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Research Output 1997 2019

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2019

Mapping the minimum domain of the fibronectin binding site on transglutaminase 2 (TG2) and its importance in mediating signaling, adhesion, and migration in TG2-expressing cells

Soluri, M. F., Boccafoschi, F., Cotella, D., Moro, L., Forestieri, G., Autiero, I., Cavallo, L., Oliva, R., Griffin, M., Wang, Z., Santoro, C. & Sblattero, D., 30 Jan 2019, In : FASEB Journal . 33, 2, p. 2327-2342 16 p.

Research output: Contribution to journalArticle

Fibronectins
Adhesion
Binding Sites
Gelatin
Cell Adhesion

Transglutaminase 2 maintains a colorectal cancer stem phenotype by regulating epithelial-mesenchymal transition

Ayinde, O., Wang, Z., Pinton, G., Moro, L. & Griffin, M., 16 Jul 2019, In : Oncotarget. 10, 44, p. 4556-4569 14 p.

Research output: Contribution to journalArticle

Open Access
File
Epithelial-Mesenchymal Transition
Colorectal Neoplasms
Phenotype
Neoplastic Stem Cells
Vascular Endothelial Growth Factor A
2018

Cardiac fibrosis can be attenuated by blocking the activity of transglutaminase 2 using a selective small-molecule inhibitor

Wang, Z., Stuckey, D. J., Murdoch, C. E., Camelliti, P., Lip, G. Y. H. & Griffin, M., 27 Apr 2018, In : Cell Death and Disease. 9, 613.

Research output: Contribution to journalArticle

Open Access
File
Fibrosis
Myofibroblasts
transglutaminase 2
Angiotensin II
Lysine
2017

Involvement of cell surface TG2 in the aggregation of K562 cells triggered by gluten

Feriotto, G., Calza, R., Bergamini, C. M., Griffin, M., Wang, Z., Beninati, S., Ferretti, V., Marzola, E., Guerrini, R., Pagnoni, A., Cavazzini, A., Casciano, F. & Mischiati, C., 1 Mar 2017, In : Amino Acids. 49, 3, p. 551–565

Research output: Contribution to journalArticle

Open Access
File
K562 Cells
Glutens
Agglomeration
Calcium
Guanosine Triphosphate
Open Access
File
Transforming Growth Factors
Endothelial Cells
transglutaminase 2
Myofibroblasts
Coculture Techniques

Tissue transglutaminase (TG2) enables survival of human malignant pleural mesothelioma cells in hypoxia

Zonca, S., Pinton, G., Wang, Z., Soluri, M. F., Tavian, D., Griffin, M., Sblattero, D. & Moro, L., 2 Feb 2017, In : Cell Death and Disease. 8, 2, 7 p., e2592.

Research output: Contribution to journalArticle

Open Access
File
Cell Hypoxia
Survival
Cell Survival
Epithelioid Cells
Malignant Mesothelioma

Tissue transglutaminase induces epithelial-mesenchymal-transition and the acquisition of stem cell like characteristics in colorectal cancer cells

Ayinde, O., Wang, Z. & Griffin, M., 16 Feb 2017, In : Oncotarget. 8, 12, p. 20025-20041 17 p.

Research output: Contribution to journalArticle

Open Access
File
Catenins
Epithelial-Mesenchymal Transition
Colorectal Neoplasms
Stem Cells
Cell Line
2016

A novel regulatory role for tissue transglutaminase in epithelial-mesenchymal transition in cystic fibrosis

Nyabam, S., Wang, Z., Thibault, T., Ayinde, O., Basar, R., Marshall, L. & Griffin, M., Sep 2016, In : BBA - Molecular Cell Research. 1863, 9, p. 2234-2244 11 p.

Research output: Contribution to journalArticle

Open Access
File
Cystic Fibrosis Transmembrane Conductance Regulator
Epithelial-Mesenchymal Transition
Cystic Fibrosis
Cysteamine
Inborn Genetic Diseases

Isopeptidase activity of human transglutaminase 2: disconnection from transamidation and characterization by kinetic parameters

Kiraly, R., Thangaraju, K., Nagy, Z., Collighan, R., Nemes, Z., Griffin, M. & Fésüs, L., Jan 2016, In : Amino Acids. 48, 1, p. 31-40 10 p.

