A cytostatic drug from the class of triazine derivatives:   Its properties in aqueous solutions, cytotoxicity, and therapeutic activity

Olga V. Mikolaichuk; Elena A. Popova; Alexandra V. Protas; Ilnaz T. Rakipov; Dmitry A. Nerukh; Andrey V. Petrov; Nikolay A. Charykov; Sergei V. Ageev; Grigorii V. Tochilnikov; Iulia G. Zmitrichenko; Aleksandr N. Stukov; Konstantin N. Semenov; Vladimir V. Sharoyko

doi:10.1016/j.molliq.2022.119043

A cytostatic drug from the class of triazine derivatives: Its properties in aqueous solutions, cytotoxicity, and therapeutic activity

Olga V. Mikolaichuk
, Elena A. Popova
, Alexandra V. Protas
, Ilnaz T. Rakipov
, Dmitry A. Nerukh
, Andrey V. Petrov
, Nikolay A. Charykov
, Sergei V. Ageev
, Grigorii V. Tochilnikov
, Iulia G. Zmitrichenko
, Aleksandr N. Stukov
, Konstantin N. Semenov^*
, Vladimir V. Sharoyko

^*Corresponding author for this work

Aston University

Pavlov First Saint Petersburg State Medical University
Graduate School of Management
Kazan Federal University
Saint Petersburg State Technological Institute (Technical University)
Petrov Research Institute of Oncology

Research output: Contribution to journal › Article › peer-review

10 Citations (Scopus)

16 Downloads (Pure)

Abstract

We present a comprehensive study of a water-soluble substance from the class of triazine derivatives alkylating agents. The performed physicochemical investigations of this cytostatic drug's aqueous solutions include the measurements of density, viscosity, speed of sound, refraction index, stability, solubility, distribution between water and octan-1-ol, as well as electronic structure calculations and molecular dynamics modelling. Biologically, the substance was investigated for its cytotoxicity as well as in vitro (on Capan-2 and SK-MEL-1 cell lines) and in vivo (transplantable Ehrlich ascites carcinoma model) therapeutic activity.

Original language	English
Article number	119043
Journal	Journal of Molecular Liquids
Volume	356
Early online date	31 Mar 2022
DOIs	https://doi.org/10.1016/j.molliq.2022.119043
Publication status	Published - 15 Jun 2022

Bibliographical note

© 2022 Elsevier B.V. This accepted manuscript version is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International https://creativecommons.org/licenses/by-nc-nd/4.0/

Funding Information: The work was supported by Russian Foundation for Basic Research (project number 21-515-10007).

Funding

The work was supported by Russian Foundation for Basic Research (project number 21-515-10007). The equipment of the following Resource Centres of the Research Park of Saint Petersburg State University was used: Resource Centre ‘GeoModel’, the Centre for Diagnostics of Functional Materials for Medicine, Pharmacology and Nanoelectronics, Interdisciplinary Resource Centre for Nanotechnology, Magnetic Resonance Research Centre, Centre for Physical Methods of Surface Investigation, Centre for Chemical Analysis and Materials Research, Thermogravimetric and Calorimetric Research Centre.

Keywords

Cytostatic Agent
Cytotoxicity
Ehrlich ascites carcinoma
Electronic structure
Molecular Dynamics
Solutions

Access to Document

10.1016/j.molliq.2022.119043

Mikolaichuk et al Dioxadet (physchem) cytotoxic drug triazine derivative class Article Manuscript
© 2022 Elsevier B.V. This accepted manuscript version is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International https://creativecommons.org/licenses/by-nc-nd/4.0/
Accepted author manuscript, 1.45 MBLicence: CC BY-NC-ND 4.0

Cite this

Mikolaichuk, O. V., Popova, E. A., Protas, A. V., Rakipov, I. T., Nerukh, D. A., Petrov, A. V., Charykov, N. A., Ageev, S. V., Tochilnikov, G. V., Zmitrichenko, I. G., Stukov, A. N., Semenov, K. N., & Sharoyko, V. V. (2022). A cytostatic drug from the class of triazine derivatives: Its properties in aqueous solutions, cytotoxicity, and therapeutic activity. Journal of Molecular Liquids, 356, Article 119043. https://doi.org/10.1016/j.molliq.2022.119043

