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  • Aston University, Aston Triangle

    B4 7ET Birmingham

20122020
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Research Output 2012 2020

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Article
2020

Effect of Amoxicillin in combination with Imipenem-Relebactam against Mycobacterium abscessus

Lopeman, R. C., Harrison, J., Rathbone, D., Desai, M., Lambert, P. & Cox, J. A. G., 27 Jan 2020, In : Scientific Reports. 10, 1, 928.

Research output: Contribution to journalArticle

Open Access
File
Imipenem
Amoxicillin
Mycobacterium
Mycobacterium Infections
Cystic Fibrosis
Public Opinion
Microbial Drug Resistance
Public Health
Learning
Pharmaceutical Preparations
2019

Changing the Rules of TB-Drug Discovery

Harrison, J. & Cox, J. A. G., 12 Dec 2019, In : Journal of Medicinal Chemistry. 62, 23, p. 10583-10585 3 p.

Research output: Contribution to journalArticle

Fumarate Hydratase
Drug Discovery
Mycobacterium tuberculosis
Tuberculosis
Anti-Bacterial Agents

Crystal structure of Mycobacterium tuberculosis FadB2 implicated in mycobacterial β-oxidation

Cox, J. A. G., Taylor, R. C., Brown, A. K., Attoe, S., Besra, G. S. & Fütterer, K., 1 Jan 2019, In : Acta Crystallographica Section D: Structural Biology. 75, Pt 1, p. 101-108 8 p.

Research output: Contribution to journalArticle

Open Access
File
Coenzyme A
Mycobacterium tuberculosis
Tuberculosis
Enoyl-CoA Hydratase
3-Hydroxyacyl-CoA Dehydrogenase
2018

Antimycobacterial drug discovery using Mycobacteria-infected amoebae identifies anti-infectives and new molecular targets

Trofimov, V., Kicka, S., Mucaria, S., Hanna, N., Ramon-Olayo, F., Del Peral, L. V. G., Lelièvre, J., Ballell, L., Scapozza, L., Besra, G. S., Cox, J. A. G. & Soldati, T., 2 Mar 2018, In : Scientific Reports. 8, 1, 3939.

Research output: Contribution to journalArticle

Open Access
File
Mycobacterium marinum
Amoeba
Drug Discovery
Mycobacterium
Protozoan Infections
2017

Inhibiting mycobacterial tryptophan synthase by targeting the inter-subunit interface

Abrahams, K. A., Cox, J. A. G., Fütterer, K., Rullas, J., Ortega-Muro, F., Loman, N. J., Moynihan, P. J., Pérez-Herrán, E., Jiménez, E., Esquivias, J., Barros, D., Ballell, L., Alemparte, C. & Besra, G. S., 25 Aug 2017, In : Scientific Reports. 7, 15 p., 9430.

Research output: Contribution to journalArticle

Open Access
File
Tryptophan Synthase
Mycobacterium tuberculosis
Growth Inhibitors
Mutation
Mycobacterium Infections

The 'Antibiotic Apocalypse' - scaremongering or scientific reporting?

Cox, J. A. G. & Worthington, T., 1 Mar 2017, In : Trends in Microbiology. 25, 3, p. 167-169 3 p.

Research output: Contribution to journalArticle

Open Access
File
Anti-Bacterial Agents
2016

Identification of KasA as the cellular target of an anti-tubercular scaffold

Abrahams, K. A., Chung, C-W., Ghidelli-Disse, S., Rullas, J., Rebollo-López, M. J., Gurcha, S. S., Cox, J. A. G., Mendoza, A., Jiménez-Navarro, E., Martínez-Martínez, M. S., Neu, M., Shillings, A., Homes, P., Argyrou, A., Casanueva, R., Loman, N. J., Moynihan, P. J., Lelièvre, J., Selenski, C., Axtman, M. & 10 others, Kremer, L., Bantscheff, M., Angulo-Barturen, I., Izquierdo, M. C., Cammack, N. C., Drewes, G., Ballell, L., Barros, D., Besra, G. S. & Bates, R. H., 1 Sep 2016, In : Nature Communications. 7, 13 p., 12581.

