Mohammed Elasrag

Aston Triangle
B4 7ET Birmingham
United Kingdom
School of Life & Health Sciences, Aston University, Aston Triangle
B4 7ET Birmingham
United Kingdom

Accepting PhD Students

PhD projects

1. Integrative Genomics of Rare Diseases
Objective: Identify novel genetic variants associated with rare diseases using integrated multi-omics sequencing and advanced bioinformatics techniques.

2. Precision Oncology: Genomic Profiling of Tumors
Objective: Investigate the genomic landscape of various cancers to inform personalized treatment strategies and address the knowledge gap in tumor biology.

For more information and to explore other available research projects, please email Dr. Mo Elasrag at [email protected]

26 Article
2 Abstract
1 Review article
1 Preprint

30 results

2024
Faecal Microbiota Transplantation [FMT] in the Treatment of Chronic Refractory Pouchitis: A Systematic Review and Meta-analysis
Zaman, S., Akingboye, A., Mohamedahmed, A. Y. Y., Peterknecht, E., Bhattacharya, P., El-Asrag, M. E., Iqbal, T. H., Quraishi, M. N. & Beggs, A. D., Jan 2024, In: Journal of Crohn's and Colitis. 18, 1, p. 144-161 18 p.
Research output: Contribution to journal › Review article › peer-review

Open Access
The Effect of Colesevelam on the Microbiome in Postoperative Crohn's Disease
Kumar, A., Quraishi, M. N., Al-Hassi, H. O., Elasrag, M., Segal, J. P., Jain, M., Steed, H., Butterworth, J., Farmer, A., Mclaughlin, J., Beggs, A. D. & Brookes, M. J., 18 Oct 2024, (E-pub ahead of print) In: Inflammatory Bowel Diseases.
Research output: Contribution to journal › Article › peer-review
2023
Derivation of a new model of lung adenocarcinoma using canine lung cancer organoids for translational research in pulmonary medicine
Shiota Sato, Y., Elbadawy, M., Suzuki, K., Tsunedomi, R., Nagano, H., Ishihara, Y., Yamamoto, H., Azakami, D., Uchide, T., Fukushima, R., Tanaka, R., Yoshida, T., Mori, T., Abugomaa, A., Kaneda, M., Yamawaki, H., Shinohara, Y., Aboubakr, M., El-Asrag, M. E. & Usui, T. & 1 others, Sasaki, K., Sept 2023, In: Biomedicine & Pharmacotherapy. 165, 13 p., 115079.
Research output: Contribution to journal › Article › peer-review

Open Access
File
Elucidating the mechanisms via which the proto-oncogene PBF stimulates cell motility in thyroid tumour progression
Manivannan, S., Kocbiyik, M., Alshahrani, M., El-Asrag, M. E., Zha, L., Brookes, K., Nieto, H. R., Read, M. L., Beggs, A., McCabe, C. J. & Smith, V. E., 11 Jul 2023, In: Thyroid Research. 16, Suppl.1, 1 p., PO2.
Research output: Contribution to journal › Article › peer-review

Open Access
Feasibility of mass cytometry proteomic characterisation of circulating tumour cells in head and neck squamous cell carcinoma for deep phenotyping
Payne, K., Brooks, J., Batis, N., Khan, N., El-Asrag, M., Nankivell, P., Mehanna, H. & Taylor, G., 9 Nov 2023, In: British Journal of Cancer. 129, 10, p. 1590-1598 9 p.
Research output: Contribution to journal › Article › peer-review

Open Access
Impaired protein hydroxylase activity causes replication stress and developmental abnormalities in humans
Fletcher, S. C., Hall, C., Kennedy, T. J., Pajusalu, S., Wojcik, M. H., Boora, U., Li, C., Oja, K. T., Hendrix, E., Westrip, C. A. E., Andrijes, R., Piasecka, S. K., Singh, M., El-Asrag, M. E., Ptasinska, A., Tillmann, V., Higgs, M. R., Carere, D. A., Beggs, A. D. & Pappas, J. & 5 others, Rabin, R., Smerdon, S. J., Stewart, G. S., Õunap, K. & Coleman, M. L., 3 Apr 2023, In: Journal of Clinical Investigation. 133, 7, 15 p., e152784.
Research output: Contribution to journal › Article › peer-review

Open Access
Late-Onset Autosomal Dominant Macular Degeneration Caused by Deletion of the CRX Gene
Yahya, S., Smith, C. E. L., Poulter, J. A., McKibbin, M., Arno, G., Ellingford, J., Kämpjärvi, K., Khan, M. I., Cremers, F. P. M., Hardcastle, A. J., Castle, B., Steel, D. H. W., Webster, A. R., Black, G. C., El-Asrag, M. E., Ali, M., Toomes, C. & Inglehearn, C. F., Jan 2023, In: Ophthalmology. 130, 1, p. 68-76 9 p.
Research output: Contribution to journal › Article › peer-review

