Research output per year
Research output per year
Personal profile
Biography
I became a lecturer in pharmaceutical sciences in the Aston School of Pharmacy in 1999. Prior to that I had undertaken postdoctoral research in synthetic chemistry at Bonn and Aston as well as nearly six years working for a contract research company. My research interests have broadened out from synthetic chemistry to include molecular modelling and drug design. The current focus is on the design and synthesis of antimicrobial compounds, tissue transglutaminase inhibitors and the application of computational methods to pharmaceutical formulations.
Research Interests
- Design, synthesis and screening of libraries of new antimycobacterial compounds
- Computer aided drug design
- Design of targetting ligands for nanoparticulate drug delivery to the CNS
- Design and synthesis of transglutaminase inhibitors
Teaching Activity
Aston Pharmacy School MPharm course: Chemical aspects of pharmacy.
Various MSc courses: Drug design and drug discovery.
Qualifications
PhD (Chemistry, Warwick University, 1987)
BA (Chemistry, St Edmund Hall, Oxford University)
Membership of Professional Bodies
Member of the Royal Society of Chemistry
Contact Details
Telephone: +44 (0) 121 204 4002
Room: MB357D
Email: D.L.Rathbone@aston.ac.uk
Education/Academic qualification
Aston Molecules Ltd.
1 Apr 1991 → 30 Nov 1995
Keywords
- QD Chemistry
- Molecular modelling
- Drug design
- Antimicrobial compounds
- Transglutaminase inhibitors
- Chemical synthesis
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Author Correction: Effect of Amoxicillin in combination with Imipenem-Relebactam against Mycobacterium abscessus (Scientific Reports, (2020), 10, 1, (928), 10.1038/s41598-020-57844-8)
Lopeman, R. C., Harrison, J., Rathbone, D. L., Desai, M., Lambert, P. A. & Cox, J. A. G., 1 Dec 2020, In: Scientific Reports. 10, 1, 4540.Research output: Contribution to journal › Correction › peer-review
Open Access -
Effect of Amoxicillin in combination with Imipenem-Relebactam against Mycobacterium abscessus
Lopeman, R. C., Harrison, J., Rathbone, D., Desai, M., Lambert, P. & Cox, J. A. G., 27 Jan 2020, In: Scientific Reports. 10, 1, 928.Research output: Contribution to journal › Article › peer-review
Open AccessFile -
Design, Stability and Efficacy of a New Targeting Peptide for Nanoparticulate Drug Delivery to SH-SY5Y Neuroblastoma Cells
Huey, R., Rathbone, D., McCarron, P. & Hawthorne, S., 21 Oct 2019, In: Journal of Drug Targeting. 27, 9, p. 959-970 12 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile -
Reaction profiling of a set of acrylamide-based human tissue transglutaminase inhibitors
Jasim, M. & Rathbone, D. L., 1 Jan 2018, In: Journal of Molecular Graphics and Modelling . 79, p. 157-165 9 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile -
Development of potent and selective tissue transglutaminase inhibitors: their effect on TG2 function and application in pathological conditions
Badarau, E., Wang, Z., Rathbone, D. L., Costanzi, A., Thibault, T., Murdoch, C. E., El Alaoui, S., Bartkeviciute, M. & Griffin, M., 22 Oct 2015, In: Chemistry and Biology. 22, 10, p. 1347-1361 15 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile