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Personal profile

Research Interests

Dr Zhuo Wang (ZW), Early Career Academic, has over 13 year working experience in the field of Transglutaminase. Her research has been involved in establishing the importance of the protein crosslinking enzyme tissue transglutaminase (TG2) in cell adhesion through its interaction with fibronectin and cell surface syndecans. This has subsequently resulted in characterisation of the heparin binding site on TG2 and its importance in the translocation of TG2 into the ECM where many of its pathological events important to human disease occur. ZW’s current work is focused on the pathological role of Tissue Transglutaminase in human diseases, including pathological angiogenesis (such as tumour angiogenesis), cancer metastases (especially colon cancer) and fibrosis (including lung, heart and cystic fibrosis). 

Funding Applications and Awards

Aston 50th Anniversary  PhD studentship
Industrial collaboration with UCB Cell-Tech, UK

Teaching Activity

MSc Cell Biology Module

Employment

2016 – date: Lecturer in Biology and Biomedical Science, School of Life & Health Sciences, Aston University.
2010 – 2016: Postdoctoral Research Fellow, School of Life & Health Sciences, Aston University

Qualifications

  • Fellow of the Higher Education Academy
  • PhD in Cell Biology, Aston University, 2010
  • Master in Clinical Immunology, Tianjin Medical University, China, 2006
  • Bachelor in Clinical Medicine, Tianjin Medical University, China, 2003

PhD Supervision

Main supervising one PhD student starting in January 2017.

Co-supervising four PhD students

Contact Details

Room: MB433a

Education/Academic qualification

PhD

Fingerprint Dive into the research topics where Zhuo Wang is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

  • 3 Similar Profiles
Syndecan-4 Medicine & Life Sciences
Fibronectins Medicine & Life Sciences
Integrins Chemical Compounds
Cell Adhesion Medicine & Life Sciences
Epithelial-Mesenchymal Transition Medicine & Life Sciences
Syndecan-2 Medicine & Life Sciences
Celiac Disease Medicine & Life Sciences
transglutaminase 2 Medicine & Life Sciences

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Research Output 2003 2019

Mapping the minimum domain of the fibronectin binding site on transglutaminase 2 (TG2) and its importance in mediating signaling, adhesion, and migration in TG2-expressing cells

Soluri, M. F., Boccafoschi, F., Cotella, D., Moro, L., Forestieri, G., Autiero, I., Cavallo, L., Oliva, R., Griffin, M., Wang, Z., Santoro, C. & Sblattero, D., 30 Jan 2019, In : FASEB Journal . 33, 2, p. 2327-2342 16 p.

Research output: Contribution to journalArticle

Fibronectins
Adhesion
Binding Sites
Gelatin
Cell Adhesion

Transglutaminase 2 maintains a colorectal cancer stem phenotype by regulating epithelial-mesenchymal transition

Ayinde, O., Wang, Z., Pinton, G., Moro, L. & Griffin, M., 16 Jul 2019, In : Oncotarget. 10, 44, p. 4556-4569 14 p.

Research output: Contribution to journalArticle

Open Access
File
Epithelial-Mesenchymal Transition
Colorectal Neoplasms
Phenotype
Neoplastic Stem Cells
Vascular Endothelial Growth Factor A

Cardiac fibrosis can be attenuated by blocking the activity of transglutaminase 2 using a selective small-molecule inhibitor

Wang, Z., Stuckey, D. J., Murdoch, C. E., Camelliti, P., Lip, G. Y. H. & Griffin, M., 27 Apr 2018, In : Cell Death and Disease. 9, 613.

Research output: Contribution to journalArticle

Open Access
File
Fibrosis
Myofibroblasts
transglutaminase 2
Angiotensin II
Lysine

Involvement of cell surface TG2 in the aggregation of K562 cells triggered by gluten

Feriotto, G., Calza, R., Bergamini, C. M., Griffin, M., Wang, Z., Beninati, S., Ferretti, V., Marzola, E., Guerrini, R., Pagnoni, A., Cavazzini, A., Casciano, F. & Mischiati, C., 1 Mar 2017, In : Amino Acids. 49, 3, p. 551–565

Research output: Contribution to journalArticle

Open Access
File
K562 Cells
Glutens
Agglomeration
Calcium
Guanosine Triphosphate
Open Access
File
Transforming Growth Factors
Endothelial Cells
transglutaminase 2
Myofibroblasts
Coculture Techniques

Thesis

Tissue Transglutaminase (TG2) is a potential therapeutic target in the treatment of chemoresistant breast cancer

Author: Rajasekaran, V., 11 Mar 2014

Supervisor: Griffin, M. (Supervisor), Wang, Z. (Supervisor) & Collighan, R. J. (Supervisor)

Student thesis: Doctoral ThesisDoctor of Philosophy

File