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    Personal profile

    Research Interests

    Dr Zhuo Wang (ZW), Early Career Academic, has over 13 year working experience in the field of Transglutaminase. Her research has been involved in establishing the importance of the protein crosslinking enzyme tissue transglutaminase (TG2) in cell adhesion through its interaction with fibronectin and cell surface syndecans. This has subsequently resulted in characterisation of the heparin binding site on TG2 and its importance in the translocation of TG2 into the ECM where many of its pathological events important to human disease occur. ZW’s current work is focused on the pathological role of Tissue Transglutaminase in human diseases, including pathological angiogenesis (such as tumour angiogenesis), cancer metastases (especially colon cancer) and fibrosis (including lung, heart and cystic fibrosis). 

    Funding Applications and Awards

    Aston 50th Anniversary  PhD studentship
    Industrial collaboration with UCB Cell-Tech, UK

    Teaching Activity

    MSc Cell Biology Module

    Employment

    2016 – date: Lecturer in Biology and Biomedical Science, School of Life & Health Sciences, Aston University.
    2010 – 2016: Postdoctoral Research Fellow, School of Life & Health Sciences, Aston University

    Qualifications

    • Fellow of the Higher Education Academy
    • PhD in Cell Biology, Aston University, 2010
    • Master in Clinical Immunology, Tianjin Medical University, China, 2006
    • Bachelor in Clinical Medicine, Tianjin Medical University, China, 2003

    PhD Supervision

    Main supervising one PhD student starting in January 2017.

    Co-supervising four PhD students

    Contact Details

    Room: MB433a

    Education/Academic qualification

    PhD

    Fingerprint Dive into the research topics where Zhuo Wang is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

    • 3 Similar Profiles
    Syndecan-4 Medicine & Life Sciences
    Fibronectins Medicine & Life Sciences
    Integrins Chemical Compounds
    Cell Adhesion Medicine & Life Sciences
    Epithelial-Mesenchymal Transition Medicine & Life Sciences
    Syndecan-2 Medicine & Life Sciences
    Celiac Disease Medicine & Life Sciences
    transglutaminase 2 Medicine & Life Sciences

    Network Recent external collaboration on country level. Dive into details by clicking on the dots.

    Research Output 2003 2019

    Mapping the minimum domain of the fibronectin binding site on transglutaminase 2 (TG2) and its importance in mediating signaling, adhesion, and migration in TG2-expressing cells

    Soluri, M. F., Boccafoschi, F., Cotella, D., Moro, L., Forestieri, G., Autiero, I., Cavallo, L., Oliva, R., Griffin, M., Wang, Z., Santoro, C. & Sblattero, D., 30 Jan 2019, In : FASEB Journal . 33, 2, p. 2327-2342 16 p.

    Research output: Contribution to journalArticle

    Fibronectins
    Adhesion
    Binding Sites
    Gelatin
    Cell Adhesion

    Transglutaminase 2 maintains a colorectal cancer stem phenotype by regulating epithelial-mesenchymal transition

    Ayinde, O., Wang, Z., Pinton, G., Moro, L. & Griffin, M., 16 Jul 2019, In : Oncotarget. 10, 44, p. 4556-4569 14 p.

    Research output: Contribution to journalArticle

    Open Access
    File
    Epithelial-Mesenchymal Transition
    Colorectal Neoplasms
    Phenotype
    Neoplastic Stem Cells
    Vascular Endothelial Growth Factor A

    Cardiac fibrosis can be attenuated by blocking the activity of transglutaminase 2 using a selective small-molecule inhibitor

    Wang, Z., Stuckey, D. J., Murdoch, C. E., Camelliti, P., Lip, G. Y. H. & Griffin, M., 27 Apr 2018, In : Cell Death and Disease. 9, 613.

    Research output: Contribution to journalArticle

    Open Access
    File
    Fibrosis
    Myofibroblasts
    transglutaminase 2
    Angiotensin II
    Lysine

    Involvement of cell surface TG2 in the aggregation of K562 cells triggered by gluten

    Feriotto, G., Calza, R., Bergamini, C. M., Griffin, M., Wang, Z., Beninati, S., Ferretti, V., Marzola, E., Guerrini, R., Pagnoni, A., Cavazzini, A., Casciano, F. & Mischiati, C., 1 Mar 2017, In : Amino Acids. 49, 3, p. 551–565

    Research output: Contribution to journalArticle

    Open Access
    File
    K562 Cells
    Glutens
    Agglomeration
    Calcium
    Guanosine Triphosphate
    Open Access
    File
    Transforming Growth Factors
    Endothelial Cells
    transglutaminase 2
    Myofibroblasts
    Coculture Techniques

    Thesis

    Tissue Transglutaminase (TG2) is a potential therapeutic target in the treatment of chemoresistant breast cancer

    Author: Rajasekaran, V., 11 Mar 2014

    Supervisor: Griffin, M. (Supervisor), Wang, Z. (Supervisor) & Collighan, R. J. (Supervisor)

    Student thesis: Doctoral ThesisDoctor of Philosophy

    File