Research output: Contribution to journalArticle

Open Access
File
tuberculosis
Mycobacterium tuberculosis
Scaffolds
Tuberculosis
Genes

Novel inhibitors of Mycobacterium tuberculosis GuaB2 identified by a target based high-throughput phenotypic screen

Cox, J. A. G., Mugumbate, G., Vela-Glez del Peral, L., Jankute, M., Abrahams, K. A., Jervis, P., Jackenkroll, S., Perez, A., Alemparte, C., Esquivias, J., Lelièvre, J., Ramon, F., Barros, D., Ballell, L. & Besra, G. S., 16 Dec 2016, In : Scientific Reports. 6, 10 p., 38986.

Research output: Contribution to journalArticle

Open Access
File
Pharmaceutical Chemistry
Mycobacterium bovis
Mycobacterium tuberculosis
Inosine Monophosphate
Pharmaceutical Preparations

THPP target assignment reveals EchA6 as an essential fatty acid shuttle in mycobacteria

Cox, J. A. G., Abrahams, K. A., Alemparte, C., Ghidelli-Disse, S., Rullas, J., Angulo-Barturen, I., Singh, A., Gurcha, S. S., Nataraj, V., Bethell, S., Remuiñán, M. J., Encinas, L., Jervis, P. J., Cammack, N. C., Bhatt, A., Kruse, U., Bantscheff, M., Fütterer, K., Barros, D., Ballell, L. & 2 others, Drewes, G. & Besra, G. S., 18 Jan 2016, In : Nature Microbiology. 1, 15006.

Research output: Contribution to journalArticle

Open Access
File
Essential Fatty Acids
Type II Fatty Acid Synthase
Mycobacterium
Coenzyme A
Mycolic Acids
2015

Mycobacterial dihydrofolate reductase inhibitors identified using chemogenomic methods and in vitro validation.

Mugumbate, G., Abrahams, KA., Cox, JA., Papadatos, G., van, W. G., Lelièvre, J., Calus, ST., Loman, NJ., Ballell, L., Barros, D., Overington, JP. & Besra, GS., 23 Mar 2015, In : PLoS ONE. 10, 3, e0121492.

Research output: Contribution to journalArticle

Open Access
File
dihydrofolate reductase
Folic Acid Antagonists
Mycobacterium tuberculosis
Screening
screening
2014

Biochemical and structural characterization of mycobacterial aspartyl-tRNA synthetase AspS, a promising TB drug target.

Gurcha, SS., Usha, V., Cox, JA., Fütterer, K., Abrahams, KA., Bhatt, A., Alderwick, LJ., Reynolds, RC., Loman, NJ., Nataraj, V., Alemparte, C., Barros, D., Lloyd, AJ., Ballell, L., Hobrath, JV. & Besra, GS., 19 Nov 2014, In : PLoS ONE. 9, 11, e113568.

Research output: Contribution to journalArticle

Open Access
File
Aspartate-tRNA Ligase
RNA, Transfer, Asp
Mycobacterium tuberculosis
Viperidae
Polymorphism
2012

Identification of novel imidazo[1,2-a]pyridine inhibitors targeting M. tuberculosis QcrB.

Abrahams, KA., Cox, JA., Spivey, VL., Loman, NJ., Pallen, MJ., Constantinidou, C., Fernández, R., Alemparte, C., Remuiñán, MJ., Barros, D., Ballell, L. & Besra, GS., 31 Dec 2012, In : PLoS ONE. 7, 12, e52951.

Research output: Contribution to journalArticle

Open Access
File
Mycobacterium bovis BCG
pyridines
Mycobacterium bovis
tuberculosis
Tuberculosis