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  • David Poyner
2016

An allosteric role for receptor activity-modifying proteins in defining GPCR pharmacology

Gingell, J. J., Simms, J., Barwell, J., Poyner, D. R., Watkins, H. A., Pioszak, AA., Sexton, P. M. & Hay, D. L., 17 May 2016, In : Cell Discovery. 2, 16012.

Research output: Contribution to journalArticle

Open Access
File

GPCR-styrene maleic acid lipid particles (GPCR-SMALPs): their nature and potential

Wheatley, M., Charlton, J., Jamshad, M., Routledge, S. J., Bailey, S., La-Borde, P. J., Azam, M. T., Logan, R. T., Bill, R. M., Dafforn, T. R. & Poyner, D. R., 15 Apr 2016, In : Biochemical Society Transactions. 44, 2, p. 619-623 5 p.

Research output: Contribution to journalReview article

Open Access
File

Receptor activity-modifying protein-directed G protein signaling specificity for the calcitonin gene-related peptide family of receptors

Weston, C., Winfield, I., Harris, M., Hodgson, R., Shah, A., Dowell, S. J., Mobarec, J. C., Woodlock, D. A., Reynolds, C. A., Poyner, D. R., Watkins, H. A. & Ladds, G., 14 Oct 2016, In : Journal of Biological Chemistry. 291, 42, p. 21925-21944 20 p.

Research output: Contribution to journalArticle

Open Access
File

Receptor activity-modifying proteins; multifunctional G protein-coupled receptor accessory proteins

Hay, D. L., Walker, C. S., Gingell, J. J., Ladds, G., Reynolds, C. A. & Poyner, D. R., 15 Apr 2016, In : Biochemical Society Transactions. 44, 2, p. 568-573 6 p.

Research output: Contribution to journalReview article

Receptor activity-modifying proteins 2 and 3 generate adrenomedullin receptor subtypes with distinct molecular properties

Watkins, H. A., Chakravarthy, M., Abhayawardana, R. S., Gingell, J. J., Garelja, M., Pardamwar, M., McElhinney, J. M. W. R., Lathbridge, A., Constantine, A., Harris, P. W. R., Yuen, T-Y., Brimble, M. A., Barwell, J., Poyner, D. R., Woolley, M. J., Conner, A. C., Pioszak, AA., Reynolds, C. A. & Hay, D. L., 27 May 2016, In : Journal of Biological Chemistry. 291, 22, p. 11657-11675 19 p.

Research output: Contribution to journalArticle

Open Access
File
2017

Receptor activity-modifying protein dependent and independent activation mechanisms in the coupling of calcitonin gene-related peptide and adrenomedullin receptors to Gs

Woolley, M. J., Reynolds, C. A., Simms, J., Walker, C. S., Mobarec, J. C., Garelja, M. L., Conner, A. C., Poyner, D. R. & Hay, D. L., 15 Oct 2017, In : Biochemical Pharmacology. 142, p. 96-110

Research output: Contribution to journalArticle

Open Access
File
Open Access
File

The effects of RAMPs upon cell signalling

Routledge, S. J., Ladds, G. & Poyner, D. R., 5 Apr 2017, In : Molecular and Cellular Endocrinology. in press

Research output: Contribution to journalArticle

Open Access
File
Open Access
File

Update on the pharmacology of calcitonin/CGRP family of peptides: IUPHAR Review 25

Hay, D. L., Garelja, M. L., Poyner, D. R. & Walker, C. S., 28 Nov 2017, In : British Journal of Pharmacology. In press, 41 p.

Research output: Contribution to journalArticle

Open Access
File
2018

Functional characterisation of G protein-coupled receptors

Uddin, R., Simms, J. & Poyner, D., 1 Sep 2018, In : Methods. 147, p. 213-220

Research output: Contribution to journalArticle

Open Access
File

hCALCRL mutation causes autosomal recessive nonimmune hydrops fetalis with lymphatic dysplasia

Mackie, D. I., Al Mutairi, F., Davis, R. B., Kechele, D. O., Nielsen, N. R., Snyder, J. C., Caron, M. G., Kliman, H. J., Berg, J. S., Simms, J., Poyner, D. R. & Caron, K. M., 16 Aug 2018, In : Journal of Experimental Medicine . 215, 9, p. 2339-2353

Research output: Contribution to journalArticle

Open Access
File

Microbial expression systems for membrane proteins

Dilworth, M. V., Piel, M. S., Bettaney, K. E., Ma, P., Luo, J., Sharples, D., Poyner, D. R., Gross, S. R., Moncoq, K., J. F. Henderson, P., Miroux, B. & Bill, R. M., 12 Apr 2018, In : Methods.

Research output: Contribution to journalArticle

Open Access
File

Photoaffinity cross-linking and unnatural amino acid mutagenesis reveal insights into calcitonin gene-related peptide binding to the calcitonin receptor-like receptor/receptor activity-modifying protein 1 (CLR/RAMP1) complex

Simms, J., Uddin, R., Sakmar, T. P., Gingell, J. J., Garelja, M. L., Hay, D. L., Brimble, M. A., Harris, P. W. R., Reynolds, C. A. & Poyner, D. R., 14 Aug 2018, In : Biochemistry. 57, 32, p. 4915-4922

Research output: Contribution to journalArticle

Open Access
File

The structure of the CGRP and related receptors

Simms, J., Routledge, S., Uddin, R. & Poyner, D., 25 May 2018, Handbook of Experimental Pharmacology. Brain, S. & Gepetti, P. (eds.). Springer, p. 23-36 14 p. (Handbook of Experimental Pharmacology; vol. 255).

Research output: Chapter in Book/Report/Conference proceedingChapter

2019

Interactions Between RAMP2 And CRF Receptors: The Effect Of Receptor Subtypes, Splice Variants And Cell Context

Bailey, S., Harris, M., Barkan, K., Winfield, I., Thomas-Harper, M., Simms, J. W., Ladds, G., Wheatley, M. & Poyner, D. R., 1 May 2019, In : BBA -Biomembranes. 1861, 5, p. 997-1003 7 p.

Research output: Contribution to journalArticle

Open Access
File