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Research Output 1997 2019

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Activation of ERK1/2, JNK and PKB by hydrogen peroxide in human SH-SY5Y neuroblastoma cells: role of ERK1/2 in H2O2-induced cell death

Ruffels, J., Griffin, M. & Dickenson, J. M., 12 Jan 2004, In : European Journal of Pharmacology. 483, 2-3, p. 163-173 11 p.

Research output: Contribution to journalArticle

Proto-Oncogene Proteins c-akt
Mitogen-Activated Protein Kinase 3
Mitogen-Activated Protein Kinase 1
Neuroblastoma
Hydrogen Peroxide

Activation of protein kinase B by adenosine A1 and A3 receptors in newborn rat cardiomyocytes

Germack, R., Griffin, M. & Dickenson, J. M., Nov 2004, In : Journal of Molecular and Cellular Cardiology. 37, 5, p. 989-999 11 p.

Research output: Contribution to journalArticle

Adenosine A3 Receptors
Adenosine A1 Receptors
Proto-Oncogene Proteins c-akt
Cardiac Myocytes
Adenosine
Open Access
File
Fibroblasts
Cell Movement
Conformations
Enzymes
Extracellular Matrix

An extracellular transglutaminase is required for apple pollen tube growth

Di Sandro, A., Del Duca, S., Verderio, E., Hargreaves, A. J., Scarpellini, A., Cai, G., Cresti, M., Faleri, C., Iorio, R. A., Hirose, S., Furutani, Y., Coutts, I. G. C., Griffin, M., Bonner, P. L. R. & Serafini-Fracassini, D., 5 May 2010, In : Biochemical Journal. 429, 2, p. 261-271 11 p.

Research output: Contribution to journalArticle

Pollen Tube
Transglutaminases
Malus
Growth
Substrates

An improved colorimetric assay for the measurement of transglutaminase (type II) ε-(γ-glutamyl) lysine cross-linking activity

Trigwell, S. M., Lynch, P. T., Griffin, M., Hargreaves, A. J. & Bonner, P. L. R., 1 Jul 2004, In : Analytical Biochemistry. 330, 1, p. 164-166 3 p.

Research output: Contribution to journalArticle

Open Access
File

A novel extracellular role for tissue transglutaminase in matrix-bound VEGF-mediated angiogenesis

Wang, Z., Perez, M., Caja, S., Melino, G., Johnson, T. S., Lindfors, K. & Griffin, M., 2013, In : Cell Death and Disease. 4, 9, 13 p., e808.

Research output: Contribution to journalArticle

Open Access
File
Human Umbilical Vein Endothelial Cells
Vascular Endothelial Growth Factor A
Cell Culture Techniques
Vascular Endothelial Growth Factor Receptor-2
Coculture Techniques

A novel regulatory role for tissue transglutaminase in epithelial-mesenchymal transition in cystic fibrosis

Nyabam, S., Wang, Z., Thibault, T., Ayinde, O., Basar, R., Marshall, L. & Griffin, M., Sep 2016, In : BBA - Molecular Cell Research. 1863, 9, p. 2234-2244 11 p.

Research output: Contribution to journalArticle

Open Access
File
Cystic Fibrosis Transmembrane Conductance Regulator
Epithelial-Mesenchymal Transition
Cystic Fibrosis
Cysteamine
Inborn Genetic Diseases

A novel RGD-independent cel adhesion pathway mediated by fibronectin-bound tissue transglutaminase rescues cells from anoikis

Verderio, E. A. M., Telci, D., Okoye, A., Melino, G. & Griffin, M., 24 Oct 2003, In : Journal of Biological Chemistry. 278, 43, p. 42604-42614 11 p.

Research output: Contribution to journalArticle

Open Access
File
Anoikis
Fibronectins
Adhesion
Cell adhesion
Cell Adhesion

Application of transglutaminases in the modification of wool textiles

Cortez, J., Bonner, P. L. R. & Griffin, M., 5 Jan 2004, In : Enzyme and Microbial Technology. 34, 1, p. 64-72 9 p.

Research output: Contribution to journalArticle

Transglutaminases
Wool
Textiles
Amines
Yarn

Are transglutaminase 2 inhibitors able to reduce gliadin-induced toxicity related to celiac disease? A proof-of-concept study

Rauhavirta, T., Oittinen, M., Kivistö, R., Männistö, P. T., Garcia-Horsman, J. A., Wang, Z., Griffin, M., Mäki, M., Kaukinen, K. & Lindfors, K., Jan 2013, In : Journal of Clinical Immunology. 33, 1, p. 134-142 9 p.

