A Longitudinal Correlational Study of Psychological Resilience, Depression Disorder, and Brain Functional–Structural Hybrid Connectome in Breast Cancer

Mu Zi Liang; Jin Zhou; Peng Chen; Ya Lan Song; Shu Han Li; Yu Yan Liang; Guang Yun Hu; Qu Hu; Zhe Sun; Yuan Liang Yu; Alex Molassiotis; M. Tish Knobf; Zeng Jie Ye

doi:10.1155/2024/9294268

A Longitudinal Correlational Study of Psychological Resilience, Depression Disorder, and Brain Functional–Structural Hybrid Connectome in Breast Cancer

Mu Zi Liang
, Jin Zhou
, Peng Chen
, Ya Lan Song
, Shu Han Li
, Yu Yan Liang
, Guang Yun Hu
, Qu Hu
, Zhe Sun
, Yuan Liang Yu
, Alex Molassiotis
, M. Tish Knobf^*
, Zeng Jie Ye^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

4 Citations (Scopus)

Abstract

Purposes: To evaluate the association between psychological resilience, depression disorder (DD), and brain functional–structural hybrid connectome in patients with breast cancer before treatment (T0) and at 1 year.

Methods: Between February 2017 and October 2019, 172 patients were longitudinally enrolled from a multicenter trial named as Be Resilient to Breast Cancer (BRBC) and completed resting-state functional magnetic resonance imaging (rs-fMRI) and diffusion tensor imaging (DTI) before the T0. Data-driven multivoxel pattern analysis (MVPA) and correlational tractography (CT) were performed to identify distinct functional-structural hybrid connectome. DD was diagnosed by psychiatry physicians according to Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5). Psychological resilience was collected by Resilience Scale Specific to Cancer (RS-SC) and tested as the mediation variable between hybrid connectome and DD.

Results: Of the total sample of 172, 14.5% (N = 25) were diagnosed with DD. High psychological resilience was associated with a lower risk of DD (hazard ratio (HR) = 0.37, 95% confidence interval (CI), 0.17–0.82, p = 0.0368). Frontal pole right (88.0%) in rs-fMRI and arcuate fasciculus_L (75.2%) in DTI were identified as main significant brain areas. Psychological resilience accounted for 10.01%–12.14% of direct effect between brain functional–structural hybrid connectome and 1-year DD.

Conclusion: Psychological resilience predicts DD at 1 year and mediates the association between brain functional–structural hybrid connectome and DD at 1 year in patients diagnosed with breast cancer. Trial Registration: ClinicalTrials.gov identifier: NCT03026374.

Original language	English
Article number	9294268
Number of pages	11
Journal	Depression and Anxiety
Volume	2024
Issue number	1
DOIs	https://doi.org/10.1155/2024/9294268
Publication status	Published - 17 Nov 2024

Bibliographical note

Copyright © 2024 Mu Zi Liang et al.
Open Access, CC BY - https://creativecommons.org/licenses/by/4.0/

Data Access Statement

The data that support the findings of this study are available on request from the corresponding author. The data are not publicly available due to privacy or ethical restrictions.

Funding

This research was funded by grants from National Natural Science Foundation of China (10.13039/501100001809) (Grant 72274043, 71904033), Young Elite Scientists Sponsorship Program by CACM (Grant 2021-QNRC2-B08), and Sanming Project of Medicine in Shenzhen (Grant SZZYSM202206014).

