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Research Output

2020
Open Access
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Open Access
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2019

Abundant Active Ingredients of Green Tea Regulate Glucose Metabolism in 3T3-L1 Cell Line

Al-shaeli, S. J. J., Ethaeb, A. M. & Brown, J. E., 27 Nov 2019, In : Indian Journal of Forensic Medicine & Toxicology. 13, 4, p. 738-744 7 p.

Research output: Contribution to journalArticle

Anti-neoplastic effect of epigallocatechin gallate on breast cancer cells through glucose metabolism

Al-shaeli, S. J., Ethaeb, A. M. & Brown, J. E., 5 Jul 2019, In : Journal of Physics: Conference Series. 1234, 1, 012073.

Research output: Contribution to journalConference article

Open Access
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Can this new anti-ageing supplement turn back the clock?

Brown, J., 19 Nov 2019

Research output: Other contributionBlog Post

Open Access
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Exercise, or exercise and diet for the management of polycystic ovary syndrome: a systematic review and meta-analysis

Kite, C., Lahart, I. M., Afzal, I., Broom, D., Randeva, H. S., Kyrou, I. & Brown, J. E., 12 Feb 2019, In : Systematic Reviews. 8, 1, p. 51 1 p., 51.

Research output: Contribution to journalArticle

Open Access
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Phenotypic characteristics and risk factors in a multi-ethnic cohort of young adults with type 2 diabetes

Lascar, N., Altaf, Q-A., Raymond, N. T., Brown, J. E., Pattison, H., Barnett, A., Bailey, C. J. & Bellary, S., 2 Nov 2019, In : Current Medical Research and Opinion. 35, 11, p. 1893-1900 8 p.

Research output: Contribution to journalArticle

Open Access
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Reducing readmission rates through a discharge follow-up service

Vernon, D., Brown, J. E., Griffiths, E., Nevill, A. M. & Pinkney, M., 19 Jun 2019, In : Future Healthcare Journal. 6, 2, p. 114-117 4 p.

Research output: Contribution to journalArticle

Open Access
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Open Access
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2018

An investigation into E-cigarette cytotoxicity in-vitro using a novel 3D differentiated co-culture model of human airways

Vasanthi Bathri Narayanan, P., Brown, J. E., Marshall, L. & Leslie, L. J., 27 Jun 2018, In : Toxicology in Vitro . 52, p. 255-264

Research output: Contribution to journalArticle

Open Access
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Downregulation of aquaporin 3 inhibits cellular proliferation, migration and invasion in the MDA‑MB‑231 breast cancer cell line

Arif, M., Kitchen, P., Conner, M., Hill, E., Nagel, D., Bill, R., Dunmore, S., Armesilla, A., Gross, S., Carmichael, A., Conner, A. & Brown, J., May 2018, In : Oncology Letters. 16, 1, p. 713-720

Research output: Contribution to journalArticle

Open Access
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Evidence that Differences in Fructosamine-3-Kinase Activity May be Associated with the Glycation Gap in Human Diabetes

Dunmore, S. J., Al-Derawi, A. S., Nayak, A. U., Narshi, A., Nevill, A. M., Hellwig, A., Majebi, A., Kirkham, P., Brown, J. E. & Singh, B. M., 1 Jan 2018, In : Diabetes. 67, 1

Research output: Contribution to journalArticle

Open Access
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2017

An investigation into the effects of E-cigarette aerosols using a physiologically relevant in-vitro model

Vasanthi Bathri Narayanan, P., Marshall, L. J., Brown, J. E. & Leslie, L. J., 20 Oct 2017, In : Toxicology Letters. 280, Supplement 1, p. S266 1 p.

Research output: Contribution to journalConference abstract

Open Access
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Bardoxolone-methyl inhibits migration and metabolism in MCF7 cells

Refaat, A., Pararasa, C., Arif, M., Brown, J. E. P., Carmichael, A., Ali, S. S., Sakurai, H. & Griffiths, H. R., 2017, In : Free Radical Research. 51, 2, p. 211-221 11 p.

