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2019

Mapping the minimum domain of the fibronectin binding site on transglutaminase 2 (TG2) and its importance in mediating signaling, adhesion, and migration in TG2-expressing cells

Soluri, M. F., Boccafoschi, F., Cotella, D., Moro, L., Forestieri, G., Autiero, I., Cavallo, L., Oliva, R., Griffin, M., Wang, Z., Santoro, C. & Sblattero, D., 30 Jan 2019, In : FASEB Journal . 33, 2, p. 2327-2342 16 p.

Research output: Contribution to journalArticle

Fibronectins
Adhesion
Binding Sites
Gelatin
Cell Adhesion

Transglutaminase 2 maintains a colorectal cancer stem phenotype by regulating epithelial-mesenchymal transition

Ayinde, O., Wang, Z., Pinton, G., Moro, L. & Griffin, M., 16 Jul 2019, In : Oncotarget. 10, 44, p. 4556-4569 14 p.

Research output: Contribution to journalArticle

Open Access
File
Epithelial-Mesenchymal Transition
Colorectal Neoplasms
Phenotype
Neoplastic Stem Cells
Vascular Endothelial Growth Factor A
2018

Cardiac fibrosis can be attenuated by blocking the activity of transglutaminase 2 using a selective small-molecule inhibitor

Wang, Z., Stuckey, D. J., Murdoch, C. E., Camelliti, P., Lip, G. Y. H. & Griffin, M., 27 Apr 2018, In : Cell Death and Disease. 9, 613.

Research output: Contribution to journalArticle

Open Access
File
Fibrosis
Myofibroblasts
transglutaminase 2
Angiotensin II
Lysine
2017

Involvement of cell surface TG2 in the aggregation of K562 cells triggered by gluten

Feriotto, G., Calza, R., Bergamini, C. M., Griffin, M., Wang, Z., Beninati, S., Ferretti, V., Marzola, E., Guerrini, R., Pagnoni, A., Cavazzini, A., Casciano, F. & Mischiati, C., 1 Mar 2017, In : Amino Acids. 49, 3, p. 551–565

Research output: Contribution to journalArticle

Open Access
File
K562 Cells
Glutens
Agglomeration
Calcium
Guanosine Triphosphate
Open Access
File
Transforming Growth Factors
Endothelial Cells
transglutaminase 2
Myofibroblasts
Coculture Techniques

Tissue transglutaminase (TG2) enables survival of human malignant pleural mesothelioma cells in hypoxia

Zonca, S., Pinton, G., Wang, Z., Soluri, M. F., Tavian, D., Griffin, M., Sblattero, D. & Moro, L., 2 Feb 2017, In : Cell Death and Disease. 8, 2, 7 p., e2592.

Research output: Contribution to journalArticle

Open Access
File
Cell Hypoxia
Survival
Cell Survival
Epithelioid Cells
Malignant Mesothelioma

Tissue transglutaminase induces epithelial-mesenchymal-transition and the acquisition of stem cell like characteristics in colorectal cancer cells

Ayinde, O., Wang, Z. & Griffin, M., 16 Feb 2017, In : Oncotarget. 8, 12, p. 20025-20041 17 p.

Research output: Contribution to journalArticle

Open Access
File
Catenins
Epithelial-Mesenchymal Transition
Colorectal Neoplasms
Stem Cells
Cell Line
2016

A novel regulatory role for tissue transglutaminase in epithelial-mesenchymal transition in cystic fibrosis

Nyabam, S., Wang, Z., Thibault, T., Ayinde, O., Basar, R., Marshall, L. & Griffin, M., Sep 2016, In : BBA - Molecular Cell Research. 1863, 9, p. 2234-2244 11 p.

Research output: Contribution to journalArticle

Open Access
File
Cystic Fibrosis Transmembrane Conductance Regulator
Epithelial-Mesenchymal Transition
Cystic Fibrosis
Cysteamine
Inborn Genetic Diseases

Isopeptidase activity of human transglutaminase 2: disconnection from transamidation and characterization by kinetic parameters

Kiraly, R., Thangaraju, K., Nagy, Z., Collighan, R., Nemes, Z., Griffin, M. & Fésüs, L., Jan 2016, In : Amino Acids. 48, 1, p. 31-40 10 p.

Research output: Contribution to journalArticle

Open Access
File
Kinetic parameters
Human Activities
Mutation
Amines
Physiological Phenomena
2015

Development of potent and selective tissue transglutaminase inhibitors: their effect on TG2 function and application in pathological conditions

Badarau, E., Wang, Z., Rathbone, D. L., Costanzi, A., Thibault, T., Murdoch, C. E., El Alaoui, S., Bartkeviciute, M. & Griffin, M., 22 Oct 2015, In : Chemistry and Biology. 22, 10, p. 1347-1361 15 p.

Research output: Contribution to journalArticle

Open Access
File
Endothelial cells
Fibronectins
Syndecan-4
Umbilical Cord
Peptidomimetics

TG2: a credible therapeutic target in fibrotic diseasedue to its multifunctional roles

Griffin, M., Wang, Z., Thibault, T., Murdoch, C. & Rathbone, D., 31 Aug 2015, In : Amino Acids. 47, 8, p. 1629 1 p.

Research output: Contribution to journalMeeting abstract

Fibrosis
Collagen
Fibronectins
Proteins
Chemical activation

Transglutaminase 2 interacts with syndecan-4 and CD44 at the surface of human macrophages to promote removal of apoptotic cells

Nadella, V., Wang, Z., Johnson, T. S., Griffin, M. & Devitt, A., Jan 2015, In : BBA - Molecular Cell Research. 1853, 1, p. 201-212 12 p.

Research output: Contribution to journalArticle

File
Syndecan-4
Macrophages
Heparitin Sulfate
Cell Adhesion
transglutaminase 2