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Dan Ma

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Adult brain stem cells in central nervous system remyelination

Personal profile

Biography

Dr Dan Ma is a Lecturer in Biomedical Sciences at Aston Medical School, Aston University, where she contributes to medical education and leads research into stem cell-mediated myelin repair and the neurovascular mechanisms of neurodegeneration. Her research explores how brain stem cells, oligodendrocyte lineage cells and vascular endothelial cells regulate myelin integrity, with particular interest in ageing, Alzheimer’s disease, multiple sclerosis and related white matter pathology. Her work aims to advance translational neuroscience by developing human-relevant models to better understand mechanisms of myelin damage and repair.

Dan obtained her medical degree and MD in China before moving to the UK as a Royal Society Visiting Scholar at the University of Nottingham. She later completed her DPhil in Neuroanatomy at the University of Oxford and continued her biomedical research at the University of Cambridge. At the Cambridge Stem Cell Institute and the Department of Clinical Neurosciences, she investigated adult brain stem cells and mechanisms of myelin regeneration.

Since joining Aston Medical School, Dan has developed an independent research programme on endothelial regulation of oligodendrocyte function and neuroregeneration. The Ma Lab uses iPSC-derived endothelial cells, oligodendrocyte progenitor cells, 3D nanomatrix myelination models and brain organoids to model neurovascular interactions, focusing on how endothelial function regulates white matter health and informs future therapeutic development.

Qualifications

  • PGCert in Teaching & Learning in Higher Education. Aston University, UK
  • D.Phil. in neuroanatomy, University of Oxford, UK
  • Master of Medicine (MD) in neuroendocrinology, The Fourth Military Medical University, Xi’an, PR China
  • Bachelor of Medicine and Bachelor of Surgery (BMBCh), The Fourth Military Medical University, Xi’an, PR China

Research Interests

  • Stem cell-mediated myelin repair and remyelination
  • Endothelial regulation of oligodendrocyte function and white matter health
  • Human iPSC-based models of neurovascular interactions in neurodegeneration

Teaching Activity

·        SFHEA

·        MBChB courses on Regeneration and Repair (Pathological Processes block), Autonomic Nervous System (Physiology and Pharmacology block), Neurons and Neuroglia, and Intracranial Contents (Head and Neck block).

·        MIBTP PhD Masterclass on Experimental Neuro Immunohistochemistry

·        MSc in Bioinformatics and Genomic Medicine on Cell Based Models in Human Disease Research

·        PhD examiner

·        Tutor for medical students

·        Supervisor for research students

Contact Details

External positions

Visiting Researcher, Department of Clinical Neurosciences, University of Cambridge, UK

2 Jan 201830 Apr 2019

Keywords

  • RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
  • Regenerative Medicine
  • Remyelination

Expertise related to UN Sustainable Development Goals

In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):

  1. SDG 3 - Good Health and Well-being
    SDG 3 Good Health and Well-being

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