Research output: Contribution to journalArticle

Open Access
File
Kinetic parameters
Human Activities
Mutation
Amines
Physiological Phenomena
2015

Development of potent and selective tissue transglutaminase inhibitors: their effect on TG2 function and application in pathological conditions

Badarau, E., Wang, Z., Rathbone, D. L., Costanzi, A., Thibault, T., Murdoch, C. E., El Alaoui, S., Bartkeviciute, M. & Griffin, M., 22 Oct 2015, In : Chemistry and Biology. 22, 10, p. 1347-1361 15 p.

Research output: Contribution to journalArticle

Open Access
File
Endothelial cells
Fibronectins
Syndecan-4
Umbilical Cord
Peptidomimetics

Transglutaminase 2 interacts with syndecan-4 and CD44 at the surface of human macrophages to promote removal of apoptotic cells

Nadella, V., Wang, Z., Johnson, T. S., Griffin, M. & Devitt, A., Jan 2015, In : BBA - Molecular Cell Research. 1853, 1, p. 201-212 12 p.

Research output: Contribution to journalArticle

File
Syndecan-4
Macrophages
Heparitin Sulfate
Cell Adhesion
transglutaminase 2
2014

Celiac disease patient IgA antibodies induce endothelial adhesion and cell polarization defects via extracellular transglutaminase 2

Nadalutti, C. A., Korponay-Szabó, I. R., Kaukinen, K., Griffin, M., Mäki, M. & Lindfors, K., Apr 2014, In : Cellular and Molecular Life Sciences. 71, 7, p. 1315-1326 12 p.

Research output: Contribution to journalArticle

Celiac Disease
Abdomen
Immunoglobulin A
Endothelial Cells
Antibodies

Cross-linking of collagen I by tissue transglutaminase provides a promising biomaterial for promoting bone healing

Fortunati, D., Chau, D. Y. S., Wang, Z., Collighan, R. J. & Griffin, M., 31 Jul 2014, In : Amino Acids. 46, 7, p. 1751-1761 11 p.

Research output: Contribution to journalArticle

Biocompatible Materials
Bone
Collagen
Bone and Bones
Osteoblasts
2013

A novel extracellular role for tissue transglutaminase in matrix-bound VEGF-mediated angiogenesis

Wang, Z., Perez, M., Caja, S., Melino, G., Johnson, T. S., Lindfors, K. & Griffin, M., 2013, In : Cell Death and Disease. 4, 9, 13 p., e808.

Research output: Contribution to journalArticle

Open Access
File
Human Umbilical Vein Endothelial Cells
Vascular Endothelial Growth Factor A
Cell Culture Techniques
Vascular Endothelial Growth Factor Receptor-2
Coculture Techniques

Are transglutaminase 2 inhibitors able to reduce gliadin-induced toxicity related to celiac disease? A proof-of-concept study

Rauhavirta, T., Oittinen, M., Kivistö, R., Männistö, P. T., Garcia-Horsman, J. A., Wang, Z., Griffin, M., Mäki, M., Kaukinen, K. & Lindfors, K., Jan 2013, In : Journal of Clinical Immunology. 33, 1, p. 134-142 9 p.

Research output: Contribution to journalArticle

Gliadin
Celiac Disease
Glutens
Interleukin-15
Caco-2 Cells

Celiac disease-specific TG2-targeted autoantibodies inhibit angiogenesis ex vivo and in vivo in mice by interfering with endothelial cell dynamics

Kalliokoski, S., Sulic, A-M., Korponay-Szabó, I. R., Szondy, Z., Frias, R., Perez, M. A., Martucciello, S., Roivainen, A., Pelliniemi, L. J., Esposito, C., Griffin, M., Sblattero, D., Mäki, M., Kaukinen, K., Lindfors, K. & Caja, S., 18 Jun 2013, In : PLoS ONE. 8, 6, 8 p., e65887.

Research output: Contribution to journalArticle

Open Access
File
autoantibodies
celiac disease
protein-glutamine gamma-glutamyltransferase
Endothelial cells
Celiac Disease
Factor XIIIa
Transglutaminases
Blood Coagulation Factors
Water
Scaffolds
Indwelling Catheters
Catheters
Central Venous Catheters
Equipment and Supplies
Factor XIIIa

Inhibition of collagen I accumulation reduces glomerulosclerosis by a Hic-5-dependent mechanism in experimental diabetic nephropathy

Hornigold, N., Johnson, T. S., Huang, L., Haylor, J. L., Griffin, M. & Mooney, A., May 2013, In : Laboratory Investigation. 93, 5, p. 553-565 13 p.

