20002020

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2020

Pravastatin for early-onset pre-eclampsia: a randomised, blinded, placebo-controlled trial

Ahmed, A., Williams, D., Cheed, V., Middleton, L. J., Ahmad, S., Wang, K., Vince, A. T., Hewett, P., Spencer, K., Khan, K. S., Daniels, J. P., Barber, K., Kilby, M., Knox, E., Sellman, T., Trinham, P., Tuffnell, D., Jones, V., Syson, J., Shah, N. & 50 others, Deeks, L., Carter, W., Dorman, E., Thomas, S., Harrington, D., Higgins, N., Wilmott‐powell, M., Simpson, N., Dolby, V., Bricker, L., Walkinshaw, S., Houghton, G., Longworth, H., Williamson, C., Dhanjal, M., Noori, M., Machirori, M., Howard, R., Murray, R., Weist, S., Denison, F., Crawford, I., Robson, S., Allan, C., Myers, J., Bernatavicius, G., Moorhead, L., Chappell, L., Nelson‐piercy, C., Williams, D., Daley, R., Rosas, M., Greer, I., Vitek, L., Shennan, A., Marlow, N., Marie Barnard, A., Thornton, J., Rennie, J., Peacock, J., Gao Smith, F., Hyde, C., Crawford, I., Cudmore, M., Furmston, A., Fulcher, L., Homer, L., Howman, A., Hilken, N. & Brown, S., 1 Mar 2020, In : BJOG. 127, 4, p. 478-488 11 p.

Research output: Contribution to journalArticle

Open Access
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2019

Establishment of porcine and human expanded potential stem cells

Gao, X., Nowak-imialek, M., Chen, X., Chen, D., Herrmann, D., Ruan, D., Chen, A. C. H., Eckersley-maslin, M. A., Ahmad, S., Lee, Y. L., Kobayashi, T., Ryan, D., Zhong, J., Zhu, J., Wu, J., Lan, G., Petkov, S., Yang, J., Antunes, L., Campos, L. S. & 27 others, Fu, B., Wang, S., Yong, Y., Wang, X., Xue, S., Ge, L., Liu, Z., Huang, Y., Nie, T., Li, P., Wu, D., Pei, D., Zhang, Y., Lu, L., Yang, F., Kimber, S. J., Reik, W., Zou, X., Shang, Z., Lai, L., Surani, A., Tam, P. P. L., Ahmed, A., Yeung, W. S. B., Teichmann, S. A., Niemann, H. & Liu, P., 3 Jun 2019, In : Nature Cell Biology. 21, 6, p. 687-699 13 p.

Research output: Contribution to journalArticle

Open Access
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2018

S100P enhances the motility and invasion of human trophoblast cell lines

Ebrahimzadeh Asl Tabrizi, M., Lancaster, T., Ismail, T. M., Ganguly, A., Georgiadou, A., Wang, K., Rudland, P. S., Ahmad, S. S. & Gross, S. R., 31 Jul 2018, In : Scientific Reports. 8, 11488.

Research output: Contribution to journalArticle

Open Access
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2017

Angiopoietin-1 promotes atherosclerosis by increasing the proportion of circulating Gr1+ monocytes

Fujisawa, T., Wang, K., Niu, X-L., Egginton, S., Ahmad, S., Hewett, P. W., Kontos, C. D. & Ahmed, A., 17 Oct 2017, In : Cardiovascular Research. 113, 1, p. 81-89 9 p.

Research output: Contribution to journalArticle

Open Access
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Inorganic nitrate in angina study: A randomized double-blind placebo-controlled trial

Schwarz, K., Singh, S., Parasuraman, S. K., Rudd, A., Shepstone, L., Feelisch, M., Minnion, M., Ahmad, S., Madhani, M., Horowitz, J., Dawson, D. K. & Frenneaux, M. P., 8 Sep 2017, In : Journal of the American Heart Association. 6, 9, e006478.

Research output: Contribution to journalArticle

Open Access
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2016

A randomized double-blind placebo-controlled crossover trial of sodium nitrate in patients with stable angina INAS

Schwarz, K., Singh, S., Parasuraman, S. K., Bruce, M., Shepstone, L., Feelisch, M., Minnion, M., Ahmad, S., Horowitz, J., Dawson, D. K. & Frenneaux, M. P., 12 Oct 2016, In : Future Cardiology. 12, 6, p. 617-626 10 p.

