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  • Phone0121 204 5040
  • School of Life & Health Sciences, Aston Triangle

    B4 7ET Birmingham

    United Kingdom

20072019
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Research Output 2007 2019

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Article
2019

Distinct conformations, aggregation and cellular internalization of different tau strains

Karikari, T. K., Nagel, D. A., Grainger, A., Clarke-Bland, C., Crowe, J., Hill, E. J. & Moffat, K. G., 9 Jul 2019, In : Frontiers in Cellular Neuroscience. 13, 296.

Research output: Contribution to journalArticle

Open Access
File
Frontotemporal Dementia
Tauopathies
Induced Pluripotent Stem Cells
tau Proteins
Mutation

Preparation of stable tau oligomers for cellular and biochemical studies

Karikari, T. K., Nagel, D. A., Grainger, A., Clarke-bland, C., Hill, E. J. & Moffat, K. G., 1 Feb 2019, In : Analytical Biochemistry. 566, p. 67-74 8 p.

Research output: Contribution to journalArticle

Open Access
File
Oligomers
Tauopathies
Ethylmaleimide
Structure-Activity Relationship
Neuroblastoma
2018

A closer look at neuron interaction with track-etched microporous membranes

George, J. H., Nagel, D., Waller, S., Hill, E., Parri, H. R., Coleman, M. D., Cui, Z. & Ye, H., 19 Oct 2018, In : Scientific Reports. 8, 1, 15552.

Research output: Contribution to journalArticle

Open Access
File
Neurites
Neurons
Membranes
Growth
Electron Scanning Microscopy

Downregulation of aquaporin 3 inhibits cellular proliferation, migration and invasion in the MDA‑MB‑231 breast cancer cell line

Arif, M., Kitchen, P., Conner, M., Hill, E., Nagel, D., Bill, R., Dunmore, S., Armesilla, A., Gross, S., Carmichael, A., Conner, A. & Brown, J., May 2018, In : Oncology Letters. 16, 1, p. 713-720

Research output: Contribution to journalArticle

Open Access
File
Aquaporin 3
Aquaporins
Aquaglyceroporins
Glycerol
Gene Knockdown Techniques
2017

Expression and purification of tau protein and its frontotemporal dementia variants using a cleavable histidine tag

Karikari, T. K., Turner, A., Stass, R., Lee, L. C. Y., Wilson, B., Nagel, D. A., Hill, E. J. & Moffat, K. G., Feb 2017, In : Protein Expression and Purification. 130, p. 44-54 11 p.

Research output: Contribution to journalArticle

Open Access
File
tau Proteins
Frontotemporal Dementia
Histidine
Poisons
Alzheimer Disease

Plasma irisin is elevated in type 2 diabetes and is associated with increased E-selectin levels

Rana, K. S., Pararasa, C., Afzal, I., Nagel, D. A., Hill, E. J., Bailey, C. J., Griffiths, H. R., Kyrou, I., Randeva, H. S., Bellary, S. & Brown, J. E., 9 Nov 2017, In : Cardiovascular Diabetology. 16, 1

Research output: Contribution to journalArticle

Open Access
File
E-Selectin
Type 2 Diabetes Mellitus
Obesity
Adiposity
Adipose Tissue
2015

Amyloid β 1-42 induces hypometabolism in human stem cell-derived neuron and astrocyte networks

Tarczyluk, M. A., Nagel, D. A., Parri, H. R., Tse, E. H. Y., Brown, J. E., Coleman, M. D. & Hill, E. J., 1 Aug 2015, In : Journal of Cerebral Bood Fow and Metabolism. 35, 8, p. 1348-1357 10 p.

Research output: Contribution to journalArticle

Open Access
File
Amyloid
Astrocytes
Alzheimer Disease
Stem Cells
Neurons

A predictive in vitro model of the impact of drugs with anticholinergic properties on human neuronal and astrocytic systems

Woehrling, E. K., Parri, H. R., Tse, E. H. Y., Hill, E. J., Maidment, I. D., Fox, G. C. & Coleman, M. D., 4 Mar 2015, In : PLoS ONE. 10, 3, 18 p., e0118786.

Research output: Contribution to journalArticle

Open Access
File
Cholinergic Antagonists
astrocytes
cholinergic agents
cimetidine
drugs
2014

Plasma irisin levels predict telomere length in healthy adults

Rana, K. S., Arif, M., Hill, E. J., Aldred, S., Nagel, D. A., Nevill, A., Randeva, H. S., Bailey, C. J., Bellary, S. & Brown, J. E., Apr 2014, In : Age. 36, 2, p. 995-1001 7 p.

Research output: Contribution to journalArticle

Open Access
File
Telomere
Body Composition
Adipose Tissue
Abdominal Fat
Intra-Abdominal Fat

The effects of the fungicides fenhexamid and myclobutanil on SH-SY5Y and U-251 MG human cell lines

Nagel, D. A., Hill, E. J., O'Neil, J., Mireur, A. & Coleman, M. D., Nov 2014, In : Environmental Toxicology and Pharmacology. 38, 3, p. 968-976 9 p.

