20122018

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Personal profile

Research Interests

Professor Yuchun Gu is a medically trained physiologist and is current the director of the Regenerative Medicine Centre of Aston Medical School. In 2017, he was awarded a professor and chair in Molecular Physiology at Aston Medical School and has held the positions of Professor and Chair of Molecular Pharmacology at the Institute of Molecular Medicine, Peking University since 2010.

Professor Gu’s expertise lies in cardiovascular disease, mitochondria biology and ion channel studies. His research made a significant contribution in understanding of the role of CO in human physiological and path-physiological process. His discoveries identified three novel signal pathways mediated by CO. CO activates ENAC channels to promote water and salt reabsorption in renal tubules cells and fluid clearance in the lung. CO inhibits inward rectified potassium channels, which maintain the resting membrane potential in ventricle, neuron and excitable cells. CO could prevent ventricular arrhythmia after cardiac infarction. Additionally, CO activates PLCδ but not PLCβ. It therefore results in insulin release from diabetic animal or patients, but not health individuals. It reveals the great potential to apply CO clinically in treatment of diabetes. Moreover, recent discovery in his laboratory found that insulin sensitive glucose transporter 4 was under control by PIP2 and CFTR receptors.

In the past 6 years, his research also moved into the field of immune cell engineering in challenging the prostate cancer and the clinic application of stem cell for a variety of degenerative diseases.

Contact Details

  • Telephone: 0121 204 4526
  • Email: y.gu1@aston.ac.uk

Education/Academic qualification

PhD

Award Date: 1 Aug 2000

MSc

Award Date: 18 Jul 1997

MD

Award Date: 18 Jul 1994

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Research Output

CRL4 antagonizes SCFFbxo7-mediated turnover of cereblon and BK channel to regulate learning and memory

Song, T., Liang, S., Liu, J., Zhang, T., Yin, Y., Geng, C., Gao, S., Feng, Y., Xu, H., Guo, D., Roberts, A., Gu, Y. & Cang, Y., 25 Jan 2018, In : PLoS Genetics. 14, 1, e1007165.

Research output: Contribution to journalArticle

Open Access
File
  • Elevated mitochondrial SLC25A29 in cancer modulates metabolic status by increasing mitochondria-derived nitric oxide

    Zhang, H., Wang, Q., Gu, J., Yin, L., Liang, S., Wu, L., Xu, H., Zhao, C. & Gu, Y., 20 Feb 2018, In : Oncogene. 37, p. 2545-2558

    Research output: Contribution to journalArticle

  • Heterodimerisation between VEGFR-1 and VEGFR-2 and not the homodimers of VEGFR-1 inhibit VEGFR-2 activity

    Cai, M., Wang, K., Murdoch, C. E., Gu, Y. & Ahmed, A., Jan 2017, In : Vascular Pharmacology. 88, p. 11-20 10 p.

    Research output: Contribution to journalArticle

    Open Access
    File
  • Vascular endothelial growth factor signaling requires glycine to promote angiogenesis

    Guo, D., Murdoch, C. E., Xu, H., Shi, H., Duan, D. D., Ahmed, A. & Gu, Y., 7 Nov 2017, In : Scientific Reports. 7, 1, p. 14749

    Research output: Contribution to journalArticle

    Open Access
    File
  • Vesicle miR-195 derived from endothelial cells inhibits expression of serotonin transporter in vessel smooth muscle cells

    Gu, J., Zhang, H., Ji, B., Jiang, H., Zhao, T., Jiang, R., Zhang, Z., Tan, S., Ahmed, A. & Gu, Y., 8 Mar 2017, In : Scientific Reports. 7, 10 p., 43546.

    Research output: Contribution to journalArticle

    Open Access
    File