A novel purine analogue bearing nitrate ester prevents platelet activation by ROCK activity inhibition

Keyphrases

• Activity Inhibition 100%
• Adenosine 33%
• ADP Receptor Antagonists 33%
• Anti-inflammatory Effect 33%
• Antiplatelet Activity 33%
• Blockage 33%
• CGMP Signaling 33%
• Collagen Receptor 33%
• Drug Development 33%
• Ester Group 33%
• Functional Response 33%
• Ischemic Stroke 33%
• Kinase Activity 100%
• Molecular Mechanism 33%
• Myocardial Infarction 33%
• Myocardial Ischemia 33%
• Myosin Phosphatase Target Subunit 1 33%
• Nitrate Esters 100%
• Nitric Oxide 66%
• Observed Effects 33%
• Pharmacological Mechanism 33%
• Phosphorylation 33%
• Platelet Activation 100%
• Platelet Physiology 33%
• Platelets 66%
• Purine 33%
• Purine Analogues 100%
• Purinergic Receptors 33%
• Receptor Agonist 66%
• Rho Kinase 100%
• Signaling System 33%
• Thrombin Receptor 33%
• Thrombotic Events 33%
• Thromboxane A2 Receptor 33%

Pharmacology, Toxicology and Pharmaceutical Science

• Adenosine 25%
• Adenosine Diphosphate 50%
• Adenosine Triphosphate 25%
• Antiinflammatory Activity 25%
• Antiplatelet 25%
• Brain Ischemia 25%
• Collagen Receptor 25%
• Drug Development 25%
• Heart Infarction 25%
• Nitric Oxide 50%
• Phosphatase 25%
• Purine 100%
• Purine Derivative 100%
• Purinergic Receptor 25%
• Receptor Agonist 50%
• Receptor Antagonist 25%
• Rho Kinase 100%
• Thrombin Receptor 25%
• Thromboxane A2 Receptor 25%