Photo of Jaimy Saif

Jaimy Saif

Dr

    20092018

    Research output per year

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    Personal profile

    Research Interests

    • Evaluating the effects of anti-angiogenic growth factors and developing therapeutic targets for vascular disorders, in particular preeclampsia.
    • Development and optimization of in vivo models of preeclampsia
    • Immunotherapy and therapeutic angiogenesis

    General

    My background is in immunotherapy (from PhD studies) and therapeutic angiogenesis. My research interest in vascular biology and angiogenesis was developed under the mentorships of Prof. Aicher and Prof. Heeschen. I have worked on reparative angiogenesis in different labs in Ludwig Maximilian University of Munich in Germany, Spanish National Cancer Research Centre in Spain, University of Nottingham and Nottingham Trent University in UK.

    I spent 4 years as a post-doctoral scientist in the lab of Prof. Emanueli, who is a pioneer in the field of reparative angiogenesis. During this time I was investigating the therapeutic potential of human embryonic stem cell derived endothelial cells in mouse models of hindlimb ischemia and diabetes mellitus (published in Molecular Therapy). I also worked on characterisation and functional assessment of mechanisms guiding mouse embryonic stem cell differentiation into endothelial cells, with focus on the neurotrophin system (published in ATVB). Another project that I worked on during this period was investigating the role of human pericardial fluid exosomes in vascular complications of diabetes (manuscript in preparation).

    I am a PhD scientist but most of my past mentors were clinical academics which helped me to be part of translational research to influence the clinical practice. I have now joined the Vascular Team at Aston Medical Research Institute led by Prof. Asif Ahmed who has an international reputation in angiogenesis and vascular protection.  Indeed, my new line of research bridges my past studies in vascular regenerative medicine looking at the etiology and developing new therapies for pre-eclampsia, which is one of the deadliest maternal hypertensive disorder. 

    Qualifications

    PhD in cancer immunotherapy, Nottingham Trent University, 2014

    MSc in stem cell technology, University of Nottingham, 2008

    BSc in Biotechnology, Bangalore University, 2007

    Employment

    Postdoctoral Research Fellow, Aston University, 2018-current

    Postdoctoral Research Associate, University of Bristol, 2014-2018

    Graduate Research Assistant, Nottingham Trent University, 2011-2014

    Research Assistant, Nottingham Trent University, 2008-2011

    Contact Details

    • Telephone: 0121 204 5052
    • Email: j.saif@aston.ac.uk
    • Room Number: MB310

    Education/Academic qualification

    PhD

    2 Jul 20112 Jul 2014

    Award Date: 2 Jul 2014

    MSc

    21 Sep 200729 Sep 2008

    Award Date: 29 Sep 2007

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    Research Output

    • 9 Article
    • 3 Review article
    • 1 Conference article
    Open Access
    File
  • Robust Revascularization in Models of Limb Ischemia Using a Clinically Translatable Human Stem Cell-Derived Endothelial Cell Product

    MacAskill, M. G., Saif, J., Condie, A., Jansen, M. A., MacGillivray, T. J., Tavares, A. A. S., Fleisinger, L., Spencer, H. L., Besnier, M., Martin, E., Biglino, G., Newby, D. E., Hadoke, P. W. F., Mountford, J. C., Emanueli, C. & Baker, A. H., 5 Jul 2018, In : Molecular Therapy. 26, 7, p. 1669-1684 16 p.

    Research output: Contribution to journalArticle

    Open Access
    File
  • Synthetic microparticles conjugated with VEGF165 improve the survival of endothelial progenitor cells via microRNA-17 inhibition

    Aday, S., Zoldan, J., Besnier, M., Carreto, L., Saif, J., Fernandes, R., Santos, T., Bernardino, L., Langer, R., Emanueli, C. & Ferreira, L., 29 Sep 2017, In : Nature Communications. 8, 1, 747.

    Research output: Contribution to journalArticle

    Open Access
    File
  • The miR-25-93-106b cluster regulates tumor metastasis and immune evasion via modulation of CXCL12 and PD-L1

    Cioffi, M., Trabulo, S. M., Vallespinos, M., Raj, D., Kheir, T. B., Lin, M-L., Begum, J., Baker, A-M., Amgheib, A., Saif, J., Perez, M., Soriano, J., Desco, M., Gomez-Gaviro, M. V., Cusso, L., Megias, D., Aicher, A. & Heeschen, C., 17 Feb 2017, In : Oncotarget. 8, 13, p. 21609-21625 17 p.

    Research output: Contribution to journalArticle

    Open Access
    File
  • MicroRNA transport in cardiovascular complication of diabetes

    Caporali, A., Miscianinov, V., Saif, J. & Emanueli, C., 1 Dec 2016, In : BBA - Molecular and Cell Biology of Lipids . 1861, 12 Pt B, p. 2111-2120 10 p.

    Research output: Contribution to journalReview article