Research output: Contribution to journalArticle

Gliadin
Celiac Disease
Glutens
Interleukin-15
Caco-2 Cells

Assessment of cell viability in a three-dimensional enzymatically cross-linked collagen scaffold

Garcia, Y., Collighan, R., Griffin, M. & Pandit, A. S., Oct 2007, In : Journal of Materials Science : Materials in Medicine. 18, 10, p. 1991-2001 11 p.

Research output: Contribution to journalArticle

Scaffolds (biology)
Collagen
Scaffolds
Cell Survival
Cells

Biocomposites of non-crosslinked natural and synthetic polymers

Coombes, A. G. A., Verderio, E., Shaw, B., Li, X., Griffin, M. & Downes, S., May 2002, In : Biomaterials. 23, 10, p. 2113-2118 6 p.

Research output: Contribution to journalArticle

Collagen
Polymers
Osteoblasts
Biocompatible Materials
Biomaterials

Bottom-up risk regulation? How nanotechnology risk knowledge gaps challenge federal and state environmental agencies

Powell, M. C., Griffin, M. P. A. & Tai, S., Sep 2008, In : Environmental Management. 42, 3, p. 426-443 18 p.

Research output: Contribution to journalArticle

nanotechnology
Nanotechnology
environmental risk
toxic substance
emission control

Cardiac fibrosis can be attenuated by blocking the activity of transglutaminase 2 using a selective small-molecule inhibitor

Wang, Z., Stuckey, D. J., Murdoch, C. E., Camelliti, P., Lip, G. Y. H. & Griffin, M., 27 Apr 2018, In : Cell Death and Disease. 9, 613.

Research output: Contribution to journalArticle

Open Access
File
Fibrosis
Myofibroblasts
transglutaminase 2
Angiotensin II
Lysine

Celiac disease IgA modulates vascular permeability in vitro through the activity of transglutaminase 2 and RhoA

Myrsky, E., Caja, S., Simon-Vecsei, Z., Korponay-Szabo, I. R., Nadalutti, C., Collighan, R., Mongeot, A., Griffin, M., Mäki, M., Kaukinen, K. & Lindfors, K., Oct 2009, In : Cellular and Molecular Life Sciences. 66, 20, p. 3375-85 11 p.

Research output: Contribution to journalArticle

Capillary Permeability
Celiac Disease
Autoantibodies
Immunoglobulin A
Endothelium

Celiac disease patient IgA antibodies induce endothelial adhesion and cell polarization defects via extracellular transglutaminase 2

Nadalutti, C. A., Korponay-Szabó, I. R., Kaukinen, K., Griffin, M., Mäki, M. & Lindfors, K., Apr 2014, In : Cellular and Molecular Life Sciences. 71, 7, p. 1315-1326 12 p.

Research output: Contribution to journalArticle

Celiac Disease
Abdomen
Immunoglobulin A
Endothelial Cells
Antibodies

Celiac disease-specific TG2-targeted autoantibodies inhibit angiogenesis ex vivo and in vivo in mice by interfering with endothelial cell dynamics

Kalliokoski, S., Sulic, A-M., Korponay-Szabó, I. R., Szondy, Z., Frias, R., Perez, M. A., Martucciello, S., Roivainen, A., Pelliniemi, L. J., Esposito, C., Griffin, M., Sblattero, D., Mäki, M., Kaukinen, K., Lindfors, K. & Caja, S., 18 Jun 2013, In : PLoS ONE. 8, 6, 8 p., e65887.

Research output: Contribution to journalArticle

Open Access
File
autoantibodies
celiac disease
protein-glutamine gamma-glutamyltransferase
Endothelial cells
Celiac Disease

Characterization of a microbial transglutaminase cross-linked type II collagen scaffold

O Halloran, D. M., Collighan, R., Griffin, M. & Pandit, A. S., 17 Jul 2006, In : Tissue Engineering. 12, 6, p. 1467-1474 8 p.

Research output: Contribution to journalArticle

Transglutaminases
Collagen Type II
Scaffolds
Scaffolds (biology)
Covalent bonds
Open Access
File
Cell signaling
Heparitin Sulfate
Heparin
Binding Sites
Extracellular Matrix

Characterization of tissue transglutaminase in human osteoblast-like cells

Heath, D. J., Downes, S., Verderio, E. & Griffin, M., Aug 2001, In : Journal of Bone and Mineral Research. 16, 8, p. 1477-1485 9 p.

