19972019

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2019

Mapping the minimum domain of the fibronectin binding site on transglutaminase 2 (TG2) and its importance in mediating signaling, adhesion, and migration in TG2-expressing cells

Soluri, M. F., Boccafoschi, F., Cotella, D., Moro, L., Forestieri, G., Autiero, I., Cavallo, L., Oliva, R., Griffin, M., Wang, Z., Santoro, C. & Sblattero, D., 30 Jan 2019, In : FASEB Journal . 33, 2, p. 2327-2342 16 p.

Research output: Contribution to journalArticle

Transglutaminase 2 maintains a colorectal cancer stem phenotype by regulating epithelial-mesenchymal transition

Ayinde, O., Wang, Z., Pinton, G., Moro, L. & Griffin, M., 16 Jul 2019, In : Oncotarget. 10, 44, p. 4556-4569 14 p.

Research output: Contribution to journalArticle

Open Access
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2018

Cardiac fibrosis can be attenuated by blocking the activity of transglutaminase 2 using a selective small-molecule inhibitor

Wang, Z., Stuckey, D. J., Murdoch, C. E., Camelliti, P., Lip, G. Y. H. & Griffin, M., 27 Apr 2018, In : Cell Death and Disease. 9, 613.

Research output: Contribution to journalArticle

Open Access
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2017

Involvement of cell surface TG2 in the aggregation of K562 cells triggered by gluten

Feriotto, G., Calza, R., Bergamini, C. M., Griffin, M., Wang, Z., Beninati, S., Ferretti, V., Marzola, E., Guerrini, R., Pagnoni, A., Cavazzini, A., Casciano, F. & Mischiati, C., 1 Mar 2017, In : Amino Acids. 49, 3, p. 551–565

Research output: Contribution to journalArticle

Open Access
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Open Access
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Tissue transglutaminase (TG2) enables survival of human malignant pleural mesothelioma cells in hypoxia

Zonca, S., Pinton, G., Wang, Z., Soluri, M. F., Tavian, D., Griffin, M., Sblattero, D. & Moro, L., 2 Feb 2017, In : Cell Death and Disease. 8, 2, 7 p., e2592.

Research output: Contribution to journalArticle

Open Access
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Open Access
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2016

A novel regulatory role for tissue transglutaminase in epithelial-mesenchymal transition in cystic fibrosis

Nyabam, S., Wang, Z., Thibault, T., Ayinde, O., Basar, R., Marshall, L. & Griffin, M., Sep 2016, In : BBA - Molecular Cell Research. 1863, 9, p. 2234-2244 11 p.

Research output: Contribution to journalArticle

Open Access
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Isopeptidase activity of human transglutaminase 2: disconnection from transamidation and characterization by kinetic parameters

Kiraly, R., Thangaraju, K., Nagy, Z., Collighan, R., Nemes, Z., Griffin, M. & Fésüs, L., Jan 2016, In : Amino Acids. 48, 1, p. 31-40 10 p.

Research output: Contribution to journalArticle

Open Access
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2015

Development of potent and selective tissue transglutaminase inhibitors: their effect on TG2 function and application in pathological conditions

Badarau, E., Wang, Z., Rathbone, D. L., Costanzi, A., Thibault, T., Murdoch, C. E., El Alaoui, S., Bartkeviciute, M. & Griffin, M., 22 Oct 2015, In : Chemistry and Biology. 22, 10, p. 1347-1361 15 p.

Research output: Contribution to journalArticle

Open Access
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Transglutaminase 2 interacts with syndecan-4 and CD44 at the surface of human macrophages to promote removal of apoptotic cells

Nadella, V., Wang, Z., Johnson, T. S., Griffin, M. & Devitt, A., Jan 2015, In : BBA - Molecular Cell Research. 1853, 1, p. 201-212 12 p.

Research output: Contribution to journalArticle

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2014

Celiac disease patient IgA antibodies induce endothelial adhesion and cell polarization defects via extracellular transglutaminase 2

Nadalutti, C. A., Korponay-Szabó, I. R., Kaukinen, K., Griffin, M., Mäki, M. & Lindfors, K., Apr 2014, In : Cellular and Molecular Life Sciences. 71, 7, p. 1315-1326 12 p.

