Photo of John Simms

John Simms

Dr

    • School of Life & Health Sciences, Aston University, Aston Triangle

      B4 7ET Birmingham

      United Kingdom

    20042020

    Research output per year

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    Research Interests

    Understanding how the binding of a single ligand influences the behaviour of a membrane protein target is a fundamental concept of both molecular pharmacology and drug discovery. My research examines this question in detail using a multitude of approaches from ligand docking and Molecular Dynamics simulations in computational biology for drug discovery, through to using microfluidics and building ‘organs on a chip’ to define the actions of drugs on cells in a realistic setting. This multifaceted approach is well suited to study this rich and complex topic and will aid the future development of new drugs and novel treatments for disease.

     

    Keywords

    Computational Biology,

    Drug Discovery/Drug Screening,

    Molecular Dynamics/Monte Carlo Simulations

     

    Molecular Pharmacology,

    G Protein-Coupled Receptors, 

    Molecular Biology,

    3D cell culture,

    Organ on a chip,

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