A cytostatic drug from the class of triazine derivatives: Its properties in aqueous solutions, cytotoxicity, and therapeutic activity

Olga V. Mikolaichuk, Elena A. Popova, Alexandra V. Protas, Ilnaz T. Rakipov, Dmitry A. Nerukh, Andrey V. Petrov, Nikolay A. Charykov, Sergei V. Ageev, Grigorii V. Tochilnikov, Iulia G. Zmitrichenko, Aleksandr N. Stukov, Konstantin N. Semenov*, Vladimir V. Sharoyko

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

We present a comprehensive study of a water-soluble substance from the class of triazine derivatives alkylating agents. The performed physicochemical investigations of this cytostatic drug's aqueous solutions include the measurements of density, viscosity, speed of sound, refraction index, stability, solubility, distribution between water and octan-1-ol, as well as electronic structure calculations and molecular dynamics modelling. Biologically, the substance was investigated for its cytotoxicity as well as in vitro (on Capan-2 and SK-MEL-1 cell lines) and in vivo (transplantable Ehrlich ascites carcinoma model) therapeutic activity.

Original languageEnglish
Article number119043
JournalJournal of Molecular Liquids
Volume356
Early online date31 Mar 2022
DOIs
Publication statusE-pub ahead of print - 31 Mar 2022

Bibliographical note

© 2022 Elsevier B.V. This accepted manuscript version is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International https://creativecommons.org/licenses/by-nc-nd/4.0/

Funding Information: The work was supported by Russian Foundation for Basic Research (project number 21-515-10007).

Keywords

  • Cytostatic Agent
  • Cytotoxicity
  • Ehrlich ascites carcinoma
  • Electronic structure
  • Molecular Dynamics
  • Solutions

Fingerprint

Dive into the research topics of 'A cytostatic drug from the class of triazine derivatives: Its properties in aqueous solutions, cytotoxicity, and therapeutic activity'. Together they form a unique fingerprint.

Cite this