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Personal profile

Research Interests

My research interests are focused on the study of membrane proteins, spanning from single molecule studies to advanced tissue engineering. Current projects in the lab include developing iPSC-based models of the human blood-brain barrier, drug discovery for brain oedema by inhibiting aquaporin channel function or localisation, characterising the interactome of various membrane proteins, using mass photometry to characterise membrane protein oligomerisation, optimising solubilisation conditions for G protein-coupled receptors, and cryo-EM studies of aquaporins using novel membrane solubilising agents.

I have capacity for supervision of undergraduate and Masters level research projects, and am happy to receive expressions of interest for PhD study.

Biography

I am a physicist by training (MPhys, University of Warwick). I completed my PhD in the Molecular Organisation and Assembly in Cells doctoral training centre at the University of Warwick, where I developed biophysical tools to study aquaporin water channel proteins. I am currently a BBSRC Discovery fellow based in the School of Biosciences.

Education/Academic qualification

PhD, University of Warwick

1 Sept 20121 Sept 2016

Award Date: 1 Sept 2016

MSc, Mathematical Biology and Biophysical Chemistry, University of Warwick

1 Sept 20111 Sept 2012

Award Date: 1 Sept 2012

MPhys Physics, University of Warwick

1 Sept 20071 Jun 2011

Award Date: 1 Jul 2011

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  • Aquaporin-4 and GPRC5B: old and new players in controlling brain oedema

    Passchier, E. M. J., Kerst, S., Brouwers, E., Hamilton, E. M. C., Bisseling, Q., Bugiani, M., Waisfisz, Q., Kitchen, P., Unger, L., Breur, M., Hoogterp, L., de Vries, S. I., Abbink, T. E. M., Kole, M. H. P., Leurs, R., Vischer, H. F., Brignone, M. S., Ambrosini, E., Feillet, F., Born, A. P., & 4 othersEpstein, L. G., Mansvelder, H. D., Min, R. & van der Knaap, M. S., 1 Aug 2023, In: Brain. 146, 8, p. 3444-3454 11 p.

    Research output: Contribution to journalArticlepeer-review

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  • Astrocytes in functional recovery following central nervous system injuries

    Alhadidi, Q. M., Bahader, G. A., Arvola, O., Kitchen, P., Shah, Z. A. & Salman, M. M., 13 Sept 2023, (E-pub ahead of print) In: Journal of Physiology.

    Research output: Contribution to journalReview articlepeer-review

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  • Mechanisms of aquaporin-4 vesicular trafficking in mammalian cells

    Markou, A., Kitchen, P., Aldabbagh, A., Repici, M., Salman, M. M., Bill, R. & Balklava, Z., 16 Dec 2023, (E-pub ahead of print) In: Journal of Neurochemistry.

    Research output: Contribution to journalArticlepeer-review

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  • The Concise Guide to PHARMACOLOGY 2023/24: Ion channels

    Alexander, S. P. H., Mathie, A. A., Peters, J. A., Veale, E. L., Striessnig, J., Kelly, E., Armstrong, J. F., Faccenda, E., Harding, S. D., Davies, J. A., Aldrich, R. W., Attali, B., Baggetta, A. M., Becirovic, E., Biel, M., Bill, R. M., Caceres, A. I., Catterall, W. A., Conner, A. C., Davies, P., & 53 othersDe Clerq, K., Delling, M., Di Virgilio, F., Falzoni, S., Fenske, S., Fortuny-Gomez, A., Fountain, S., George, C., Goldstein, S. A. N., Grimm, C., Grissmer, S., Ha, K., Hammelmann, V., Hanukoglu, I., Hu, M., Ijzerman, A. P., Jabba, S. V., Jarvis, M., Jensen, A. A., Jordt, S. E., Kaczmarek, L. K., Kellenberger, S., Kennedy, C., King, B., Kitchen, P., Liu, Q., Lynch, J. W., Meades, J., Mehlfeld, V., Nicke, A., Offermanns, S., Perez-Reyes, E., Plant, L. D., Rash, L., Ren, D., Salman, M. M., Sieghart, W., Sivilotti, L. G., Smart, T. G., Snutch, T. P., Tian, J., Trimmer, J. S., Van den Eynde, C., Vriens, J., Wei, A. D., Winn, B. T., Wulff, H., Xu, H., Yang, F., Fang, W., Yue, L., Zhang, X. & Zhu, M., 20 Dec 2023, In: British Journal of Pharmacology. 180, Suppl.2, p. S145-S222

    Research output: Contribution to journalArticlepeer-review

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  • Assessing water permeability of aquaporins in a proteoliposome-based stopped-flow setup

    Steffen, J. H., Missel, J. W., Al-Jubair, T., Kitchen, P., Salman, M. M., Bill, R. M., Törnroth-Horsefield, S. & Gourdon, P., 17 Jun 2022, In: STAR protocols. 3, 2, 101312.

    Research output: Contribution to journalArticlepeer-review

    Open Access
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