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Personal profile

Qualifications

PhD in "Human Biology: cellular and molecular bases", University of Torino, Italy

MSc in Biological Sciences, University of Torino, Italy

Research Interests

My research focuses on understanding the molecular and cellular mechanisms leading to neuronal death and neurodegeneration in central nervous system diseases. I am particularly interested in mechanisms underlying Parkinson’s disease by elucidating the cellular functions of DJ-1 – a protein linked to rare inherited forms of Parkinson’s. This work may ultimately provide insight into novel therapeutic strategies for this disorder.

Teaching Activity

Undergraduate modules

BY1DA1 Development and Human Anatomy

BY1HP1 Physiology for Biologists

Contact Details

Telephone: 0121 204 5219
Email:  m.repici@aston.ac.uk

External positions

Wellcome-Trust Institutional Strategic Support Fund (WT-ISSF) Fellow, University of Leicester

Sep 2018Feb 2019

Research Associate, University of Leicester

Oct 2009Aug 2018

Post-doctoral position

Jan 2007Sep 2009

Post doctoral fellowship , Université de Lausanne

Jun 2004Dec 2006

Fingerprint Dive into the research topics where Mariaelena Repici is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

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JNK Mitogen-Activated Protein Kinases Medicine & Life Sciences
Neurons Medicine & Life Sciences
Parkinson Disease Medicine & Life Sciences
Geniculate Bodies Medicine & Life Sciences
Caspase 3 Medicine & Life Sciences
Cell Death Medicine & Life Sciences
Brain Ischemia Medicine & Life Sciences
Phosphotransferases Medicine & Life Sciences

Research Output 2006 2019

DJ-1 in Parkinson’s Disease: Clinical Insights and Therapeutic Perspectives

Repici, M. & Giorgini, F., 3 Sep 2019, In : Journal of clinical Medicine . 8, 9, 1377.

Research output: Contribution to journalReview article

Open Access
File
Parkinson Disease
Therapeutics
Brain
Oxidative Stress
Biomarkers

The Parkinson's Disease-Linked Protein DJ-1 Associates with Cytoplasmic mRNP Granules During Stress and Neurodegeneration

Repici, M., Hassanjani, M., Maddison, D. C., Garção, P., Cimini, S., Patel, B., Szegö, É. M., Straatman, K. R., Lilley, K. S., Borsello, T., Outeiro, T. F., Panman, L. & Giorgini, F., 1 Jan 2019, In : Molecular Neurobiology. 56, 1, p. 61-77 17 p.

Research output: Contribution to journalArticle

Open Access
File
Cytoplasmic Granules
Parkinson Disease
Oxidative Stress
RNA
Messenger RNA

Adaptive and Behavioral Changes in Kynurenine 3-Monooxygenase Knockout Mice: Relevance to Psychotic Disorders

Erhardt, S., Pocivavsek, A., Repici, M., Liu, X-C., Imbeault, S., Maddison, D. C., Thomas, M. A. R., Smalley, J. L., Larsson, M. K., Muchowski, P. J., Giorgini, F. & Schwarcz, R., 15 Nov 2017, In : Biological Psychiatry. 82, 10, p. 756-765 10 p.

Research output: Contribution to journalArticle

Open Access
File
Kynurenine 3-Monooxygenase
Knockout Mice
Psychotic Disorders
Kynurenic Acid
Kynurenine

Copy-number variation of the neuronal glucose transporter gene SLC2A3 and age of onset in Huntington's disease

15 Jun 2014, In : Human Molecular Genetics. 23, 12, p. 3129-3137 9 p.

Research output: Contribution to journalArticle

Open Access
File
Facilitative Glucose Transport Proteins
Huntington Disease
Age of Onset
Genes
Trinucleotide Repeat Expansion

DJ-1 interactions with α-synuclein attenuate aggregation and cellular toxicity in models of Parkinson's disease

Zondler, L., Miller-Fleming, L., Repici, M., Gonçalves, S., Tenreiro, S., Rosado-Ramos, R., Betzer, C., Straatman, K. R., Jensen, P. H., Giorgini, F. & Outeiro, T. F., 24 Jul 2014, In : Cell Death and Disease. 5, e1350.

Research output: Contribution to journalArticle

Open Access
File
Synucleins
Parkinson Disease
Mutation
Lewy Bodies
Neurons