & 131 others, Aslan, M., Bachschmid, M. M., Barbosa, R. M., Belousov, V., Berndt, C., Bernlohr, D., Bertrán, E., Bindoli, A., Bottari, S. P., Brito, P. M., Carrara, G., Casas, A. I., Chatzi, A., Chondrogianni, N., Conrad, M., Cooke, M. S., Costa, J. G., Cuadrado, A., My-Chan Dang, P., De Smet, B., Debelec-Butuner, B., Dias, I. H. K., Dunn, J. D., Edson, A. J., El Assar, M., El-Benna, J., Ferdinandy, P., Fernandes, A. S., Fladmark, K. E., Förstermann, U., Giniatullin, R., Giricz, Z., Görbe, A., Griffiths, H., Hampl, V., Hanf, A., Herget, J., Hernansanz-Agustín, P., Hillion, M., Huang, J., Ilikay, S., Jansen-Dürr, P., Jaquet, V., Joles, J. A., Kalyanaraman, B., Kaminskyy, D., Karbaschi, M., Kleanthous, M., Klotz, L. O., Korac, B., Korkmaz, K. S., Koziel, R., Kračun, D., Krause, K. H., Křen, V., Krieg, T., Laranjinha, J., Lazou, A., Li, H., Martínez-Ruiz, A., Matsui, R., McBean, G. J., Meredith, S. P., Messens, J., Miguel, V., Mikhed, Y., Milisav, I., Milković, L., Miranda-Vizuete, A., Mojović, M., Monsalve, M., Mouthuy, P. A., Mulvey, J., Münzel, T., Muzykantov, V., Nguyen, I. T. N., Oelze, M., Oliveira, N. G., Palmeira, C. M., Papaevgeniou, N., Pavićević, A., Pedre, B., Peyrot, F., Phylactides, M., Pircalabioru, G. G., Pitt, A. R., Poulsen, H. E., Prieto, I., Rigobello, M. P., Robledinos-Antón, N., Rodríguez-Mañas, L., Rolo, A. P., Rousset, F., Ruskovska, T., Saraiva, N., Sasson, S., Schröder, K., Semen, K., Seredenina, T., Shakirzyanova, A., Smith, G. L., Soldati, T., Sousa, B. C., Spickett, C. M., Stancic, A., Stasia, M. J., Steinbrenner, H., Stepanić, V., Steven, S., Tokatlidis, K., Tuncay, E., Turan, B., Ursini, F., Vacek, J., Vajnerova, O., Valentová, K., Van Breusegem, F., Varisli, L., Veal, E. A., Yalçin, A. S., Yelisyeyeva, O., Žarković, N., Zatloukalová, M., Zielonka, J., Touyz, R. M., Papapetropoulos, A., Grune, T., Lamas, S., Schmidt, H. H. H. W., Di Lisa, F. & Daiber, A., 26 Oct 2017, In : Redox Biology. In press

Research output: Contribution to journalArticle

Open Access
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European contribution to the study of ROS: a summary of the findings and prospects for the future from the COST Action BM1203 (EU-ROS)