Keywords

Be Resilient to Breast Cancer
brain functional–structural hybrid connectome
breast cancer
depression disorder
psychological resilience

Access to Document

10.1155/2024/9294268

Depression and Anxiety - 2024 - Liang - A Longitudinal Correlational Study of Psychological Resilience Depression Disorder
(c) The Authors 2024. Open Access, CC BY - https://creativecommons.org/licenses/by/4.0/
Final published version, 2.89 MBLicence: CC BY 4.0

Cite this

Liang, M. Z., Zhou, J., Chen, P., Song, Y. L., Li, S. H., Liang, Y. Y., Hu, G. Y., Hu, Q., Sun, Z., Yu, Y. L., Molassiotis, A., Knobf, M. T., & Ye, Z. J. (2024). A Longitudinal Correlational Study of Psychological Resilience, Depression Disorder, and Brain Functional–Structural Hybrid Connectome in Breast Cancer. Depression and Anxiety, 2024(1), Article 9294268. https://doi.org/10.1155/2024/9294268

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title = "A Longitudinal Correlational Study of Psychological Resilience, Depression Disorder, and Brain Functional–Structural Hybrid Connectome in Breast Cancer",

abstract = "Purposes: To evaluate the association between psychological resilience, depression disorder (DD), and brain functional–structural hybrid connectome in patients with breast cancer before treatment (T0) and at 1 year. Methods: Between February 2017 and October 2019, 172 patients were longitudinally enrolled from a multicenter trial named as Be Resilient to Breast Cancer (BRBC) and completed resting-state functional magnetic resonance imaging (rs-fMRI) and diffusion tensor imaging (DTI) before the T0. Data-driven multivoxel pattern analysis (MVPA) and correlational tractography (CT) were performed to identify distinct functional-structural hybrid connectome. DD was diagnosed by psychiatry physicians according to Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5). Psychological resilience was collected by Resilience Scale Specific to Cancer (RS-SC) and tested as the mediation variable between hybrid connectome and DD. Results: Of the total sample of 172, 14.5\% (N = 25) were diagnosed with DD. High psychological resilience was associated with a lower risk of DD (hazard ratio (HR) = 0.37, 95\% confidence interval (CI), 0.17–0.82, p = 0.0368). Frontal pole right (88.0\%) in rs-fMRI and arcuate fasciculus\_L (75.2\%) in DTI were identified as main significant brain areas. Psychological resilience accounted for 10.01\%–12.14\% of direct effect between brain functional–structural hybrid connectome and 1-year DD. Conclusion: Psychological resilience predicts DD at 1 year and mediates the association between brain functional–structural hybrid connectome and DD at 1 year in patients diagnosed with breast cancer. Trial Registration: ClinicalTrials.gov identifier: NCT03026374.",

keywords = "Be Resilient to Breast Cancer, brain functional–structural hybrid connectome, breast cancer, depression disorder, psychological resilience",

author = "Liang, \{Mu Zi\} and Jin Zhou and Peng Chen and Song, \{Ya Lan\} and Li, \{Shu Han\} and Liang, \{Yu Yan\} and Hu, \{Guang Yun\} and Qu Hu and Zhe Sun and Yu, \{Yuan Liang\} and Alex Molassiotis and Knobf, \{M. Tish\} and Ye, \{Zeng Jie\}",

note = "Copyright {\textcopyright} 2024 Mu Zi Liang et al. Open Access, CC BY - https://creativecommons.org/licenses/by/4.0/",

year = "2024",

month = nov,

day = "17",

doi = "10.1155/2024/9294268",

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Liang, MZ, Zhou, J, Chen, P, Song, YL, Li, SH, Liang, YY, Hu, GY, Hu, Q, Sun, Z, Yu, YL, Molassiotis, A, Knobf, MT & Ye, ZJ 2024, 'A Longitudinal Correlational Study of Psychological Resilience, Depression Disorder, and Brain Functional–Structural Hybrid Connectome in Breast Cancer', Depression and Anxiety, vol. 2024, no. 1, 9294268. https://doi.org/10.1155/2024/9294268

TY - JOUR

T1 - A Longitudinal Correlational Study of Psychological Resilience, Depression Disorder, and Brain Functional–Structural Hybrid Connectome in Breast Cancer

