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Personal profile

General

Dan Ma is a research fellow in Aston Medical School working on neuroregeneration. She is also the Deputy Director of Novolife Regenerative Medicine Centre. She is interested in the research on neural stem cells in remyelination. Dan Ma obtained her medical degree and MD on neuroendocrinology in China; she then worked as a university lecturer in medical teaching and research. She came to UK as a Royal Society Visiting Scholar at University of Nottingham, following which she completed her D.Phil on neuroanatomy at the University of Oxford. She moved to the University of Cambridge to continue biomedical research in several labs focusing on neurosciences.  While working in the Cambridge Stem Cell Institute and the Department of Clinical Neurosciences, she conducted various projects on adult neural stem cells in myelin regeneration, with a focus on translational medicine. Recently she has also carried out the study on the neural stem cell and endothelial cell which were derived from human induced pluripotent stem cells (iPSC), and their preclinical applications in neurodegenerative diseases.

 

Qualifications

  • PGCert in Teaching & Learning in Higher Education. Aston University, UK
  • D.Phil. in neuroanatomy, University of Oxford, UK
  • Master of Medicine (MD) in neuroendocrinology, The Fourth Military Medical University, Xi’an, PR China
  • Bachelor of Medicine and Bachelor of Surgery (MBBS), The Fourth Military Medical University, Xi’an, PR China

Research Interests

  • Human iPSC derived neural stem cell and endothelial cell in the therapy for neurodegenerative diseases
  • Oligodendrocyte progenitor cell (OPC) and remyelination
  • Hydrogen sulfide and its pathways in remyelination

Teaching Activity

  • Lecture on regeneration and repair
  • Tutor for medical students
  • Supervisor for research students

Research Projects/Collaborations

Adult neural stem cells in central nervous system remyelination

Dr. Chao Zhao, Cambridge Stem Cell Institute and the Department of Clinical Neurosciences, the University of Cambridge

Contact Details

  • Telephone: 0121 204 4526
  • Email: d.ma@aston.ac.uk
  • Room Number: MB314C

Keywords

  • RM Therapeutics. Pharmacology
  • Regenerative Medicine

Fingerprint Dive into the research topics where Dan Ma is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

  • 4 Similar Profiles
Oligodendroglia Medicine & Life Sciences
Stem Cells Medicine & Life Sciences
Schwann Cells Medicine & Life Sciences
Myelin Sheath Medicine & Life Sciences
DNA Methylation Medicine & Life Sciences
Central Nervous System Medicine & Life Sciences
Neurodegenerative Diseases Medicine & Life Sciences
Demyelinating Diseases Medicine & Life Sciences

Research Output 2015 2018

A Subpopulation of Foxj1-Expressing, Nonmyelinating Schwann Cells of the Peripheral Nervous System Contribute to Schwann Cell Remyelination in the Central Nervous System

Ma, D., Wang, B., Zawadzka, M., Gonzalez, G., Wu, Z., Yu, B., Rawlins, E. L., Franklin, R. J. M. & Zhao, C., 24 Oct 2018, In : Journal of Neuroscience. 38, 43, p. 9228-9239

Research output: Contribution to journalArticle

Open Access
File
Schwann Cells
Peripheral Nervous System
Central Nervous System
Myelin Sheath
Oligodendroglia

Efficient Remyelination Requires DNA Methylation

Moyon, S., Ma, D., Huynh, J. L., Coutts, D. J. C., Zhao, C., Casaccia, P. & Franklin, R. J. M., 20 Mar 2017, In : eNeuro. 4, 2, ENEURO.0336-16.2017.

Research output: Contribution to journalArticle

Open Access
File
Oligodendroglia
DNA Methylation
Methyltransferases
Stem Cells
DNA

Functional Characterization of DNA Methylation in the Oligodendrocyte Lineage

Moyon, S., Huynh, J., Dutta, D., Zhang, F., Ma, D., Yoo, S., Lawrence, R., Wegner, M., John, G., Emery, B., Lubetzki, C., Franklin, R. M., Fan, G., Zhu, J., Dupree, J. & Casaccia, P., 14 Apr 2016, In : Cell Reports. 15, 4, p. 748-760

Research output: Contribution to journalArticle

Open Access
File
RNA Splicing
RNA Sequence Analysis
Endoplasmic Reticulum Stress
Neurogenesis
Oligodendroglia

Astrocyte Activation via Stat3 Signaling Determines the Balance of Oligodendrocyte versus Schwann Cell Remyelination

Monteiro De Castro, G., Deja, N. A., Ma, D., Zhao, C. & Franklin, R. J. M., 1 Sep 2015, In : American Journal of Pathology. 185, 9, p. 2431-2440

Research output: Contribution to journalArticle

Schwann Cells
Oligodendroglia
Astrocytes
Central Nervous System
Knockout Mice

Discovery of a novel neuroprotectant, BHDPC, that protects against MPP + /MPTP-induced neuronal death in multiple experimental models

Chong, C., Ma, D., Zhao, C., Franklin, R. J. M., Zhou, Z., Ai, N., Li, C., Yu, H., Hou, T., Sa, F. & Ming-yuen Lee, S., 1 Dec 2015, In : Free Radical Biology and Medicine. 89, p. 1057-1066

Research output: Contribution to journalArticle

1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine
Neuroprotective Agents
Neurons
Theoretical Models
Neurodegenerative diseases