Personal profile
Research Interests
My research group focuses upon DNA replication, replication stress and replication-associated DNA damage and repair. The aim of our work is to understand how these processes take place within the context of the nucleus in healthy cells, and in ageing-related disease such as cancer and progeroid syndromes.
We are currently optimising methods to directly extract and analyse components of the nuclear membrane through nuclei isolation and extraction with co-polymers.
I have experience of working with a wide range of techniques for studying the dynamics of DNA replication. Such techniques include immunofluorescence microscopy, chromatin isolation, DNA fibres, replication foci formation, alkaline gel electrophoresis, affinity chromatography and cell viability assays.
For an overview of my publications, please visit: Rebecca M Jones - Google Scholar
I am keen to collaborate, so please get in touch if you are interested ([email protected]).
Current lab members
Antonio Borriello - PhD student - funded by Muscular Dystrophy UK
Past lab members
Dr Olivia Hawkins - Post-doctoral researcher - funded by the Aston Institute for Membrane Excellence (AIME).
Anika Khan - Summer studentship - funded by the Royal Society.
Qualifications
Fellow of the Higher Education Academy, University of Birmingham, 2023.
Associate Fellow of the Higher Education Academy, University of Birmingham, 2018.
PhD Biochemistry, University of Sheffield, 2010.
BSc (Hons) Biochemistry, Lancaster University, 2006.
Employment
2024 – date: Lecturer in School of Biosciences, Aston University.
2016 – 2024: Senior post doctoral researcher, University of Birmingham with Prof Aga Gambus.
2010 – 2016: Post doctoral researcher, University of Birmingham with Prof Eva Petermann.
Education/Academic qualification
FHEA, University of Birmingham
Award Date: 12 Apr 2023
PhD, A study into the nuclear exosome cofactor, Rrp47, University of Sheffield
Award Date: 17 Jan 2011
BSc, Biochemistry, Lancaster University
Award Date: 1 Jul 2006
External positions
BBSRC People and Talent Strategy Advisory Panel - Researcher subgroup, UKRI BBSRC
Jan 2026 → …
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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SDG 3 Good Health and Well-being
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Collaborations and top research areas from the last five years
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A Decade of Discovery—Eukaryotic Replisome Disassembly at Replication Termination
Jones, R. M., Reynolds-Winczura, A. & Gambus, A., Apr 2024, In: Biology. 13, 4, 24 p., 233.Research output: Contribution to journal › Review article › peer-review
Open AccessFile6 Link opens in a new tab Citations (Scopus)14 Downloads (Pure) -
Characterizing replisome disassembly in human cells
Jones, R. M., Ruiz, J. H., Scaramuzza, S., Nath, S., Liu, C., Henklewska, M., Natsume, T., Bristow, R. G., Romero, F., Kanemaki, M. T. & Gambus, A., 19 Jul 2024, In: iScience. 27, 7, 26 p., 110260.Research output: Contribution to journal › Article › peer-review
Open AccessFile3 Link opens in a new tab Citations (Scopus)21 Downloads (Pure) -
TRAIP resolves DNA replication-transcription conflicts during the S-phase of unperturbed cells
Scaramuzza, S., Jones, R. M., Sadurni, M. M., Reynolds-Winczura, A., Poovathumkadavil, D., Farrell, A., Natsume, T., Rojas, P., Cuesta, C. F., Kanemaki, M. T., Saponaro, M. & Gambus, A., 21 Aug 2023, In: Nature Communications. 14, 20 p., 5071.Research output: Contribution to journal › Article › peer-review
Open AccessFile13 Link opens in a new tab Citations (Scopus)9 Downloads (Pure) -
Characterising replisome disassembly in human cells
Jones, R. M., Ruiz, J. H., Scaramuzza, S., Nath, S., Henklewska, M., Natsume, T., Romero, F., Kanemaki, M. T. & Gambus, A., 12 Jul 2022, 42 p.Research output: Preprint or Working paper › Preprint
Open Access -
Mitotic replisome disassembly depends on TRAIP ubiquitin ligase activity
Moreno, S. P., Jones, R. M., Poovathumkadavil, D., Scaramuzza, S. & Gambus, A., 12 Apr 2019, In: Life Science Alliance. 2, 2, 12 p., e201900390.Research output: Contribution to journal › Article › peer-review
Open Access41 Link opens in a new tab Citations (Scopus)