Research output: Contribution to journalArticle

Diabetic Nephropathies
Collagen
Mesangial Cells
Apoptosis
Smooth Muscle

In vivo effects of tailored laminin-332 α3 conjugated scaffolds enhances wound healing: a histomorphometric analysis

Damodaran, G., Tiong, W. H. C., Collighan, R., Navsaria, H., Griffin, M. & Pandit, A., 5 Mar 2013, In : Journal of Biomedical Materials Research: Part A. 101, 10, p. 2788-2795 8 p.

Research output: Contribution to journalArticle

Transglutaminases
Scaffolds
Peptides
Scaffolds (biology)
Cell adhesion

Pituitary adenylate cyclase-activating polypeptide type 1 receptor (PAC1) gene is suppressed by transglutaminase 2 activation

Miura, A., Kambe, Y., Inoue, K., Tatsukawa, H., Kurihara, T., Griffin, M., Kojima, S. & Miyata, A., 8 Nov 2013, In : Journal of Biological Chemistry. 288, 45, p. 32720-32730 11 p.

Research output: Contribution to journalArticle

Open Access
File
Receptors, Pituitary Adenylate Cyclase-Activating Polypeptide, Type I
Endoplasmic Reticulum Stress
Gene expression
Genes
Chemical activation

Recent advances in the development of tissue transglutaminase (TG2) inhibitors

Badarau, E., Collighan, R. J. & Griffin, M., Jan 2013, In : Amino Acids. 44, 1, p. 119-127 9 p.

Research output: Contribution to journalArticle

Open Access
File
Biological Phenomena
Transglutaminases
Enzyme Activation
Huntington Disease
Celiac Disease

The role of TG2 in ECV304-related vasculogenic mimicry

Jones, R. A., Wang, Z., Dookie, S. & Griffin, M., Jan 2013, In : Amino Acids. 44, 1, p. 89-101 13 p.

Research output: Contribution to journalArticle

Tumors
Fibronectins
Cell Line
Neoplasms
Focal Adhesions

The role of TG2 in regulating S100A4-mediated mammary tumour cell migration

Wang, Z. & Griffin, M., 1 Mar 2013, In : PLoS ONE. 8, 3, 16 p., e57017.

Research output: Contribution to journalArticle

Open Access
File
mammary neoplasms (animal)
cell movement
Crosslinking
Cell Movement
Tumors

Thioredoxin is involved in endothelial cell extracellular transglutaminase 2 activation mediated by celiac disease patient IgA

Nadalutti, C. A., Korponay-Szabo, I. R., Kaukinen, K., Wang, Z., Griffin, M., Mäki, M. & Lindfors, K., 9 Oct 2013, In : PLoS ONE. 8, 10, 12 p., e77277.

Research output: Contribution to journalArticle

Open Access
File
Thioredoxins
celiac disease
protein-glutamine gamma-glutamyltransferase
Endothelial cells
Celiac Disease

Transglutaminase 2 interaction with small heat shock proteins mediate cell survival upon excitotoxic stress

Caccamo, D., Condello, S., Ferlazzo, N., Currò, M., Griffin, M. & Ientile, R., Jan 2013, In : Amino Acids. 44, 1, p. 151-159 9 p.

Research output: Contribution to journalArticle

Small Heat-Shock Proteins
N-Methylaspartate
Cell Survival
Cells
Transglutaminases
2012
Open Access
File
Cell signaling
Heparitin Sulfate
Heparin
Binding Sites
Extracellular Matrix

Interactions among secretory immunoglobulin A, CD71, and transglutaminase-2 affect permeability of intestinal epithelial cells to gliadin peptides

Lebreton, C., Ménard, S., Abed, J., Moura, I. C., Coppo, R., Dugave, C., Monteiro, R. C., Fricot, A., Traore, M. G., Griffin, M., Cellier, C., Malamut, G., Cerf-Bensussan, N. & Heyman, M., 1 Sep 2012, In : Gastroenterology. 143, 3, p. 698–707 10 p.

Research output: Contribution to journalArticle

Gliadin
Secretory Immunoglobulin A
Permeability
Epithelial Cells
Caco-2 Cells

TG2, a novel extracellular protein with multiple functions

Wang, Z. & Griffin, M., Feb 2012, In : Amino Acids. 42, 2-3, p. 939-949 11 p.

Research output: Contribution to journalArticle

Syndecan-4
Multifunctional Enzymes
Military electronic countermeasures
Heparan Sulfate Proteoglycans
Proteins
2011

Epithelial transport and deamidation of gliadin peptides: a role for coeliac disease patient immunoglobulin A

Rauhavirta, T., Qiao, S-W., Jiang, Z., Myrsky, E., Loponen, J., Korponay-Szabó, I. R., Salovaara, H., Garcia-Horsman, J. A., Venäläinen, J., Männistö, P. T., Collighan, R., Mongeot, A., Griffin, M., Mäki, M., Kaukinen, K. & Lindfors, K., Apr 2011, In : Clinical and Experimental Immunology. 164, 1, p. 127-136 10 p.

