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Research Output 1997 2019

2019

Mapping the minimum domain of the fibronectin binding site on transglutaminase 2 (TG2) and its importance in mediating signaling, adhesion, and migration in TG2-expressing cells

Soluri, M. F., Boccafoschi, F., Cotella, D., Moro, L., Forestieri, G., Autiero, I., Cavallo, L., Oliva, R., Griffin, M., Wang, Z., Santoro, C. & Sblattero, D., 30 Jan 2019, In : FASEB Journal . 33, 2, p. 2327-2342 16 p.

Research output: Contribution to journalArticle

Fibronectins
Adhesion
Binding Sites
Gelatin
Cell Adhesion

Transglutaminase 2 maintains a colorectal cancer stem phenotype by regulating epithelial-mesenchymal transition

Ayinde, O., Wang, Z., Pinton, G., Moro, L. & Griffin, M., 16 Jul 2019, In : Oncotarget. 10, 44, p. 4556-4569 14 p.

Research output: Contribution to journalArticle

Open Access
File
Epithelial-Mesenchymal Transition
Colorectal Neoplasms
Phenotype
Neoplastic Stem Cells
Vascular Endothelial Growth Factor A
2018

Cardiac fibrosis can be attenuated by blocking the activity of transglutaminase 2 using a selective small-molecule inhibitor

Wang, Z., Stuckey, D. J., Murdoch, C. E., Camelliti, P., Lip, G. Y. H. & Griffin, M., 27 Apr 2018, In : Cell Death and Disease. 9, 613.

Research output: Contribution to journalArticle

Open Access
File
Fibrosis
Myofibroblasts
transglutaminase 2
Angiotensin II
Lysine
2017

Involvement of cell surface TG2 in the aggregation of K562 cells triggered by gluten

Feriotto, G., Calza, R., Bergamini, C. M., Griffin, M., Wang, Z., Beninati, S., Ferretti, V., Marzola, E., Guerrini, R., Pagnoni, A., Cavazzini, A., Casciano, F. & Mischiati, C., 1 Mar 2017, In : Amino Acids. 49, 3, p. 551–565

Research output: Contribution to journalArticle

Open Access
File
K562 Cells
Glutens
Agglomeration
Calcium
Guanosine Triphosphate
Open Access
File
Transforming Growth Factors
Endothelial Cells
transglutaminase 2
Myofibroblasts
Coculture Techniques

Tissue transglutaminase (TG2) enables survival of human malignant pleural mesothelioma cells in hypoxia

Zonca, S., Pinton, G., Wang, Z., Soluri, M. F., Tavian, D., Griffin, M., Sblattero, D. & Moro, L., 2 Feb 2017, In : Cell Death and Disease. 8, 2, 7 p., e2592.

Research output: Contribution to journalArticle

Open Access
File
Cell Hypoxia
Survival
Cell Survival
Epithelioid Cells
Malignant Mesothelioma

Tissue transglutaminase induces epithelial-mesenchymal-transition and the acquisition of stem cell like characteristics in colorectal cancer cells

Ayinde, O., Wang, Z. & Griffin, M., 16 Feb 2017, In : Oncotarget. 8, 12, p. 20025-20041 17 p.

Research output: Contribution to journalArticle

Open Access
File
Catenins
Epithelial-Mesenchymal Transition
Colorectal Neoplasms
Stem Cells
Cell Line
2016

A novel regulatory role for tissue transglutaminase in epithelial-mesenchymal transition in cystic fibrosis

Nyabam, S., Wang, Z., Thibault, T., Ayinde, O., Basar, R., Marshall, L. & Griffin, M., Sep 2016, In : BBA - Molecular Cell Research. 1863, 9, p. 2234-2244 11 p.

Research output: Contribution to journalArticle

Open Access
File
Cystic Fibrosis Transmembrane Conductance Regulator
Epithelial-Mesenchymal Transition
Cystic Fibrosis
Cysteamine
Inborn Genetic Diseases

Isopeptidase activity of human transglutaminase 2: disconnection from transamidation and characterization by kinetic parameters

Kiraly, R., Thangaraju, K., Nagy, Z., Collighan, R., Nemes, Z., Griffin, M. & Fésüs, L., Jan 2016, In : Amino Acids. 48, 1, p. 31-40 10 p.

