Ivan Wall

Professor, Dr, Professor

20072019
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Personal profile

General

Ivan joined Aston School of Life & Health Sciences in January 2018, having previously been Reader in Cell & Gene Therapy Bioprocessing at University College London (UCL).

He graduated with a PhD in cell and molecular biology from Cardiff University School of Dentistry in 2006. His thesis, under supervision of Prof Phil Stephens and Prof David Thomas, focussed on dysfunctional behaviour of skin fibroblasts in chronic wounds that fail to heal. This underpinned a longstanding interest in why some tissues fail to heal and how stem cells and regenerative medicine might be applied to restore failing tissues and organs.

He moved to UCL at the end of 2005, undertaking post-doctoral research first at Eastman Dental Institute (2005-2007) to continue studies into regenerative medicine and then at the Institute of Ophthalmology (2007-2009), where he studied the molecular basis of angiogenesis and neurogenesis with Prof Christiana Ruhrberg. He joined UCL’s Department of Biochemical Engineering in 2009 and established a successful multi-disciplinary research group working in the area of regenerative medicine, cell & gene therapy.

Ivan's research interfaces cell biology with bioprocessing, biomaterials and novel devices. His work spans fundamental research through to applied and translation studies with industry and clinical collaborators. He has been awarded funding from EPSRC, BBSRC, MRC, Wellcome, Innovate UK, EU, as well as industry. He has been part of, as PI or co-I, successful grant applications totalling over £40M in grant funding as principal investigator, published 70 peer-reviewed papers and am a visiting professor at Dankook University in South Korea.

Research Projects/Collaborations

  • Gene-modified cells (biology and biomanufacturing of existing and novel cell types to create regenerative therapies)
  • T-cells (bioprocessing of T-cells to advance towards safe and potent products with consistent quality)
  • Extracellular vesicles (biology and biomanufacturing)
  • Applications of biomaterials as substrates for cell therapy manufacture and tissue engineering
  • Applications of new device technologies for manipulation, culture and characterisation of cell therapy products

Teaching Activity

Ivan coordinates a new MSc programme, Regenerative Medicine Manufacturing and supervises undergraduate project students and placement students, as well as MSc project students. 

Contact Details

Email: i.wall@aston.ac.uk
Phone: +44 (0) 121 204 4202
Room:MB433j

Education/Academic qualification

PhD, Cardiff University

MPhil, Cardiff University

BSc, Cardiff University

Fingerprint Dive into the research topics where Ivan Wall is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

Bone Engineering & Materials Science
Tissue engineering Engineering & Materials Science
Stem cells Engineering & Materials Science
Tissue Engineering Medicine & Life Sciences
Cell culture Engineering & Materials Science
Bone Regeneration Medicine & Life Sciences
Fibroblasts Medicine & Life Sciences
Scaffolds Engineering & Materials Science

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Research Output 2007 2019

A parameterised mathematical model to elucidate osteoblast cell growth in a phosphate-glass microcarrier culture

Burova, I., Peticone, C., De Silva Thompson, D., Knowles, J. C., Wall, I. & Shipley, R. J., 5 Mar 2019, In : Journal of Tissue Engineering. 10, p. 1-14

Research output: Contribution to journalArticle

Open Access
File
Osteoblasts
Cell growth
Cell culture
Glass
Phosphates

Assessing behaviour of osteoblastic cells in dynamic culture conditions using titanium-doped phosphate glass microcarriers

De Silva Thompson, D., Peticone, C., Burova, I., Shipley, R. J., Knowles, J. C., Kim, H-W., Micheletti, M. & Wall, I. B., 26 Feb 2019, In : Journal of Tissue Engineering. 10, p. 2041731419825772

Research output: Contribution to journalArticle

Open Access
File
Titanium
Microspheres
Cell culture
Glass
Bone

Generation of c-MycERTAM-transduced human late-adherent olfactory mucosa cells for potential regenerative applications

Santiago-toledo, G., Georgiou, M., Dos Reis, J., Roberton, V. H., Valinhas, A., Wood, R. C., Phillips, J. B., Mason, C., Li, D., Li, Y., Sinden, J. D., Choi, D., Jat, P. S. & Wall, I. B., 13 Sep 2019, In : Scientific Reports. 9, 1, 13190.

Research output: Contribution to journalArticle

Open Access
File
Olfactory Mucosa
Cell- and Tissue-Based Therapy
Cell Line
Nestin
Oligodendroglia

Mathematical and computational models for bone tissue engineering in bioreactor systems

Burova, I., Wall, I. & Shipley, R. J., 6 Mar 2019, In : Journal of Tissue Engineering. 10, p. 1-25

Research output: Contribution to journalArticle

Open Access
File
Bioreactors
Tissue Engineering
Tissue engineering
Bone
Theoretical Models

Bioprocessing strategies to enhance the challenging isolation of neuro-regenerative cells from olfactory mucosa

Georgiou, M., Reis, J. N. D., Wood, R., Esteban, P. P., Roberton, V., Mason, C., Li, D., Li, Y., Choi, D. & Wall, I., 1 Dec 2018, In : Scientific Reports. 8, 1, 14440.

Research output: Contribution to journalArticle

Open Access
File
Olfactory Mucosa
Laminin
Cell- and Tissue-Based Therapy
Spinal Cord Regeneration
Oxygen