Research output: Contribution to journalArticle

Open Access
Gliadin
Celiac Disease
Abdomen
Immunoglobulin A
Peptides
Syndecan-2
Syndecan-4
Osteoblasts
Fibronectins
Cell Adhesion
Transglutaminases
Liposomes
Liver Cirrhosis
Liver
Fibrosis

The role of tissue transglutaminase (TG2) in regulating the tumour progression of the mouse colon carcinoma CT26

Kotsakis, P., Wang, Z., Collighan, R. J. & Griffin, M., Oct 2011, In : Amino Acids. 41, 4, p. 909-921 13 p.

Research output: Contribution to journalArticle

Open Access
File
Fibronectins
Integrins
Tumors
Colon
Carcinoma

Transglutaminase 2 null macrophages respond to lipopolysaccharide stimulation by elevated proinflammatory cytokine production due to an enhanced αvβ3 integrin-induced Src tyrosine kinase signaling

Sarang, Z., Köröskényi, K., Pallai, A., Duró, E., Melino, G., Griffin, M., Fésüs, L. & Szondy, Z., Jul 2011, In : Immunology Letters. 138, 1, p. 71-78 8 p.

Research output: Contribution to journalArticle

Open Access
File
src-Family Kinases
Integrins
Lipopolysaccharides
Macrophages
Cytokines
2010

An extracellular transglutaminase is required for apple pollen tube growth

Di Sandro, A., Del Duca, S., Verderio, E., Hargreaves, A. J., Scarpellini, A., Cai, G., Cresti, M., Faleri, C., Iorio, R. A., Hirose, S., Furutani, Y., Coutts, I. G. C., Griffin, M., Bonner, P. L. R. & Serafini-Fracassini, D., 5 May 2010, In : Biochemical Journal. 429, 2, p. 261-271 11 p.

Research output: Contribution to journalArticle

Pollen Tube
Transglutaminases
Malus
Growth
Substrates

Do changes in transglutaminase activity alter latent transforming growth factor beta activation in experimental diabetic nephropathy?

Huang, L., Haylor, J. L., Fisher, M., Hau, Z., El Nahas, A. M., Griffin, M. & Johnson, T. S., Dec 2010, In : Nephrology, Dialysis, Transplantation. 25, 12, p. 3897-3910 14 p.

Research output: Contribution to journalArticle

Transglutaminases
Diabetic Nephropathies
Transforming Growth Factor beta
Extracellular Matrix
Opossums

Inhibition of transglutaminase 2 enzymatic activity ameliorates the anti-angiogenic effects of coeliac disease autoantibodies

Caja, S., Myrsky, E., Korponay-Szabo, I. R., Nadalutti, C., Sulic, A-M., Lavric, M., Sblattero, D., Marzari, R., Collighan, R., Mongeot, A., Griffin, M., Mäki, M., Kaukinen, K. & Lindfors, K., Apr 2010, In : Scandinavian Journal of Gastroenterology. 45, 4, p. 421-427 7 p.

Research output: Contribution to journalArticle

Celiac Disease
Autoantibodies
Abdomen
Endothelial Cells
Genetic Recombination

Model thrombi formed under flow reveal the role of factor XIII-mediated cross-linking in resistance to fibrinolysis

Mutch, N. J., Koikkalainen, J. S., Fraser, S. R., Duthie, K. M., Griffin, M., Mitchell, J., Watson, H. G. & Booth, N. A., Sep 2010, In : Journal of Thrombosis and Haemostasis. 8, 9, p. 2017-2024 8 p.

Research output: Contribution to journalArticle

Open Access
File
Factor XIII
Fibrinolysis
Thrombosis
Fibrin
Transglutaminases
Open Access
File
Syndecan-2
Syndecan-4
Cell adhesion
Fibronectins
Cell Adhesion

The visualisation of vitreous using surface modified poly(lactic-co-glycolic acid) microparticles

Chau, D. Y. S., Tint, N. L., Collighan, R. J., Griffin, M., Dua, H. S., Shakesheff, K. M. & Rose, F. R. A. J., 2010, In : British Journal of Ophthalmology. 94, 5, p. 648-653 6 p.

