3D Mueller-matrix diffusive tomography of polycrystalline blood films for cancer diagnosis

Volodimir Ushenko, Anton Sdobnov, Anna Syvokorovskaya, Alexander Dubolazov, Oleh Vanchulyak, Alexander Ushenko, Yurii Ushenko, Mykhailo Gorsky, Maxim Sidor, Alexander Bykov, Igor Meglinski*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


The decomposition of the Mueller matrix of blood films has been carried out using differential matrices with polarized and depolarized parts. The use of a coherent reference wave is applied and the algorithm of digital holographic reconstruction of the field of complex amplitudes is used. On this basis, the 3D Mueller-matrix diffuse tomography method-the reconstruction of distributions of fluctuations of linear and circular birefringence of depolarizing polycrystalline films of human blood is analytically justified and experimentally tested. The dynamics of the change in the magnitude of the statistical moments of the first-fourth order, which characterize layer-by-layer distributions of fluctuations in the phase anisotropy of the blood film, is examined and analyzed. The most sensitive parameters for prostate cancer are the statistical moments of the third and fourth orders, which characterize the asymmetry and kurtosis of fluctuations in the linear and circular birefringence of blood films. The excellent accuracy of differentiation obtained polycrystalline films of blood from healthy donors and patients with cancer patients was achieved.

Original languageEnglish
Article number54
Issue number4
Publication statusPublished - 1 Dec 2018

Bibliographical note

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).


  • Blood
  • Cancer diagnostics
  • Mueller-matrix
  • Polarimetry
  • Polarization


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