Research output: Contribution to journalArticle

Open Access
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2015

Carbon monoxide inhibits sprouting angiogenesis and vascular endothelial growth factor receptor-2 phosphorylation

Ahmad, S., Hewett, P. W., Fujisawa, T., Sissaoui, S., Cai, M., Gueron, G., Al-Ani, B., Cudmore, M., Ahmed, S. F., Wong, M. K. K., Wegiel, B., Otterbein, L. E., Vítek, L., Ramma, W., Wang, K. & Ahmed, A., 1 Feb 2015, In : Thrombosis and Haemostasis. 113, 2, p. 329-337 9 p.

Research output: Contribution to journalArticle

Preeclampsia : an accelerator–brake defect disorder

Ahmed, A., Ahmad, S. & Wang, K., 1 May 2015, In : Nitric Oxide. 47, Suppl.1, p. S9 1 p., OP14.

Research output: Contribution to journalArticle

2014

Antiproliferative effects of carbon monoxide on pancreatic cancer

Vítek, L., Gbelcová, H., Muchová, L., Váňová, K., Zelenka, J., Koníčková, R., Šuk, J., Zadinova, M., Knejzlík, Z., Ahmad, S., Fujisawa, T., Ahmed, A. & Ruml, T., Apr 2014, In : Digestive and Liver Disease. 46, 4, p. 369-375 7 p.

Research output: Contribution to journalArticle

Response to letter regarding article, "Dysregulation of hydrogen sulfide (H2S) producing enzyme cystathionine γ-lyase (CSE) contributes to maternal hypertension and placental abnormalities in preeclampsia"

Wang, K., Ahmad, S., Cai, M., Rennie, J., Fujisawa, T., Crispi, F., Baily, J., Miller, M. R., Cudmore, M., Hadoke, P. W. F., Wang, R., Gratacós, E., Buhimschi, I. A., Buhimschi, C. S. & Ahmed, A., 3 Jun 2014, In : Circulation. 129, 22, p. e517-e518 2 p.

Research output: Contribution to journalArticle

β-cell-specific glucocorticoid reactivation attenuates inflammatory β-cell destruction

Liu, X., Turban, S., Carter, R. N., Ahmad, S., Ramage, L., Webster, S. P., Walker, B. R., Seckl, J. R. & Morton, N. M., 11 Oct 2014, In : Frontiers in Endocrinology. 5, 7 p., 165.

Research output: Contribution to journalArticle

Open Access
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2013

Dysregulation of hydrogen sulfide producing enzyme cystathionine γ-lyase contributes to maternal hypertension and placental abnormalities in preeclampsia

Wang, K., Ahmad, S., Cai, M., Rennie, J., Fujisawa, T., Crispi, F., Baily, J., Miller, M. R., Cudmore, M., Hadoke, P. W. F., Wang, R., Gratacós, E., Buhimschi, I. A., Buhimschi, C. S. & Ahmed, A., 25 Jun 2013, In : Circulation. 127, 25, p. 2514-2522 9 p.

Research output: Contribution to journalArticle

2012

Loss of Akt activity increases circulating soluble endoglin release in preeclampsia: identification of inter-dependency between Akt-1 and heme oxygenase-1

Cudmore, M. J., Ahmad, S., Sissaoui, S., Ramma, W., Ma, B., Fujisawa, T., Al-Ani, B., Wang, K., Cai, M., Crispi, F., Hewett, P. W., Gratacós, E., Egginton, S. & Ahmed, A., May 2012, In : European Heart Journal. 33, 9, p. 1150-1158 9 p.

Research output: Contribution to journalArticle

Open Access
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Resveratrol inhibits the release of soluble fms-like tyrosine kinase (sFlt-1) from human placenta

Cudmore, M. J., Ramma, W., Cai, M., Fujisawa, T., Ahmad, S., Al-Ani, B. & Ahmed, A., Mar 2012, In : American Journal of Obstetrics and Gynecology. 206, 3, p. 253.e10–253.e15 6 p.

Research output: Contribution to journalArticle

The role of heterodimerization between VEGFR-1 and VEGFR-2 in the regulation of endothelial cell homeostasis

Cudmore, M. J., Hewett, P. W., Ahmad, S., Wang, K-Q., Cai, M., Al-Ani, B., Fujisawa, T., Ma, B., Sissaoui, S., Ramma, W., Miller, M. R., Newby, D. E., Gu, Y., Barleon, B., Weich, H. & Ahmed, A., 24 Jul 2012, In : Nature Communications. 3, 972.

