TY - JOUR
T1 - A Hypothalamic Mechanism Regulates the Duration of a Migraine Attack:
T2 - Insights from Microstructural and Temporal Complexity of Cortical Functional Networks Analysis
AU - Porcaro, Camillo
AU - Di Renzo, Antonio
AU - Tinelli, Emanuele
AU - Parisi, Vincenzo
AU - Di Lorenzo, Cherubino
AU - Caramia, Francesca
AU - Fiorelli, Marco
AU - Giuliani, Giada
AU - Cioffi, Ettore
AU - Seri, Stefano
AU - Di Piero, Vittorio
AU - Pierelli, Francesco
AU - Di Lorenzo, Giorgio
AU - Coppola, Gianluca
A2 - Tuttolomondo, Antonino
A2 - Simonetta, Irene
N1 - Copyright: © 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/
4.0/).
PY - 2022/11
Y1 - 2022/11
N2 - The role of the hypothalamus and the limbic system at the onset of a migraine attack has recently received significant interest. We analyzed diffusion tensor imaging (DTI) parameters of the entire hypothalamus and its subregions in 15 patients during a spontaneous migraine attack and in 20 control subjects. We also estimated the non-linear measure resting-state functional MRI BOLD signal’s complexity using Higuchi fractal dimension (FD) and correlated DTI/fMRI findings with patients’ clinical characteristics. In comparison with healthy controls, patients had significantly altered diffusivity metrics within the hypothalamus, mainly in posterior ROIs, and higher FD values in the salience network (SN). We observed a positive correlation of the hypothalamic axial diffusivity with migraine severity and FD of SN. DTI metrics of bilateral anterior hypothalamus positively correlated with the mean attack duration. Our results show plastic structural changes in the hypothalamus related to the attacks severity and the functional connectivity of the SN involved in the multidimensional neurocognitive processing of pain. Plastic changes to the hypothalamus may play a role in modulating the duration of the attack.
AB - The role of the hypothalamus and the limbic system at the onset of a migraine attack has recently received significant interest. We analyzed diffusion tensor imaging (DTI) parameters of the entire hypothalamus and its subregions in 15 patients during a spontaneous migraine attack and in 20 control subjects. We also estimated the non-linear measure resting-state functional MRI BOLD signal’s complexity using Higuchi fractal dimension (FD) and correlated DTI/fMRI findings with patients’ clinical characteristics. In comparison with healthy controls, patients had significantly altered diffusivity metrics within the hypothalamus, mainly in posterior ROIs, and higher FD values in the salience network (SN). We observed a positive correlation of the hypothalamic axial diffusivity with migraine severity and FD of SN. DTI metrics of bilateral anterior hypothalamus positively correlated with the mean attack duration. Our results show plastic structural changes in the hypothalamus related to the attacks severity and the functional connectivity of the SN involved in the multidimensional neurocognitive processing of pain. Plastic changes to the hypothalamus may play a role in modulating the duration of the attack.
KW - resting-state networks (RSN)
KW - fractal dimension (FD)
KW - migraine ictal
KW - hypothalamus
KW - diffusion tensor imaging (DTI)
UR - https://www.mdpi.com/1422-0067/23/21/13238
UR - http://www.scopus.com/inward/record.url?scp=85141589306&partnerID=8YFLogxK
U2 - 10.3390/ijms232113238
DO - 10.3390/ijms232113238
M3 - Article
SN - 1661-6596
VL - 23
JO - International Journal of Molecular Sciences
JF - International Journal of Molecular Sciences
IS - 21
M1 - 13238
ER -