Having qualified as a Pharmacist in 2013 and having an interest in pharmaceutical formualtion development and oncology, I began a PhD focusing on the development of a novel skin cancer treatment. An ever increasing search in in progress for novel active pharmaceutical ingredients. However we must go beyond the simple identification of useful active's that provide the basis for novel claims and benefits. As formulation scientists we must determine the active compounds absoption, body distribution, metabolism and excretion thus formulate a suitable delivery system. I aim to reduce side effects via effective targetting, and, in view of the high cost that can accompany new materials, incorportate these compounds into targerted, controlled-release delivery systems.
My current research concerns the development of a drug delivery system in Preeclampsia (PE); a major cause of maternal and perinatal mortality and morbidity worldwide. The molecular mechanism underlying its pathogenesis are unclear thus no cure is available except for premature delivery of fetus and placenta. My research includes the developement of placenta targetted liposomes able to carry and deliver potential new therapeutics directly to the placenta thus minimising drug dosing and reducing off site effects.
This research may be important for the development of new therapeutic approaches for the clinical treatment of PE.
5 Oct 2013 → 5 Sep 2017
Award Date: 10 Apr 2018
Award Date: 9 Jan 2017
Development of a novel deformable liposomal formulation for the dermal drug delivery of an anticancer agentsAuthor: Marwah, M., 2017
Supervisor: Lowry, D. (Supervisor) & Perrie, Y. (Supervisor)
Student thesis: Doctoral Thesis › Doctor of Philosophy