Research output: Contribution to journalArticle

Cross-linking of collagen I by tissue transglutaminase provides a promising biomaterial for promoting bone healing

Fortunati, D., Chau, D. Y. S., Wang, Z., Collighan, R. J. & Griffin, M., 31 Jul 2014, In : Amino Acids. 46, 7, p. 1751-1761 11 p.

Research output: Contribution to journalArticle

2013

A novel extracellular role for tissue transglutaminase in matrix-bound VEGF-mediated angiogenesis

Wang, Z., Perez, M., Caja, S., Melino, G., Johnson, T. S., Lindfors, K. & Griffin, M., 2013, In : Cell Death and Disease. 4, 9, 13 p., e808.

Research output: Contribution to journalArticle

Open Access
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Are transglutaminase 2 inhibitors able to reduce gliadin-induced toxicity related to celiac disease? A proof-of-concept study

Rauhavirta, T., Oittinen, M., Kivistö, R., Männistö, P. T., Garcia-Horsman, J. A., Wang, Z., Griffin, M., Mäki, M., Kaukinen, K. & Lindfors, K., Jan 2013, In : Journal of Clinical Immunology. 33, 1, p. 134-142 9 p.

Research output: Contribution to journalArticle

Celiac disease-specific TG2-targeted autoantibodies inhibit angiogenesis ex vivo and in vivo in mice by interfering with endothelial cell dynamics

Kalliokoski, S., Sulic, A-M., Korponay-Szabó, I. R., Szondy, Z., Frias, R., Perez, M. A., Martucciello, S., Roivainen, A., Pelliniemi, L. J., Esposito, C., Griffin, M., Sblattero, D., Mäki, M., Kaukinen, K., Lindfors, K. & Caja, S., 18 Jun 2013, In : PLoS ONE. 8, 6, 8 p., e65887.

Research output: Contribution to journalArticle

Open Access
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Inhibition of collagen I accumulation reduces glomerulosclerosis by a Hic-5-dependent mechanism in experimental diabetic nephropathy

Hornigold, N., Johnson, T. S., Huang, L., Haylor, J. L., Griffin, M. & Mooney, A., May 2013, In : Laboratory Investigation. 93, 5, p. 553-565 13 p.

Research output: Contribution to journalArticle

In vivo effects of tailored laminin-332 α3 conjugated scaffolds enhances wound healing: a histomorphometric analysis

Damodaran, G., Tiong, W. H. C., Collighan, R., Navsaria, H., Griffin, M. & Pandit, A., 5 Mar 2013, In : Journal of Biomedical Materials Research: Part A. 101, 10, p. 2788-2795 8 p.

Research output: Contribution to journalArticle

Pituitary adenylate cyclase-activating polypeptide type 1 receptor (PAC1) gene is suppressed by transglutaminase 2 activation

Miura, A., Kambe, Y., Inoue, K., Tatsukawa, H., Kurihara, T., Griffin, M., Kojima, S. & Miyata, A., 8 Nov 2013, In : Journal of Biological Chemistry. 288, 45, p. 32720-32730 11 p.

Research output: Contribution to journalArticle

Open Access
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Recent advances in the development of tissue transglutaminase (TG2) inhibitors

Badarau, E., Collighan, R. J. & Griffin, M., Jan 2013, In : Amino Acids. 44, 1, p. 119-127 9 p.

Research output: Contribution to journalArticle

Open Access
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The role of TG2 in ECV304-related vasculogenic mimicry

Jones, R. A., Wang, Z., Dookie, S. & Griffin, M., Jan 2013, In : Amino Acids. 44, 1, p. 89-101 13 p.

Research output: Contribution to journalArticle

The role of TG2 in regulating S100A4-mediated mammary tumour cell migration

Wang, Z. & Griffin, M., 1 Mar 2013, In : PLoS ONE. 8, 3, 16 p., e57017.

Research output: Contribution to journalArticle

Open Access
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Thioredoxin is involved in endothelial cell extracellular transglutaminase 2 activation mediated by celiac disease patient IgA

Nadalutti, C. A., Korponay-Szabo, I. R., Kaukinen, K., Wang, Z., Griffin, M., Mäki, M. & Lindfors, K., 9 Oct 2013, In : PLoS ONE. 8, 10, 12 p., e77277.

