Understanding how the binding of a single ligand influences the behaviour of a membrane protein target is a fundamental concept of both molecular pharmacology and drug discovery. My research examines this question in detail using a multitude of approaches from ligand docking and Molecular Dynamics simulations in computational biology for drug discovery, through to using microfluidics and building ‘organs on a chip’ to define the actions of drugs on cells in a realistic setting. This multifaceted approach is well suited to study this rich and complex topic and will aid the future development of new drugs and novel treatments for disease.

Keywords

Computational Biology,

Drug Discovery/Drug Screening,

Molecular Dynamics/Monte Carlo Simulations

Molecular Pharmacology,

G Protein-Coupled Receptors, 

Molecular Biology,

3D cell culture,

Organ on a chip,