AU - Liang, Mu Zi

AU - Zhou, Jin

AU - Chen, Peng

AU - Song, Ya Lan

AU - Li, Shu Han

AU - Liang, Yu Yan

AU - Hu, Guang Yun

AU - Hu, Qu

AU - Sun, Zhe

AU - Yu, Yuan Liang

AU - Molassiotis, Alex

AU - Knobf, M. Tish

AU - Ye, Zeng Jie

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N2 - Purposes: To evaluate the association between psychological resilience, depression disorder (DD), and brain functional–structural hybrid connectome in patients with breast cancer before treatment (T0) and at 1 year. Methods: Between February 2017 and October 2019, 172 patients were longitudinally enrolled from a multicenter trial named as Be Resilient to Breast Cancer (BRBC) and completed resting-state functional magnetic resonance imaging (rs-fMRI) and diffusion tensor imaging (DTI) before the T0. Data-driven multivoxel pattern analysis (MVPA) and correlational tractography (CT) were performed to identify distinct functional-structural hybrid connectome. DD was diagnosed by psychiatry physicians according to Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5). Psychological resilience was collected by Resilience Scale Specific to Cancer (RS-SC) and tested as the mediation variable between hybrid connectome and DD. Results: Of the total sample of 172, 14.5% (N = 25) were diagnosed with DD. High psychological resilience was associated with a lower risk of DD (hazard ratio (HR) = 0.37, 95% confidence interval (CI), 0.17–0.82, p = 0.0368). Frontal pole right (88.0%) in rs-fMRI and arcuate fasciculus_L (75.2%) in DTI were identified as main significant brain areas. Psychological resilience accounted for 10.01%–12.14% of direct effect between brain functional–structural hybrid connectome and 1-year DD. Conclusion: Psychological resilience predicts DD at 1 year and mediates the association between brain functional–structural hybrid connectome and DD at 1 year in patients diagnosed with breast cancer. Trial Registration: ClinicalTrials.gov identifier: NCT03026374.

AB - Purposes: To evaluate the association between psychological resilience, depression disorder (DD), and brain functional–structural hybrid connectome in patients with breast cancer before treatment (T0) and at 1 year. Methods: Between February 2017 and October 2019, 172 patients were longitudinally enrolled from a multicenter trial named as Be Resilient to Breast Cancer (BRBC) and completed resting-state functional magnetic resonance imaging (rs-fMRI) and diffusion tensor imaging (DTI) before the T0. Data-driven multivoxel pattern analysis (MVPA) and correlational tractography (CT) were performed to identify distinct functional-structural hybrid connectome. DD was diagnosed by psychiatry physicians according to Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5). Psychological resilience was collected by Resilience Scale Specific to Cancer (RS-SC) and tested as the mediation variable between hybrid connectome and DD. Results: Of the total sample of 172, 14.5% (N = 25) were diagnosed with DD. High psychological resilience was associated with a lower risk of DD (hazard ratio (HR) = 0.37, 95% confidence interval (CI), 0.17–0.82, p = 0.0368). Frontal pole right (88.0%) in rs-fMRI and arcuate fasciculus_L (75.2%) in DTI were identified as main significant brain areas. Psychological resilience accounted for 10.01%–12.14% of direct effect between brain functional–structural hybrid connectome and 1-year DD. Conclusion: Psychological resilience predicts DD at 1 year and mediates the association between brain functional–structural hybrid connectome and DD at 1 year in patients diagnosed with breast cancer. Trial Registration: ClinicalTrials.gov identifier: NCT03026374.

KW - Be Resilient to Breast Cancer

KW - brain functional–structural hybrid connectome

KW - breast cancer

KW - depression disorder

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DO - 10.1155/2024/9294268

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VL - 2024

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ER -

A Longitudinal Correlational Study of Psychological Resilience, Depression Disorder, and Brain Functional–Structural Hybrid Connectome in Breast Cancer

Abstract

Bibliographical note

Data Access Statement

Funding

Keywords

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