Research output per year
Research output per year
Personal profile
Research Interests
Dr Emma Shepherd is an experimental biologist who specialises in developing in vitro and ex vivo models to examine the processes by which human tissue scars and repairs. Emma’s research group investigates molecular pathways in liver disease to identify candidate molecules for use as either biomarkers or as druggable targets. Advanced fibrotic disease is characterised by extensive deposition of extracellular matrix, which is highly cross-linked and resistant to breakdown, and this represents a major challenge in predicting drug efficacy. The chemical and mechanical properties of the microenvironment surrounding a cell play a major role in regulating cell fate and function. To model this, Emma’s research examines the role of the matrix composition on promoting fibrogenesis or repair.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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SDG 3 Good Health and Well-being
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Collaborations and top research areas from the last five years
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Firewater, fructose and appetite
Shepherd, E. L. & Lalor, P. F., 10 Nov 2025, In: Nature Metabolism. 7, 11, p. 2187-2188 2 p.Research output: Contribution to journal › Article › peer-review
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Evaluation of Gremlin-1 as a therapeutic target in metabolic dysfunction-associated steatohepatitis
Horn, P., Norlin, J., Almholt, K., Viuff, B. M., Galsgaard, E. D., Hald, A., Zosel, F., Demuth, H., Poulsen, S., Norby, P. L., Rasch, M. G., Vyberg, M., Fleckner, J., Werge, M. P., Gluud, L. L., Rink, M. R., Shepherd, E., Northall, E., Lalor, P. F. & Weston, C. J. & 2 others, , 3 Oct 2024, In: eLife. 13, 27 p., 95185.Research output: Contribution to journal › Article › peer-review
Open AccessFile5 Downloads (Pure) -
Decellularization of the Human Liver to Generate Native Extracellular Matrix for Use in Automated Functional Assays with Stellate Cells
Shepherd, E. L., Northall, E., Papakyriacou, P., Safranska, K., Sorensen, K. K. & Lalor, P. F., 30 May 2023, Hepatic Stellate Cells. Weiskirchen, R. & Friedman, S. L. (eds.). Humana Press, Vol. 2669. p. 233-244 12 p. (Methods in molecular biology (Clifton, N.J.)).Research output: Chapter in Book/Published conference output › Chapter (peer-reviewed) › peer-review
2 Link opens in a new tab Citations (Scopus) -
Post-exercise muscle glycogen synthesis with glucose, galactose and combined galactose-glucose ingestion
Podlogar, T., Shad, B. J., Seabright, A. P., Odell, O. J., Lord, S. O., Salgueiro, R. B., Civil, R., Shepherd, E. L., Lalor, P. F., Elhassan, Y. S., Lai, Y.-C., Rowlands, D. S. & Wallis, G. A., 1 Dec 2023, In: American Journal of Physiology. 325, 6, p. E672-E681Research output: Contribution to journal › Article › peer-review
Open AccessFile9 Link opens in a new tab Citations (SciVal)25 Downloads (Pure) -
The senescent secretome drives PLVAP expression in cultured human hepatic endothelial cells to promote monocyte transmigration
Wilkinson, A. L., Hulme, S., Kennedy, J. I., Mann, E. R., Horn, P., Shepherd, E. L., Yin, K., Zaki, M. Y. W., Hardisty, G., Lu, W.-Y., Rantakari, P., Adams, D. H., Salmi, M., Hoare, M., Patten, D. A. & Shetty, S., 20 Oct 2023, In: iScience. 26, 10, p. 107966 107966.Research output: Contribution to journal › Article › peer-review
Open AccessFile7 Link opens in a new tab Citations (SciVal)9 Downloads (Pure)