Photo of John Simms
    • School of Life & Health Sciences, Aston University, Aston Triangle

      B4 7ET Birmingham

      United Kingdom

    20042020

    Research output per year

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    Personal profile

    Research Interests

    Understanding how the binding of a single ligand influences the behaviour of a membrane protein target is a fundamental concept of both molecular pharmacology and drug discovery. My research examines this question in detail using a multitude of approaches from ligand docking and Molecular Dynamics simulations in computational biology for drug discovery, through to using microfluidics and building ‘organs on a chip’ to define the actions of drugs on cells in a realistic setting. This multifaceted approach is well suited to study this rich and complex topic and will aid the future development of new drugs and novel treatments for disease.

     

    Keywords

    Computational Biology,

    Drug Discovery/Drug Screening,

    Molecular Dynamics/Monte Carlo Simulations

     

    Molecular Pharmacology,

    G Protein-Coupled Receptors, 

    Molecular Biology,

    3D cell culture,

    Organ on a chip,

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    Research Output

    Calcitonin receptor N-glycosylation enhances peptide hormone affinity by controlling receptor dynamics

    Lee, S., Jeong, Y., Simms, J., Warner, M. L., Poyner, D. R., Chung, K. Y. & Pioszak, A. A., 6 Feb 2020, In : Journal of Molecular Biology .

    Research output: Contribution to journalArticle

    Open Access
    File
  • Ligand-induced conformational changes in a SMALP-encapsulated GPCR.

    Routledge, S. J., Jamshad, M., Little, H. A., Lin, Y. P., Simms, J., Thakker, A., Spickett, C. M., Bill, R. M., Dafforn, T. R., Poyner, D. R. & Wheatley, M., 29 Feb 2020, In : Biochimica et Biophysica Acta - Biomembranes. 1862, 6, 183235.

    Research output: Contribution to journalArticle

    Open Access
    File
  • Receptor component protein, an endogenous allosteric modulator of family B G protein coupled receptors

    Routledge, S. J., Simms, J., Clark, A., Yeung, H. Y., Wigglesworth, M. J., Dickerson, I. M., Kitchen, P., Ladds, G. & Poyner, D. R., 1 Mar 2020, In : BBA -Biomembranes. 1862, 3, 183174.

    Research output: Contribution to journalArticle

    Open Access
    File
  • Functional characterisation of G protein-coupled receptors

    Uddin, R., Simms, J. & Poyner, D., 1 Sep 2018, In : Methods. 147, p. 213-220

    Research output: Contribution to journalArticle

    Open Access
    File
  • hCALCRL mutation causes autosomal recessive nonimmune hydrops fetalis with lymphatic dysplasia

    Mackie, D. I., Al Mutairi, F., Davis, R. B., Kechele, D. O., Nielsen, N. R., Snyder, J. C., Caron, M. G., Kliman, H. J., Berg, J. S., Simms, J., Poyner, D. R. & Caron, K. M., 16 Aug 2018, In : Journal of Experimental Medicine . 215, 9, p. 2339-2353

    Research output: Contribution to journalArticle

    Open Access
    File