Research output: Contribution to journalArticle

Open Access
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Transglutaminase 2 interaction with small heat shock proteins mediate cell survival upon excitotoxic stress

Caccamo, D., Condello, S., Ferlazzo, N., Currò, M., Griffin, M. & Ientile, R., Jan 2013, In : Amino Acids. 44, 1, p. 151-159 9 p.

Research output: Contribution to journalArticle

2012
Open Access
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Interactions among secretory immunoglobulin A, CD71, and transglutaminase-2 affect permeability of intestinal epithelial cells to gliadin peptides

Lebreton, C., Ménard, S., Abed, J., Moura, I. C., Coppo, R., Dugave, C., Monteiro, R. C., Fricot, A., Traore, M. G., Griffin, M., Cellier, C., Malamut, G., Cerf-Bensussan, N. & Heyman, M., 1 Sep 2012, In : Gastroenterology. 143, 3, p. 698–707 10 p.

Research output: Contribution to journalArticle

TG2, a novel extracellular protein with multiple functions

Wang, Z. & Griffin, M., Feb 2012, In : Amino Acids. 42, 2-3, p. 939-949 11 p.

Research output: Contribution to journalArticle

2011

Epithelial transport and deamidation of gliadin peptides: a role for coeliac disease patient immunoglobulin A

Rauhavirta, T., Qiao, S-W., Jiang, Z., Myrsky, E., Loponen, J., Korponay-Szabó, I. R., Salovaara, H., Garcia-Horsman, J. A., Venäläinen, J., Männistö, P. T., Collighan, R., Mongeot, A., Griffin, M., Mäki, M., Kaukinen, K. & Lindfors, K., Apr 2011, In : Clinical and Experimental Immunology. 164, 1, p. 127-136 10 p.

Research output: Contribution to journalArticle

Open Access

The role of tissue transglutaminase (TG2) in regulating the tumour progression of the mouse colon carcinoma CT26

Kotsakis, P., Wang, Z., Collighan, R. J. & Griffin, M., Oct 2011, In : Amino Acids. 41, 4, p. 909-921 13 p.

Research output: Contribution to journalArticle

Open Access
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Transglutaminase 2 null macrophages respond to lipopolysaccharide stimulation by elevated proinflammatory cytokine production due to an enhanced αvβ3 integrin-induced Src tyrosine kinase signaling

Sarang, Z., Köröskényi, K., Pallai, A., Duró, E., Melino, G., Griffin, M., Fésüs, L. & Szondy, Z., Jul 2011, In : Immunology Letters. 138, 1, p. 71-78 8 p.

Research output: Contribution to journalArticle

Open Access
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2010

An extracellular transglutaminase is required for apple pollen tube growth

Di Sandro, A., Del Duca, S., Verderio, E., Hargreaves, A. J., Scarpellini, A., Cai, G., Cresti, M., Faleri, C., Iorio, R. A., Hirose, S., Furutani, Y., Coutts, I. G. C., Griffin, M., Bonner, P. L. R. & Serafini-Fracassini, D., 5 May 2010, In : Biochemical Journal. 429, 2, p. 261-271 11 p.

Research output: Contribution to journalArticle

Do changes in transglutaminase activity alter latent transforming growth factor beta activation in experimental diabetic nephropathy?

Huang, L., Haylor, J. L., Fisher, M., Hau, Z., El Nahas, A. M., Griffin, M. & Johnson, T. S., Dec 2010, In : Nephrology, Dialysis, Transplantation. 25, 12, p. 3897-3910 14 p.

Research output: Contribution to journalArticle

Inhibition of transglutaminase 2 enzymatic activity ameliorates the anti-angiogenic effects of coeliac disease autoantibodies

Caja, S., Myrsky, E., Korponay-Szabo, I. R., Nadalutti, C., Sulic, A-M., Lavric, M., Sblattero, D., Marzari, R., Collighan, R., Mongeot, A., Griffin, M., Mäki, M., Kaukinen, K. & Lindfors, K., Apr 2010, In : Scandinavian Journal of Gastroenterology. 45, 4, p. 421-427 7 p.

