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    • United Kingdom

    Accepting PhD Students

    PhD projects

    Research areas: the role of Tissue Transglutaminase in fibrotic diseases, cancer and pathological angiogenesis, and the application of transglutaminase-crosslinked collagen as a novel biomaterial for wound healing and bone regeneration.

    20032019

    Research output per year

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    Personal profile

    Research Interests

    Dr Zhuo Wang (ZW), Early Career Academic, has over 13 year working experience in the field of Transglutaminase. Her research has been involved in establishing the importance of the protein crosslinking enzyme tissue transglutaminase (TG2) in cell adhesion through its interaction with fibronectin and cell surface syndecans. This has subsequently resulted in characterisation of the heparin binding site on TG2 and its importance in the translocation of TG2 into the ECM where many of its pathological events important to human disease occur. ZW’s current work is focused on the pathological role of Tissue Transglutaminase in human diseases, including pathological angiogenesis (such as tumour angiogenesis), cancer metastases (especially colon cancer) and fibrosis (including lung, heart and cystic fibrosis). 

    Funding Applications and Awards

    Aston 50th Anniversary  PhD studentship
    Industrial collaboration with UCB Cell-Tech, UK

    Teaching Activity

    MSc Cell Biology Module

    Employment

    2016 – date: Lecturer in Biology and Biomedical Science, School of Life & Health Sciences, Aston University.
    2010 – 2016: Postdoctoral Research Fellow, School of Life & Health Sciences, Aston University

    Qualifications

    • Fellow of the Higher Education Academy
    • PhD in Cell Biology, Aston University, 2010
    • Master in Clinical Immunology, Tianjin Medical University, China, 2006
    • Bachelor in Clinical Medicine, Tianjin Medical University, China, 2003

    PhD Supervision

    Main supervising one PhD student starting in January 2017.

    Co-supervising four PhD students

    Contact Details

    Room: MB433a

    Education/Academic qualification

    PhD

    Award Date: 2 Aug 2001

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    Research Output

    Mapping the minimum domain of the fibronectin binding site on transglutaminase 2 (TG2) and its importance in mediating signaling, adhesion, and migration in TG2-expressing cells

    Soluri, M. F., Boccafoschi, F., Cotella, D., Moro, L., Forestieri, G., Autiero, I., Cavallo, L., Oliva, R., Griffin, M., Wang, Z., Santoro, C. & Sblattero, D., 30 Jan 2019, In : FASEB Journal . 33, 2, p. 2327-2342 16 p.

    Research output: Contribution to journalArticle

  • Transglutaminase 2 maintains a colorectal cancer stem phenotype by regulating epithelial-mesenchymal transition

    Ayinde, O., Wang, Z., Pinton, G., Moro, L. & Griffin, M., 16 Jul 2019, In : Oncotarget. 10, 44, p. 4556-4569 14 p.

    Research output: Contribution to journalArticle

    Open Access
    File
  • Cardiac fibrosis can be attenuated by blocking the activity of transglutaminase 2 using a selective small-molecule inhibitor

    Wang, Z., Stuckey, D. J., Murdoch, C. E., Camelliti, P., Lip, G. Y. H. & Griffin, M., 27 Apr 2018, In : Cell Death and Disease. 9, 613.

    Research output: Contribution to journalArticle

    Open Access
    File
  • Involvement of cell surface TG2 in the aggregation of K562 cells triggered by gluten

    Feriotto, G., Calza, R., Bergamini, C. M., Griffin, M., Wang, Z., Beninati, S., Ferretti, V., Marzola, E., Guerrini, R., Pagnoni, A., Cavazzini, A., Casciano, F. & Mischiati, C., 1 Mar 2017, In : Amino Acids. 49, 3, p. 551–565

    Research output: Contribution to journalArticle

    Open Access
    File
  • Open Access
    File