Theo Kantidakis

Accepting PhD Students

PhD projects

Funded PhD Project available! Deadline for applications: 19.02.2023
https://www.findaphd.com/phds/project/the-roles-of-epigenetic-regulators-mll3-kmt2c-and-mll2-kmt2d-in-genomic-and-transcriptional-homeostasis/?p154036

Open position for a motivated self-funded PhD student! Available research projects on the effects of GTP depletion on transcription, DNA damage and repair, as well as the molecular and cellular consequences of mutations in histone modifiers like KMT2D, KMT2C and JMJD6. Feel free to contact me if interested. Queries on published, related, interdisciplinary or novel projects are welcome.
https://www.findaphd.com/phds/project/novel-functions-of-the-hydroxylase-and-arginine-demethylase-jmjd6/?p152599

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2022
Integrated genome and transcriptome analyses reveal the mechanism of genome instability in ataxia with oculomotor apraxia 2
Kanagaraj, R., Mitter, R., Kantidakis, T., Edwards, M. M., Benitez, A., Chakravarty, P., Fu, B., Becherel, O., Yang, F., Lavin, M. F., Koren, A., Stewart, A. & West, S. C., 25 Jan 2022, In: Proceedings of the National Academy of Sciences of the United States of America. 119, 4, e2114314119.
Research output: Contribution to journal › Article › peer-review

Open Access
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The Aminoacyl-tRNA Synthetase and tRNA Expression Levels Are Deregulated in Cancer and Correlate Independently with Patient Survival
Sangha, A. K. & Kantidakis, T., 2 Jul 2022, In: Current Issues in Molecular Biology. 44, 7, p. 3001-3017 17 p.
Research output: Contribution to journal › Article › peer-review

Open Access
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2019
Inhibition of tRNA Gene Transcription by the Immunosuppressant Mycophenolic Acid
Jurkiewicz, A., Leśniewska, E., Cieśla, M., Gorjão, N., Kantidakis, T., White, R. J., Boguta, M. & Graczyk, D., 11 Dec 2019, In: Molecular and Cellular Biology. 40, 1
Research output: Contribution to journal › Article › peer-review

Open Access
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2017
UV Irradiation Induces a Non-coding RNA that Functionally Opposes the Protein Encoded by the Same Gene
Williamson, L., Saponaro, M., Boeing, S., East, P., Mitter, R., Kantidakis, T., Kelly, G. P., Lobley, A., Walker, J., Spencer-Dene, B., Howell, M., Stewart, A. & Svejstrup, J. Q., 23 Feb 2017, In: Cell. 168, 5, p. 843-855.e13
Research output: Contribution to journal › Article › peer-review

Open Access
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2016
Mutation of cancer driver MLL2 results in transcription stress and genome instability
Kantidakis, T., Saponaro, M., Mitter, R., Horswell, S., Kranz, A., Boeing, S., Aygün, O., Kelly, G. P., Matthews, N., Stewart, A., Stewart, A. F. & Svejstrup, J. Q., 15 Feb 2016, In: Genes and Development. 30, 4, p. 408-420 13 p.
Research output: Contribution to journal › Article › peer-review

Open Access
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2014
RECQL5 controls transcript elongation and suppresses genome instability associated with transcription stress
Saponaro, M., Kantidakis, T., Mitter, R., Kelly, G. P., Heron, M., Williams, H., Söding, J., Stewart, A. & Svejstrup, J. Q., 22 May 2014, In: Cell. 157, 5, p. 1037-1049 13 p.
Research output: Contribution to journal › Article › peer-review

Open Access
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2010
mTOR associates with TFIIIC, is found at tRNA and 5S rRNA genes, and targets their repressor Maf1
Kantidakis, T., Ramsbottom, B. A., Birch, J. L., Dowding, S. N. & White, R. J., 29 Jun 2010, In: Proceedings of the National Academy of Sciences of the United States of America. 107, 26, p. 11823-11828 6 p.
Research output: Contribution to journal › Article › peer-review

Open Access
2009
Characterization of two distinct binding modes between syntaxin 4 and Munc18c
Aran, V., Brandie, F. M., Boyd, A. R., Kantidakis, T., Rideout, E. J., Kelly, S. M., Gould, G. W. & Bryant, N. J., 1 May 2009, In: Biochemical Journal. 419, 3, p. 655-660 6 p.
Research output: Contribution to journal › Article › peer-review
Dr1 (NC2) is present at tRNA genes and represses their transcription in human cells
Kantidakis, T. & White, R. J., 3 Dec 2009, In: Nucleic Acids Research. 38, 4, p. 1228-1239 12 p., gkp1102.
Research output: Contribution to journal › Article › peer-review

Open Access
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2008
Autoimmune disease-associated histamine receptor H₁ alleles exhibit differential protein trafficking and cell surface expression
Noubade, R., Saligrama, N., Spach, K., Del Rio, R., Blankenhorn, E. P., Kantidakis, T., Milligan, G., Rincon, M. & Teuscher, C., 1 Jan 2008, In: Journal of Immunology. 180, 11, p. 7471-7479 9 p.
Research output: Contribution to journal › Article › peer-review

Open Access
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Regulation of RNA Polymerase III Transcription by Maf1 in Mammalian Cells
Goodfellow, S. J., Graham, E. L., Kantidakis, T., Marshall, L., Coppins, B. A., Oficjalska-Pham, D., Gérard, M., Lefebvre, O. & White, R. J., 2 May 2008, In: Journal of Molecular Biology . 378, 3, p. 481-491 11 p.
Research output: Contribution to journal › Article › peer-review
2007
RNA polymerase III transcription is repressed in response to the tumour suppressor ARF
Morton, J. P., Kantidakis, T. & White, R. J., 1 May 2007, In: Nucleic Acids Research. 35, 9, p. 3046-3052 7 p.
Research output: Contribution to journal › Article › peer-review

Open Access
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2006
Activation by c-Myc of transcription by RNA polymerases I, II and III
Gomez-Roman, N., Felton-Edkins, Z. A., Kenneth, N. S., Goodfellow, S. J., Athineos, D., Zhang, J., Ramsbottom, B. A., Innes, F., Kantidakis, T., Kerr, E. R., Brodie, J., Grandori, C. & White, R. J., 1 Jan 2006, In: Biochemical Society Symposium. 73, p. 141-154 14 p.
Research output: Contribution to journal › Article › peer-review
2005
Human La is found at RNA polymerase III-transcribed genes in vivo
Fairley, J. A., Kantidakis, T., Kenneth, N. S., Intine, R. V., Maraia, R. J. & White, R. J., 20 Dec 2005, In: Proceedings of the National Academy of Sciences of the United States of America. 102, 51, p. 18350-18355 6 p.
Research output: Contribution to journal › Article › peer-review

Open Access
Interaction of paxillin with poly(A)-binding protein 1 and its role in focal adhesion turnover and cell migration
Woods, A. J., Kantidakis, T., Sabe, H., Critchley, D. R. & Norman, J. C., 1 May 2005, In: Molecular and Cellular Biology. 25, 9, p. 3763-3773 11 p.
Research output: Contribution to journal › Article › peer-review

Open Access

Theo Kantidakis

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