Research output: Contribution to journalArticle

Open Access
File
Kinetic parameters
Human Activities
Mutation
Amines
Physiological Phenomena
2015

Development of potent and selective tissue transglutaminase inhibitors: their effect on TG2 function and application in pathological conditions

Badarau, E., Wang, Z., Rathbone, D. L., Costanzi, A., Thibault, T., Murdoch, C. E., El Alaoui, S., Bartkeviciute, M. & Griffin, M., 22 Oct 2015, In : Chemistry and Biology. 22, 10, p. 1347-1361 15 p.

Research output: Contribution to journalArticle

Open Access
File
Endothelial cells
Fibronectins
Syndecan-4
Umbilical Cord
Peptidomimetics

TG2: a credible therapeutic target in fibrotic diseasedue to its multifunctional roles

Griffin, M., Wang, Z., Thibault, T., Murdoch, C. & Rathbone, D., 31 Aug 2015, In : Amino Acids. 47, 8, p. 1629 1 p.

Research output: Contribution to journalMeeting abstract

Fibrosis
Collagen
Fibronectins
Proteins
Chemical activation

Transglutaminase 2 interacts with syndecan-4 and CD44 at the surface of human macrophages to promote removal of apoptotic cells

Nadella, V., Wang, Z., Johnson, T. S., Griffin, M. & Devitt, A., Jan 2015, In : BBA - Molecular Cell Research. 1853, 1, p. 201-212 12 p.

Research output: Contribution to journalArticle

File
Syndecan-4
Macrophages
Heparitin Sulfate
Cell Adhesion
transglutaminase 2
2014

Celiac disease patient IgA antibodies induce endothelial adhesion and cell polarization defects via extracellular transglutaminase 2

Nadalutti, C. A., Korponay-Szabó, I. R., Kaukinen, K., Griffin, M., Mäki, M. & Lindfors, K., Apr 2014, In : Cellular and Molecular Life Sciences. 71, 7, p. 1315-1326 12 p.

Research output: Contribution to journalArticle

Celiac Disease
Abdomen
Immunoglobulin A
Endothelial Cells
Antibodies

Cross-linking of collagen I by tissue transglutaminase provides a promising biomaterial for promoting bone healing

Fortunati, D., Chau, D. Y. S., Wang, Z., Collighan, R. J. & Griffin, M., 31 Jul 2014, In : Amino Acids. 46, 7, p. 1751-1761 11 p.

Research output: Contribution to journalArticle

Biocompatible Materials
Bone
Collagen
Bone and Bones
Osteoblasts

Importance of tissue transglutaminasenitrosylation in fibroblasts migration and MMPregulation

Kurt, I., Kiliç, A. N., Griffin, M. & Telci, D., 30 Sep 2014, In : FEBS journal. 281, Suppl.1, p. 528 1 p., TUE-295.

Research output: Contribution to journalMeeting abstract

Syndecan-4
Fibroblasts
Matrix Metalloproteinases
Tissue
Nitric Oxide
2013

A novel extracellular role for tissue transglutaminase in matrix-bound VEGF-mediated angiogenesis

Wang, Z., Perez, M., Caja, S., Melino, G., Johnson, T. S., Lindfors, K. & Griffin, M., 2013, In : Cell Death and Disease. 4, 9, 13 p., e808.

Research output: Contribution to journalArticle

Open Access
File
Human Umbilical Vein Endothelial Cells
Vascular Endothelial Growth Factor A
Cell Culture Techniques
Vascular Endothelial Growth Factor Receptor-2
Coculture Techniques

Are transglutaminase 2 inhibitors able to reduce gliadin-induced toxicity related to celiac disease? A proof-of-concept study

Rauhavirta, T., Oittinen, M., Kivistö, R., Männistö, P. T., Garcia-Horsman, J. A., Wang, Z., Griffin, M., Mäki, M., Kaukinen, K. & Lindfors, K., Jan 2013, In : Journal of Clinical Immunology. 33, 1, p. 134-142 9 p.

Research output: Contribution to journalArticle

Gliadin
Celiac Disease
Glutens
Interleukin-15
Caco-2 Cells

Celiac disease-specific TG2-targeted autoantibodies inhibit angiogenesis ex vivo and in vivo in mice by interfering with endothelial cell dynamics

Kalliokoski, S., Sulic, A-M., Korponay-Szabó, I. R., Szondy, Z., Frias, R., Perez, M. A., Martucciello, S., Roivainen, A., Pelliniemi, L. J., Esposito, C., Griffin, M., Sblattero, D., Mäki, M., Kaukinen, K., Lindfors, K. & Caja, S., 18 Jun 2013, In : PLoS ONE. 8, 6, 8 p., e65887.

