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Personal profile

General

I became a lecturer in pharmaceutical sciences in the Aston School of Pharmacy in 1999. Prior to that I had undertaken postdoctoral research in synthetic chemistry at Bonn and Aston as well as nearly six years working for a contract research company. My research interests have broadened out from synthetic chemistry to include molecular modelling and drug design. The current focus is on the design and synthesis of antimicrobial compounds, tissue transglutaminase inhibitors and the application of computational methods to pharmaceutical formulations.

Research Interests

  • Design, synthesis and screening of libraries of new antimycobacterial compounds
  • Computer aided drug design
  • Molecular recognition in fluorescent imprinted polymers and their use as sensors and receptor mimics
  • Design and synthesis of transglutaminase inhibitors

Teaching Activity

Aston Pharmacy School MPharm course: Chemical aspects of pharmacy.

Various MSc courses: Drug design and drug discovery.

Undergraduate biology and biochemistry  courses: Chemistry for biology

Qualifications

PhD (Chemistry, Warwick University, 1987)

BA (Chemistry, St Edmund Hall, Oxford University)

Contact Details

Telephone: +44 (0) 121 204 4002

Room: MB357D

Email: D.L.Rathbone@aston.ac.uk

Keywords

  • QD Chemistry
  • Molecular modelling
  • Drug design
  • Antimicrobial compounds
  • Transglutaminase inhibitors
  • Chemical synthesis

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Research Output

Open Access
  • Effect of Amoxicillin in combination with Imipenem-Relebactam against Mycobacterium abscessus

    Lopeman, R. C., Harrison, J., Rathbone, D., Desai, M., Lambert, P. & Cox, J. A. G., 27 Jan 2020, In : Scientific Reports. 10, 1, 928.

    Research output: Contribution to journalArticle

    Open Access
    File
  • Design, Stability and Efficacy of a New Targeting Peptide for Nanoparticulate Drug Delivery to SH-SY5Y Neuroblastoma Cells

    Huey, R., Rathbone, D., McCarron, P. & Hawthorne, S., 21 Oct 2019, In : Journal of Drug Targeting. 27, 9, p. 959-970 12 p.

    Research output: Contribution to journalArticle

    Open Access
    File
  • Reaction profiling of a set of acrylamide-based human tissue transglutaminase inhibitors

    Jasim, M. & Rathbone, D. L., 1 Jan 2018, In : Journal of Molecular Graphics and Modelling . 79, p. 157-165 9 p.

    Research output: Contribution to journalArticle

    Open Access
    File
  • Development of potent and selective tissue transglutaminase inhibitors: their effect on TG2 function and application in pathological conditions

    Badarau, E., Wang, Z., Rathbone, D. L., Costanzi, A., Thibault, T., Murdoch, C. E., El Alaoui, S., Bartkeviciute, M. & Griffin, M., 22 Oct 2015, In : Chemistry and Biology. 22, 10, p. 1347-1361 15 p.

    Research output: Contribution to journalArticle

    Open Access
    File
  • Thesis

    Automated synthesis and evaluation of potential new anti-microbial agents

    Author: Tims, K. J., 2002

    Supervisor: Rathbone, D. L. (Supervisor) & Billington, D. C. (Supervisor)

    Student thesis: Doctoral ThesisDoctor of Philosophy

    File

    Computational investigation of small-molecule human tissue transglutaminase inhibitors

    Author: Jasim, M., 9 Oct 2017

    Supervisor: Rathbone, D. L. (Supervisor) & Flower, D. R. (Supervisor)

    Student thesis: Doctoral ThesisDoctor of Philosophy

    File

    Computer-aided design, synthesis and screening of potential anti-microbial compounds

    Author: Ren, J., Aug 2009

    Supervisor: Rathbone, D. L. (Supervisor)

    Student thesis: Doctoral ThesisDoctor of Philosophy

    File

    Design and synthesis of potential antimicrobial agents

    Author: Sikdar, S., Jul 2010

    Supervisor: Rathbone, D. L. (Supervisor)

    Student thesis: Doctoral ThesisDoctor of Philosophy

    File

    Design and synthesis of potential antimicrobial agents

    Author: Khan, N. B., Apr 2007

    Supervisor: Rathbone, D. L. (Supervisor)

    Student thesis: Doctoral ThesisDoctor of Philosophy

    File