Research Output per year
Personal profile
Research Interests
Understanding how the binding of a single ligand influences the behaviour of a membrane protein target is a fundamental concept of both molecular pharmacology and drug discovery. My research examines this question in detail using a multitude of approaches from ligand docking and Molecular Dynamics simulations in computational biology for drug discovery, through to using microfluidics and building ‘organs on a chip’ to define the actions of drugs on cells in a realistic setting. This multifaceted approach is well suited to study this rich and complex topic and will aid the future development of new drugs and novel treatments for disease.
Keywords
Computational Biology,
Drug Discovery/Drug Screening,
Molecular Dynamics/Monte Carlo Simulations
Molecular Pharmacology,
G Protein-Coupled Receptors,
Molecular Biology,
3D cell culture,
Organ on a chip,
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Research Output
Calcitonin receptor N-glycosylation enhances peptide hormone affinity by controlling receptor dynamics
Lee, S., Jeong, Y., Simms, J., Warner, M. L., Poyner, D. R., Chung, K. Y. & Pioszak, A. A., 6 Feb 2020, In : Journal of Molecular Biology .Research output: Contribution to journal › Article
Open Access
File
Ligand-induced conformational changes in a SMALP-encapsulated GPCR.
Routledge, S. J., Jamshad, M., Little, H. A., Lin, Y. P., Simms, J., Thakker, A., Spickett, C. M., Bill, R. M., Dafforn, T. R., Poyner, D. R. & Wheatley, M., 29 Feb 2020, In : Biochimica et Biophysica Acta - Biomembranes. 1862, 6, 183235.Research output: Contribution to journal › Article
Open Access
File
Receptor component protein, an endogenous allosteric modulator of family B G protein coupled receptors
Routledge, S. J., Simms, J., Clark, A., Yeung, H. Y., Wigglesworth, M. J., Dickerson, I. M., Kitchen, P., Ladds, G. & Poyner, D. R., 1 Mar 2020, In : BBA -Biomembranes. 1862, 3, 183174.Research output: Contribution to journal › Article
Open Access
File
Functional characterisation of G protein-coupled receptors
Uddin, R., Simms, J. & Poyner, D., 1 Sep 2018, In : Methods. 147, p. 213-220Research output: Contribution to journal › Article
Open Access
File
hCALCRL mutation causes autosomal recessive nonimmune hydrops fetalis with lymphatic dysplasia
Mackie, D. I., Al Mutairi, F., Davis, R. B., Kechele, D. O., Nielsen, N. R., Snyder, J. C., Caron, M. G., Kliman, H. J., Berg, J. S., Simms, J., Poyner, D. R. & Caron, K. M., 16 Aug 2018, In : Journal of Experimental Medicine . 215, 9, p. 2339-2353Research output: Contribution to journal › Article
Open Access
File