3D Mueller-matrix diffusive tomography of polycrystalline blood films for cancer diagnosis

Volodimir Ushenko; Anton Sdobnov; Anna Syvokorovskaya; Alexander Dubolazov; Oleh Vanchulyak; Alexander Ushenko; Yurii Ushenko; Mykhailo Gorsky; Maxim Sidor; Alexander Bykov; Igor Meglinski

doi:10.3390/photonics5040054

3D Mueller-matrix diffusive tomography of polycrystalline blood films for cancer diagnosis

Volodimir Ushenko, Anton Sdobnov, Anna Syvokorovskaya, Alexander Dubolazov, Oleh Vanchulyak, Alexander Ushenko, Yurii Ushenko, Mykhailo Gorsky, Maxim Sidor, Alexander Bykov, Igor Meglinski^*

^*Corresponding author for this work

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Abstract

The decomposition of the Mueller matrix of blood films has been carried out using differential matrices with polarized and depolarized parts. The use of a coherent reference wave is applied and the algorithm of digital holographic reconstruction of the field of complex amplitudes is used. On this basis, the 3D Mueller-matrix diffuse tomography method-the reconstruction of distributions of fluctuations of linear and circular birefringence of depolarizing polycrystalline films of human blood is analytically justified and experimentally tested. The dynamics of the change in the magnitude of the statistical moments of the first-fourth order, which characterize layer-by-layer distributions of fluctuations in the phase anisotropy of the blood film, is examined and analyzed. The most sensitive parameters for prostate cancer are the statistical moments of the third and fourth orders, which characterize the asymmetry and kurtosis of fluctuations in the linear and circular birefringence of blood films. The excellent accuracy of differentiation obtained polycrystalline films of blood from healthy donors and patients with cancer patients was achieved.

Original language	English
Article number	54
Journal	Photonics
Volume	5
Issue number	4
DOIs	https://doi.org/10.3390/photonics5040054
Publication status	Published - 1 Dec 2018

Bibliographical note

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

Funding

Funding: Authors acknowledge financial support of the Academy of Finland (grant projects: 314369 and 311698). ASand IM would like to express sincere thanks to INFOTECH. IM acknowledges partial support from the MEPhI Academic Excellence Project (Contract No. 02.a03.21.0005), and National Research Tomsk State University Academic D.I. Mendeleev Fund Program.

Keywords

Blood
Cancer diagnostics
Mueller-matrix
Polarimetry
Polarization

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10.3390/photonics5040054Licence: CC BY 3.0

3D Mueller-Matrix Diffusive Tomography of Polycrystalline Blood Films for Cancer DiagnosisFinal published version, 3.73 MBLicence: CC BY 3.0

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title = "3D Mueller-matrix diffusive tomography of polycrystalline blood films for cancer diagnosis",

abstract = "The decomposition of the Mueller matrix of blood films has been carried out using differential matrices with polarized and depolarized parts. The use of a coherent reference wave is applied and the algorithm of digital holographic reconstruction of the field of complex amplitudes is used. On this basis, the 3D Mueller-matrix diffuse tomography method-the reconstruction of distributions of fluctuations of linear and circular birefringence of depolarizing polycrystalline films of human blood is analytically justified and experimentally tested. The dynamics of the change in the magnitude of the statistical moments of the first-fourth order, which characterize layer-by-layer distributions of fluctuations in the phase anisotropy of the blood film, is examined and analyzed. The most sensitive parameters for prostate cancer are the statistical moments of the third and fourth orders, which characterize the asymmetry and kurtosis of fluctuations in the linear and circular birefringence of blood films. The excellent accuracy of differentiation obtained polycrystalline films of blood from healthy donors and patients with cancer patients was achieved.",

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T1 - 3D Mueller-matrix diffusive tomography of polycrystalline blood films for cancer diagnosis

AU - Ushenko, Volodimir

AU - Sdobnov, Anton

AU - Syvokorovskaya, Anna

AU - Dubolazov, Alexander

AU - Vanchulyak, Oleh

AU - Ushenko, Alexander

AU - Ushenko, Yurii

AU - Gorsky, Mykhailo

AU - Sidor, Maxim

AU - Bykov, Alexander

AU - Meglinski, Igor

N1 - This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

PY - 2018/12/1

Y1 - 2018/12/1

N2 - The decomposition of the Mueller matrix of blood films has been carried out using differential matrices with polarized and depolarized parts. The use of a coherent reference wave is applied and the algorithm of digital holographic reconstruction of the field of complex amplitudes is used. On this basis, the 3D Mueller-matrix diffuse tomography method-the reconstruction of distributions of fluctuations of linear and circular birefringence of depolarizing polycrystalline films of human blood is analytically justified and experimentally tested. The dynamics of the change in the magnitude of the statistical moments of the first-fourth order, which characterize layer-by-layer distributions of fluctuations in the phase anisotropy of the blood film, is examined and analyzed. The most sensitive parameters for prostate cancer are the statistical moments of the third and fourth orders, which characterize the asymmetry and kurtosis of fluctuations in the linear and circular birefringence of blood films. The excellent accuracy of differentiation obtained polycrystalline films of blood from healthy donors and patients with cancer patients was achieved.

AB - The decomposition of the Mueller matrix of blood films has been carried out using differential matrices with polarized and depolarized parts. The use of a coherent reference wave is applied and the algorithm of digital holographic reconstruction of the field of complex amplitudes is used. On this basis, the 3D Mueller-matrix diffuse tomography method-the reconstruction of distributions of fluctuations of linear and circular birefringence of depolarizing polycrystalline films of human blood is analytically justified and experimentally tested. The dynamics of the change in the magnitude of the statistical moments of the first-fourth order, which characterize layer-by-layer distributions of fluctuations in the phase anisotropy of the blood film, is examined and analyzed. The most sensitive parameters for prostate cancer are the statistical moments of the third and fourth orders, which characterize the asymmetry and kurtosis of fluctuations in the linear and circular birefringence of blood films. The excellent accuracy of differentiation obtained polycrystalline films of blood from healthy donors and patients with cancer patients was achieved.

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KW - Cancer diagnostics

KW - Mueller-matrix

KW - Polarimetry

KW - Polarization

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3D Mueller-matrix diffusive tomography of polycrystalline blood films for cancer diagnosis

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