3D Mueller-matrix diffusive tomography of polycrystalline blood films for cancer diagnosis

Volodimir Ushenko, Anton Sdobnov, Anna Syvokorovskaya, Alexander Dubolazov, Oleh Vanchulyak, Alexander Ushenko, Yurii Ushenko, Mykhailo Gorsky, Maxim Sidor, Alexander Bykov, Igor Meglinski*

*Corresponding author for this work

Research output: Contribution to journalArticle

Abstract

The decomposition of the Mueller matrix of blood films has been carried out using differential matrices with polarized and depolarized parts. The use of a coherent reference wave is applied and the algorithm of digital holographic reconstruction of the field of complex amplitudes is used. On this basis, the 3D Mueller-matrix diffuse tomography method-the reconstruction of distributions of fluctuations of linear and circular birefringence of depolarizing polycrystalline films of human blood is analytically justified and experimentally tested. The dynamics of the change in the magnitude of the statistical moments of the first-fourth order, which characterize layer-by-layer distributions of fluctuations in the phase anisotropy of the blood film, is examined and analyzed. The most sensitive parameters for prostate cancer are the statistical moments of the third and fourth orders, which characterize the asymmetry and kurtosis of fluctuations in the linear and circular birefringence of blood films. The excellent accuracy of differentiation obtained polycrystalline films of blood from healthy donors and patients with cancer patients was achieved.

Original languageEnglish
Article number54
JournalPhotonics
Volume5
Issue number4
DOIs
Publication statusPublished - 1 Dec 2018

Fingerprint

blood
Tomography
Blood
tomography
cancer
Birefringence
matrices
distribution moments
Neoplasms
birefringence
Anisotropy
Blood Donors
kurtosis
Prostatic Neoplasms
asymmetry
Decomposition
decomposition
anisotropy

Bibliographical note

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

Keywords

  • Blood
  • Cancer diagnostics
  • Mueller-matrix
  • Polarimetry
  • Polarization

Cite this

Ushenko, V., Sdobnov, A., Syvokorovskaya, A., Dubolazov, A., Vanchulyak, O., Ushenko, A., ... Meglinski, I. (2018). 3D Mueller-matrix diffusive tomography of polycrystalline blood films for cancer diagnosis. Photonics, 5(4), [54]. https://doi.org/10.3390/photonics5040054
Ushenko, Volodimir ; Sdobnov, Anton ; Syvokorovskaya, Anna ; Dubolazov, Alexander ; Vanchulyak, Oleh ; Ushenko, Alexander ; Ushenko, Yurii ; Gorsky, Mykhailo ; Sidor, Maxim ; Bykov, Alexander ; Meglinski, Igor. / 3D Mueller-matrix diffusive tomography of polycrystalline blood films for cancer diagnosis. In: Photonics. 2018 ; Vol. 5, No. 4.
@article{601321c10f5549e1b69840a7facbbc5f,
title = "3D Mueller-matrix diffusive tomography of polycrystalline blood films for cancer diagnosis",
abstract = "The decomposition of the Mueller matrix of blood films has been carried out using differential matrices with polarized and depolarized parts. The use of a coherent reference wave is applied and the algorithm of digital holographic reconstruction of the field of complex amplitudes is used. On this basis, the 3D Mueller-matrix diffuse tomography method-the reconstruction of distributions of fluctuations of linear and circular birefringence of depolarizing polycrystalline films of human blood is analytically justified and experimentally tested. The dynamics of the change in the magnitude of the statistical moments of the first-fourth order, which characterize layer-by-layer distributions of fluctuations in the phase anisotropy of the blood film, is examined and analyzed. The most sensitive parameters for prostate cancer are the statistical moments of the third and fourth orders, which characterize the asymmetry and kurtosis of fluctuations in the linear and circular birefringence of blood films. The excellent accuracy of differentiation obtained polycrystalline films of blood from healthy donors and patients with cancer patients was achieved.",
keywords = "Blood, Cancer diagnostics, Mueller-matrix, Polarimetry, Polarization",
author = "Volodimir Ushenko and Anton Sdobnov and Anna Syvokorovskaya and Alexander Dubolazov and Oleh Vanchulyak and Alexander Ushenko and Yurii Ushenko and Mykhailo Gorsky and Maxim Sidor and Alexander Bykov and Igor Meglinski",
note = "This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).",
year = "2018",
month = "12",
day = "1",
doi = "10.3390/photonics5040054",
language = "English",
volume = "5",
number = "4",