Open Access
Long-Read Nanopore Sequencing of RPGR ORF15 is Enhanced Following DNase I Treatment of MinION Flow Cells
Yahya, S., Watson, C. M., Carr, I., McKibbin, M., Crinnion, L. A., Taylor, M., Bonin, H., Fletcher, T., El-Asrag, M. E., Ali, M., Toomes, C. & Inglehearn, C. F., Jul 2023, In: Molecular diagnosis & therapy. 27, 4, p. 525-535 11 p.
Research output: Contribution to journal › Article › peer-review

Open Access
The analysis of gut microbiota in patients with bile acid diarrhoea treated with colesevelam
Kumar, A., Quraishi, M. N., Al-Hassi, H. O., El-Asrag, M. E., Segal, J. P., Jain, M., Steed, H., Butterworth, J., Farmer, A., Mclaughlin, J., Beggs, A. & Brookes, M. J., 17 Mar 2023, In: Frontiers in Microbiology. 14, 11 p., 1134105.
Research output: Contribution to journal › Article › peer-review

Open Access
2022
Meta-analysis of the demographic and prognostic significance of gastrointestinal symptoms in COVID-19 patients
Zaman, S., Hajibandeh, S., Hajibandeh, S., Mohamedahmed, A. Y. Y., El-Asrag, M. E., Quraishi, N., Iqbal, T. H. & Beggs, A. D., Oct 2022, In: JGH open : an open access journal of gastroenterology and hepatology. 6, 10, p. 711-22 12 p.
Research output: Contribution to journal › Article › peer-review

Open Access
Novel homozygous mutations in the transcription factor NRL cause non-syndromic retinitis pigmentosa
El-Asrag, M. E., Corton, M., McKibbin, M., Avila-Fernandez, A., Mohamed, M. D., Blanco-Kelly, F., Toomes, C., Inglehearn, C. F., Ayuso, C. & Ali, M., 17 May 2022, In: Molecular Vision. 28, p. 48-56 9 p.
Research output: Contribution to journal › Article › peer-review
Patient Derived Organoids Confirm That PI3K/AKT Signalling Is an Escape Pathway for Radioresistance and a Target for Therapy in Rectal Cancer
Wanigasooriya, K., Barros-Silva, J. D., Tee, L., El-Asrag, M. E., Stodolna, A., Pickles, O. J., Stockton, J., Bryer, C., Hoare, R., Whalley, C. M., Tyler, R., Sillo, T., Yau, C., Ismail, T. & Beggs, A. D., 4 Jul 2022, In: Frontiers in Oncology. 12, 14 p., 920444.
Research output: Contribution to journal › Article › peer-review

Open Access
PDZD8 Disruption Causes Cognitive Impairment in Humans, Mice, and Fruit Flies
Al-Amri, A. H., Armstrong, P., Amici, M., Ligneul, C., Rouse, J., El-Asrag, M. E., Pantiru, A., Vancollie, V. E., Ng, H. W. Y., Ogbeta, J. A., Goodchild, K., Ellegood, J., Lelliott, C. J., Mullins, J. G. L., Bretman, A., Al-Ali, R., Beetz, C., Al-Gazali, L., Al Shamsi, A. & Lerch, J. P. & 5 others, Mellor, J. R., Al Sayegh, A., Ali, M., Inglehearn, C. F. & Clapcote, S. J., 15 Aug 2022, In: Biological Psychiatry. 92, 4, p. 323-334 12 p.
Research output: Contribution to journal › Article › peer-review

Open Access
2021
A Recessively Inherited Risk Locus on Chromosome 13q22-31 Conferring Susceptibility to Schizophrenia
Mahmood, T., El-Asrag, M. E., Poulter, J. A., Cardno, A. G., Tomlinson, A., Ahmed, S., Al-Amri, A., Nazari, J., Neill, J., Chamali, R. S., Kiwan, N., Ghuloum, S., Alhaj, H. A., Randerson Moor, J., Khan, S., Al-Amin, H., Johnson, C. A., Woodruff, P., Wilkinson, I. D. & Ali, M. & 2 others, Clapcote, S. J. & Inglehearn, C. F., May 2021, In: Schizophrenia Bulletin. 47, 3, p. 796-802 7 p.
Research output: Contribution to journal › Article › peer-review

