A compartmental CFD-PBM model of high shear wet granulation

Xi Yu; Michael J Hounslow; Gavin K Reynolds; Anders Rasmuson; Ingela Niklasson Björn; Per J Abrahamsson

doi:10.1002/aic.15401

A compartmental CFD-PBM model of high shear wet granulation

Xi Yu^*, Michael J Hounslow, Gavin K Reynolds, Anders Rasmuson, Ingela Niklasson Björn, Per J Abrahamsson

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

Abstract

The conventional, geometrically lumped description of the physical processes inside a high shear granulator is not reliable for process design and scale-up. In this study, a compartmental Population Balance Model (PBM) with spatial dependence is developed and validated in two lab-scale high shear granulation processes using a 1.9L MiPro granulator and 4L DIOSNA granulator. The compartmental structure is built using a heuristic approach based on computational fluid dynamics (CFD) analysis, which includes the overall flow pattern, velocity and solids concentration. The constant volume Monte Carlo approach is implemented to solve the multi-compartment population balance equations. Different spatial dependent mechanisms are included in the compartmental PBM to describe granule growth. It is concluded that for both cases (low and high liquid content), the adjustment of parameters (e.g. layering, coalescence and breakage rate) can provide a quantitative prediction of the granulation process.

Original language	English
Pages (from-to)	438-458
Number of pages	21
Journal	AIChE Journal
Volume	63
Issue number	2
Early online date	15 Jul 2016
DOIs	https://doi.org/10.1002/aic.15401
Publication status	Published - Feb 2017

Bibliographical note

This is the peer reviewed version of the following article: Yu, X., Hounslow, M. J., Reynolds, G. K., Rasmuson, A., Niklasson Björn, I., & Abrahamsson, P. J. (2017). A compartmental CFD-PBM model of high shear wet granulation. AIChE Journal, 63(2), 438-458, which has been published in final form at http://dx.doi.org/10.1002/aic.15401. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.

Keywords

high shear wet granulation
population balance model
multiple compartments
Monte Carlo
CFD

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10.1002/aic.15401

Compartmental CFD-PBM model of high shear wet granulation
This is the peer reviewed version of the following article: Yu, X., Hounslow, M. J., Reynolds, G. K., Rasmuson, A., Niklasson Björn, I., & Abrahamsson, P. J. (2017). A compartmental CFD-PBM model of high shear wet granulation. AIChE Journal, 63(2), 438-458, which has been published in final form at http://dx.doi.org/10.1002/aic.15401. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.
Accepted author manuscript, 4.54 MB

Cite this

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title = "A compartmental CFD-PBM model of high shear wet granulation",

abstract = "The conventional, geometrically lumped description of the physical processes inside a high shear granulator is not reliable for process design and scale-up. In this study, a compartmental Population Balance Model (PBM) with spatial dependence is developed and validated in two lab-scale high shear granulation processes using a 1.9L MiPro granulator and 4L DIOSNA granulator. The compartmental structure is built using a heuristic approach based on computational fluid dynamics (CFD) analysis, which includes the overall flow pattern, velocity and solids concentration. The constant volume Monte Carlo approach is implemented to solve the multi-compartment population balance equations. Different spatial dependent mechanisms are included in the compartmental PBM to describe granule growth. It is concluded that for both cases (low and high liquid content), the adjustment of parameters (e.g. layering, coalescence and breakage rate) can provide a quantitative prediction of the granulation process.",

keywords = "high shear wet granulation, population balance model, multiple compartments, Monte Carlo, CFD",

author = "Xi Yu and Hounslow, {Michael J} and Reynolds, {Gavin K} and Anders Rasmuson and {Niklasson Bj{\"o}rn}, Ingela and Abrahamsson, {Per J}",

note = "This is the peer reviewed version of the following article: Yu, X., Hounslow, M. J., Reynolds, G. K., Rasmuson, A., Niklasson Bj{\"o}rn, I., & Abrahamsson, P. J. (2017). A compartmental CFD-PBM model of high shear wet granulation. AIChE Journal, 63(2), 438-458, which has been published in final form at http://dx.doi.org/10.1002/aic.15401. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.",

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AU - Niklasson Björn, Ingela

AU - Abrahamsson, Per J

N1 - This is the peer reviewed version of the following article: Yu, X., Hounslow, M. J., Reynolds, G. K., Rasmuson, A., Niklasson Björn, I., & Abrahamsson, P. J. (2017). A compartmental CFD-PBM model of high shear wet granulation. AIChE Journal, 63(2), 438-458, which has been published in final form at http://dx.doi.org/10.1002/aic.15401. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.

PY - 2017/2

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N2 - The conventional, geometrically lumped description of the physical processes inside a high shear granulator is not reliable for process design and scale-up. In this study, a compartmental Population Balance Model (PBM) with spatial dependence is developed and validated in two lab-scale high shear granulation processes using a 1.9L MiPro granulator and 4L DIOSNA granulator. The compartmental structure is built using a heuristic approach based on computational fluid dynamics (CFD) analysis, which includes the overall flow pattern, velocity and solids concentration. The constant volume Monte Carlo approach is implemented to solve the multi-compartment population balance equations. Different spatial dependent mechanisms are included in the compartmental PBM to describe granule growth. It is concluded that for both cases (low and high liquid content), the adjustment of parameters (e.g. layering, coalescence and breakage rate) can provide a quantitative prediction of the granulation process.

AB - The conventional, geometrically lumped description of the physical processes inside a high shear granulator is not reliable for process design and scale-up. In this study, a compartmental Population Balance Model (PBM) with spatial dependence is developed and validated in two lab-scale high shear granulation processes using a 1.9L MiPro granulator and 4L DIOSNA granulator. The compartmental structure is built using a heuristic approach based on computational fluid dynamics (CFD) analysis, which includes the overall flow pattern, velocity and solids concentration. The constant volume Monte Carlo approach is implemented to solve the multi-compartment population balance equations. Different spatial dependent mechanisms are included in the compartmental PBM to describe granule growth. It is concluded that for both cases (low and high liquid content), the adjustment of parameters (e.g. layering, coalescence and breakage rate) can provide a quantitative prediction of the granulation process.

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A compartmental CFD-PBM model of high shear wet granulation

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Keywords

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