Research output: Contribution to journalArticle

Open Access
File
autoantibodies
celiac disease
protein-glutamine gamma-glutamyltransferase
Endothelial cells
Celiac Disease
Factor XIIIa
Transglutaminases
Blood Coagulation Factors
Water
Scaffolds
Indwelling Catheters
Catheters
Central Venous Catheters
Equipment and Supplies
Factor XIIIa

Inhibition of collagen I accumulation reduces glomerulosclerosis by a Hic-5-dependent mechanism in experimental diabetic nephropathy

Hornigold, N., Johnson, T. S., Huang, L., Haylor, J. L., Griffin, M. & Mooney, A., May 2013, In : Laboratory Investigation. 93, 5, p. 553-565 13 p.

Research output: Contribution to journalArticle

Diabetic Nephropathies
Collagen
Mesangial Cells
Apoptosis
Smooth Muscle

In vivo effects of tailored laminin-332 α3 conjugated scaffolds enhances wound healing: a histomorphometric analysis

Damodaran, G., Tiong, W. H. C., Collighan, R., Navsaria, H., Griffin, M. & Pandit, A., 5 Mar 2013, In : Journal of Biomedical Materials Research: Part A. 101, 10, p. 2788-2795 8 p.

Research output: Contribution to journalArticle

Transglutaminases
Scaffolds
Peptides
Scaffolds (biology)
Cell adhesion

Pituitary adenylate cyclase-activating polypeptide type 1 receptor (PAC1) gene is suppressed by transglutaminase 2 activation

Miura, A., Kambe, Y., Inoue, K., Tatsukawa, H., Kurihara, T., Griffin, M., Kojima, S. & Miyata, A., 8 Nov 2013, In : Journal of Biological Chemistry. 288, 45, p. 32720-32730 11 p.

Research output: Contribution to journalArticle

Open Access
File
Receptors, Pituitary Adenylate Cyclase-Activating Polypeptide, Type I
Endoplasmic Reticulum Stress
Gene expression
Genes
Chemical activation

Recent advances in the development of tissue transglutaminase (TG2) inhibitors

Badarau, E., Collighan, R. J. & Griffin, M., Jan 2013, In : Amino Acids. 44, 1, p. 119-127 9 p.

Research output: Contribution to journalArticle

Open Access
File
Biological Phenomena
Transglutaminases
Enzyme Activation
Huntington Disease
Celiac Disease

The role of TG2 in ECV304-related vasculogenic mimicry

Jones, R. A., Wang, Z., Dookie, S. & Griffin, M., Jan 2013, In : Amino Acids. 44, 1, p. 89-101 13 p.

Research output: Contribution to journalArticle

Tumors
Fibronectins
Cell Line
Neoplasms
Focal Adhesions

The role of TG2 in regulating S100A4-mediated mammary tumour cell migration

Wang, Z. & Griffin, M., 1 Mar 2013, In : PLoS ONE. 8, 3, 16 p., e57017.

Research output: Contribution to journalArticle

Open Access
File
mammary neoplasms (animal)
cell movement
Crosslinking
Cell Movement
Tumors

Thioredoxin is involved in endothelial cell extracellular transglutaminase 2 activation mediated by celiac disease patient IgA

Nadalutti, C. A., Korponay-Szabo, I. R., Kaukinen, K., Wang, Z., Griffin, M., Mäki, M. & Lindfors, K., 9 Oct 2013, In : PLoS ONE. 8, 10, 12 p., e77277.

Research output: Contribution to journalArticle

Open Access
File
Thioredoxins
celiac disease
protein-glutamine gamma-glutamyltransferase
Endothelial cells
Celiac Disease

Transglutaminase 2 interaction with small heat shock proteins mediate cell survival upon excitotoxic stress

Caccamo, D., Condello, S., Ferlazzo, N., Currò, M., Griffin, M. & Ientile, R., Jan 2013, In : Amino Acids. 44, 1, p. 151-159 9 p.

