Abstract: The article describes a multiparametric approach to the assessment of cutaneous microcirculation in dermatological patients (using the example of psoriasis patients). The multiparametric diagnostic approach consisted of three stages of successive measurements performed according to the methodology of laser speckle contrast imaging (LSCI), laser Doppler flowmetry (LDF), and videocapillaroscopy (VCS). Experimental studies on hemodynamic parameters were conducted in psoriatic patients with a course of conservative treatment. A combined application of optical noninvasive diagnostic methods allowed physicians to record changes taking place in the microcirculatory bed during treatment. It has been found that microcirculatory disorders observed before the start of treatment in the field of psoriatic plaques (an increase in the density of the capillary network, an increase in the indicator of microcirculation, nutritive blood flow and the amplitudes of myogenic and cardiac oscillations) were normalized due to the applied treatment, on which the assessment of its efficacy may be based. The suggested approach may be used for diagnosing microcirculatory disorders emerging in psoriasis in its preclinical stage, as well as for developing and testing new pharmacological means for its treatment.
|Number of pages||9|
|Publication status||Published - 16 Dec 2021|
Bibliographical noteFunding Information:
The study was supported by the Russian Foundation for Basic Research (RFBR), project no. 19-32-50007. V.V. Dremin kindly acknowledges personal support from the European Union’s Horizon 2020 research and innovation program under the Marie Skłodowska-Curie grant agreement No. 839888.
© 2021, Pleiades Publishing, Inc.
- blood microcirculation
- laser Doppler flowmetry
- laser speckle contrast imaging
- noninvasive diagnostics