Research output: Contribution to journalArticle

Osteoblasts
Transglutaminases
Cadaverine
Putrescine
Extracellular Matrix Proteins

Cross-linking of cellular proteins by tissue transglutaminase during necrotic cell death: a mechanism for maintaining tissue integrity

Nicholas, B., Smethurst, P., Verderio, E., Jones, R. & Griffin, M., Apr 2003, In : Biochemical Journal. 371, 2, p. 413-422 10 p.

Research output: Contribution to journalArticle

Open Access
Cell death
Cell Death
Tissue
Proteins
Electroporation

Cross-linking of collagen I by tissue transglutaminase provides a promising biomaterial for promoting bone healing

Fortunati, D., Chau, D. Y. S., Wang, Z., Collighan, R. J. & Griffin, M., 31 Jul 2014, In : Amino Acids. 46, 7, p. 1751-1761 11 p.

Research output: Contribution to journalArticle

Biocompatible Materials
Bone
Collagen
Bone and Bones
Osteoblasts

Decreased efficiency of trypsinization of cells following photodynamic therapy: evaluation of a role for tissue transglutaminase

Ball, D. J., Mayhew, S., Vernon, D. I., Griffin, M. & Brown, S. B., 2001, In : Photochemistry and Photobiology. 73, 1, p. 47-53 7 p.

Research output: Contribution to journalArticle

Photodynamic therapy
Photochemotherapy
therapy
evaluation
fluence

Development of potent and selective tissue transglutaminase inhibitors: their effect on TG2 function and application in pathological conditions

Badarau, E., Wang, Z., Rathbone, D. L., Costanzi, A., Thibault, T., Murdoch, C. E., El Alaoui, S., Bartkeviciute, M. & Griffin, M., 22 Oct 2015, In : Chemistry and Biology. 22, 10, p. 1347-1361 15 p.

Research output: Contribution to journalArticle

Open Access
File
Endothelial cells
Fibronectins
Syndecan-4
Umbilical Cord
Peptidomimetics

Do changes in transglutaminase activity alter latent transforming growth factor beta activation in experimental diabetic nephropathy?

Huang, L., Haylor, J. L., Fisher, M., Hau, Z., El Nahas, A. M., Griffin, M. & Johnson, T. S., Dec 2010, In : Nephrology, Dialysis, Transplantation. 25, 12, p. 3897-3910 14 p.

Research output: Contribution to journalArticle

Transglutaminases
Diabetic Nephropathies
Transforming Growth Factor beta
Extracellular Matrix
Opossums

Elevated ε-(γ-glutamyl)lysine in human diabetic nephropathy results from increased expression and cellular release of tissue transglutaminase

El Nahas, A. M., Abo-Zenah, H., Skill, N. J., Bex, S., Wild, G., Griffin, M. & Johnson, T. S., Jul 2004, In : Nephron Clinical Practice. 97, 3, p. 108-117 10 p.

Research output: Contribution to journalArticle

Diabetic Nephropathies
Lysine
Kidney
Extracellular Matrix
Confocal Microscopy

Enzymatic stabilization of gelatin-based scaffolds

Broderick, E. P., O'Halloran, D. M., Rochev, Y. A., Griffin, M., Collighan, R. & Pandit, A. S., 15 Jan 2005, In : Journal of biomedical materials research: part B. 72, 1, p. 37-42 6 p.

Research output: Contribution to journalArticle

Transglutaminases
Gelatin
Scaffolds
Gels
Stabilization

Epithelial transport and deamidation of gliadin peptides: a role for coeliac disease patient immunoglobulin A

Rauhavirta, T., Qiao, S-W., Jiang, Z., Myrsky, E., Loponen, J., Korponay-Szabó, I. R., Salovaara, H., Garcia-Horsman, J. A., Venäläinen, J., Männistö, P. T., Collighan, R., Mongeot, A., Griffin, M., Mäki, M., Kaukinen, K. & Lindfors, K., Apr 2011, In : Clinical and Experimental Immunology. 164, 1, p. 127-136 10 p.

Research output: Contribution to journalArticle

Open Access
Gliadin
Celiac Disease
Abdomen
Immunoglobulin A
Peptides

Fibronectin-tissue transglutaminase matrix rescues RGD-impaired celladhesion through syndecan-4 and β integrin co-signaling

Telci, D., Wang, Z., Li, X., Verderio, E. A. M., Humphries, M. J., Baccarini, M., Basaga, H. & Griffin, M., 25 Jul 2008, In : Journal of Biological Chemistry. 283, 30, p. 20937-20947 11 p.

