Photo of Jaimy Saif

Jaimy Saif

Dr

    20092018
    If you made any changes in Pure these will be visible here soon.

    Personal profile

    Research Interests

    • Evaluating the effects of anti-angiogenic growth factors and developing therapeutic targets for vascular disorders, in particular preeclampsia.
    • Development and optimization of in vivo models of preeclampsia
    • Immunotherapy and therapeutic angiogenesis

    General

    My background is in immunotherapy (from PhD studies) and therapeutic angiogenesis. My research interest in vascular biology and angiogenesis was developed under the mentorships of Prof. Aicher and Prof. Heeschen. I have worked on reparative angiogenesis in different labs in Ludwig Maximilian University of Munich in Germany, Spanish National Cancer Research Centre in Spain, University of Nottingham and Nottingham Trent University in UK.

    I spent 4 years as a post-doctoral scientist in the lab of Prof. Emanueli, who is a pioneer in the field of reparative angiogenesis. During this time I was investigating the therapeutic potential of human embryonic stem cell derived endothelial cells in mouse models of hindlimb ischemia and diabetes mellitus (published in Molecular Therapy). I also worked on characterisation and functional assessment of mechanisms guiding mouse embryonic stem cell differentiation into endothelial cells, with focus on the neurotrophin system (published in ATVB). Another project that I worked on during this period was investigating the role of human pericardial fluid exosomes in vascular complications of diabetes (manuscript in preparation).

    I am a PhD scientist but most of my past mentors were clinical academics which helped me to be part of translational research to influence the clinical practice. I have now joined the Vascular Team at Aston Medical Research Institute led by Prof. Asif Ahmed who has an international reputation in angiogenesis and vascular protection.  Indeed, my new line of research bridges my past studies in vascular regenerative medicine looking at the etiology and developing new therapies for pre-eclampsia, which is one of the deadliest maternal hypertensive disorder. 

    Qualifications

    PhD in cancer immunotherapy, Nottingham Trent University, 2014

    MSc in stem cell technology, University of Nottingham, 2008

    BSc in Biotechnology, Bangalore University, 2007

    Employment

    Postdoctoral Research Fellow, Aston University, 2018-current

    Postdoctoral Research Associate, University of Bristol, 2014-2018

    Graduate Research Assistant, Nottingham Trent University, 2011-2014

    Research Assistant, Nottingham Trent University, 2008-2011

    Contact Details

    • Telephone: 0121 204 5052
    • Email: j.saif@aston.ac.uk
    • Room Number: MB310

    Education/Academic qualification

    PhD

    2 Jul 20112 Jul 2014

    MSc

    21 Sep 200729 Sep 2008

    Fingerprint Dive into the research topics where Jaimy Saif is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

    • 5 Similar Profiles
    MicroRNAs Medicine & Life Sciences
    Blood Vessels Medicine & Life Sciences
    Cell- and Tissue-Based Therapy Medicine & Life Sciences
    Tissue Engineering Medicine & Life Sciences
    Endothelial Cells Medicine & Life Sciences
    Stem Cells Medicine & Life Sciences
    Vascular Endothelial Growth Factor A Medicine & Life Sciences
    Tumor Escape Medicine & Life Sciences

    Network Recent external collaboration on country level. Dive into details by clicking on the dots.

    Research Output 2009 2018

    • 9 Article
    • 3 Review article
    • 1 Conference article
    Open Access
    File
    Nitric Oxide Synthase Type III
    Brain-Derived Neurotrophic Factor
    Embryonic Stem Cells
    MicroRNAs
    Cell Differentiation

    Robust Revascularization in Models of Limb Ischemia Using a Clinically Translatable Human Stem Cell-Derived Endothelial Cell Product

    MacAskill, M. G., Saif, J., Condie, A., Jansen, M. A., MacGillivray, T. J., Tavares, A. A. S., Fleisinger, L., Spencer, H. L., Besnier, M., Martin, E., Biglino, G., Newby, D. E., Hadoke, P. W. F., Mountford, J. C., Emanueli, C. & Baker, A. H., 5 Jul 2018, In : Molecular Therapy. 26, 7, p. 1669-1684 16 p.

    Research output: Contribution to journalArticle

    Open Access
    File
    Stem Cells
    Ischemia
    Extremities
    Endothelial Cells
    Cell Tracking

    Synthetic microparticles conjugated with VEGF165 improve the survival of endothelial progenitor cells via microRNA-17 inhibition

    Aday, S., Zoldan, J., Besnier, M., Carreto, L., Saif, J., Fernandes, R., Santos, T., Bernardino, L., Langer, R., Emanueli, C. & Ferreira, L., 29 Sep 2017, In : Nature Communications. 8, 1, 747.

    Research output: Contribution to journalArticle

    Open Access
    File
    Endothelial cells
    microparticles
    MicroRNAs
    Vascular Endothelial Growth Factor A
    cells

    The miR-25-93-106b cluster regulates tumor metastasis and immune evasion via modulation of CXCL12 and PD-L1

    Cioffi, M., Trabulo, S. M., Vallespinos, M., Raj, D., Kheir, T. B., Lin, M-L., Begum, J., Baker, A-M., Amgheib, A., Saif, J., Perez, M., Soriano, J., Desco, M., Gomez-Gaviro, M. V., Cusso, L., Megias, D., Aicher, A. & Heeschen, C., 17 Feb 2017, In : Oncotarget. 8, 13, p. 21609-21625 17 p.

    Research output: Contribution to journalArticle

    Open Access
    File
    Tumor Escape
    MicroRNAs
    Neoplasm Metastasis
    Neoplasms
    Immune Evasion

    MicroRNA transport in cardiovascular complication of diabetes

    Caporali, A., Miscianinov, V., Saif, J. & Emanueli, C., 1 Dec 2016, In : BBA - Molecular and Cell Biology of Lipids . 1861, 12 Pt B, p. 2111-2120 10 p.

    Research output: Contribution to journalReview article

    Diabetes Complications
    MicroRNAs
    Exosomes
    Biological Phenomena
    Complementary RNA