Research output: Contribution to journalArticle

Small Heat-Shock Proteins
N-Methylaspartate
Cell Survival
Cells
Transglutaminases
2012
Open Access
File
Cell signaling
Heparitin Sulfate
Heparin
Binding Sites
Extracellular Matrix

Characterization of tissue transglutaminase 2 in macrophage function

Nadella, V., Wang, V., Griffin, M. & Devitt, A., May 2012.

Research output: Contribution to conferencePoster

Macrophages
Syndecan-4
Syndecan-3
transglutaminase 2
Cell Surface Receptors

Characterization of tissue transglutaminase 2 in macrophage function

Nadella, V., Wang, V., Griffin, M. & Devitt, A., 2012, p. 74. 1 p.

Research output: Contribution to conferencePoster

Macrophages
Syndecan-4
Guanosine Triphosphate
Syndecan-3
transglutaminase 2

Importance of tissue transglutaminase on the activation of secretory phospholipase A2 in the oxidized LDL-treated vascular smooth muscle cells

Ilter, A. Z., Griffin, M. & Telci, D., Sep 2012, In : FEBS journal. 279, s1, p. 181 1 p., P06-150.

Research output: Contribution to journalMeeting abstract

Secretory Phospholipase A2
Vascular Smooth Muscle
Smooth Muscle Myocytes
Muscle
Chemical activation

Interactions among secretory immunoglobulin A, CD71, and transglutaminase-2 affect permeability of intestinal epithelial cells to gliadin peptides

Lebreton, C., Ménard, S., Abed, J., Moura, I. C., Coppo, R., Dugave, C., Monteiro, R. C., Fricot, A., Traore, M. G., Griffin, M., Cellier, C., Malamut, G., Cerf-Bensussan, N. & Heyman, M., 1 Sep 2012, In : Gastroenterology. 143, 3, p. 698–707 10 p.

Research output: Contribution to journalArticle

Gliadin
Secretory Immunoglobulin A
Permeability
Epithelial Cells
Caco-2 Cells

TG2, a novel extracellular protein with multiple functions

Wang, Z. & Griffin, M., Feb 2012, In : Amino Acids. 42, 2-3, p. 939-949 11 p.

Research output: Contribution to journalArticle

Syndecan-4
Multifunctional Enzymes
Military electronic countermeasures
Heparan Sulfate Proteoglycans
Proteins
2011

Analysis of Transglutaminase-2 in Macrophage function

Nadella, V., Wang, Z., Griffin, M. & Devitt, A., 2011.

Research output: Contribution to conferencePoster

Dipeptide inhibitors of angiogenesis

Griffin, M. & Perez, M., 6 May 2011, IPC No. A61K38/05, Patent No. GB 1107576.9

Research output: Patent

Open Access
Angiogenesis Inhibitors
Eye Diseases
Dipeptides
Macular Degeneration
Diabetic Retinopathy

Epithelial transport and deamidation of gliadin peptides: a role for coeliac disease patient immunoglobulin A

Rauhavirta, T., Qiao, S-W., Jiang, Z., Myrsky, E., Loponen, J., Korponay-Szabó, I. R., Salovaara, H., Garcia-Horsman, J. A., Venäläinen, J., Männistö, P. T., Collighan, R., Mongeot, A., Griffin, M., Mäki, M., Kaukinen, K. & Lindfors, K., Apr 2011, In : Clinical and Experimental Immunology. 164, 1, p. 127-136 10 p.

Research output: Contribution to journalArticle

Open Access
Gliadin
Celiac Disease
Abdomen
Immunoglobulin A
Peptides
Syndecan-2
Syndecan-4
Osteoblasts
Fibronectins
Cell Adhesion

Novel Polypeptides and Use Thereof

Collighan, R., Griffin, M., Pytel, K. & Wang, Z., 28 Apr 2011, IPC No. A61K38/04, Patent No. GB 1107147.9

Research output: Patent

Open Access
Heparin
Binding Sites
Peptides
Syndecan-4
Antibodies

Structure and regulation of type 2 transglutaminase in relation to its physiological functions and pathological roles

Bergamini, C. M., Collighan, R. J., Wang, Z. & Griffin, M., 16 Dec 2011, Advances in enzymology: and related areas of molecular biology. Toone, E. J. (ed.). Hoboken, NJ (US): Wiley, Vol. 78. p. 1-46 46 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

transglutaminase 2
Transglutaminases
Liposomes
Liver Cirrhosis
Liver
Fibrosis

The role of tissue transglutaminase (TG2) in regulating the tumour progression of the mouse colon carcinoma CT26

Kotsakis, P., Wang, Z., Collighan, R. J. & Griffin, M., Oct 2011, In : Amino Acids. 41, 4, p. 909-921 13 p.