Research output: Contribution to journalArticle

Fungicides
Pesticides
Cells
Cell Line
Cell Survival
2013
Brain-Derived Neurotrophic Factor
Neurology
Cell culture
Animals
Central Nervous System

Effects of lithium and valproic acid on gene expression and phenotypic markers in an NT2 neurosphere model of neural development

Hill, E., Nagel, D., O'Neil, J., Torr, L., Woehrling, E., Devitt, A. & Coleman, M., 19 Mar 2013, In : PLoS ONE. 8, 3, 9 p., e58822.

Research output: Contribution to journalArticle

Open Access
File
valproic acid
neurodevelopment
lithium
Valproic Acid
Lithium

Functional astrocyte-neuron lactate shuttle in a human stem cell-derived neuronal network

Tarczyluk, M. A., Nagel, D. A., O'Neil, J., Parri, H. R., Tse, E. H. Y., Coleman, M. D. & Hill, E. J., Sep 2013, In : Journal of Cerebral Bood Fow and Metabolism. 33, 9, p. 1386-1393 8 p.

Research output: Contribution to journalArticle

Open Access
File
Astrocytes
Lactic Acid
Stem Cells
Neurons
Coculture Techniques

Sulforaphane restores cellular glutathione levels and reduces chronic periodontitis neutrophil hyperactivity in vitro

Dias, I. H. K., Chapple, I. L. C., Milward, M., Grant, M. M., Hill, E., Brown, J. & Griffiths, H. R., 24 Jun 2013, In : PLoS ONE. 8, 6, 13 p., e66407.

Research output: Contribution to journalArticle

Open Access
File
Chronic Periodontitis
Glutathione
neutrophils
glutathione
Neutrophils

α7 nicotinic receptor-mediated astrocytic gliotransmitter release: Aβ effects in a preclinical Alzheimer's mouse model

Pirttimaki, T. M., Codadu, N. K., Awni, A., Pratik, P., Nagel, D. A., Hill, E. J., Dineley, T. K. & Parri, H. R., 28 Nov 2013, In : PLoS ONE. 8, 11, 12 p., e81828.

Research output: Contribution to journalArticle

Open Access
File
Nicotinic Receptors
Alzheimer disease
astrocytes
Alzheimer Disease
Astrocytes
2012

A preliminary investigation into the impact of a pesticide combination on human neuronal and glial cell lines in vitro

Coleman, M., O'Neil, J., Woehrling, E., Ndunge, O., Hill, E., Menache, A. & Reiss, C., 3 Aug 2012, In : PLoS ONE. 7, 8, 8 p., e42768.

Research output: Contribution to journalArticle

Open Access
File
cyprodinil
Poisons
neuroglia
Pesticides
Neuroglia

NT2 derived neuronal and astrocytic network signalling

Hill, E., Jiménez-González, M., Tarczyluk, M., Nagel, D. A., Coleman, M. D. & Parri, R., 2 May 2012, In : PLoS ONE. 7, 5, 10 p., e36098.

Research output: Contribution to journalArticle

Open Access
File
astrocytes
Astrocytes
Neurons
neurons
Calcium
2011

Single-cell ELISA and flow cytometry as methods for highlighting potential neuronal and astrocytic toxicant specificity

Woehrling, E., J. Hill, E., Torr, E. E. & Coleman, M., Apr 2011, In : Neurotoxicity Research. 19, 3, p. 472-483 12 p.

Research output: Contribution to journalArticle

Flow cytometry
Glial Fibrillary Acidic Protein
Intermediate Filaments
Flow Cytometry
Cytotoxicity
2010

Evaluation of the importance of astrocytes when screening for acute toxicity in neuronal cell systems

Woehrling, E., J. Hill, E. & Coleman, M., Feb 2010, In : Neurotoxicity Research. 17, 2, p. 103-113 11 p.

Research output: Contribution to journalArticle

Astrocytes
Toxicity
Screening
Poisons
Mitochondrial Membrane Potential
2008

Differentiating human NT2/D1 neurospheres as a versatile in vitro 3D model system for developmental neurotoxicity testing

Hill, E. J., Woehrling, E. K., Prince, M. & Coleman, M. D., 30 Jul 2008, In : Toxicology. 249, 2-3, p. 243-250 8 p.

Research output: Contribution to journalArticle

Hydroxyurea
Acrylamide
Clone Cells
Neurogenesis
Valproic Acid

Polarized secretion of leukemia inhibitory factor

Hill, E. J. & Vernallis, A. B., 18 Sep 2008, In : BMC Cell Biology. 9, 53, 10 p., 53.

Research output: Contribution to journalArticle

Open Access
File
Leukemia Inhibitory Factor
Protein Sorting Signals
Interleukin-1beta
Interleukin-6
Clone Cells
2007

Development of a neurotoxicity test-system, using human post-mitotic, astrocytic and neuronal cell lines in co-culture

Woehrling, E. K., Hill, E. J. & Coleman, M. D., Oct 2007, In : Toxicology in Vitro . 21, 7, p. 1241-1246 6 p.

Research output: Contribution to journalArticle

Coculture Techniques
Cell culture
Astrocytes
Neurons
Cells