β-Amyloid (Aβ) deposition in elderly non-demented patients and patients with Alzheimer's disease

Richard A. Armstrong*

*Corresponding author for this work

Research output: Contribution to journalArticle

Abstract

β-amyloid (Aβ) deposition in the medial temporal lobe (MTL) was studied in elderly non-demented (ND) cases and in patients with Alzheimer's disease (AD). In AD, Aβ deposits were present throughout the MTL although density was less in the hippocampus than the adjacent cortical regions. In the ND cases, no Aβ deposits were recorded in 6 cases and in the remaining 8 cases, Aβ deposits were confined to the cortical regions adjacent to the hippocampus. The mean density of Aβ deposits in the cortical regions examined was greater in AD than in the ND cases but there was a significant overlap between the two groups. The ratio of mature to diffuse Aβ deposits was greater in the ND than the AD cases. In both patient groups, Aβ deposits formed clusters in the cortex and many tissues exhibited a regular distribution of clusters along the cortex parallel to the pia. The mean dimension of the Aβ clusters was greater in AD than in the ND cases. Hence, few aspects of Aβ deposition appeared to consistently separate AD from ND cases. However, the spread of Aβ pathology between modular units of the cortex and into regions of the hippocampus could be factors in the development of AD. © 1994.

Original languageEnglish
Pages (from-to)59-62
Number of pages4
JournalNeuroscience Letters
Volume178
Issue number1
DOIs
Publication statusPublished - 29 Aug 1994

Fingerprint

Amyloid
Alzheimer Disease
Hippocampus
Temporal Lobe
Pathology

Keywords

  • Alzheimer's disease
  • Aβ deposition
  • hippocampus
  • medial temporal lobe
  • non-demented brain

Cite this

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β-Amyloid (Aβ) deposition in elderly non-demented patients and patients with Alzheimer's disease. / Armstrong, Richard A.

In: Neuroscience Letters, Vol. 178, No. 1, 29.08.1994, p. 59-62.

Research output: Contribution to journalArticle

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