Research Output per year
Research Output per year
Dr
School of Life & Health Sciences, Aston University, Aston Triangle
B4 7ET Birmingham
United Kingdom
Research output per year
Understanding how the binding of a single ligand influences the behaviour of a membrane protein target is a fundamental concept of both molecular pharmacology and drug discovery. My research examines this question in detail using a multitude of approaches from ligand docking and Molecular Dynamics simulations in computational biology for drug discovery, through to using microfluidics and building ‘organs on a chip’ to define the actions of drugs on cells in a realistic setting. This multifaceted approach is well suited to study this rich and complex topic and will aid the future development of new drugs and novel treatments for disease.
Keywords
Computational Biology,
Drug Discovery/Drug Screening,
Molecular Dynamics/Monte Carlo Simulations
Molecular Pharmacology,
G Protein-Coupled Receptors,
Molecular Biology,
3D cell culture,
Organ on a chip,
Research output: Contribution to journal › Article › peer-review
Research output: Contribution to journal › Article › peer-review
Research output: Contribution to journal › Article › peer-review
Research output: Contribution to journal › Article › peer-review
Research output: Contribution to journal › Article › peer-review
Poyner, D. (Creator) & Simms, J. (Creator), Aston Data Explorer, 26 Jul 2018
DOI: 10.17036/researchdata.aston.ac.uk.00000369, https://rupress.org/jem/article/215/9/2339/124276/hCALCRL-mutation-causes-autosomal-recessive
Dataset
Poyner, D. (Creator), Simms, J. (Creator), Hay, D. L. (Creator) & Garelja, M. L. (Creator), Aston Data Explorer, 24 Jul 2018
DOI: 10.17036/researchdata.aston.ac.uk.00000368, https://pubs.acs.org/doi/10.1021/acs.biochem.8b00502
Dataset
Poyner, D. (Creator) & Simms, J. (Creator), Aston Data Explorer, 21 Jul 2015
DOI: 10.17036/3d96d65d-5c12-42d3-ac48-63d91174b32a, https://www.nature.com/articles/celldisc201612
Dataset
Poyner, D. (Creator), Simms, J. (Creator) & Kuteyi, G. (Creator), Aston Data Explorer, 15 May 2015
DOI: 10.17036/9d1b0812-ddb0-4b57-ae1d-38784befa82a, https://www.sciencedirect.com/science/article/pii/S1097276515003007
Dataset
Simms, J. (Creator) & Poyner, D. (Creator), Aston Data Explorer, 6 Aug 2019
DOI: 10.17036/researchdata.aston.ac.uk.00000433, https://www.sciencedirect.com/science/article/pii/S0022283620300929
Dataset