Research output: Contribution to journalArticle

Open Access
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Open Access
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Plasma irisin is elevated in type 2 diabetes and is associated with increased E-selectin levels

Rana, K. S., Pararasa, C., Afzal, I., Nagel, D. A., Hill, E. J., Bailey, C. J., Griffiths, H. R., Kyrou, I., Randeva, H. S., Bellary, S. & Brown, J. E., 9 Nov 2017, In : Cardiovascular Diabetology. 16, 1

Research output: Contribution to journalArticle

Open Access
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Poly lactic-co-glycolic acid controlled delivery of Disulfiram to target liver cancer stem-like cells

Wang, Z., Tan, J., McConville, C., Kannappan, V., Erebi Tawari, P., Brown, J., Ding, J., Armesilla, A. L., Irache, J. M., Mei, Q-B., Tan, Y., Liu, Y., Jiang, W., Bian, X. & Wang, W., Feb 2017, In : Nanomedicine: Nanotechnology, Biology, and Medicine. 13, 2, p. 641-657 17 p.

Research output: Contribution to journalArticle

Open Access
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Type 2 diabetes in adolescents and young adults

Lascar, N., Brown, J., Pattison, H., Barnett, A. H., Bailey, C. J. & Bellary, S., 5 Oct 2017, In : The Lancet Diabetes and Endocrinology. in press

Research output: Contribution to journalArticle

Open Access
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2016

Age-associated changes in long-chain fatty acid profile during healthy aging promote pro-inflammatory monocyte polarization via PPARγ

Pararasa, C., Ikwuobe, J., Shigdar, S., Boukouvalas, A., Nabney, I. T., Brown, J. E., Devitt, A., Bailey, C. J., Bennett, S. J. & Griffiths, H. R., Feb 2016, In : Aging Cell. 15, 1, p. 128-139 12 p.

Research output: Contribution to journalArticle

Open Access
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The harder you run, the longer (and smoother) the road: exercise, muscle and ageing

Close, G. L. & Brown, J. E., 30 Jun 2016, In : Biogerontology. 17, 3, p. 431-433 3 p.

Research output: Contribution to journalEditorial

Towards an in-vitro multi-cellular human airways model for evaluating the effects of Electronic cigarettes

Vasanthi Bathri Narayanan, P., Leslie, L. J., Brown, J. E. & Marshall, L. J., 2016, p. P20.

Research output: Contribution to conferencePoster

2015

Amyloid β 1-42 induces hypometabolism in human stem cell-derived neuron and astrocyte networks

Tarczyluk, M. A., Nagel, D. A., Parri, H. R., Tse, E. H. Y., Brown, J. E., Coleman, M. D. & Hill, E. J., 1 Aug 2015, In : Journal of Cerebral Bood Fow and Metabolism. 35, 8, p. 1348-1357 10 p.

Research output: Contribution to journalArticle

Open Access
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Evaluating the evidence for targeting FOXO3a in breast cancer: a systematic review

Taylor, S., Lam, M., Pararasa, C., Brown, J. E. P., Carmichael, A. R. & Griffiths, H. R., 2015, In : Cancer Cell International. 15, 1, 9 p.

Research output: Contribution to journalArticle

Open Access
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The effect of the senescence-associated secretory phenotype (SASP) on glucose homeostasis in metabolic cells

Rana, K. S., Hill, E. J., Bellary, S. & Brown, J. E., 11 Mar 2015, In : Diabetic Medicine. 32, Suppl.1, p. 93-94 2 p., P208.

Research output: Contribution to journalConference abstract

The interconnectedness of ageing: does the convoy principal apply?

Saffrey, J. & Brown, J. E., Apr 2015, In : Biogerontology. 16, 2, p. 131-132 2 p.

Research output: Contribution to journalArticle

Open Access
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2014

A novel role of plasma membrane calcium atpase 4 as a negative-regulator of VEGF-induced angiogenesis

Baggott, R. R., Alfranca, A., López-Maderuelo, M., Mohamed, T. M. A., Escolano, A., Oller, J., Ornés, B. C., Rowther, F., Oceandy, D., Kurusamy, S., Brown, J., Cartwright, E. J., Wang, W., Gómez-del Arco, P., Martínez-Martínez, S., Neyses, L., Redondo, J. M. & Armesilla, A. L., 1 Dec 2014, In : Heart. 100, Suppl.4, p. A17-A17 1 p., 050.

Research output: Contribution to journalConference abstract

Can restricting calories help you to live longer?

