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    • United Kingdom

    Accepting PhD Students

    PhD projects

    Research areas: the role of Tissue Transglutaminase in fibrotic diseases, cancer and pathological angiogenesis, and the application of transglutaminase-crosslinked collagen as a novel biomaterial for wound healing and bone regeneration.

    20032019

    Research output per year

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    Research Output

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    Article

    A novel extracellular role for tissue transglutaminase in matrix-bound VEGF-mediated angiogenesis

    Wang, Z., Perez, M., Caja, S., Melino, G., Johnson, T. S., Lindfors, K. & Griffin, M., 2013, In : Cell Death and Disease. 4, 9, 13 p., e808.

    Research output: Contribution to journalArticle

    Open Access
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    A novel regulatory role for tissue transglutaminase in epithelial-mesenchymal transition in cystic fibrosis

    Nyabam, S., Wang, Z., Thibault, T., Ayinde, O., Basar, R., Marshall, L. & Griffin, M., Sep 2016, In : BBA - Molecular Cell Research. 1863, 9, p. 2234-2244 11 p.

    Research output: Contribution to journalArticle

    Open Access
    File

    Are transglutaminase 2 inhibitors able to reduce gliadin-induced toxicity related to celiac disease? A proof-of-concept study

    Rauhavirta, T., Oittinen, M., Kivistö, R., Männistö, P. T., Garcia-Horsman, J. A., Wang, Z., Griffin, M., Mäki, M., Kaukinen, K. & Lindfors, K., Jan 2013, In : Journal of Clinical Immunology. 33, 1, p. 134-142 9 p.

    Research output: Contribution to journalArticle

    Cardiac fibrosis can be attenuated by blocking the activity of transglutaminase 2 using a selective small-molecule inhibitor

    Wang, Z., Stuckey, D. J., Murdoch, C. E., Camelliti, P., Lip, G. Y. H. & Griffin, M., 27 Apr 2018, In : Cell Death and Disease. 9, 613.

    Research output: Contribution to journalArticle

    Open Access
    File
    Open Access
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    Cross-linking of collagen I by tissue transglutaminase provides a promising biomaterial for promoting bone healing

    Fortunati, D., Chau, D. Y. S., Wang, Z., Collighan, R. J. & Griffin, M., 31 Jul 2014, In : Amino Acids. 46, 7, p. 1751-1761 11 p.

    Research output: Contribution to journalArticle

    Development of potent and selective tissue transglutaminase inhibitors: their effect on TG2 function and application in pathological conditions

    Badarau, E., Wang, Z., Rathbone, D. L., Costanzi, A., Thibault, T., Murdoch, C. E., El Alaoui, S., Bartkeviciute, M. & Griffin, M., 22 Oct 2015, In : Chemistry and Biology. 22, 10, p. 1347-1361 15 p.

    Research output: Contribution to journalArticle

    Open Access
    File

    Expression of the human cachexia-associated protein (HCAP) in prostate cancer and in a prostate cancer animal model of cachexia

    Wang, Z., Corey, E., Hass, G. M., Higano, C. S., True, L. D., Wallace, D., Tisdale, M. J. & Vessella, R. L., 20 May 2003, In : International Journal of Cancer. 105, 1, p. 123-129 7 p.

    Research output: Contribution to journalArticle

    Fibronectin-tissue transglutaminase matrix rescues RGD-impaired celladhesion through syndecan-4 and β integrin co-signaling

    Telci, D., Wang, Z., Li, X., Verderio, E. A. M., Humphries, M. J., Baccarini, M., Basaga, H. & Griffin, M., 25 Jul 2008, In : Journal of Biological Chemistry. 283, 30, p. 20937-20947 11 p.

    Research output: Contribution to journalArticle

    Open Access
    File

    Involvement of cell surface TG2 in the aggregation of K562 cells triggered by gluten

    Feriotto, G., Calza, R., Bergamini, C. M., Griffin, M., Wang, Z., Beninati, S., Ferretti, V., Marzola, E., Guerrini, R., Pagnoni, A., Cavazzini, A., Casciano, F. & Mischiati, C., 1 Mar 2017, In : Amino Acids. 49, 3, p. 551–565

    Research output: Contribution to journalArticle

    Open Access
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    Mapping the minimum domain of the fibronectin binding site on transglutaminase 2 (TG2) and its importance in mediating signaling, adhesion, and migration in TG2-expressing cells

    Soluri, M. F., Boccafoschi, F., Cotella, D., Moro, L., Forestieri, G., Autiero, I., Cavallo, L., Oliva, R., Griffin, M., Wang, Z., Santoro, C. & Sblattero, D., 30 Jan 2019, In : FASEB Journal . 33, 2, p. 2327-2342 16 p.

    Research output: Contribution to journalArticle

    Open Access
    File

    TG2, a novel extracellular protein with multiple functions

    Wang, Z. & Griffin, M., Feb 2012, In : Amino Acids. 42, 2-3, p. 939-949 11 p.

    Research output: Contribution to journalArticle

    Open Access
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    The role of TG2 in ECV304-related vasculogenic mimicry

    Jones, R. A., Wang, Z., Dookie, S. & Griffin, M., Jan 2013, In : Amino Acids. 44, 1, p. 89-101 13 p.

    Research output: Contribution to journalArticle

    The role of TG2 in regulating S100A4-mediated mammary tumour cell migration

    Wang, Z. & Griffin, M., 1 Mar 2013, In : PLoS ONE. 8, 3, 16 p., e57017.

    Research output: Contribution to journalArticle

    Open Access
    File

    The role of tissue transglutaminase (TG2) in regulating the tumour progression of the mouse colon carcinoma CT26

    Kotsakis, P., Wang, Z., Collighan, R. J. & Griffin, M., Oct 2011, In : Amino Acids. 41, 4, p. 909-921 13 p.

    Research output: Contribution to journalArticle

    Open Access
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    Thioredoxin is involved in endothelial cell extracellular transglutaminase 2 activation mediated by celiac disease patient IgA

    Nadalutti, C. A., Korponay-Szabo, I. R., Kaukinen, K., Wang, Z., Griffin, M., Mäki, M. & Lindfors, K., 9 Oct 2013, In : PLoS ONE. 8, 10, 12 p., e77277.

    Research output: Contribution to journalArticle

    Open Access
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    Tissue transglutaminase (TG2) enables survival of human malignant pleural mesothelioma cells in hypoxia

    Zonca, S., Pinton, G., Wang, Z., Soluri, M. F., Tavian, D., Griffin, M., Sblattero, D. & Moro, L., 2 Feb 2017, In : Cell Death and Disease. 8, 2, 7 p., e2592.

    Research output: Contribution to journalArticle

    Open Access
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    Open Access
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    Transglutaminase 2 interacts with syndecan-4 and CD44 at the surface of human macrophages to promote removal of apoptotic cells

    Nadella, V., Wang, Z., Johnson, T. S., Griffin, M. & Devitt, A., Jan 2015, In : BBA - Molecular Cell Research. 1853, 1, p. 201-212 12 p.

    Research output: Contribution to journalArticle

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    Transglutaminase 2 maintains a colorectal cancer stem phenotype by regulating epithelial-mesenchymal transition

    Ayinde, O., Wang, Z., Pinton, G., Moro, L. & Griffin, M., 16 Jul 2019, In : Oncotarget. 10, 44, p. 4556-4569 14 p.

    Research output: Contribution to journalArticle

    Open Access
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