Research output: Contribution to journalArticle

Open Access
File
Fibronectins
Integrins
Tumors
Colon
Carcinoma

Transglutaminase 2 null macrophages respond to lipopolysaccharide stimulation by elevated proinflammatory cytokine production due to an enhanced αvβ3 integrin-induced Src tyrosine kinase signaling

Sarang, Z., Köröskényi, K., Pallai, A., Duró, E., Melino, G., Griffin, M., Fésüs, L. & Szondy, Z., Jul 2011, In : Immunology Letters. 138, 1, p. 71-78 8 p.

Research output: Contribution to journalArticle

Open Access
File
src-Family Kinases
Integrins
Lipopolysaccharides
Macrophages
Cytokines
2010

Analysis of Transglutaminase-2 in macrophage function

Nadella, V., Griffin, M. & Devitt, A., 3 Dec 2010.

Research output: Contribution to conferencePoster

Macrophages
Apoptosis
transglutaminase 2
Integrins
Monocytes

An extracellular transglutaminase is required for apple pollen tube growth

Di Sandro, A., Del Duca, S., Verderio, E., Hargreaves, A. J., Scarpellini, A., Cai, G., Cresti, M., Faleri, C., Iorio, R. A., Hirose, S., Furutani, Y., Coutts, I. G. C., Griffin, M., Bonner, P. L. R. & Serafini-Fracassini, D., 5 May 2010, In : Biochemical Journal. 429, 2, p. 261-271 11 p.

Research output: Contribution to journalArticle

Pollen Tube
Transglutaminases
Malus
Growth
Substrates

Do changes in transglutaminase activity alter latent transforming growth factor beta activation in experimental diabetic nephropathy?

Huang, L., Haylor, J. L., Fisher, M., Hau, Z., El Nahas, A. M., Griffin, M. & Johnson, T. S., Dec 2010, In : Nephrology, Dialysis, Transplantation. 25, 12, p. 3897-3910 14 p.

Research output: Contribution to journalArticle

Transglutaminases
Diabetic Nephropathies
Transforming Growth Factor beta
Extracellular Matrix
Opossums

Inhibition of transglutaminase 2 enzymatic activity ameliorates the anti-angiogenic effects of coeliac disease autoantibodies

Caja, S., Myrsky, E., Korponay-Szabo, I. R., Nadalutti, C., Sulic, A-M., Lavric, M., Sblattero, D., Marzari, R., Collighan, R., Mongeot, A., Griffin, M., Mäki, M., Kaukinen, K. & Lindfors, K., Apr 2010, In : Scandinavian Journal of Gastroenterology. 45, 4, p. 421-427 7 p.

Research output: Contribution to journalArticle

Celiac Disease
Autoantibodies
Abdomen
Endothelial Cells
Genetic Recombination

Model thrombi formed under flow reveal the role of factor XIII-mediated cross-linking in resistance to fibrinolysis

Mutch, N. J., Koikkalainen, J. S., Fraser, S. R., Duthie, K. M., Griffin, M., Mitchell, J., Watson, H. G. & Booth, N. A., Sep 2010, In : Journal of Thrombosis and Haemostasis. 8, 9, p. 2017-2024 8 p.

Research output: Contribution to journalArticle

Open Access
File
Factor XIII
Fibrinolysis
Thrombosis
Fibrin
Transglutaminases
Open Access
File
Syndecan-2
Syndecan-4
Cell adhesion
Fibronectins
Cell Adhesion

The visualisation of vitreous using surface modified poly(lactic-co-glycolic acid) microparticles

Chau, D. Y. S., Tint, N. L., Collighan, R. J., Griffin, M., Dua, H. S., Shakesheff, K. M. & Rose, F. R. A. J., 2010, In : British Journal of Ophthalmology. 94, 5, p. 648-653 6 p.

Research output: Contribution to journalArticle

Open Access
File
Triamcinolone
Suspensions
Transglutaminases
Vitrectomy
Swine