Brown, J. E., 13 Mar 2014, In : Post Reproductive Health. 20, 1, p. 16-18 3 p.

Research output: Contribution to journalArticle

Open Access
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Does metabolic reprogramming underpin age-associated changes in T cell phenotype and function?

Torrão, R. C., Bennett, S. J., Brown, J. E. & Griffiths, H. R., Jun 2014, In : Free Radical Biology and Medicine. 71, p. 26–35 10 p.

Research output: Contribution to journalArticle

Open Access
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Heparanase and COX-2 expression as predictors of lymph node metastasis in large, high-grade breast tumors

Gawthorpe, S., Brown, J. E., Arif, M., Nightingale, P., Nevill, A. & Carmichael, A. R., 30 Jun 2014, In : Anticancer Research. 34, 6, p. 2797-2800 4 p.

Research output: Contribution to journalArticle

Open Access
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Novel expression of microRNAs in serum samples of Iraqi breast cancer women

Saad, Z., Arif, M., Yassen, N., Jasim, H., Jelawe, M. & Brown, J., 1 May 2014, In : American Journal of Biomedicine. 2, 5, p. 567-574 8 p.

Research output: Contribution to journalArticle

Open Access
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Plasma irisin levels predict telomere length in healthy adults

Rana, K. S., Arif, M., Hill, E. J., Aldred, S., Nagel, D. A., Nevill, A., Randeva, H. S., Bailey, C. J., Bellary, S. & Brown, J. E., Apr 2014, In : Age. 36, 2, p. 995-1001 7 p.

Research output: Contribution to journalArticle

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Plasma membrane calcium ATPase isoform 4 inhibits vascular endothelial growth factor-mediated angiogenesis through interaction with calcineurin

Baggott, R. R., Alfranca, A., López-Maderuelo, D., Mohamed, T. M. A., Escolano, A., Oller, J., Ornes, B. C., Kurusamy, S., Rowther, F. B., Brown, J. E., Oceandy, D., Cartwright, E. J., Wang, W., Gómez-del Arco, P., Martínez-Martínez, S., Neyses, L., Redondo, J. M. & Armesilla, A. L., 31 Oct 2014, In : Arteriosclerosis, Thrombosis, and Vascular biology. 34, 10, p. 2310-2320 11 p.

Research output: Contribution to journalArticle

The interaction between metabolic disease and ageing

Rana, K. S., Griffiths, H. R., Brown, J. E., Navas, P. & Brown, J., 22 Sep 2014, In : Global Journal of Obesity, Diabetes and Metabolic Syndrome. 1, 1, 5 p., 102.

Research output: Contribution to journalArticle

Open Access
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2013

Expression profiling of type 2 diabetes susceptibility genes in the pancreatic islets, adipose tissue and liver of obese mice

Morrison, F., Locke, J., Arif, M., Murray, A., Brown, J. E. & Harries, L. W., 17 Jul 2013, In : Experimental and Clinical Endocrinology and Diabetes . 121, 7, p. 413-419 7 p.

Research output: Contribution to journalArticle

Intermittent fasting: a dietary intervention for prevention of diabetes and cardiovascular disease?

Brown, J. E., Mosley, M. J. & Aldred, S., Mar 2013, In : British Journal of Diabetes and Vascular Disease. 13, 2, p. 68-72 5 p.

Research output: Contribution to journalArticle

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Phytoestrogen-ind uced glucose uptake and cellular proliferation in L6 myotubesadipocyte function

Choudry, N., Robinson, J., Arif, M., Rana, K. S., Hill, E. J., Turner, S., Bailey, C. J. & Brown, J. E., Mar 2013, In : Diabetic Medicine. 30, S1, p. 39 1 p., P37.

Research output: Contribution to journalConference abstract

Sulforaphane restores cellular glutathione levels and reduces chronic periodontitis neutrophil hyperactivity in vitro

Dias, I. H. K., Chapple, I. L. C., Milward, M., Grant, M. M., Hill, E., Brown, J. & Griffiths, H. R., 24 Jun 2013, In : PLoS ONE. 8, 6, 13 p., e66407.