Egea, J., Fabregat, I., Frapart, Y. M., Ghezzi, P., Görlach, A., Kietzmann, T., Kubaichuk, K., Knaus, U. G., Lopez, M. G., Olaso-Gonzalez, G., Petry, A., Schulz, R., Vina, J., Winyard, P., Abbas, K., Ademowo, S., Afonso, C. B., Andreadou, I., Antelmann, H., Antunes, F. & 131 others, Aslan, M., Bachschmid, M. M., Barbosa, R. M., Belousov, V., Berndt, C., Bernlohr, D., Bertrán, E., Bindoli, A., Bottari, S. P., Brito, P. M., Carrara, G., Casas, A. I., Chatzi, A., Chondrogianni, N., Conrad, M., Cooke, M. S., Costa, J. G., Cuadrado, A., My-Chan Dang, P., De Smet, B., Debelec–butuner, B., Dias, I., Dunn, J. D., Edson, A. J., El Assar, M., El-Benna, J., Ferdinandy, P., Fernandes, A. S., Fladmark, K. E., Förstermann, U., Giniatullin, R., Giricz, Z., Görbe, A., Griffiths, H., Hampl, V., Hanf, A., Herget, J., Hernansanz-Agustín, P., Hillion, M., Huang, J., Ilikay, S., Jansen-Dürr, P., Jaquet, V., Joles, J. A., Kalyanaraman, B., Kaminskyy, D., Karbaschi, M., Kleanthous, M., Klotz, L-O., Korac, B., Korkmaz, K. S., Koziel, R., Kračun, D., Krause, K-H., Křen, V., Krieg, T., Laranjinha, J., Lazou, A., Li, H., Martínez-Ruiz, A., Matsui, R., Mcbean, G. J., Meredith, S. P., Messens, J., Miguel, V., Mikhed, Y., Milisav, I., Milković, L., Miranda-Vizuete, A., Mojović, M., Monsalve, M., Mouthuy, P-A., Mulvey, J., Münzel, T., Muzykantov, V., Nguyen, I. T. N., Oelze, M., Oliveira, N. G., Palmeira, C. M., Papaevgeniou, N., Pavićević, A., Pedre, B., Peyrot, F., Phylactides, M., Pircalabioru, G. G., Pitt, A. R., Poulsen, H. E., Prieto, I., Rigobello, M. P., Robledinos-Antón, N., Rodríguez-mañas, L., Rolo, A. P., Rousset, F., Ruskovska, T., Saraiva, N., Sasson, S., Schröder, K., Semen, K., Seredenina, T., Shakirzyanova, A., Smith, G. L., Soldati, T., Sousa, B. C., Spickett, C. M., Stancic, A., Stasia, M. J., Steinbrenner, H., Stepanić, V., Steven, S., Tokatlidis, K., Tuncay, E., Turan, B., Ursini, F., Vacek, J., Vajnerova, O., Valentová, K., van Breusegem, F., Varisli, L., Veal, E. A., Yalçın, A. S., Yelisyeyeva, O., Žarković, N., Zatloukalová, M., Zielonka, J., Touyz, R. M., Papapetropoulos, A., Grune, T., Lamas, S., Schmidt, H. H. H. W., di Lisa, F. & Daiber, A., 1 Oct 2017, In : Redox biology. 13, p. 94-162 69 p.

Research output: Contribution to journalArticle

Open Access
File

Proteomics in cardiovascular diseases: Unveiling sex and gender differences in the era of precision medicine

Baetta, R., Pontremoli, M., Fernandez, A. M., Spickett, C. M. & Banfi, C., 24 Nov 2017, In : Journal of Proteomics. Early online

Research output: Contribution to journalArticle

Open Access
File
2016

Reversible oxidation of phosphatase and tensin homolog (PTEN) alters its interactions with signaling and regulatory proteins

Verrastro, I., Tveen-Jensen, K., Woscholski, R., Spickett, C. M. & Pitt, A. R., 1 Jan 2016, In : Free Radical Biology and Medicine. 90, p. 24-34 11 p.

Research output: Contribution to journalArticle

Open Access
File
2015

Copper complexes as a source of redox active MRI contrast agents

Dunbar, L., Sowden, R. J., Trotter, K. D., Taylor, M. K., Smith, D., Kennedy, A. R., Reglinski, J. & Spickett, C. M., 2015, In : BioMetals. 28, 5, p. 903-912 10 p.

Research output: Contribution to journalArticle

Open Access
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Differential effects of chlorinated and oxidized phospholipids in vascular tissue: implications for neointima formation

Greig, F. H., Hutchison, L., Spickett, C. M. & Kennedy, S., 1 May 2015, In : Clinical Science. 128, 9, p. 579-592 14 p.

Research output: Contribution to journalArticle

Open Access
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Exploring oxidative modifications of tyrosine: an update on mechanisms of formation, advances in analysis and biological consequences

Houée-Lévin, C., Bobrowski, K., Horakova, L., Karademir, B., Schöneich, C., Davies, M. J. & Spickett, C. M., 2015, In : Free Radical Research. 49, 4, p. 347-373 27 p.

Research output: Contribution to journalArticle

Open Access
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Interfacing low-energy SAW nebulization with liquid chromatography-mass spectrometry for the analysis of biological samples

Tveen Jensen, K., Gesellchen, F., Wilson, R., Spickett, C., Cooper, J. M. & Pitt, A., 15 May 2015, In : Scientific Reports. 5, 5 p., 9736.