Research output: Contribution to journalArticle

Open Access
File
Syndecan-4
Fibronectins
Integrins
Proto-Oncogene Proteins c-raf
Protein Kinases
Factor XIIIa
Transglutaminases
Blood Coagulation Factors
Water
Scaffolds
Syndecan-2
Syndecan-4
Osteoblasts
Fibronectins
Cell Adhesion
Cell death
Fibroblasts
Extracellular Matrix
Repair
Cell Death
File
NF-kappa B
Transforming Growth Factors
Transforming Growth Factor beta
Nitric Oxide
Fibroblasts

Increases in renal ε-(γ-glutamyl)-lysine crosslinks result from compartment-specific changes in tissue transglutaminase in early experimental diabetic nephropathy: Pathologic implications

Skill, N. J., Griffin, M., El Nahas, A. M., Sanai, T., Haylor, J. L., Fisher, M., Jamie, M. F., Mould, N. N. & Johnson, T. S., May 2001, In : Laboratory Investigation. 81, 5, p. 705-716 12 p.

Research output: Contribution to journalArticle

Diabetic Nephropathies
Lysine
Transglutaminases
Kidney
Extracellular Matrix
Indwelling Catheters
Catheters
Central Venous Catheters
Equipment and Supplies
Factor XIIIa

Inhibition of collagen I accumulation reduces glomerulosclerosis by a Hic-5-dependent mechanism in experimental diabetic nephropathy

Hornigold, N., Johnson, T. S., Huang, L., Haylor, J. L., Griffin, M. & Mooney, A., May 2013, In : Laboratory Investigation. 93, 5, p. 553-565 13 p.

Research output: Contribution to journalArticle

Diabetic Nephropathies
Collagen
Mesangial Cells
Apoptosis
Smooth Muscle

Inhibition of transglutaminase 2 enzymatic activity ameliorates the anti-angiogenic effects of coeliac disease autoantibodies

Caja, S., Myrsky, E., Korponay-Szabo, I. R., Nadalutti, C., Sulic, A-M., Lavric, M., Sblattero, D., Marzari, R., Collighan, R., Mongeot, A., Griffin, M., Mäki, M., Kaukinen, K. & Lindfors, K., Apr 2010, In : Scandinavian Journal of Gastroenterology. 45, 4, p. 421-427 7 p.

Research output: Contribution to journalArticle

Celiac Disease
Autoantibodies
Abdomen
Endothelial Cells
Genetic Recombination

Inhibition of transglutaminase activity reduces extracellular matrix accumulation induced by high glucose levels in proximal tubular epithelial cells

Skill, N. J., Johnson, T. S., Coutts, I. G. . C., Saint, R. E., Fisher, M., Huang, L., El Nahas, A. M., Collighan, R. & Griffin, M., 12 Nov 2004, In : Journal of Biological Chemistry. 279, 46, p. 47754-47762 9 p.

Research output: Contribution to journalArticle

Open Access
File
Transglutaminases
Extracellular Matrix
Epithelial Cells
Glucose
Collagen

Interactions among secretory immunoglobulin A, CD71, and transglutaminase-2 affect permeability of intestinal epithelial cells to gliadin peptides

Lebreton, C., Ménard, S., Abed, J., Moura, I. C., Coppo, R., Dugave, C., Monteiro, R. C., Fricot, A., Traore, M. G., Griffin, M., Cellier, C., Malamut, G., Cerf-Bensussan, N. & Heyman, M., 1 Sep 2012, In : Gastroenterology. 143, 3, p. 698–707 10 p.

Research output: Contribution to journalArticle

Gliadin
Secretory Immunoglobulin A
Permeability
Epithelial Cells
Caco-2 Cells

In vitro characterization of a collagen scaffold enzymatically cross-linked with a tailored elastin-like polymer

Garcia, Y., Hemantkumar, N., Collighan, R., Griffin, M., Rodriguez-Cabello, J. C. & Pandit, A., 10 Jul 2009, In : Tissue Engineering: Parts A, B and C. 15, 4, p. 887-899 13 p.

Research output: Contribution to journalArticle

Elastin
Scaffolds (biology)
Collagen
Scaffolds
Polymers

In vivo effects of tailored laminin-332 α3 conjugated scaffolds enhances wound healing: a histomorphometric analysis

Damodaran, G., Tiong, W. H. C., Collighan, R., Navsaria, H., Griffin, M. & Pandit, A., 5 Mar 2013, In : Journal of Biomedical Materials Research: Part A. 101, 10, p. 2788-2795 8 p.