Research output: Contribution to journalArticle

Open Access
File
2011

Autocrine activity of soluble Flt-1 controls endothelial cell function and angiogenesis

Ahmad, S., Hewett, P. W., Al-Ani, B., Sissaoui, S., Fujisawa, T., Cudmore, M. J. & Ahmed, A., 13 Jul 2011, In : Vascular Cell. 3, 1, 15.

Research output: Contribution to journalArticle

Open Access
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Heparin elevates circulating soluble fms-like tyrosine kinase-1 immunoreactivity in pregnant women receiving anticoagulation therapy

Rosenberg, V. A., Buhimschi, I. A., Lockwood, C. J., Paidas, M. J., Dulay, A. T., Ramma, W., Abdel-Razeq, S. S., Zhao, G., Ahmad, S., Ahmed, A. & Buhimschi, C. S., 6 Dec 2011, In : Circulation. 124, 23, p. 2543-2553 11 p.

Research output: Contribution to journalArticle

2010

Activation of proteinase-activated receptor 2 stimulates soluble vascular endothelial growth factor receptor 1 release via epidermal growth factor receptor transactivation in endothelial cells

Al-Ani, B., Hewett, P. W., Cudmore, M. J., Fujisawa, T., Saifeddine, M., Williams, H., Ramma, W., Sissaoui, S., Jayaraman, P-S., Ohba, M., Ahmad, S., Hollenberg, M. D. & Ahmed, A., Mar 2010, In : Hypertension. 55, 3, p. 689-697 9 p.

Research output: Contribution to journalArticle

Angiopoietin-1 induces migration of monocytes in a tie-2 and integrin-independent manner

Ahmad, S., Cudmore, M. J., Wang, K., Hewett, P. W., Potluri, R., Fujisawa, T. & Ahmed, A., Sep 2010, In : Hypertension. 56, 3, p. 477-483 7 p.

Research output: Contribution to journalArticle

Nitric oxide-dependent bone marrow progenitor mobilization by carbon monoxide enhances endothelial repair after vascular injury

Wegiel, B., Gallo, D. J., Raman, K. G., Karlsson, J. M., Ozanich, B., Chin, B. Y., Tzeng, E., Ahmad, S., Ahmed, A., Baty, C. J. & Otterbein, L. E., Feb 2010, In : Circulation. 121, 4, p. 537-548 12 p.

Research output: Contribution to journalArticle

Open Access
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Reduction of circulating soluble Flt-1 alleviates preeclampsia-like symptoms in a mouse model

Bergmann, A., Ahmad, S., Cudmore, M. J., Gruber, A. D., Wittschen, P., Lindenmaier, W., Christofori, G., Gross, V., Ch. da Costa Gonzalves, A., Gröne, H-J., Ahmed, A. & Weich, H. A., Jun 2010, In : Journal of Cellular and Molecular Medicine. 14, 6b, p. 1857-1867 11 p.

Research output: Contribution to journalArticle

Open Access
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Upregulation of urotensin II receptor in preeclampsia causes in vitro placental release of soluble vascular endothelial growth factor receptor 1 in hypoxia

Gould, P. S., Gu, M., Liao, J., Ahmad, S., Cudmore, M. J., Ahmed, A. & Vatish, M., Jul 2010, In : Hypertension. 56, 1, p. 172-178 7 p.

Research output: Contribution to journalArticle

2009

Angiopoietin-2 confers Atheroprotection in apoE-/- mice by inhibiting LDL oxidation via nitric oxide

Ahmed, A., Fujisawa, T., Niu, X-L., Ahmad, S., Al-Ani, B., Chudasama, K., Abbas, A., Potluri, R., Bhandari, V., Findley, C. M., Lam, G. K. W., Huang, J., Hewett, P. W., Cudmore, M. J. & Kontos, C. D., 19 Jun 2009, In : Circulation Research. 104, 12, p. 1333-1336 4 p.

Research output: Contribution to journalArticle

Open Access
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Hypoxia induces dilated cardiomyopathy in the chick embryo: mechanism, intervention, and long-term consequences

Tintu, A., Rouwet, E., Verlohren, S., Brinkmann, J., Ahmad, S., Crispi, F., van Bilsen, M., Carmeliet, P., Staff, A. C., Tjwa, M., Cetin, I., Gratacos, E., Hernandez-Andrade, E., Hofstra, L., Jacobs, M., Lamers, W. H., Morano, I., Safak, E., Ahmed, A. & le Noble, F., 9 Apr 2009, In : PLoS ONE. 4, 4, 11 p., e5155.