Research output: Contribution to journalArticle

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2012

Disruption of the interaction between PMCA2 and calcineurin triggers apoptosis and enhances paclitaxel-induced cytotoxicity in breast cancer cells

Baggott, R. R., Mohamed, T. M. A., Oceandy, D., Holton, M., Blanc, M. C., Roux-Soro, S. C., Brown, S., Brown, J. E., Cartwright, E. J., Wang, W., Neyses, L. & Armesilla, A. L., Dec 2012, In : Carcinogenesis . 33, 12, p. 2362-2368 7 p., bgs282.

Research output: Contribution to journalArticle

Rapid aquaporin translocation regulates cellular water flow: the mechanism of hypotonicity-induced sub-cellular localization of the aquaporin 1 water channel

Conner, M. T., Conner, A. C., Bland, C. E., Taylor, L. H. J., Brown, J., Parri, H. R. & Bill, R. M., 30 Mar 2012, In : Journal of Biological Chemistry. 287, 14, p. 11516-11525 10 p.

Research output: Contribution to journalArticle

Open Access
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The ageing pancreas

Brown, J. E., May 2012, In : British Journal of Diabetes and Vascular Disease. 12, 3, p. 141-145 5 p.

Research output: Contribution to journalArticle

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The role of adipokines in beta-cell failure of type 2 diabetes

Dunmore, S. J. & Brown, J. E., 2012, In : Journal of Endocrinology. 216, 1, p. T37-T45 9 p.

Research output: Contribution to journalArticle

2011

Adiponectin (15-36) stimulates steroidogenic acute regulatory (StAR) protein expression and cortisol production in human adrenocortical cells: role of AMPK and MAPK kinase pathways

Ramanjaneya, M., Conner, A. C., Brown, J., Chen, J., Digby, J. E., Barber, T. M., Lehnert, H. & Randeva, H. S., May 2011, In : BBA - Molecular Cell Research. 1813, 5, p. 802-809 9 p.

Research output: Contribution to journalArticle

2010

A novel role for the adipokine visfatin/pre-B cell colony-enhancing factor 1 in prostate carcinogenesis

Patel, S. T., Mistry, T., Brown, J., Digby, J. E., Adya, R., Desai, K. M. & Randeva, H. S., Jan 2010, In : Peptides. 31, 1, p. 51-57 7 p.

Research output: Contribution to journalArticle

Aspirin and alterations in DNA repair proteins in the SW480 colorectal cancer cell line

Dibra, H. K., Brown, J., Hooley, P. & Nicholl, I. D., Jul 2010, In : Oncology Reports. 21, 1, p. 37-46 10 p.

Research output: Contribution to journalArticle

Open Access
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Disulfiram/copper complex inhibiting NFκB activity and potentiating cytotoxic effect of gemcitabine on colon and breast cancer cell lines

Guo, X., Xu, B., Pandey, S., Goessl, E., Brown, J., Armesilla, A. L., Darling, J. L. & Wang, W., 1 Apr 2010, In : Cancer Letters. 290, 1, p. 104-113 10 p.

Research output: Contribution to journalArticle

Identification of nesfatin-1 in human and murine adipose tissue: a novel depot-specific adipokine with increased levels in obesity

Ramanjaneya, M., Chen, J., Brown, J., Tripathi, G., Hallschmid, M., Patel, S., Kern, W., Hillhouse, E. W., Lehnert, H., Tan, B. K. & Randeva, H. S., 1 Jul 2010, In : Endocrinology. 151, 7, p. 3169-3180 12 p.

Research output: Contribution to journalArticle

Membrane trafficking of aquaporin 1 is mediated by protein kinase C via microtubules and regulated by tonicity

Conner, M. T., Conner, A. C., Brown, J. & Bill, R. M., 9 Feb 2010, In : Biochemistry. 49, 5, p. 821-823 3 p.

Research output: Contribution to journalArticle

Pseudoislets as primary islet replacements for research: report on a symposium at King's College London, London UK

Persaud, S. J., Arden, C., Bergsten, P., Bone, A. J., Brown, J., Dunmore, S., Harrison, M., Hauge-Evans, A., Kelly, C., King, A., Maffucci, T., Marriott, C. E., McClenaghan, N., Morgan, N. G., Reers, C., Russell, M. A., Turner, M. D., Willoughby, E., Younis, M. Y. G., Zhi, Z. L. & 1 others, Jones, P. M., Jul 2010, In : Islets. 2, 4, p. 236-239 4 p.

Research output: Contribution to journalArticle