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Personal profile

General

I became a lecturer in pharmaceutical sciences in the Aston School of Pharmacy in 1999. Prior to that I had undertaken postdoctoral research in synthetic chemistry at Bonn and Aston as well as nearly six years working for a contract research company. My research interests have broadened out from synthetic chemistry to include molecular modelling and drug design. The current focus is on the design and synthesis of antimicrobial compounds, tissue transglutaminase inhibitors and the application of computational methods to pharmaceutical formulations.

Research Interests

  • Design, synthesis and screening of libraries of new antimycobacterial compounds
  • Computer aided drug design
  • Molecular recognition in fluorescent imprinted polymers and their use as sensors and receptor mimics
  • Design and synthesis of transglutaminase inhibitors

Teaching Activity

Aston Pharmacy School MPharm course: Chemical aspects of pharmacy.

Various MSc courses: Drug design and drug discovery.

Undergraduate biology and biochemistry  courses: Chemistry for biology

Qualifications

PhD (Chemistry, Warwick University, 1987)

BA (Chemistry, St Edmund Hall, Oxford University)

Contact Details

Telephone: +44 (0) 121 204 4002

Room: MB357D

Email: D.L.Rathbone@aston.ac.uk

Keywords

  • QD Chemistry
  • Molecular modelling
  • Drug design
  • Antimicrobial compounds
  • Transglutaminase inhibitors
  • Chemical synthesis

Fingerprint Dive into the research topics where Dan Rathbone is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

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Research Output 2000 2019

Design, Stability and Efficacy of a New Targeting Peptide for Nanoparticulate Drug Delivery to SH-SY5Y Neuroblastoma Cells

Huey, R., Rathbone, D., McCarron, P. & Hawthorne, S., 21 Oct 2019, In : Journal of Drug Targeting. 27, 9, p. 959-970 12 p.

Research output: Contribution to journalArticle

amsonic acid
Neuroblastoma
Peptides
Rabies virus
Nanoparticles

Reaction profiling of a set of acrylamide-based human tissue transglutaminase inhibitors

Jasim, M. & Rathbone, D. L., 1 Jan 2018, In : Journal of Molecular Graphics and Modelling . 79, p. 157-165 9 p.

Research output: Contribution to journalArticle

Open Access
File
Neurodegenerative diseases
Acrylamide
Protonation
Michael reaction
Crosslinking

Development of potent and selective tissue transglutaminase inhibitors: their effect on TG2 function and application in pathological conditions

Badarau, E., Wang, Z., Rathbone, D. L., Costanzi, A., Thibault, T., Murdoch, C. E., El Alaoui, S., Bartkeviciute, M. & Griffin, M., 22 Oct 2015, In : Chemistry and Biology. 22, 10, p. 1347-1361 15 p.

Research output: Contribution to journalArticle

Open Access
File
Endothelial cells
Fibronectins
Syndecan-4
Umbilical Cord
Peptidomimetics

TG2: a credible therapeutic target in fibrotic diseasedue to its multifunctional roles

Griffin, M., Wang, Z., Thibault, T., Murdoch, C. & Rathbone, D., 31 Aug 2015, In : Amino Acids. 47, 8, p. 1629 1 p.

Research output: Contribution to journalMeeting abstract

Fibrosis
Collagen
Fibronectins
Proteins
Chemical activation

Compound for treating clostridium difficile

Rathbone, D. L., Worthington, A., Al-Malaika, S., Hird, M. & Quayle, A., 2014, Patent No. US20170320906A1, Priority date 27 Nov 2014

Research output: Patent

Open Access

Thesis

Automated synthesis and evaluation of potential new anti-microbial agents

Author: Tims, K. J., 2002

Supervisor: Rathbone, D. L. (Supervisor) & Billington, D. C. (Supervisor)

Student thesis: Doctoral ThesisDoctor of Philosophy

File

Computational investigation of small-molecule human tissue transglutaminase inhibitors

Author: Jasim, M., 9 Oct 2017

Supervisor: Rathbone, D. L. (Supervisor) & Flower, D. R. (Supervisor)

Student thesis: Doctoral ThesisDoctor of Philosophy

File

Computer-aided design, synthesis and screening of potential anti-microbial compounds

Author: Ren, J., Aug 2009

Supervisor: Rathbone, D. L. (Supervisor)

Student thesis: Doctoral ThesisDoctor of Philosophy

File

Design and synthesis of potential antimicrobial agents

Author: Sikdar, S., Jul 2010

Supervisor: Rathbone, D. L. (Supervisor)

Student thesis: Doctoral ThesisDoctor of Philosophy

File

Design and synthesis of potential antimicrobial agents

Author: Khan, N. B., Apr 2007

Supervisor: Rathbone, D. L. (Supervisor)

Student thesis: Doctoral ThesisDoctor of Philosophy

File