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    • School of Life & Health Sciences, Aston University, Aston Triangle

      B4 7ET Birmingham

      United Kingdom

    20042020
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    Personal profile

    Research Interests

    Understanding how the binding of a single ligand influences the behaviour of a membrane protein target is a fundamental concept of both molecular pharmacology and drug discovery. My research examines this question in detail using a multitude of approaches from ligand docking and Molecular Dynamics simulations in computational biology for drug discovery, through to using microfluidics and building ‘organs on a chip’ to define the actions of drugs on cells in a realistic setting. This multifaceted approach is well suited to study this rich and complex topic and will aid the future development of new drugs and novel treatments for disease.

     

    Keywords

    Computational Biology,

    Drug Discovery/Drug Screening,

    Molecular Dynamics/Monte Carlo Simulations

     

    Molecular Pharmacology,

    G Protein-Coupled Receptors, 

    Molecular Biology,

    3D cell culture,

    Organ on a chip,

    Fingerprint Dive into the research topics where John Simms is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

    • 4 Similar Profiles
    G-Protein-Coupled Receptors Medicine & Life Sciences
    Calcitonin Receptor-Like Protein Medicine & Life Sciences
    Receptor Activity-Modifying Proteins Medicine & Life Sciences
    Calcitonin Gene-Related Peptide Receptors Medicine & Life Sciences
    Receptor Activity-Modifying Protein 1 Medicine & Life Sciences
    Ligands Medicine & Life Sciences
    Peptides Medicine & Life Sciences
    Chemical activation Chemical Compounds

    Network Recent external collaboration on country level. Dive into details by clicking on the dots.

    Research Output 2004 2020

    Receptor component protein, an endogenous allosteric modulator of family B G protein coupled receptors

    Routledge, S. J., Simms, J., Clark, A., Yeung, H. Y., Wigglesworth, M. J., Dickerson, I. M., Kitchen, P., Ladds, G. & Poyner, D. R., 27 Dec 2019, In : BBA -Biomembranes. 1862, 3, 183174.

    Research output: Contribution to journalArticle

    Open Access
    File
    G-Protein-Coupled Receptors
    Calcitonin Gene-Related Peptide Receptors
    Modulators
    Adrenomedullin
    Receptor Activity-Modifying Protein 1

    Functional characterisation of G protein-coupled receptors

    Uddin, R., Simms, J. & Poyner, D., 1 Sep 2018, In : Methods. 147, p. 213-220

    Research output: Contribution to journalArticle

    Open Access
    File
    G-Protein-Coupled Receptors
    Ligands
    Fluorescence Resonance Energy Transfer
    GTP-Binding Proteins
    Chemical activation

    hCALCRL mutation causes autosomal recessive nonimmune hydrops fetalis with lymphatic dysplasia

    Mackie, D. I., Al Mutairi, F., Davis, R. B., Kechele, D. O., Nielsen, N. R., Snyder, J. C., Caron, M. G., Kliman, H. J., Berg, J. S., Simms, J., Poyner, D. R. & Caron, K. M., 16 Aug 2018, In : Journal of Experimental Medicine . 215, 9, p. 2339-2353

    Research output: Contribution to journalArticle

    Open Access
    File
    Hydrops Fetalis
    Mutation
    Receptor Activity-Modifying Proteins
    Calcitonin Receptor-Like Protein
    Fetal Death

    Photoaffinity cross-linking and unnatural amino acid mutagenesis reveal insights into calcitonin gene-related peptide binding to the calcitonin receptor-like receptor/receptor activity-modifying protein 1 (CLR/RAMP1) complex

    Simms, J., Uddin, R., Sakmar, T. P., Gingell, J. J., Garelja, M. L., Hay, D. L., Brimble, M. A., Harris, P. W. R., Reynolds, C. A. & Poyner, D. R., 14 Aug 2018, In : Biochemistry. 57, 32, p. 4915-4922

    Research output: Contribution to journalArticle

    Open Access
    File
    Receptor Activity-Modifying Protein 1
    Calcitonin Receptor-Like Protein
    Mutagenesis
    Calcitonin Gene-Related Peptide
    Amino Acids

    The structure of the CGRP and related receptors

    Simms, J., Routledge, S., Uddin, R. & Poyner, D., 25 May 2018, Handbook of Experimental Pharmacology. Brain, S. & Gepetti, P. (eds.). Springer, p. 23-36 14 p. (Handbook of Experimental Pharmacology; vol. 255).

    Research output: Chapter in Book/Report/Conference proceedingChapter

    Calcitonin Receptor-Like Protein
    Calcitonin Gene-Related Peptide Receptors
    Receptor Activity-Modifying Protein 1
    Calcitonin Receptors
    G-Protein-Coupled Receptors