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Sarah Routledge

Dr

    20112020

    Research output per year

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    Personal profile

    Research Interests

    Microbes are used in many industrial processes to produce high-value chemicals. However, these products are often toxic to the cells, limiting the yields obtained. My project aims to identify the changes to microbial membrane protein and lipid compositions which allow them adapt to product toxicity and production stresses; this will ultimately allow us to engineer more tolerant strains to improve the yields and efficiency of these biotechnological processes.

    I am also interested in the interactions of a peripheral membrane protein, receptor component protein (RCP), which is thought to modulate signalling of the calcitonin gene-related (CGRP) receptor. This GPCR is implicated in migraine, and a better understanding of its interaction parteners could uncover additional drug targets. I use signalling assays to study this in mammalian cell lines as well as using yeast to overexpress and purify the interacting proteins of interest.  

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    Research Output

    Expression and purification of recombinant G protein-coupled receptors: A review

    Wiseman, D. N., Otchere, A., Patel, J. H., Uddin, R., Pollock, N. L., Routledge, S. J., Rothnie, A. J., Slack, C., Poyner, D. R., Bill, R. M. & Goddard, A. D., 1 Mar 2020, In : Protein Expression and Purification. 167, 105524.

    Research output: Contribution to journal › Article

    Open Access
    File

    • Ligand-induced conformational changes in a SMALP-encapsulated GPCR.

    Routledge, S. J., Jamshad, M., Little, H. A., Lin, Y. P., Simms, J., Thakker, A., Spickett, C. M., Bill, R. M., Dafforn, T. R., Poyner, D. R. & Wheatley, M., 1 Jun 2020, In : Biochimica et Biophysica Acta - Biomembranes. 1862, 6, 183235.

    Research output: Contribution to journal › Article

    Open Access
    File

    • Receptor component protein, an endogenous allosteric modulator of family B G protein coupled receptors

    Routledge, S. J., Simms, J., Clark, A., Yeung, H. Y., Wigglesworth, M. J., Dickerson, I. M., Kitchen, P., Ladds, G. & Poyner, D. R., 1 Mar 2020, In : BBA -Biomembranes. 1862, 3, 183174.

    Research output: Contribution to journal › Article

    Open Access
    File

    • Liposomes as models for membrane integrity

    Routledge, S. J., Linney, J. A. & Goddard, A. D., 28 Jun 2019, In : Biochemical Society Transactions. 47, 3, p. 919-932 14 p.

    Research output: Contribution to journal › Review article

    Open Access
    File

    • The structure of the CGRP and related receptors

    Simms, J., Routledge, S., Uddin, R. & Poyner, D., 25 May 2018, Handbook of Experimental Pharmacology. Brain, S. & Gepetti, P. (eds.). Springer, p. 23-36 14 p. (Handbook of Experimental Pharmacology; vol. 255).

    Research output: Chapter in Book/Report/Conference proceeding › Chapter

    • Datasets

    Effects of receptor component protein on family B GPCRs

    Routledge, S. (Creator), Poyner, D. (Creator), Ladds, G. (Creator), Clark, A. (Creator) & Yeung, H. H. (Creator), Aston Data Explorer, 9 Dec 2019

    DOI: 10.17036/researchdata.aston.ac.uk.00000451, https://www.sciencedirect.com/science/article/pii/S0005273619303220

    Dataset