β-Amyloid (Aβ) deposition in the medial temporal lobe of patients with dementia with Lewy bodies

Richard A. Armstrong, Nigel J. Cairns, Peter L. Lantos

Research output: Contribution to journalArticle

Abstract

The distribution and density of diffuse, primitive and classic β-amyloid (Aβ) deposits in the medial temporal lobe (MTL) was studied in cases of dementia with Lewy bodies (DLB) with and without associated Alzheimer's disease (AD) and 15 cases of sporadic AD. In the 'pure' DLB cases, virtually no Aβ deposits were observed in the CA regions of the hippocampus or dentate gyrus whereas deposits were distributed throughout the MTL in DLB/AD and AD cases. Densities of diffuse and primitive Aβ deposits were similar in AD and DLB/AD cases but density was significantly reduced in the 'pure' DLB cases. The density of the classic deposits was significantly reduced in DLB cases with or without associated AD compared with AD cases. These results suggest that Aβ deposition in the MTL in 'pure' DLB cases is similar to that of elderly non-demented patients while, with the exception of the classic deposits, Aβ deposition in DLB/AD cases is similar to that in cases of AD alone.

Original languageEnglish
Pages (from-to)193-196
Number of pages4
JournalNeuroscience Letters
Volume227
Issue number3
DOIs
Publication statusPublished - 23 May 1997

Fingerprint

Lewy Body Disease
Temporal Lobe
Amyloid
Alzheimer Disease
Dementia
Dentate Gyrus
Amyloid Plaques
Hippocampus

Keywords

  • Aβ deposition
  • Alzheimer's disease
  • amyloid cascade hypothesis
  • dementia with Lewy bodies
  • medial temporal lobe

Cite this

Armstrong, Richard A. ; Cairns, Nigel J. ; Lantos, Peter L. / β-Amyloid (Aβ) deposition in the medial temporal lobe of patients with dementia with Lewy bodies. In: Neuroscience Letters. 1997 ; Vol. 227, No. 3. pp. 193-196.
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β-Amyloid (Aβ) deposition in the medial temporal lobe of patients with dementia with Lewy bodies. / Armstrong, Richard A.; Cairns, Nigel J.; Lantos, Peter L.

In: Neuroscience Letters, Vol. 227, No. 3, 23.05.1997, p. 193-196.

Research output: Contribution to journalArticle

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