Research output: Contribution to journalArticle

Open Access
File
Triamcinolone
Suspensions
Transglutaminases
Vitrectomy
Swine
2009

Celiac disease IgA modulates vascular permeability in vitro through the activity of transglutaminase 2 and RhoA

Myrsky, E., Caja, S., Simon-Vecsei, Z., Korponay-Szabo, I. R., Nadalutti, C., Collighan, R., Mongeot, A., Griffin, M., Mäki, M., Kaukinen, K. & Lindfors, K., Oct 2009, In : Cellular and Molecular Life Sciences. 66, 20, p. 3375-85 11 p.

Research output: Contribution to journalArticle

Capillary Permeability
Celiac Disease
Autoantibodies
Immunoglobulin A
Endothelium
File
NF-kappa B
Transforming Growth Factors
Transforming Growth Factor beta
Nitric Oxide
Fibroblasts

In vitro characterization of a collagen scaffold enzymatically cross-linked with a tailored elastin-like polymer

Garcia, Y., Hemantkumar, N., Collighan, R., Griffin, M., Rodriguez-Cabello, J. C. & Pandit, A., 10 Jul 2009, In : Tissue Engineering: Parts A, B and C. 15, 4, p. 887-899 13 p.

Research output: Contribution to journalArticle

Elastin
Scaffolds (biology)
Collagen
Scaffolds
Polymers

Modulation of tissue transglutaminase in tubular epithelial cells alters extracellular matrix levels: a potential mechanism of tissue scarring

Fisher, M., Jones, R. A., Huang, L., Haylor, J. L., El Nahas, M., Griffin, M. & Johnson, T. S., Jan 2009, In : Matrix Biology. 28, 1, p. 20-31 12 p.

Research output: Contribution to journalArticle

Cicatrix
Extracellular Matrix
Epithelial Cells
Collagen
Lysine

Tailored laminin-332 alpha3 sequence is tethered through an enzymatic linker to a collagen scaffold to promote cellular adhesion

Damodaran, G., Collighan, R., Griffin, M., Navsaria, H. & Pandit, A. S., Sep 2009, In : Acta Biomaterialia. 5, 7, p. 2441-2450 10 p.

Research output: Contribution to journalArticle

Transglutaminases
Scaffolds (biology)
Collagen
Scaffolds
Peptides

Tethering a laminin peptide to a crosslinked collagen scaffold for biofunctionality

Damodaran, G., Collighan, R., Griffin, M. & Pandit, A., 15 Jun 2009, In : Journal of Biomedical Materials Research: Part A. 89A, 4, p. 1001-1010 10 p.

Research output: Contribution to journalArticle

Laminin
Scaffolds (biology)
Transglutaminases
Collagen
Peptides

Thermodynamics of binding of regulatory ligands to tissue transglutaminase

Bergamini, C. M., Dondi, A., Lanzara, V., Squerzanti, M., Cervellati, C., Montin, K., Mischiati, C., Tasco, G., Collighan, R., Griffin, M. & Casadio, R., 22 Dec 2009, In : Amino Acids. 39, 1, p. 297-304 8 p.

Research output: Contribution to journalArticle

Thermodynamics
Guanosine Triphosphate
Ligands
Calcium
Hot Temperature

Transglutaminase 2 cross-linking of matrix proteins: biological significance and medical applications

Collighan, R. & Griffin, M., Apr 2009, In : Amino Acids. 36, 4, p. 659-670 12 p.

Research output: Contribution to journalArticle

Medical applications
Transglutaminases
Cell adhesion
Biocompatible Materials
Pathology

Transglutaminase 2 is involved in autophagosome maturation

D'Eletto, M., Farrace, M. G., Falasca, L., Reali, V., Oliverio, S., Melino, G., Griffin, M., Fimia, G. M. & Piacentini, M., 16 Nov 2009, In : Autophagy. 5, 8, p. 1145-1154 10 p.

Research output: Contribution to journalArticle

Autophagy
Organelles
Mitochondria
Protein Isoforms
Light

Transglutaminase inhibition ameliorates experimental diabetic nephropathy

Huang, L., Haylor, J. L., Hau, Z., Jones, R. A., Vickers, M. E., Wagner, B., Griffin, M., Saint, R. E., Coutts, I. G. C., El Nahas, A. M. & Johnson, T. S., Aug 2009, In : Kidney international. 76, 4, p. 383-394 12 p.

Research output: Contribution to journalArticle

File
Transglutaminases
Diabetic Nephropathies
Myofibroblasts
Cicatrix
Extracellular Matrix