Research output: Contribution to journalArticle

Open Access
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2008

Autoantibody from women with preeclampsia induces soluble Fms-like tyrosine kinase-1 production via angiotensin type 1 receptor and calcineurin/nuclear factor of activated T-cells signaling

Zhou, C. C., Ahmad, S., Mi, T., Abbasi, S., Xia, L., Day, M-C., Ramin, S. M., Ahmed, A., Kellems, R. E. & Xia, Y., 2 Jul 2008, In : Hypertension. 51, 4, p. 1010-1019 10 p.

Research output: Contribution to journalArticle

Open Access
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2007

Angiotensin II induces soluble fms-Like tyrosine kinase-1 release via calcineurin signaling pathway in pregnancy

Zhou, C. C., Ahmad, S., Mi, T., Xia, L., Abbasi, S., Hewett, P. W., Sun, C., Ahmed, A., Kellems, R. E. & Xia, Y., 2007, In : Circulation Research. 100, 1, p. 88-95 8 p.

Research output: Contribution to journalArticle

Open Access
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Negative regulation of soluble Flt-1 and soluble endoglin release by heme oxygenase-1

Cudmore, M., Ahmad, S., Al-Ani, B., Fujisawa, T., Coxall, H., Chudasama, K., Devey, L. R., Wigmore, S. J., Abbas, A., Hewett, P. W. & Ahmed, A., 26 Mar 2007, In : Circulation. 115, 13, p. 1789-1797 9 p.

Research output: Contribution to journalArticle

2006

Direct evidence for endothelial vascular endothelial growth factor receptor-1 function in nitric oxide-mediated angiogenesis

Ahmad, S., Hewett, P. W., Wang, P., Al-Ani, B., Cudmore, M., Fujisawa, T., Haigh, J. J., le Noble, F., Wang, L., Mukhopadhyay, D. & Ahmed, A., Sep 2006, In : Circulation Research. 99, 7, p. 715-722 8 p.

Research output: Contribution to journalArticle

Selective inhibition of the human tie-1 promoter with triplex-forming oligonucleotides targeted to ets binding sites

Hewett, P. W., Daft, E. L., Laughton, C. A., Ahmad, S., Ahmed, A. & Murray, J. C., Jan 2006, In : Molecular Medicine. 12, 1-3, p. 8-16 9 p.

Research output: Contribution to journalArticle

Open Access
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The release of nitric oxide from S-nitrosothiols promotes angiogenesis

Al-Ani, B., Hewett, P. W., Ahmed, S., Cudmore, M., Fujisawa, T., Ahmad, S. & Ahmed, A., 20 Dec 2006, In : PLoS ONE. 1, 1, 8 p., e25.

Research output: Contribution to journalArticle

Open Access
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VEGF-E activates endothelial nitric oxide synthase to induce angiogenesis via cGMP and PKG-independent pathways

Cudmore, M., Ahmad, S., Al-Ani, B., Hewett, P., Ahmed, S. & Ahmed, A., 14 Jul 2006, In : Biochemical and Biophysical Research Communications. 345, 4, p. 1275-1282 8 p.

Research output: Contribution to journalArticle

2005

Antiangiogenic effect of soluble vascular endothelial growth factor receptor-1 in placental angiogenesis

Ahmad, S. & Ahmed, A., 2005, In : Endothelium. 12, 1-2, p. 89-95 7 p.

Research output: Contribution to journalArticle

2004
2003

Activation of vascular endothelial growth factor receptor-1 sustains angiogenesis and Bcl-2 expression via the phosphatidylinositol 3-kinase pathway in endothelial cells

Cai, J., Ahmad, S., Jiang, W. G., Huang, J., Kontos, C. D., Boulton, M. & Ahmed, A., Dec 2003, In : Diabetes . 52, 12, p. 2959-2568 10 p.

Research output: Contribution to journalArticle

2000

Regulation of placental vascular endothelial growth factor (VEGF) and placenta growth factor (PIGF) and soluble Flt-1 by oxygen - a review

Ahmed, A., Dunk, C., Ahmad, S. & Khaliq, A., Mar 2000, In : Placenta. 21 , Supplement A, p. S16-S24

Research output: Contribution to journalArticle