Photo of Yuchun Gu
20122020

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Personal profile

Research Interests

Professor Yuchun Gu is a medically trained physiologist and is current the director of the Regenerative Medicine Centre of Aston Medical School. In 2017, he was awarded a professor and chair in Molecular Physiology at Aston Medical School and has held the positions of Professor and Chair of Molecular Pharmacology at the Institute of Molecular Medicine, Peking University since 2010.

Professor Gu’s expertise lies in cardiovascular disease, mitochondria biology and ion channel studies. His research made a significant contribution in understanding of the role of CO in human physiological and path-physiological process. His discoveries identified three novel signal pathways mediated by CO. CO activates ENAC channels to promote water and salt reabsorption in renal tubules cells and fluid clearance in the lung. CO inhibits inward rectified potassium channels, which maintain the resting membrane potential in ventricle, neuron and excitable cells. CO could prevent ventricular arrhythmia after cardiac infarction. Additionally, CO activates PLCδ but not PLCβ. It therefore results in insulin release from diabetic animal or patients, but not health individuals. It reveals the great potential to apply CO clinically in treatment of diabetes. Moreover, recent discovery in his laboratory found that insulin sensitive glucose transporter 4 was under control by PIP2 and CFTR receptors.

In the past 6 years, his research also moved into the field of immune cell engineering in challenging the prostate cancer and the clinic application of stem cell for a variety of degenerative diseases.

Contact Details

  • Telephone: 0121 204 4526
  • Email: y.gu1@aston.ac.uk

Education/Academic qualification

PhD

Award Date: 1 Aug 2000

MSc

Award Date: 18 Jul 1997

MD

Award Date: 18 Jul 1994

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