In this paper, an intelligent decision support system has been proposed for skin disease diagnosis using a hybrid model of Case-Based Reasoning and Artificial Neural Network techniques. The proposed model uses nine input variables (attributes) that have a major effect on the skin diagnosing process. The output of the model is the diagnosis and the treatment. An interactive and user friendly computer application has been developed in order to realize the approach. We have applied the system on a real-world data collected from a dermatology department. The model has been validated and the system tested using a separate set of data (test cases). The results demonstrate that the proposed intelligent system is feasible, and its performance is good and acceptable.