Open Access
Myocilin mutations account for 5% of POAG in a West Yorkshire clinic
Albuainain, D., Siddiqui, S., Onsiong, C., El-Asrag, M., Galloway, P., Inglehearn, C. & Ali, M., Jun 2021, p. 1502-1502. 1 p.
Research output: Unpublished contribution to conference › Abstract › peer-review
Patient derived organoids reveal that PI3K/AKT signalling is an escape pathway for radioresistance and a target for therapy in rectal cancer
Wanigasooriya, K., Barros-Silva, J. D., Tee, L., El-Asrag, M. E., Stodolna, A., Pickles, O. J., Stockton, J., Bryer, C., Hoare, R., Whalley, C., Tyler, R., Sillo, T., Yau, C., Ismail, T. & Beggs, A. D., 1 Sept 2021, 68 p.
Research output: Preprint or Working paper › Preprint › peer-review

Open Access
2020
New missense variants in RELT causing hypomineralised amelogenesis imperfecta
Nikolopoulos, G., Smith, C. E. L., Brookes, S. J., El-Asrag, M. E., Brown, C. J., Patel, A., Murillo, G., O'Connell, M. J., Inglehearn, C. F. & Mighell, A. J., May 2020, In: Clinical genetics. 97, 5, p. 688-695 8 p.
Research output: Contribution to journal › Article › peer-review

Open Access
2019
LHFPL5 mutation: A rare cause of non-syndromic autosomal recessive hearing loss
Al-Amri, A. H., Al Saegh, A., Al-Mamari, W., El-Asrag, M. E., Al-Kindi, M. N., Al Khabouri, M., Al Wardy, N., Al Lamki, K., Gabr, A., Idris, A., Inglehearn, C. F., Clapcote, S. J. & Ali, M., Dec 2019, In: European Journal of Medical Genetics. 62, 12, 7 p., 103592.
Research output: Contribution to journal › Article › peer-review
The ciliary Frizzled-like receptor Tmem67 regulates canonical Wnt/β-catenin signalling in the developing cerebellum via Hoxb5
Abdelhamed, Z. A., Abdelmottaleb, D. I., El-Asrag, M. E., Natarajan, S., Wheway, G., Inglehearn, C. F., Toomes, C. & Johnson, C. A., 1 Apr 2019, In: Scientific Reports. 9, 1, 15 p., 5446.
Research output: Contribution to journal › Article › peer-review

Open Access
2018
Identification of Inherited Retinal Disease-Associated Genetic Variants in 11 Candidate Genes
Astuti, G. D. N., van den Born, L. I., Khan, M. I., Hamel, C. P., Bocquet, B., Manes, G., Quinodoz, M., Ali, M., Toomes, C., McKibbin, M., El-Asrag, M. E., Haer-Wigman, L., Inglehearn, C. F., Black, G. C. M., Hoyng, C. B., Cremers, F. P. M. & Roosing, S., Jan 2018, In: Genes. 9, 1, 16 p., 21.
Research output: Contribution to journal › Article › peer-review

Open Access
2017
Specific Alleles of CLN7/MFSD8, a Protein That Localizes to Photoreceptor Synaptic Terminals, Cause a Spectrum of Nonsyndromic Retinal Dystrophy
Khan, K. N., El-Asrag, M. E., Ku, C. A., Holder, G. E., McKibbin, M., Arno, G., Poulter, J. A., Carss, K., Bommireddy, T., Bagheri, S., Bakall, B., Scholl, H. P., Raymond, F. L., Toomes, C., Inglehearn, C. F., Pennesi, M. E., Moore, A. T., Michaelides, M., Webster, A. R. & Ali, M., 1 Jun 2017, In: Investigative Ophthalmology and Visual Science. 58, 7, p. 2906-2914 9 p.
Research output: Contribution to journal › Article › peer-review

