A Mahalanobis distance based approach towards the reliable detection of geriatric depression symptoms co-existing with cognitive decline

Christos A. Frantzidis*, Maria D. Diamantoudi, Eirini Grigoriadou, Anastasia Semertzidou, Antonis Billis, Evdokimos Konstantinidis, Manousos A. Klados, Ana B. Vivas, Charalampos Bratsas, Magda Tsolaki, Constantinos Pappas, Panagiotis D. Bamidis

*Corresponding author for this work

Research output: Chapter in Book/Published conference outputConference publication

Abstract

Geriatric depression is a highly frequent medical condition that influences independent living and social life of senior citizens. It also affects their medical condition due to reduced commitment to the appropriate treatment. Coexistence of depressive symptoms in Mild Cognitive Impairment (MCI) and lack of objective tools towards their reliable distinction from neurodegeneration, motivated this study to propose a computerized approach of depression recognition. Resting state electroencephalographic data of both rhythmic activity and synchronization features were extracted and the Mahalanobis Distance (MD) classifier was adopted in order to differentiate 33 depressive patients from an equal number of age-matched controls. Both groups demonstrated cognitive decline within the context of MCI. The promising results (89.39% overall classification accuracy, 93.94% sensitivity and 84.85% specificity) imply that combination of neurophysiological (EEG) and neuropsychological tools with pattern recognition techniques may provide an integrative diagnosis of geriatric depression with high accuracy.

Original languageEnglish
Title of host publicationArtificial Intelligence Applications and Innovations - AIAI 2012 International Workshops
Subtitle of host publicationAIAB, AIeIA, CISE, COPA, IIVC, ISQL, MHDW, and WADTMB, Proceedings
Pages16-25
Number of pages10
Volume382 AICT
EditionPART 2
DOIs
Publication statusPublished - 2012
Event8th International Workshop on Artificial Intelligence Applications and Innovations, AIAI 2012: AIAB, AIeIA, CISE, COPA, IIVC, ISQL, MHDW, and WADTMB - Halkidiki, Greece
Duration: 27 Sep 201230 Sep 2012

Publication series

NameIFIP Advances in Information and Communication Technology
NumberPART 2
Volume382 AICT
ISSN (Print)1868-4238

Conference

Conference8th International Workshop on Artificial Intelligence Applications and Innovations, AIAI 2012: AIAB, AIeIA, CISE, COPA, IIVC, ISQL, MHDW, and WADTMB
CountryGreece
CityHalkidiki
Period27/09/1230/09/12

Keywords

  • Electroencephalography
  • Geriatric Depression
  • Mahalanobis Distance Classifier
  • Mild Cognitive Impairment
  • Neuropsychological Estimation
  • Wavelet Entropy

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