}

Ushenko, V, Sdobnov, A, Syvokorovskaya, A, Dubolazov, A, Vanchulyak, O, Ushenko, A, Ushenko, Y, Gorsky, M, Sidor, M, Bykov, A & Meglinski, I 2018, '3D Mueller-matrix diffusive tomography of polycrystalline blood films for cancer diagnosis', Photonics, vol. 5, no. 4, 54. https://doi.org/10.3390/photonics5040054

3D Mueller-matrix diffusive tomography of polycrystalline blood films for cancer diagnosis. / Ushenko, Volodimir; Sdobnov, Anton; Syvokorovskaya, Anna; Dubolazov, Alexander; Vanchulyak, Oleh; Ushenko, Alexander; Ushenko, Yurii; Gorsky, Mykhailo; Sidor, Maxim; Bykov, Alexander; Meglinski, Igor.

In: Photonics, Vol. 5, No. 4, 54, 01.12.2018.

Research output: Contribution to journalArticle

TY - JOUR

T1 - 3D Mueller-matrix diffusive tomography of polycrystalline blood films for cancer diagnosis

AU - Ushenko, Volodimir

AU - Sdobnov, Anton

AU - Syvokorovskaya, Anna

AU - Dubolazov, Alexander

AU - Vanchulyak, Oleh

AU - Ushenko, Alexander

AU - Ushenko, Yurii

AU - Gorsky, Mykhailo

AU - Sidor, Maxim

AU - Bykov, Alexander

AU - Meglinski, Igor

N1 - This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

PY - 2018/12/1

Y1 - 2018/12/1

N2 - The decomposition of the Mueller matrix of blood films has been carried out using differential matrices with polarized and depolarized parts. The use of a coherent reference wave is applied and the algorithm of digital holographic reconstruction of the field of complex amplitudes is used. On this basis, the 3D Mueller-matrix diffuse tomography method-the reconstruction of distributions of fluctuations of linear and circular birefringence of depolarizing polycrystalline films of human blood is analytically justified and experimentally tested. The dynamics of the change in the magnitude of the statistical moments of the first-fourth order, which characterize layer-by-layer distributions of fluctuations in the phase anisotropy of the blood film, is examined and analyzed. The most sensitive parameters for prostate cancer are the statistical moments of the third and fourth orders, which characterize the asymmetry and kurtosis of fluctuations in the linear and circular birefringence of blood films. The excellent accuracy of differentiation obtained polycrystalline films of blood from healthy donors and patients with cancer patients was achieved.

AB - The decomposition of the Mueller matrix of blood films has been carried out using differential matrices with polarized and depolarized parts. The use of a coherent reference wave is applied and the algorithm of digital holographic reconstruction of the field of complex amplitudes is used. On this basis, the 3D Mueller-matrix diffuse tomography method-the reconstruction of distributions of fluctuations of linear and circular birefringence of depolarizing polycrystalline films of human blood is analytically justified and experimentally tested. The dynamics of the change in the magnitude of the statistical moments of the first-fourth order, which characterize layer-by-layer distributions of fluctuations in the phase anisotropy of the blood film, is examined and analyzed. The most sensitive parameters for prostate cancer are the statistical moments of the third and fourth orders, which characterize the asymmetry and kurtosis of fluctuations in the linear and circular birefringence of blood films. The excellent accuracy of differentiation obtained polycrystalline films of blood from healthy donors and patients with cancer patients was achieved.

KW - Blood

KW - Cancer diagnostics

KW - Mueller-matrix

KW - Polarimetry

KW - Polarization

UR - http://www.scopus.com/inward/record.url?scp=85058709765&partnerID=8YFLogxK

UR - https://www.mdpi.com/2304-6732/5/4/54

U2 - 10.3390/photonics5040054

DO - 10.3390/photonics5040054

M3 - Article

AN - SCOPUS:85058709765

VL - 5

IS - 4

M1 - 54

ER -

Ushenko V, Sdobnov A, Syvokorovskaya A, Dubolazov A, Vanchulyak O, Ushenko A et al. 3D Mueller-matrix diffusive tomography of polycrystalline blood films for cancer diagnosis. Photonics. 2018 Dec 1;5(4). 54. https://doi.org/10.3390/photonics5040054