Research output: Contribution to journalArticle

Transglutaminases
Scaffolds
Peptides
Scaffolds (biology)
Cell adhesion

Involvement of cell surface TG2 in the aggregation of K562 cells triggered by gluten

Feriotto, G., Calza, R., Bergamini, C. M., Griffin, M., Wang, Z., Beninati, S., Ferretti, V., Marzola, E., Guerrini, R., Pagnoni, A., Cavazzini, A., Casciano, F. & Mischiati, C., 1 Mar 2017, In : Amino Acids. 49, 3, p. 551–565

Research output: Contribution to journalArticle

Open Access
File
K562 Cells
Glutens
Agglomeration
Calcium
Guanosine Triphosphate

Involvement of tissue transglutaminase in the stabilisation of biomaterial/tissue interfaces important in medical devices

Heath, D. J., Christian, P. & Griffin, M., Mar 2002, In : Biomaterials. 23, 6, p. 1519-1526 8 p.

Research output: Contribution to journalArticle

Biocompatible Materials
Biomaterials
Fibronectins
Stabilization
Tissue

Isopeptidase activity of human transglutaminase 2: disconnection from transamidation and characterization by kinetic parameters

Kiraly, R., Thangaraju, K., Nagy, Z., Collighan, R., Nemes, Z., Griffin, M. & Fésüs, L., Jan 2016, In : Amino Acids. 48, 1, p. 31-40 10 p.

Research output: Contribution to journalArticle

Open Access
File
Kinetic parameters
Human Activities
Mutation
Amines
Physiological Phenomena

Job satisfaction and teamwork: The role of supervisor support

Griffin, M. A., Patterson, M. & West, M. A., Aug 2001, In : Journal of Organizational Behavior. 22, 5, p. 537-550 14 p.

Research output: Contribution to journalArticle

Job Satisfaction
teamwork
job satisfaction
Multilevel Analysis
job enrichment

Mapping the minimum domain of the fibronectin binding site on transglutaminase 2 (TG2) and its importance in mediating signaling, adhesion, and migration in TG2-expressing cells

Soluri, M. F., Boccafoschi, F., Cotella, D., Moro, L., Forestieri, G., Autiero, I., Cavallo, L., Oliva, R., Griffin, M., Wang, Z., Santoro, C. & Sblattero, D., 30 Jan 2019, In : FASEB Journal . 33, 2, p. 2327-2342 16 p.

Research output: Contribution to journalArticle

Fibronectins
Adhesion
Binding Sites
Gelatin
Cell Adhesion

Matrix changes induced by transglutaminase 2 lead to inhibition of angiogenesis and tumor growth

Jones, R. A., Kotsakis, P., Johnson, T. S., Chau, D. Y. S., Ali, S., Melino, G. & Griffin, M., Sep 2006, In : Cell Death and Differentiation. 13, 9, p. 1442-1453 12 p.

Research output: Contribution to journalArticle

Growth
Neoplasms
Extracellular Matrix
Matrix Metalloproteinase 1
Inhibition (Psychology)

Model thrombi formed under flow reveal the role of factor XIII-mediated cross-linking in resistance to fibrinolysis

Mutch, N. J., Koikkalainen, J. S., Fraser, S. R., Duthie, K. M., Griffin, M., Mitchell, J., Watson, H. G. & Booth, N. A., Sep 2010, In : Journal of Thrombosis and Haemostasis. 8, 9, p. 2017-2024 8 p.

Research output: Contribution to journalArticle

Open Access
File
Factor XIII
Fibrinolysis
Thrombosis
Fibrin
Transglutaminases

Modulation of tissue transglutaminase in tubular epithelial cells alters extracellular matrix levels: a potential mechanism of tissue scarring

Fisher, M., Jones, R. A., Huang, L., Haylor, J. L., El Nahas, M., Griffin, M. & Johnson, T. S., Jan 2009, In : Matrix Biology. 28, 1, p. 20-31 12 p.

Research output: Contribution to journalArticle

Cicatrix
Extracellular Matrix
Epithelial Cells
Collagen
Lysine

Novel approach to improving enzyme penetration

Senior, K., Griffin, M. & Collighan, R., Jan 2003, British Leather Technology Centre journal, 46.

Research output: Contribution to specialist publicationArticle