Photo of Philip Kitchen
    • United Kingdom

    20142020
    If you made any changes in Pure these will be visible here soon.

    Research Output 2014 2020

    Article

    A runaway PRH/HHEX-Notch3 positive feedback loop drives cholangiocarcinoma and determines response to CDK4/6 inhibition.

    Kitchen, P., Lee, KY., Clark, D., Lau, N., Lertsuwan, J., Sawasdichai, A., Satayavivad, J., Oltean, S., Afford, S., Gaston, K. & Jayaraman, PS., 16 Dec 2019, In : Cancer Research.

    Research output: Contribution to journalArticle

    Homeless Youth
    Cholangiocarcinoma
    Gene Regulatory Networks
    Heterografts
    Transcription Factors

    Beyond water homeostasis: diverse functional roles of mammalian aquaporins

    Kitchen, P., Day, R. E., Salman, M. M., Conner, M. T., Bill, R. M. & Conner, A. C., Dec 2015, In : BBA - General Subjects. 1850, 12, p. 2410-2421 12 p.

    Research output: Contribution to journalArticle

    Open Access
    File
    Aquaporins
    Homeostasis
    Water
    Cell signaling
    Cell Size

    Control of the Aquaporin-4 Channel Water Permeability by Structural Dynamics of Aromatic/Arginine Selectivity Filter Residues.

    Kitchen, P. & Conner, AC., 29 Oct 2015, In : Biochemistry. 54, 45, p. 6753-6755

    Research output: Contribution to journalArticle

    Aquaporin 4
    Aquaporins
    Structural dynamics
    Arginine
    Permeability

    CX-4945 Induces Methuosis in Cholangiocarcinoma Cell Lines by a CK2-Independent Mechanism

    Lertsuwan, J., Lertsuwan, K., Sawasdichai, A., Tasnawijitwong, N., Lee, K. Y., Kitchen, P., Afford, S., Gaston, K., Jayaraman, P-S. & Satayavivad, J., 23 Aug 2018, In : Cancers. 10, 9, 283.

    Research output: Contribution to journalArticle

    Open Access
    File
    Cholangiocarcinoma
    Casein Kinase II
    Cell Line
    Vacuoles
    Neoplasms

    Downregulation of aquaporin 3 inhibits cellular proliferation, migration and invasion in the MDA‑MB‑231 breast cancer cell line

    Arif, M., Kitchen, P., Conner, M., Hill, E., Nagel, D., Bill, R., Dunmore, S., Armesilla, A., Gross, S., Carmichael, A., Conner, A. & Brown, J., May 2018, In : Oncology Letters. 16, 1, p. 713-720

    Research output: Contribution to journalArticle

    Open Access
    File
    Aquaporin 3
    Aquaporins
    Aquaglyceroporins
    Glycerol
    Gene Knockdown Techniques

    HHEX is a transcriptional regulator of the VEGFC/FLT4/PROX1 signaling axis during vascular development.

    Gauvrit, S., Villasenor, A., Strilic, B., Kitchen, P., Collins, MM., Marín-Juez, R., Guenther, S., Maischein, HM., Fukuda, N., Canham, MA., Brickman, JM., Bogue, CW. & Stainier, DYR., 13 Jul 2018, In : Nature Communications. 9, 2704.

    Research output: Contribution to journalArticle

    Open Access
    File
    Vascular Endothelial Growth Factor C
    Homeobox Genes
    regulators
    Lymphangiogenesis
    Blood Vessels

    Human aquaporins: regulators of transcellular water flow

    Day, R. E., Kitchen, P., Owen, D., Bland, C., Marshall, L., Conner, A. C., Bill, R. M. & Conner, M. T., 1 May 2014, In : BBA - General Subjects. 1840, 5, p. 1492-1506

    Research output: Contribution to journalArticle

    Open Access
    File
    Aquaporins
    Flow of water
    Water
    Cell Size
    Human Body
    Open Access
    File
    Aquaporin 4
    Calcium-Sensing Receptors
    Calmodulin
    Hypothermia
    Astrocytes

    Identification and molecular mechanisms of the rapid tonicity-induced relocalization of the aquaporin 4 channel

    Kitchen, P., Day, R. E., Taylor, L. H. J., Salman, M. M., Bill, R. M., Conner, M. T. & Conner, A. C., 3 Jul 2015, In : Journal of Biological Chemistry. 290, p. 16873-16881 9 p.