Research output: Contribution to journalArticle

Open Access
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Oxidiative lipidomics coming of age: advances in analysis of oxidized phospholipids in physiology and pathology

Spickett, C. M. & Pitt, A. R., 20 Jun 2015, In : Antioxidants and Redox Signaling. 22, 18, p. 1646-1666 21 p.

Research output: Contribution to journalArticle

Open Access
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Protein lipoxidation: detection strategies and challenges

Aldini, G., Domingues, M. R., Spickett, C. M., Domingues, P., Altomare, A., Sánchez-Gómez, F. J., Oeste, C. L. & Pérez-Sala, D., Aug 2015, In : Redox biology. 5, p. 253-266 14 p.

Research output: Contribution to journalArticle

Open Access
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The hypotensive effect of acute and chronic AMP-activated protein kinase activation in normal and hyperlipidemic mice

Greig, F. H., Ewart, M-A., McNaughton, E., Cooney, J., Spickett, C. M. & Kennedy, S., Nov 2015, In : Vascular Pharmacology. 74, p. 93-102 10 p.

Research output: Contribution to journalArticle

Open Access
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Top-down lipidomics of low density lipoprotein reveal altered lipid profiles in advanced chronic kidney disease

Reis, A., Rudnitskaya, A., Chariyavilaskul, P., Dhaun, N., Melville, V., Goddard, J., Webb, D. J., Pitt, A. R. & Spickett, C. M., 1 Feb 2015, In : Journal of Lipid Research. 56, 2, p. 413-422 10 p.

Research output: Contribution to journalArticle

Open Access
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2014

Detection of phosphatidylserine with a modified polar head group in human keratinocytes exposed to the radical generator AAPH

Maciel, E., Neves, B. M., Santinha, D., Reis, A., Domingues, P., Cruz, M. T., Pitt, A. R., Spickett, C. M. & Domingues, M. R. M., 15 Apr 2014, In : Archives of Biochemistry and Biophysics. 548, p. 38–45 8 p.

Research output: Contribution to journalArticle

Open Access
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HOCl-modified phosphatidylcholines induce apoptosis and redox imbalance in HUVEC-ST cells

Robaszkiewicz, A., Bartosz, G., Pitt, A. R., Thakker, A., Armstrong, R. A., Spickett, C. M. & Soszyński, M., 15 Apr 2014, In : Archives of Biochemistry and Biophysics. 548, p. 1-10 10 p.

Research output: Contribution to journalArticle

Open Access
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Identification and relative quantification of tyrosine nitration in a model peptide using two-dimensional infrared spectroscopy

Rezende Valim, L., Davies, J. A., Tveen Jensen, K., Guo, R., Willison, K. R., Spickett, C. M., Pitt, A. R. & Klug, D. R., 13 Nov 2014, In : Journal of Physical Chemistry: Part B. 118, 45, p. 12855-12864 10 p.

Research output: Contribution to journalArticle

Open Access
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Oxidised LDL-lipids increase beta amyloid production by SH-SY5Y cells through glutathione depletion and lipid raft formation

Dias, I. H. K., Mistry, J., Fell, S., Reis, A., Spickett, C. M., Polidori, M. C., Lip, G. Y. H. & Griffiths, H. R., Oct 2014, In : Free Radical Biology and Medicine. 75, p. 48–59 12 p.

Research output: Contribution to journalArticle

Open Access
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2013

A comparison of five lipid extraction solvent systems for lipidomic studies of human LDL

Reis, A., Rudnitskaya, A., Blackburn, G. J., Fauzi, N. M., Pitt, A. R. & Spickett, C. M., Jul 2013, In : Journal of Lipid Research. 54, 7, p. 1812-1824 13 p.

Research output: Contribution to journalArticle

Impairment of calcium ATPases by high glucose and potential pharmacological protection

Horáková, L., Strosova, M. K., Spickett, C. M. & Blaskovic, D., Aug 2013, In : Free Radical Research. 47, S1, p. 81-92 12 p.

Research output: Contribution to journalArticle

Lipoxidation adducts with peptides and proteins: deleterious modifications or signalling mechanisms?

Domingues, M. R., Domingues, P., Melo, T., Pérez-Sala, D., Reis, A. & Spickett, C. M., 30 Oct 2013, In : Journal of Proteomics. 92, p. 110-131 22 p.