Open Access
Use of a gene-based case-control association approach in exome sequencing data to elucidate the molecular basis of a mendelian phenotype
Sergouniotis, P. I., Robson, A. G., El-Asrag, M. E., Ali, M., Holder, G. E., Black, G. C., Webster, A. R. & Plagnol, V., Feb 2017, In: The Lancet. 389, p. S14 1 p.
Research output: Contribution to journal › Article › peer-review
2016
Homozygous single base deletion in TUSC3 causes intellectual disability with developmental delay in an Omani family
Al-Amri, A., Saegh, A. A., Al-Mamari, W., El-Asrag, M. E., Ivorra, J. L., Cardno, A. G., Inglehearn, C. F., Clapcote, S. J. & Ali, M., Jul 2016, In: American Journal of Medical Genetics Part A . 170, 7, p. 1826-31 6 p.
Research output: Contribution to journal › Article › peer-review
Mutations in the polyglutamylase gene TTLL5, expressed in photoreceptor cells and spermatozoa, are associated with cone-rod degeneration and reduced male fertility
Bedoni, N., Haer-Wigman, L., Vaclavik, V., Tran, V. H., Farinelli, P., Balzano, S., Royer-Bertrand, B., El-Asrag, M. E., Bonny, O., Ikonomidis, C., Litzistorf, Y., Nikopoulos, K., Yioti, G. G., Stefaniotou, M. I., McKibbin, M., Booth, A. P., Ellingford, J. M., Black, G. C., Toomes, C. & Inglehearn, C. F. & 11 others, Hoyng, C. B., Bax, N., Klaver, C. C. W., Thiadens, A. A., Murisier, F., Schorderet, D. F., Ali, M., Cremers, F. P. M., Andréasson, S., Munier, F. L. & Rivolta, C., 15 Oct 2016, In: Human Molecular Genetics. 25, 20, p. 4546-4555 10 p.
Research output: Contribution to journal › Article › peer-review
2015
Association between missense mutations in the BBS2 gene and nonsyndromic retinitis pigmentosa
Shevach, E., Ali, M., Mizrahi-Meissonnier, L., McKibbin, M., El-Asrag, M., Watson, C. M., Inglehearn, C. F., Ben-Yosef, T., Blumenfeld, A., Jalas, C., Banin, E. & Sharon, D., Mar 2015, In: JAMA Ophthalmology. 133, 3, p. 312-318 7 p.
Research output: Contribution to journal › Article › peer-review
Biallelic Mutations in the Autophagy Regulator DRAM2 Cause Retinal Dystrophy with Early Macular Involvement
El-Asrag, M. E., Sergouniotis, P. I., McKibbin, M., Plagnol, V., Sheridan, E., Waseem, N., Abdelhamed, Z., McKeefry, D., Van Schil, K., Poulter, J. A., Johnson, C. A., Carr, I. M., Leroy, B. P., De Baere, E., Inglehearn, C. F., Webster, A. R., Toomes, C. & Ali, M., 4 Jun 2015, In: American Journal of Human Genetics. 96, 6, p. 948-54 7 p.
Research output: Contribution to journal › Article › peer-review
Disease Expression in Autosomal Recessive Retinal Dystrophy Associated With Mutations in the DRAM2 Gene
Sergouniotis, P., McKibbin, M., Robson, A. G., Bolz, H. J., De Baere, E., Müller, P. L., Heller, R., El-Asrag, M. E., Van Schil, K., Plagnol, V., Toomes, C., Ali, M., Holder, G. E., Issa, P. C., Leroy, B. P., Inglehearn, C. & Webster, A. R., Dec 2015, In: Investigative Ophthalmology and Visual Science. 56, 13, p. 8083-90 8 p.
Research output: Contribution to journal › Article › peer-review

Open Access
Mutations in MFSD8 can indeed cause a nonsyndromic recessive macular dystrophy.
Elasrag, M. E., McKibbin, M., Poulter, J., Inglehearn, C., Toomes, C. & Ali, M., Jun 2015, p. 2877-2877. 1 p.
Research output: Unpublished contribution to conference › Abstract › peer-review
Novel C8orf37 mutations cause retinitis pigmentosa in consanguineous families of Pakistani origin
Ravesh, Z., El Asrag, M. E., Weisschuh, N., McKibbin, M., Reuter, P., Watson, C. M., Baumann, B., Poulter, J. A., Sajid, S., Panagiotou, E. S., O'Sullivan, J., Abdelhamed, Z., Bonin, M., Soltanifar, M., Black, G. C. M., Amin-ud Din, M., Toomes, C., Ansar, M., Inglehearn, C. F. & Wissinger, B. & 1 others, Ali, M., 7 Mar 2015, In: Molecular Vision. 21, p. 236-43 8 p.
Research output: Contribution to journal › Article › peer-review

Open Access
2014
Mutation screening of retinal dystrophy patients by targeted capture from tagged pooled DNAs and next generation sequencing
Watson, C. M., El-Asrag, M., Parry, D. A., Morgan, J. E., Logan, C. V., Carr, I. M., Sheridan, E., Charlton, R., Johnson, C. A., Taylor, G., Toomes, C., McKibbin, M., Inglehearn, C. F. & Ali, M., 18 Aug 2014, In: PLoS ONE. 9, 8, 9 p., e104281.
Research output: Contribution to journal › Article › peer-review

Open Access

Dr Mohammed Elasrag

Research output

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