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Research Output 2006 2020

2020
Pharmacokinetics
Pregnancy
Protein Binding
Antipsychotic Agents
Quetiapine Fumarate
2019

High-throughput screening of excipients with a biological effect: a kinetic study on the effects of surfactants on efflux-mediated transport

Pollard, J., Rajabi-siahboomi, A., Badhan, R. K. S., Mohammed, A. R. & Perrie, Y., 1 Jun 2019, In : Journal of Pharmacy and Pharmacology. 71, 6, p. 889-897 9 p.

Research output: Contribution to journalArticle

Open Access
File
Poloxamer
Excipients
Surface-Active Agents
Polysorbates
Rhodamine 123

Intracellular uptake of EGCG-loaded deformable controlled release liposomes for skin cancer

Marwah, M., Perrie, Y., Badhan, R. K. S. & Lowry, D., 9 May 2019, In : Journal of Liposome Research. 14 p.

Research output: Contribution to journalArticle

Polysorbates
Skin Neoplasms
Liposomes
Skin
Elasticity

The optimization of methadone dosing whilst treating with rifampicin: A pharmacokinetic modeling study

Badhan, R. K. S., Gittins, R. & Al Zabit, D., 1 Jul 2019, In : Drug and Alcohol Dependence. 200, p. 168-180 13 p.

Research output: Contribution to journalArticle

Pharmacokinetics
Methadone
Rifampin
Plasmas
Drug interactions
2018

Clopidogrel Pharmacokinetics in Malaysian Population Groups: The Impact of Inter-Ethnic Variability

Zakaria, Z., Fong, A. & Badhan, R., 26 Jul 2018, In : Pharmaceuticals. 11, 3, 74.

Research output: Contribution to journalArticle

Open Access
File
clopidogrel
Population Groups
Pharmacokinetics
Malaysia
Pharmacogenetics
Open Access
File
Frontal Lobe
Hippocampus
Pharmacokinetics
Brain
Pharmaceutical Preparations
Open Access
File
Chloroquine
Pharmacokinetics
Pregnancy
Endocytosis
Malaria
Open Access
File
efavirenz
Antimalarials
Pediatrics
Cytochrome P-450 CYP3A
Drug Interactions
Open Access
File
Ivermectin
Malaria
Pharmacokinetics
Clinical Trials
efavirenz
2017

Application of pharmacokinetics modelling to predict human exposure of a cationic liposomal subunit antigen vaccine system

Badhan, R. K. S., Khadke, S. & Perrie, Y., 7 Dec 2017, In : Pharmaceutics. 9, 4, 57.

Research output: Contribution to journalArticle

Open Access
File
Subunit Vaccines
Pharmacokinetics
Antigens
Muscles
Trehalose

Fixed-dose combination orally disintegrating tablets to treat cardiovascular disease: formulation, in vitro characterization and physiologically based pharmacokinetic modelling to assess bioavailability

Dennison, T. J., Smith, J. C., Badhan, R. K. & Mohammed, A. R., 16 Mar 2017, In : Drug Design, Development and Therapy. 11, p. 811-826 16 p.

Research output: Contribution to journalArticle

Open Access
File
Therapeutic Equivalency
Biological Availability
Tablets
Cardiovascular Diseases
Pharmacokinetics
Open Access
File
Phytochemicals
Blood-Brain Barrier
Curcumin
Quercetin
Breast Neoplasms
Open Access
File
efavirenz
Antimalarials
Drug Interactions
Pharmacokinetics
Ritonavir
2016

Design of experiments to study the impact of process parameters on droplet size and development of non-invasive imaging techniques in tablet coating

Dennison, T. J., Smith, J., Hofmann, M. P., Bland, C. E., Badhan, R. K., Al-Khattawi, A. & Mohammed, A. R., 22 Aug 2016, In : PLoS ONE. 11, 8, 17 p., e0157267.