Research output: Contribution to journalArticle

Model thrombi formed under flow reveal the role of factor XIII-mediated cross-linking in resistance to fibrinolysis

Mutch, N. J., Koikkalainen, J. S., Fraser, S. R., Duthie, K. M., Griffin, M., Mitchell, J., Watson, H. G. & Booth, N. A., Sep 2010, In : Journal of Thrombosis and Haemostasis. 8, 9, p. 2017-2024 8 p.

Research output: Contribution to journalArticle

Open Access
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Open Access
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The visualisation of vitreous using surface modified poly(lactic-co-glycolic acid) microparticles

Chau, D. Y. S., Tint, N. L., Collighan, R. J., Griffin, M., Dua, H. S., Shakesheff, K. M. & Rose, F. R. A. J., 2010, In : British Journal of Ophthalmology. 94, 5, p. 648-653 6 p.

Research output: Contribution to journalArticle

Open Access
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2009

Celiac disease IgA modulates vascular permeability in vitro through the activity of transglutaminase 2 and RhoA

Myrsky, E., Caja, S., Simon-Vecsei, Z., Korponay-Szabo, I. R., Nadalutti, C., Collighan, R., Mongeot, A., Griffin, M., Mäki, M., Kaukinen, K. & Lindfors, K., Oct 2009, In : Cellular and Molecular Life Sciences. 66, 20, p. 3375-85 11 p.

Research output: Contribution to journalArticle

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In vitro characterization of a collagen scaffold enzymatically cross-linked with a tailored elastin-like polymer

Garcia, Y., Hemantkumar, N., Collighan, R., Griffin, M., Rodriguez-Cabello, J. C. & Pandit, A., 10 Jul 2009, In : Tissue Engineering: Parts A, B and C. 15, 4, p. 887-899 13 p.

Research output: Contribution to journalArticle

Modulation of tissue transglutaminase in tubular epithelial cells alters extracellular matrix levels: a potential mechanism of tissue scarring

Fisher, M., Jones, R. A., Huang, L., Haylor, J. L., El Nahas, M., Griffin, M. & Johnson, T. S., Jan 2009, In : Matrix Biology. 28, 1, p. 20-31 12 p.

Research output: Contribution to journalArticle

Tailored laminin-332 alpha3 sequence is tethered through an enzymatic linker to a collagen scaffold to promote cellular adhesion

Damodaran, G., Collighan, R., Griffin, M., Navsaria, H. & Pandit, A. S., Sep 2009, In : Acta Biomaterialia. 5, 7, p. 2441-2450 10 p.

Research output: Contribution to journalArticle

Tethering a laminin peptide to a crosslinked collagen scaffold for biofunctionality

Damodaran, G., Collighan, R., Griffin, M. & Pandit, A., 15 Jun 2009, In : Journal of Biomedical Materials Research: Part A. 89A, 4, p. 1001-1010 10 p.

Research output: Contribution to journalArticle

Thermodynamics of binding of regulatory ligands to tissue transglutaminase

Bergamini, C. M., Dondi, A., Lanzara, V., Squerzanti, M., Cervellati, C., Montin, K., Mischiati, C., Tasco, G., Collighan, R., Griffin, M. & Casadio, R., 22 Dec 2009, In : Amino Acids. 39, 1, p. 297-304 8 p.

Research output: Contribution to journalArticle

Transglutaminase 2 cross-linking of matrix proteins: biological significance and medical applications

Collighan, R. & Griffin, M., Apr 2009, In : Amino Acids. 36, 4, p. 659-670 12 p.

Research output: Contribution to journalArticle

Transglutaminase 2 is involved in autophagosome maturation

D'Eletto, M., Farrace, M. G., Falasca, L., Reali, V., Oliverio, S., Melino, G., Griffin, M., Fimia, G. M. & Piacentini, M., 16 Nov 2009, In : Autophagy. 5, 8, p. 1145-1154 10 p.

Research output: Contribution to journalArticle

Transglutaminase inhibition ameliorates experimental diabetic nephropathy

Huang, L., Haylor, J. L., Hau, Z., Jones, R. A., Vickers, M. E., Wagner, B., Griffin, M., Saint, R. E., Coutts, I. G. C., El Nahas, A. M. & Johnson, T. S., Aug 2009, In : Kidney international. 76, 4, p. 383-394 12 p.

Research output: Contribution to journalArticle

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