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abstract = "We present a comprehensive study of a water-soluble substance from the class of triazine derivatives alkylating agents. The performed physicochemical investigations of this cytostatic drug's aqueous solutions include the measurements of density, viscosity, speed of sound, refraction index, stability, solubility, distribution between water and octan-1-ol, as well as electronic structure calculations and molecular dynamics modelling. Biologically, the substance was investigated for its cytotoxicity as well as in vitro (on Capan-2 and SK-MEL-1 cell lines) and in vivo (transplantable Ehrlich ascites carcinoma model) therapeutic activity.",

keywords = "Cytostatic Agent, Cytotoxicity, Ehrlich ascites carcinoma, Electronic structure, Molecular Dynamics, Solutions",

author = "Mikolaichuk, \{Olga V.\} and Popova, \{Elena A.\} and Protas, \{Alexandra V.\} and Rakipov, \{Ilnaz T.\} and Nerukh, \{Dmitry A.\} and Petrov, \{Andrey V.\} and Charykov, \{Nikolay A.\} and Ageev, \{Sergei V.\} and Tochilnikov, \{Grigorii V.\} and Zmitrichenko, \{Iulia G.\} and Stukov, \{Aleksandr N.\} and Semenov, \{Konstantin N.\} and Sharoyko, \{Vladimir V.\}",

note = "{\textcopyright} 2022 Elsevier B.V. This accepted manuscript version is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International https://creativecommons.org/licenses/by-nc-nd/4.0/ Funding Information: The work was supported by Russian Foundation for Basic Research (project number 21-515-10007). ",

year = "2022",

month = jun,

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doi = "10.1016/j.molliq.2022.119043",

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Mikolaichuk, OV, Popova, EA, Protas, AV, Rakipov, IT, Nerukh, DA, Petrov, AV, Charykov, NA, Ageev, SV, Tochilnikov, GV, Zmitrichenko, IG, Stukov, AN, Semenov, KN & Sharoyko, VV 2022, 'A cytostatic drug from the class of triazine derivatives: Its properties in aqueous solutions, cytotoxicity, and therapeutic activity', Journal of Molecular Liquids, vol. 356, 119043. https://doi.org/10.1016/j.molliq.2022.119043

TY - JOUR

T1 - A cytostatic drug from the class of triazine derivatives

T2 - Its properties in aqueous solutions, cytotoxicity, and therapeutic activity

AU - Mikolaichuk, Olga V.

AU - Popova, Elena A.

AU - Protas, Alexandra V.

AU - Rakipov, Ilnaz T.

AU - Nerukh, Dmitry A.

AU - Petrov, Andrey V.

AU - Charykov, Nikolay A.

AU - Ageev, Sergei V.

AU - Tochilnikov, Grigorii V.

AU - Zmitrichenko, Iulia G.

AU - Stukov, Aleksandr N.

AU - Semenov, Konstantin N.

AU - Sharoyko, Vladimir V.

N1 - © 2022 Elsevier B.V. This accepted manuscript version is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International https://creativecommons.org/licenses/by-nc-nd/4.0/ Funding Information: The work was supported by Russian Foundation for Basic Research (project number 21-515-10007).

PY - 2022/6/15

Y1 - 2022/6/15

N2 - We present a comprehensive study of a water-soluble substance from the class of triazine derivatives alkylating agents. The performed physicochemical investigations of this cytostatic drug's aqueous solutions include the measurements of density, viscosity, speed of sound, refraction index, stability, solubility, distribution between water and octan-1-ol, as well as electronic structure calculations and molecular dynamics modelling. Biologically, the substance was investigated for its cytotoxicity as well as in vitro (on Capan-2 and SK-MEL-1 cell lines) and in vivo (transplantable Ehrlich ascites carcinoma model) therapeutic activity.

AB - We present a comprehensive study of a water-soluble substance from the class of triazine derivatives alkylating agents. The performed physicochemical investigations of this cytostatic drug's aqueous solutions include the measurements of density, viscosity, speed of sound, refraction index, stability, solubility, distribution between water and octan-1-ol, as well as electronic structure calculations and molecular dynamics modelling. Biologically, the substance was investigated for its cytotoxicity as well as in vitro (on Capan-2 and SK-MEL-1 cell lines) and in vivo (transplantable Ehrlich ascites carcinoma model) therapeutic activity.

KW - Cytostatic Agent

KW - Cytotoxicity

KW - Ehrlich ascites carcinoma

KW - Electronic structure

KW - Molecular Dynamics

KW - Solutions

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JO - Journal of Molecular Liquids

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