Research output: Contribution to journalArticle

Post-translational modifications and mass spectrometry detection

Silva, A. M. N., Vitorino, R., Domingues, M. R. M., Spickett, C. M. & Domingues, P., Dec 2013, In : Free Radical Biology and Medicine. 65, p. 925-941 17 p.

Research output: Contribution to journalArticle

Open Access
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Reactions of copper macrocycles with antioxidants and HOCl: potential for biological redox sensing

Sowden, R. J., Trotter, K. D., Dunbar, L., Craig, G., Erdemli, O., Spickett, C. M. & Reglinski, J., Feb 2013, In : BioMetals. 26, 1, p. 85-96 12 p.

Research output: Contribution to journalArticle

Reporter ion-based mass spectrometry approaches for the detection of non-enzymatic protein modifications in biological samples

Tveen Jensen, K., Reis, A., Mouls, L., Pitt, A. R. & Spickett, C. M., 30 Oct 2013, In : Journal of Proteomics. 92, p. 71-79 9 p.

Research output: Contribution to journalArticle

Specific lipidome signatures in central nervous system from methionine-restricted mice

Jové, M., Ayala, V., Ramírez-Núñez, O., Naudí, A., Cabré, R., Spickett, C. M., Portero-Otin, M. & Pamplona, R., 14 Apr 2013, In : Journal of Proteome Research. 12, 6, p. 2679-2689 11 p.

Research output: Contribution to journalArticle

The lipid peroxidation product 4-hydroxy-2-nonenal: advances in chemistry and analysis

Spickett, C. M., 24 Jan 2013, In : Redox biology. 1, 1, p. 145-152 8 p.

Research output: Contribution to journalArticle

Open Access
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2012

Chemistry of phospholipid oxidation

Reis Pereira, A. & Spickett, C. M., Oct 2012, In : BBA -Biomembranes. 1818, 10, p. 2374–2387 14 p.

Research output: Contribution to journalArticle

Physiological effects of oxidized phospholipids and their cellular signaling mechanisms in inflammation

Greig, F. H., Kennedy, S. & Spickett, C. M., 15 Jan 2012, In : Free Radical Biology and Medicine. 52, 2, p. 266-280 15 p.

Research output: Contribution to journalArticle

Protein oxidation: role in signalling and detection by mass spectrometry

Spickett, C. M. & Pitt, A. R., Jan 2012, In : Amino Acids. 42, 1, p. 5-21 17 p.

Research output: Contribution to journalArticle

2011

Analysis of oxidized and chlorinated lipids by mass spectrometry and relevance to signalling

Spickett, C. M. & Fauzi, N. M., Oct 2011, In : Biochemical Society Transactions. 39, 5, p. 1233-1239 7 p.

Research output: Contribution to journalArticle

Analysis of radicals and radical reaction products in cell signalling and biomolecular damage: the long hard road to gold-standard measures

Winyard, P. G., Spickett, C. M. & Griffiths, H. R., Oct 2011, In : Biochemical Society Transactions. 39, 5, p. 1217-1220 4 p.

Research output: Contribution to journalArticle

Identification of oxidized phospholipids by electrospray ionization mass spectrometry and LC-MS using a QQLIT instrument

Spickett, C. M., Reis, A. & Pitt, A. R., 15 Dec 2011, In : Free Radical Biology and Medicine. 51, 12, p. 2133-2149 17 p.

Research output: Contribution to journalArticle

Modulation of sarcoplasmic/endoplasmic reticulum Ca(2+)-ATPase activity and oxidative modification during the development of adjuvant arthritis

Strosova, M. K., Karlovska, J., Zizkova, P., Kwolek-Mirek, M., Ponist, S., Spickett, C. M. & Horakova, L., Jul 2011, In : Archives of Biochemistry and Biophysics. 511, 1-2, p. 40-47 8 p.

Research output: Contribution to journalArticle

Sensitivity of antioxidant-deficient yeast to hypochlorite and chlorite

Kwolek-Mirek, M., Bartosz, G. & Spickett, C. M., Aug 2011, In : Yeast. 28, 8, p. 595-609 15 p.

Research output: Contribution to journalArticle

2010

Advances in methods for the determination of biologically relevant lipid peroxidation products

Spickett, C. M., Wiswedel, I., Siems, W., Zarkovic, K. & Zarkovic, N., Oct 2010, In : Free Radical Research. 44, 10, p. 1172-1202 31 p.

Research output: Contribution to journalArticle