Research output: Contribution to journalArticle

Open Access
File
droplet size
Design of experiments
Tablets
coatings
X-Ray Microtomography

Development and evaluation of a novel intranasal spray for the delivery of amantadine

Lungare, S., Bowen, J. & Badhan, R., Mar 2016, In : Journal of Pharmaceutical Sciences. 105, 3, p. 1209-1220 12 p.

Research output: Contribution to journalArticle

Open Access
File
Amantadine
Carboxymethylcellulose Sodium
Nose
Poloxamer
Nasal Cavity

Phytochemical-loaded mesoporous silica nanoparticles for nose-to-brain olfactory drug delivery

Lungare, S., Hallam, K. & Badhan, R. K. S., 20 Nov 2016, In : International Journal of Pharmaceutics. 513, 1-2, p. 280-293 14 p.

Research output: Contribution to journalArticle

Open Access
File
Curcumin
Phytochemicals
Nose
Silicon Dioxide
Nanoparticles
2015

Physiologically based pharmacokinetic modelling in drug delivery

Badhan, R. K. S., 29 Jun 2015, Computational pharmaceutics: application of molecular modeling in drug delivery. Ouyang, D. & Smith, S. C. (eds.). Wiley, p. 263-291 29 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Pharmacokinetics
Drug delivery
Pharmaceutical Preparations
MATLAB
Graphical user interfaces
Open Access
File
Phytoestrogens
Cerebrospinal Fluid
Breast Neoplasms
Central Nervous System Agents
Proteins
2014

Development of a physiologically-based pharmacokinetic model of the rat central nervous system

Badhan, R. K. S., Chenel, M. & Penny, J. I., 18 Mar 2014, In : Pharmaceutics. 6, 1, p. 97-136 40 p.

Research output: Contribution to journalArticle

Open Access
File
Cerebrospinal Fluid
Central Nervous System
Pharmacokinetics
Brain
Permeability

Improving brain drug targeting through exploitation of the nose-to-brain route: a physiological and pharmacokinetic perspective

Badhan, R. K. S., Kaur, M., Lungare, S. & Obuobi, S., 30 Jun 2014, In : Current Drug Delivery. 11, 4, p. 458-471 14 p.

Research output: Contribution to journalArticle

Drug Delivery Systems
Nose
Pharmacokinetics
Brain
Central Nervous System
2012

The impact of ageing on the barriers to drug delivery

Perrie, Y., Singh Badhan, R., Kirby, D. J., Lowry, D., Mohammed, A-U-R. & Ouyang, D., 20 Jul 2012, In : Journal of Controlled Release. 161, 2, p. 389-398 10 p.

Research output: Contribution to journalArticle

Pharmaceutical Preparations
Lung Volume Measurements
Skin Absorption
Skin
Ophthalmic Solutions
2009

Identification of putative steroid-binding sites in human ABCB1 and ABCG2

Mares-Sámano, S., Badhan, R. & Penny, J., Sep 2009, In : European Journal of Medicinal Chemistry. 44, 9, p. 3601-3611 11 p.

Research output: Contribution to journalArticle

Nucleotides
Steroids
Binding Sites
Adenosine Triphosphate
Mifepristone

Methodology for development of a physiological model incorporating CYP3A and P-glycoprotein for the prediction of intestinal drug absorption

Badhan, R., Penny, J., Galetin, A. & Houston, J. B., Jun 2009, In : Journal of Pharmaceutical Sciences. 98, 6, p. 2180-2197 18 p.

Research output: Contribution to journalArticle

Cytochrome P-450 CYP3A
Intestinal Absorption
P-Glycoprotein
Cytochromes
Pharmaceutical Preparations
2006

In silico modelling of the interaction of flavonoids with human P-glycoprotein nucleotide-binding domain

Badhan, R. & Penny, J., Mar 2006, In : European Journal of Medicinal Chemistry. 41, 3, p. 285-295 11 p.

Research output: Contribution to journalArticle

P-Glycoprotein
Flavonoids
Computer Simulation
Nucleotides
Hydrogen Bonding