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Zoe Gale

Dr

    20052012

    Research output per year

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    Personal profile

    General

    I have approximately nine years of experience of technical/research work within laboratories. Mainly in the fields of high throughput screening for diagnosis using histopathology, immunocytochemistry, cell culture and molecular biological techniques. I have also gained further technical skills specific to academic research during my work with the University of Birmingham in the field of cardiovascular disease. This predominantly involved isolating endothelial cells from human umbilical cords to investigate the effect of TNFα on endothelial cells during neutrophil recruitment.  I have also contributed to work produced in the School of Dentistry. In the future this work is aimed to aid in the regeneration of dental tissues using stem cell engineering. I investigated the effect of neurotrophic growth factors on dental pulp and osteoblast-like cells. Specifically, this work focused on the in vitro differentiation of BMSC, pre-osteoblasts/osteoprogenitors and mesenchymal/stromal cells of dental pulp, those capable of differentiating and re/forming the mineralised tissue of the tooth and bone.   

     

    Research Interests

    My current research interests are: the role of Tissue Transglutaminase in fibrotic diseases, cancer and pathological angiogenesis, and the application of transglutaminase-crosslinked collagen as a novel biomaterial for wound healing and bone regeneration.

    Employment

    Examiner

    - Company Name: AQA

    - Dates Employed: May 2014 – Aug 2018

    - Employment Duration: 5 yrs 3 mos

    Marking GCSE and A level Biology exam scripts accurately and consistently. To ensure overall standards are maintained in accordance with the pre-defined mark scheme, whilst adhering to Code of Practice and examination procedures. Ensuring deadlines for marking are adhered to. Ensuring all administration is completed as specified. Using high level of subject knowledge in order to apply the marking scheme to diverse responses. Participation in training, face to face standardisation meetings and professional development. Safeguarding the welfare of young persons.

     

    Biology Teacher

    - Company Name: MPW Birmingham

    - Dates Employed: Sep 2012 – Dec 2018

    - Employment Duration: 6 yrs 11 mos

    Biology Teacher. Planning and teaching of small groups of GCSE/A level students, whilst setting high expectations which inspire, motivate and challenge students. Meeting targets for GCSE students assessments: Summer 2018 GCSE students achieved a 100% A-C pass rate, with 70% of those students gaining A*- B grades. Creating and marking weekly homework and examination style assessments.

    Managing behaviour effectively to ensure a good and safe learning environment. Writing and delivering regular reports on pupil progress to parents and guardians, giving clear and constructive feedback to encourage students progress. Attending staff meetings, staff training, CPD training.

     

    Freelance Medical Writer

    - Company Name: Core Health Ltd

    - Dates Employed: Apr 2012 – Sep 2013

    - Employment Duration: 1 yr 6 mos

    Writing and editing scientific text on medical/ health related issues for public information purposes (leaflets, brochures, websites). In depth research and structuring of scientific information/ data into concise patient guides, working to deadlines and word limits.

     

    Research Technician

    - Company Name: University of Birmingham

    - Dates Employed: Apr 2001 – Nov 2005

    - Employment Duration: 4 yrs 8 mos

    Location: Medical school, University of Birmingham

    Research Technician working on a British Heart Foundation funded research project investigating atherosclerosis, specifically the effect of TNFalpha on endothelial cells exposed to flow.

    Technical competence in a broad range of techniques along with mammalian cell culture such as; primary cell culture of human endothelium, mouse cell lines along with cryopreservation of cultured cells and retrieval of cryopreserved cells. Immunological techniques used; Immunocytochemistry, ELISA and flow cytometry. Phlembotomy, leukocyte isolations and counts. Molecular biological techniques; RNA/DNA extractions, PCR preparation, gel electrophoresis, observation of extraction protocols for proteins and western blotting.

    Data and database management and compiling databases (Reference Manager and Excel). Maintaining records, producing a variety of documents ranging from letters to scientific reports.

    Assistant Scientific Officer at the Veterinary Laboratories Agency

     

    Company Name: Civil Service

    - Dates Employed: Sep 1999 – Feb 2001

    - Employment: Duration1 yr 6 mos

    - Location: Addlestone. Surrey

    Pathology department. Research investigating infections of the mammalian CNS by B.S.E alongwith diagnostic testing for Tuberculosis, rabies and swine flu .

    Safely working within a containment level 3 laboratory with hazardous chemicals and pathogens during diagnostic research into B.S.E transmission . Attending post-mortems. Collecting tissues and performing dissections. Performing histopathological diagnostic testing, (paraffin wax embedding), microtomy, staining and immunocytochemical assays for B.S.E, T.B, Swine fever and Rabies infections. Responsibility for whole batches of samples from post- mortem to diagnosis, independently managed the workloads to ensure deadlines for sample diagnosis were met. Data handling and tracking; Whole batch labelling, tracing, tracking and filing of histological samples by using unique sample number identifiers system.

    Awards

    - British Society for Oral and Dental research: Barcelona, ES

    2010 July | GSK-Mineralised Tissue Group (MINTIG) Prize

     - Poster prize from the University of Birmingham (UoB)

    2011 December | College of Medical and Dental science conference 

     - Medici prize from UoB Graduate school festival of research and enterprise

    2008 Autumn | Category enterprise and innovation

     - Travel grants awarded UKRC and TCES 

    2010 July | Travel for conference attendance in Barcelona

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    Research Output

    Glial cell line-derived neurotrophic factor influences proliferation of osteoblastic cells

    Gale, Z., Cooper, P. R. & Scheven, B. A., Feb 2012, In : Cytokine. 57, 2, p. 276-281

    Research output: Contribution to journalArticle

    Open Access
    File
  • Effects of glial cell line-derived neurotrophic factor on dental pulp cells

    Gale, Z., Cooper, P. R. & Scheven, B. A., 1 Oct 2011, In : Journal of dental research. 90, 10, p. 1240-1245

    Research output: Contribution to journalArticle

    Open Access
    File
  • Differing mechanisms of leukocyte recruitment and sensitivity to conditioning by shear stress for endothelial cells treated with tumour necrosis factor-α or interleukin-1β

    Sheikh, S., Rahman, M., Gale, Z., Luu, N. T., Stone, P. C. W., Matharu, N. M., Rainger, G. E. L. & Nash, G. B., 1 Aug 2005, In : British Journal of Pharmacology. 145, 8, p. 1052-1061

    Research output: Contribution to journalArticle