    Research output: Contribution to journalArticle

    Open Access
    File
    Aquaporin 4
    Brain Edema
    Cyclic AMP-Dependent Protein Kinases
    Brain
    Phosphorylation

    Plasma membrane abundance of human aquaporin 5 is dynamically regulated by multiple pathways

    Kitchen, P., Öberg, F., Sjöhamn, J., Hedfalk, K., Bill, R. M., Conner, A. C., Conner, M. T. & Törnroth-Horsefield, S., 16 Nov 2015, In : PLoS ONE. 10, 11, 17 p., e0143027.

    Research output: Contribution to journalArticle

    Open Access
    File
    Aquaporin 5
    aquaporins
    Cell membranes
    plasma membrane
    Cell Membrane

    Receptor component protein, an endogenous allosteric modulator of family B G protein coupled receptors

    Routledge, S. J., Simms, J., Clark, A., Yeung, H. Y., Wigglesworth, M. J., Dickerson, I. M., Kitchen, P., Ladds, G. & Poyner, D. R., 27 Dec 2019, In : BBA -Biomembranes. 1862, 3, 183174.

    Research output: Contribution to journalArticle

    Open Access
    File
    G-Protein-Coupled Receptors
    Calcitonin Gene-Related Peptide Receptors
    Modulators
    Adrenomedullin
    Receptor Activity-Modifying Protein 1

    Structural determinants of oligomerization of the aquaporin-4 channel

    Kitchen, P., Conner, M. T., Bill, R. M. & Conner, A. C., 25 Mar 2016, In : Journal of Biological Chemistry. 291, 13, p. 6858-6871 14 p.

    Research output: Contribution to journalArticle

    Open Access
    File
    Aquaporin 4
    Oligomerization
    Aquaporins
    Permeability
    Water

    Transcriptome Analysis of Gene Expression Provides New Insights into the Effect of Mild Therapeutic Hypothermia on Primary Human Cortical Astrocytes Cultured under Hypoxia

    Salman, M. M., Kitchen, P., Woodroofe, M. N., Bill, R. M., Conner, A. C., Heath, P. R. & Conner, M. T., 14 Dec 2017, In : Frontiers in Cellular Neuroscience. 11, p. 386

    Research output: Contribution to journalArticle

    Open Access
    File
    Induced Hypothermia
    Gene Expression Profiling
    Astrocytes
    Gene Expression
    Proteins

    Transcriptome analysis suggests a role for the differential expression of cerebral aquaporins and the MAPK signalling pathway in human temporal lobe epilepsy

    Salman, M. M., Sheilabi, M. A., Bhattacharyya, D., Kitchen, P., Conner, A. C., Bill, R. M., Woodroofe, M. N., Conner, M. T. & Princivalle, A. P., 1 Sep 2017, In : European Journal of Neuroscience. 46, 5, p. 2121-2132 12 p.

    Research output: Contribution to journalArticle

    Open Access
    File
    Aquaporins
    Temporal Lobe Epilepsy
    Gene Expression Profiling
    Aquaporin 4
    Microarray Analysis

    Water channel pore size determines exclusion properties but not solute selectivity

    Kitchen, P., Salman, M. M., Pickel, S., Jennings, J., Törnroth-horsefield, S., Conner, M., Bill, R. & Conner, A. C., 30 Dec 2019, In : Scientific Reports. 9, 1, 20369.

    Research output: Contribution to journalArticle

    Open Access
    File
    solute
    permeability
    water
    filter
    urea
    Review article

    Inhibitors of Mammalian Aquaporin Water Channels

    Abir-Awan, M., Kitchen, P., Salman, M. M., Conner, M. T., Conner, A. C. & Bill, R. M., 29 Mar 2019, In : International Journal of Molecular Sciences. 20, 7, 1589.

    Research output: Contribution to journalReview article

    Open Access
    File
    Aquaporins
    inhibitors
    acetazolamide
    pathology
    metastasis